Results for 'sonic hedgehog'

387 found
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  1.  17
    Sonic Hedgehog as a mediator of long‐range signaling.John A. Goetz, Liza M. Suber, Xin Zeng & David J. Robbins - 2002 - Bioessays 24 (2):157-165.
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  2.  7
    More to patterning than Sonic hedgehog.Mary Elizabeth Pownall - 1994 - Bioessays 16 (6):381-383.
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  3.  14
    Sonic the Hedgehog: A game about aging? Emerging evidence for anti‐geriatric effects of Hedgehog signaling (retrospective on DOI 10.1002/bies.201200049). [REVIEW]Matthias Lauth - 2014 - Bioessays 36 (12):1128-1128.
  4. From Airline Reservations to Sonic the Hedgehog: A History of the Software Industry.D. Wood - 2003 - Knowledge, Technology & Policy 16 (3):175-176.
     
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  5.  10
    Growth, hedgehog and the price of GAS.José L. Mullor & Ariel Ruiz I. Altaba - 2002 - Bioessays 24 (1):22-26.
    Embryonic development in a given species is orchestrated by genes regulating growth and differentiation in a stereotyped and conserved manner, resulting in embryos of consistent size and shape. Several signaling pathways, including that of Sonic Hedgehog (SHH), have been implicated in these processes. Recent experiments with Gas1 indicate that it may act as a growth-inducing gene, challenging its previous function as a gene specifically involved in growth arrest. Moreover, GAS1, a GPI-linked membrane protein, can bind SHH, suggesting an (...)
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  6.  9
    Midline and laterality defects: Left and right meet in the middle†.Erich Roessler & Maximilian Muenke - 2001 - Bioessays 23 (10):888-900.
    The aim of this review is to summarize some of the recent advances in molecular embryology that help to explain the pathogenesis of holoprosencephaly (HPE), or its related malformation in model organisms, cyclopia, and laterality defects in humans, derived from detailed analysis of similar malformations in animal models. Recently, defects in several developmental pathways including those operated by the Sonic hedgehog and Nodal signaling factors have been implicated as causes of HPE or laterality defects in humans. Here we (...)
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  7.  2
    Cochlear tonotopy from proteins to perception.Robert Fettiplace - 2023 - Bioessays 45 (8):2300058.
    A ubiquitous feature of the auditory organ in amniotes is the longitudinal mapping of neuronal characteristic frequencies (CFs), which increase exponentially with distance along the organ. The exponential tonotopic map reflects variation in hair cell properties according to cochlear location and is thought to stem from concentration gradients in diffusible morphogenic proteins during embryonic development. While in all amniotes the spatial gradient is initiated by sonic hedgehog (SHH), released from the notochord and floorplate, subsequent molecular pathways are not (...)
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  8.  12
    Left‐right asymmetry in vertebrate embryogenesis.Michael Levin - 1997 - Bioessays 19 (4):287-296.
    Embryonic development results in animals whose body plans exhibit a variety of symmetry types. While significant progress has been made in understanding the molecular events underlying the early specification of the antero‐posterior and dorso‐ventral axes, little information has been available regarding the basis for left‐right (LR) differences in animal morphogenesis. Recently however, important advances have been made in uncovering the molecular mechanisms responsible for LR patterning. A number of genes (including well‐known signaling molecules such as Sonic hedgehog and (...)
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  9.  9
    Left‐right asymmetry in vertebrate embryogenesis.Michael Levin - 1997 - Bioessays 19 (4):287-296.
    Embryonic development results in animals whose body plans exhibit a variety of symmetry types. While significant progress has been made in understanding the molecular events underlying the early specification of the antero‐posterior and dorso‐ventral axes, little information has been available regarding the basis for left‐right (LR) differences in animal morphogenesis. Recently however, important advances have been made in uncovering the molecular mechanisms responsible for LR patterning. A number of genes (including well‐known signaling molecules such as Sonic hedgehog and (...)
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  10.  9
    Epigenetic factors and midbrain dopaminergic neurone development.Carla Perrone-Capano & Umberto di Porzio - 1996 - Bioessays 18 (10):817-824.
    In the mammalian brain dopamine systems play a central role in the control of movement, hormone release, emotional balance and reward. Alteration of dopaminergic neurotransmission is involved in Parkinson's disease and other movement disorders, as well as in some psychotic syndromes. This review summarises recent findings, which shed some light on signals and cellular interactions involved in the specification and maturation of the dopaminergic function during neurogenesis. In particular we will focus on three major issues: (1) the differentiation of dopaminergic (...)
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  11.  19
    Emerging mechanisms in morphogen‐mediated axon guidance.Cristina Sánchez-Camacho & Paola Bovolenta - 2009 - Bioessays 31 (10):1013-1025.
    Early in animal development, gradients of secreted morphogenic molecules, such as Sonic hedgehog (Shh), Wnt and TGFβ/Bmp family members, regulate cell proliferation and determine the fate and phenotype of the target cells by activating well‐characterized signalling pathways, which ultimately control gene transcription. Shh, Wnt and TGFβ/Bmp signalling also play an important and evolutionary conserved role in neural circuit assembly. They regulate neuronal polarization, axon and dendrite development and synaptogenesis, processes that require rapid and local changes in cytoskeletal organization (...)
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  12.  9
    Mechanics as a Means of Information Propagation in Development.Miriam A. Genuth & Scott A. Holley - 2020 - Bioessays 42 (11):2000121.
    New research demonstrates that mechanics can serve as a means of information propagation in developing embryos. Historically, the study of embryonic development has had a dichotomy between morphogens and pattern formation on the one hand and morphogenesis and mechanics on the other. Secreted signals are the preeminent means of information propagation between cells and used to control cell fate, while physical forces act downstream or in parallel to shape tissue morphogenesis. However, recent work has blurred this division of function by (...)
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  13.  20
    The hedgehog, the fox and the magister's pox: mending the gap between science and the humanities.Stephen Jay Gould - 2003 - London: Jonathan Cape.
    The Hedgehog, the Fox, and the Magister's Pox is a controversial discourse, rich with facts and observations gathered by one of the most erudite minds of our ...
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  14.  67
    The Hedgehog and the Fox: An Essay on Tolstoy's View of History.Isaiah Berlin - 1966 - Weidenfeld & Nicolson.
    ¿The fox knows many things, but the hedgehog knows one big thing.¿ This fragment of Archilochus, which gives this book its title, describes the central thesis of Isaiah Berlin¿s masterly essay on Tolstoy. There have been various interpretations of Archilochus¿ fragment; Isaiah Berlin has simply used it, without implying anything about the true meaning of the words, to outline a fundamental distinction that exists in mankind, between those who are fascinated by the infinite variety of things (foxes) and those (...)
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  15.  44
    Hedgehog signalling as an antagonist of ageing and its associated diseases.Monireh Dashti, Maikel P. Peppelenbosch & Farhad Rezaee - 2012 - Bioessays 34 (10):849-856.
    Hedgehog is an important morphogenic signal that directs pattern formation during embryogenesis, but its activity also remains present through adult life. It is now becoming increasingly clear that during the reproductive phase of life and beyond it continues to direct cell renewal (which is essential to combat the chronic environmental stress to which the body is constantly exposed) and counteracts vascular, osteolytic and sometimes oncological insults to the body. Conversely, down‐regulation of hedgehog signalling is associated with ageing‐related diseases (...)
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  16.  16
    Hedgehog or Fox? An Essay on James Turner Johnson's View of History.Cian O'Driscoll - 2009 - Journal of Military Ethics 8 (3):165-178.
    Drawing on Isaiah Berlin's celebrated essay on Tolstoy, this paper poses the question should James Turner Johnson be deemed a hedgehog or a fox? That is, it considers whether Johnson should be regarded as a monist (hedgehog) or a pluralist (fox) in his contribution to the just war tradition. It contends that his commitment to history, while superficially indicative of a hedgehog, serves to conceal a deep-lying pluralism ? or at least the possibility of such ? in (...)
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  17. The hedgehog and the Borg: Common morality in bioethics.John D. Arras - 2009 - Theoretical Medicine and Bioethics 30 (1):11-30.
    In this commentary, I critically discuss the respective views of Gert and Beauchamp–Childress on the nature of so-called common morality and its promise for enriching ethical reflection within the field of bioethics. Although I endorse Beauchamp and Childress’ shift from an emphasis on ethical theory as the source of moral norms to an emphasis on common morality, I question whether rouging up common morality to make it look like some sort of ultimate and universal foundation for morality, untouched by the (...)
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  18. Sonic Pictures.Jason P. Leddington - 2021 - Journal of Aesthetics and Art Criticism 79 (3):354-365.
    Winning essay of the American Society for Aesthetics' inaugural Peter Kivy Prize. Extends Kivy's notion of sonic picturing through engagement with recent work in philosophy of perception. Argues that sonic pictures are more widespread and more aesthetically and artistically important than even Kivy envisioned. Topics discussed include: the nature of sonic pictures; the nature of sounds; what we can (and more importantly, cannot) conclude from musical listening; sonic pictures in film; beatboxing as an art of (...) picturing; and cover songs as sonic pictures. To be published in the Journal of Aesthetics and Art Criticism. (shrink)
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  19.  8
    Hedgehog lipids: Promotors of alternative morphogen release and signaling?Dominique Manikowski, Kristina Ehring, Fabian Gude, Petra Jakobs, Jurij Froese & Kay Grobe - 2021 - Bioessays 43 (11):2100133.
    Two posttranslational lipid modifications present on all Hedgehog (Hh) morphogens—an N‐terminal palmitate and a C‐terminal cholesterol—are established and essential regulators of Hh biofunction. Yet, for several decades, the question of exactly how both lipids contribute to Hh signaling remained obscure. Recently, cryogenic electron microscopy revealed different modes by which one or both lipids may contribute directly to Hh binding and signaling to its receptor Patched1 (Ptc). Some of these modes demand that the established release factor Dispatched1 (Disp) extracts dual‐lipidated (...)
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  20. The Sonic Effect: Aurality and Digital Networks in Exurbia.David Cecchetto - 2013 - Evental Aesthetics 2 (2):34-62.
    This essay examines the problem of medial specificity in music and sound art, giving particular attention to Seth Kim-Cohen’s call for a non-cochlear sound art based on the notion of “expansion” that has been decisive in visual arts discourses. I argue that Kim-Cohen’s non-cochlear intervention in In the Blink of an Ear might be productively pressured towards the concept of a “sonic effect” that acknowledges the material-discursive particularity of sound without recourse to the phenomenological claims of authenticity that Kim-Cohen (...)
     
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  21.  49
    The hedgehog and the fox – two styles of science.Sunny Auyang - manuscript
    Perhaps Archilochus simply meant that the hedgehog’s single defense defeats the fox’s many tricks. Yet, the hedgehog and the fox were turned into metaphors for two types of thinkers and writers by the historian philosopher Isaiah Berlin. All the thinking and actions of the hedgehog revolve around a single vision and are structured by a single set of principles that the hedgehog holds to be universal. Foxes lack such central vision and universal principles; they seize many (...)
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  22. Sonic art and the nature of sonic events.David Roden - 2010 - Review of Philosophy and Psychology 1 (1):141-156.
    Musicians and theorists such as the radiophonic pioneer Pierre Schaeffer, view the products of new audio technologies as devices whereby the experience of sound can be displaced from its causal origins and achieve new musical or poetic resonances. Accordingly, the listening experience associated with sonic art within this perspective is ‘acousmatic’; the process of sound generation playing no role in the description or understanding of the experience as such. In this paper I shall articulate and defend a position according (...)
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  23.  12
    Sonic enrichment at the zoo.Rébecca Kleinberger - 2023 - Interaction Studies 24 (2):257-288.
    There is a strong disconnect between humans and other species in our societies. Zoos particularly expose this disconnect by displaying the asymmetry between visitors in search of entertainment, and animals often suffering from a lack of meaningful interactions and natural behaviors. In zoos, many species are unable to mate, raise young, or exhibit engagement behaviors. Enrichment is a way to enhance their quality of life, enabling them to express natural behaviors and reducing stereotypies. Prior work on sound-based enrichment and interactivity (...)
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  24. Hedgehogs, foxes and Hart's rule of recognition : the concept of law in the post -Westphalian international legal order.Axelle Reiter - 2012 - In Miodrag A. Jovanović & Bojan Spaić (eds.), Jurisprudence and political philosophy in the 21st century: reassessing legacies. Frankfurt am Main: Peter Lang.
     
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  25.  37
    Sonic Persuasion: Reading Sound in the Recorded Age by Greg Goodale (review).Byron Hawk - 2014 - Philosophy and Rhetoric 47 (2):219-226.
    Sonic Persuasion is predominantly a history of sound in twentieth-century American culture that offers examples of how sound functions argumentatively in specific historical contexts. Goodale argues that sound can be read or interpreted in a manner similar to words and images but that the field of communication has largely neglected sound and its relationship to words and images. He shows how dialect, accents, and intonations in presidential speeches; ticking clocks, rumbling locomotives, and machinic hums in literary texts; and the (...)
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  26. Justice for hedgehogs.Ronald Dworkin - 2011 - Cambridge, Mass.: Belknap Press of Harvard University Press.
    Baedeker -- Independence. Truth in morals -- External skepticism -- Morals and causes -- Internal skepticism -- Interpretation. Moral responsibility -- Interpretation in general -- Conceptual interpretation -- Ethics. Dignity -- Free will and responsibility -- Morality. From dignity to morality -- Aid -- Harm -- Obligations -- Politics. Political rights and concepts -- Equality -- Liberty -- Democracy -- Law -- Epilogue. Dignity indivisible.
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  27.  10
    Sonic flux: sound, art, and metaphysics.Christoph Cox - 2018 - London: University of Chicago Press.
    From Edison’s invention of the phonograph through contemporary field recording and sound installation, artists have become attracted to those domains against which music has always defined itself: noise, silence, and environmental sound. Christoph Cox argues that these developments in the sonic arts are not only aesthetically but also philosophically significant, revealing sound to be a continuous material flow to which human expressions contribute but which precedes and exceeds those expressions. Cox shows how, over the course of the twentieth and (...)
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  28.  28
    Sonic Environments as Systems of Places: A Critical Reading of Husserl’s Thing and Space.Martin Nitsche - 2021 - Open Philosophy 4 (1):136-148.
    This article offers a thorough and critical reading of Husserl’s Thing and Space. This reading is principally motivated by the effort to methodologically design a phenomenological–topological approach to the research of lived sonic environments. In this book, Husserl lays foundations of phenomenological topology by understanding perceptions as places and defining, consequently, the space as a system of places. The critical reading starts with pointing out the ambiguity of location in Thing and Space, which consists mainly in the insufficient implementation (...)
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  29.  36
    Greased hedgehogs: New links between hedgehog signaling and cholesterol metabolism.Rainer Breitling - 2007 - Bioessays 29 (11):1085-1094.
    The close link between signaling by the developmental regulators of the Hedgehog family and cholesterol biochemistry has been known for some time. The morphogen is covalently attached to cholesterol in a peculiar autocatalytic reaction and embryonal disruption of cholesterol synthesis leads to malformations that mimic Hh signaling defects. Recently, it was furthermore shown that secreted Hh could hitchhike on lipoprotein particles to establish its morphogenic gradient in the developing embryo. Additionally, there is new evidence that the Hh‐receptor Patched transmits (...)
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  30.  14
    The Hedgehog that Therefore He Was: On Rorty Again.Ramón del Castillo - 2014 - Journal of Philosophical Research 39:421-437.
    In this paper I take Rorty’s self-description as a “hedgehog” as the starting point for a portrait of his intellectual temperament. I re-examine in the first instance Isaiah Berlin’s contrast between hedgehogs and foxes as inspired by the proverb of Archilocus. I then analyze, in philosophical terms, some differences between foxes and hedgehogs. I distinguish different types of hedgehogs in order to make clear exactly what kind of hedgehog Rorty was. In spite of his multiple interests and conversations, (...)
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  31.  11
    Hedgehog: an unusual signal transducer.Maarten F. Bijlsma, C. Arnold Spek & Maikel P. Peppelenbosch - 2004 - Bioessays 26 (4):387-394.
    Hedgehog proteins are of pivotal importance for development and maintenance of tissue patterns in adult organisms. Despite the role of Hedgehogs in differentiation and tumorigenesis, signal transduction of Hedgehog remains a relatively uncharted area of signalling biochemistry. For proper Hedgehog distribution into tissues, two highly unusual covalent modifications are necessary, palmitoylation of a secreted protein and the attachment of a cholesterol group, making Hedgehog the only established sterolated protein in nature. Hedgehog exerts its function via (...)
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  32.  39
    Sparrows, hedgehogs and castrati: reflections on gender and enhancement.John Harris - 2011 - Journal of Medical Ethics 37 (5):262-266.
    In a number of papers, including the one published in this journal, Robert Sparrow has mounted attacks on consequentialism using principally what he takes to be an important fact, which he believes constitutes a reductio ad absurdum of consequentialism in its many forms and of this author's approach to enhancement and disability in particular (see page 276). This fact is the current longer life expectancy of women when compared with men. Here the author argues that Sparrow's arguments and entire approach (...)
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  33.  6
    Hedgehog or fox? Hayek and the idea of plan-coordination.Israel M. Kirzner - 1999 - Journal des Economistes Et des Etudes Humaines 9 (2-3):217-238.
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  34.  16
    Sonic Histories: Reckoning with Race through Campus Soundscapes.Tyler Kinnear, Robert Hunt Ferguson & Jessica M. Hayden - 2023 - Environment, Space, Place 15 (1):32-65.
    The sounds of the college campus raise important questions of participation, identity, privilege, disability, and marginalization. During the 2019–2020 academic year, three university instructors from distinct disciplines (music, history, and political science) and a student research assistant (history) used sound as a method for inquiring into contested and erased sites on the campus of Western Carolina University, a regional comprehensive university located in the southeastern United States. The project came to be called Sonic Histories. Paid student volunteers were led (...)
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  35.  18
    The Hedgehog and the Fox: An Essay on Tolstoy's View of History.Patrick Gardiner - 1955 - Philosophy 30 (114):279-282.
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  36.  17
    The sonic framing of place: Microsociology, urban atmospheres and quiet hour shopping.Eduardo de la Fuente & Michael James Walsh - 2022 - Thesis Eleven 172 (1):131-149.
    In this article we examine the sonic framing of place. Our theoretical approach combines Goffman’s microsociology (and its sociology of music/sound studies off-shoots) with an account of sound in the urban atmospheres literature. Drawing on the work of French urban sociologist Jean-Paul Thibaud and associated work on sound in urban environments by the CRESSON research centre, we propose that sound frames activity in particular ways, including by infusing self and space with a certain tone, and by rendering places more (...)
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  37.  21
    Sonic and ultrasonic equal-loudness contours.John F. Corso & Murray Levine - 1965 - Journal of Experimental Psychology 70 (4):412.
  38.  85
    Sonic Cyberfeminisms, Perceptual Coding and Phonographic Compression.Robin James - 2021 - Feminist Review 127 (1):20-34.
    I argue that sound-centric scholarship can be of use to feminist theorists if and only if it begins from a non-ideal theory of sound; this article develops such a theory. To do this, I first develop more fully my claim that perceptual coding was a good metaphor for the ways that neoliberal market logics (re)produce relations of domination and subordination, such as white supremacist patriarchy. Because it was developed to facilitate the enclosure of the audio bandwidth, perceptual coding is especially (...)
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  39.  5
    The Hedgehog and the Fox: An Essay on Tolstoy’s View of History - Second Edition.Isaiah Berlin - 2013 - Princeton University Press.
    "The fox knows many things, but the hedgehog knows one big thing." This ancient Greek aphorism, preserved in a fragment from the poet Archilochus, describes the central thesis of Isaiah Berlin's masterly essay on Leo Tolstoy and the philosophy of history, the subject of the epilogue to War and Peace. Although there have been many interpretations of the adage, Berlin uses it to mark a fundamental distinction between human beings who are fascinated by the infinite variety of things and (...)
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  40.  5
    Sonic time machines: explicit sound, sirenic voices, and implicit sonicity.Wolfgang Ernst - 2016 - Amsterdam: Amsterdam University Press.
    Our studies of aesthetics and knowledge have long tended to privilege the visual - at the expense, Wolfgang Ernst argues, of the aural. 'Sonic Time Machines' aims to correct that, presenting a striking new approach to theorising sound that investigates its split existence: as a temporal effect in a techno-cultural context and as a source of knowledge and information. Ernst creates a new term for the concept at the heart of the book, "sonicity," a flexible and powerful term that (...)
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  41.  5
    Sonic Maps: On the Acoustic (Trans)Formation of Urban Space in Straight Outta Compton (2015) and Grand Theft Auto.Martin Butler - 2020 - Avant: Trends in Interdisciplinary Studies 11 (3).
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  42.  10
    Sonic Becomings: Rhythmic Encounters in Interspecies Improvisation.Louisa Collenberg - 2021 - Open Philosophy 4 (1):224-230.
    David Rothenberg, a philosophy professor and Jazz musician, has been improvising with nonhuman animals for years, among his playing partners are birds and whales, known to be territorial animals. As Deleuze and Guattari propose that the origin of art is precisely the territorialising animal and more a function of nature than a specifically human cultural achievement, their concept of territory and rhythm offers a non-anthropocentric way of looking at these encounters. Rothenberg’s sonic experiments in resonance and interspecies interaction do (...)
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  43.  5
    Sonic Interaction Design.Karmen Franinovic & Stefania Serafin (eds.) - 2013 - MIT Press.
    This book offers an overview of the emerging SID research, discussing theories, methods, and practices, with a focus on the multisensory aspects of sonic experience.
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  44.  10
    Sonic soma: sound, body and the origins of the alphabet.Elise Kermani - 2009 - New York: Atropos Press.
    Kermani traces the history of mankind from the origins of society and language to the present, and un-mutes the silence that resulted from the moment man began to write his history instead of listening to history's story.
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  45.  8
    hedgehog and wing development in Drosophila: a morphogen at work?Michel Vervoort - 2000 - Bioessays 22 (5):460-468.
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  46. Sonic Booms in Blanchot.David Appelbaum - 2018 - Angelaki 23 (3):144-157.
    Blanchot’s rejection of vision as the fundamental philosophical metaphor is well known: “Seeing is not speaking” (The Infinite Conversation (Minneapolis: U of Minnesota P, 1993) 25). Furthermore, his central idea of the limit-experience (borrowed from Bataille) is a “detour from everything visible and invisible” (210). As part of his Heideggerian heritage, the increased importance of hearing (and aurality in general) lacks the critical appraisal it deserves. Pari passu for voice. Blanchot’s investigation of voice, spoken, interior, literary, is extensive. Various works (...)
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  47.  35
    Sonic Warfare: Sound, Affect, and the Ecology of Fear.Steve Goodman - 2009 - MIT Press.
    An exploration of the production, transmission, and mutation of affective tonality—when sound helps produce a bad vibe.
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  48.  33
    Sonic Liminality: Soundscapes, Semiotics, and Ecologies of Meaning.Jonathan Beever - 2020 - Biosemiotics 13 (1):77-88.
    The spaces between the modernist categories of human and nonhuman, or nature and culture, are collapsing in the Anthropocene. As human technological influence continues become evidenced as a global geologic force, ‘liminal spaces’ expand. Liminal spaces are spaces at the intersections and aggregations of human- and nonhuman-animal umwelten mediated by technology. Soundscapes, the collection of human and nonhuman created sounds of a particular place and time, give us unique access to the semiotic exchanges that constitute those spaces. Soundscape ecology, the (...)
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  49. Sonic forms of capture.Terri Bird - 2019 - In Paulo de Assis & Paolo Giudici (eds.), Aberrant nuptials: Deleuze and artistic research 2. Leuven University Press.
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  50.  31
    On Hedgehogs and Foxes.Jonathan Gorman - 1999 - Philosophical Inquiry 21 (1):61-86.
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