Vacuolar ATPases (V‐ATPases, V1Vo‐ATPases) are rotary motor proton pumps that acidify intracellular compartments, and, when localized to the plasma membrane, the extracellular space. V‐ATPase is regulated by a unique process referred to as reversible disassembly, wherein V1‐ATPase disengages from Vo proton channel in response to diverse environmental signals. Whereas the disassembly step of this process is ATP dependent, the (re)assembly step is not, but requires the action of a heterotrimeric chaperone referred to as the RAVE complex. Recently, an alternative pathway (...) of holoenzyme disassembly was discovered that involves binding of Oxidation Resistance 1 (Oxr1p), a poorly characterized protein implicated in oxidative stress response. Unlike conventional reversible disassembly, which depends on enzyme activity, Oxr1p induced dissociation can occur in absence of ATP. Yeast Oxr1p belongs to the family of TLDc domain containing proteins that are conserved from yeast to mammals, and have been implicated in V‐ATPase function in a variety of tissues. This brief perspective summarizes what we know about the molecular mechanisms governing both reversible (ATP dependent) and Oxr1p driven (ATP independent) V‐ATPase dissociation into autoinhibited V1 and Vo subcomplexes. (shrink)

Stalk‐eyed flies of the family Diopsidae exhibit a unique form of hypercephaly, which has evolved under both natural and sexual selection. Male hypercephaly is used by female diopsids as an indicator of male quality. By choosing to mate with males expressing the most‐exaggerated hypercephaly, females can benefit both from the enhanced fertility of these males and the transmission of other heritable advantages to their offspring. Stalk‐eyed flies are close relatives of the model organism, Drosophila melanogaster. We have shown (...) that similar genetic and cellular mechanisms regulate the initial development of the head capsule in fruitflies and diopsids. The great diversity of stalk‐eyed fly species, exhibiting varying degrees of hypercephaly and sexual dimorphism, constitutes a major advantage for comparative studies of their development and evolution. BioEssays 29: 300–307, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

In his exciting and original view of the universe, Itzhak Bentov has provided a new perspective on human consciousness and its limitless possibilities. Widely known and loved for his delightful humor and imagination, Bentov explains the familiar world of phenomena with perceptions that are as lucid as they are thrilling. He gives us a provocative picture of ourselves in an expanded, conscious, holistic universe. _.

This paper adds to our understandings of women’s post-separation experiences of coercive control through the introduction of a new concept—custody stalking. It is defined as a malevolent course of conduct involving fathers’ use of custody and/or child protection proceedings to overturn historic patterns of care for children. The experience of custody stalking is explored through three composite narratives derived from twelve mothers who participated in an exploratory, qualitative study on the involuntary loss of maternal care time following separation. The losses (...) suffered caused these mothers tremendous grief, damaged their psychological wellbeing and had a detrimental effect on their mothering relationships. Yet custody stalking, as a form of malevolent attack, is not well recognised and mothers’ resultant losses are largely culturally invisible. This is in marked contrast to paternal filicides, another form of post-separation avenging attack committed by some fathers that also leads to maternal loss experiences, albeit more absolute. (shrink)

This research takes a retrospective look at modern consumption opportunities of the U.S. poor from both sides of the marketing exchange relationship. The paper opens with a critical assessment of the consumer-behavior literature and its primary focus on middle-class Americans. The next section profiles the impoverished and their purchasing habits and closes with a summary of how both have changed over the last forty years. Then a theoretical account is presented using consumer literature from the same timeframe. The paper ends (...) with a discussion of common business practices and moral dilemmas that have continued over these decades, along with an ethical paradigm involving distributive justice to guide future management tactics. (shrink)

Philosophers of mind, both in the conceptual analysis tradition and in the empirical informed school, have been implicitly neglecting the potential conceptual role of the Peripheral Nervous System (PNS) in understanding sensory and perceptual states. Instead, the philosophical as well as the neuroscientific literature has been assuming that it is the Central Nervous System (CNS) alone, and more exactly the brain, that should prima facie be taken as conceptually and empirically crucial for a philosophical analysis of such states This (...) is the first monograph that focuses on the PNS and its constitutive role in sensory states, including pain, mechanoception, proprioception, tactile perception, and so forth. -/- The author argues that the brain-centeredness of current philosophy of mind is a prejudice, and proposes a series of original ways in which classic puzzles in the philosophy of mind can be solved once the hypothesis that PNS is a constitutive element of mental states is taken seriously. The author calls this “the Peripheral Mind Hypothesis”, and employs it in a vast range of issues, such as functionalism, physicalism, mental content, embodiment, as well as some issues in neuroethics. -/- Making equal use of conceptual analysis, empirical data from neuroscience, first-person phenomenological data, and philosophical speculation, this work offers a fresh look at, and novel solutions to many philosophical problems. (shrink)

It is often said that some kind of peripheral (or inattentional) conscious awareness accompanies our focal (attentional) consciousness. I agree that this is often the case, but clarity is needed on several fronts. In this paper, I lay out four distinct theses on peripheral awareness and show that three of them are true. However, I then argue that a fourth thesis, commonly associated with the so-called "self-representational approach to consciousness," is false. The claim here is that we have (...) outer focal consciousness accompanied often (or even always) by inner peripheral (self-)awareness. My criticisms stem from both methodological and phenomenological considerations. In doing so, I offer a diagnosis as to why the fourth thesis has seemed true to so many and also show how the so-called "transparency of experience," frequently invoked by representationalists, is importantly relevant to my diagnosis. Finally, I respond to several objections and to further attempts to show that thesis four is true. What emerges is that if one wishes to hold that some form of self-awareness accompanies all outer-directed conscious states, one is better off holding that such self-awareness is itself unconscious, as is held for example by standard higher-order theories of consciousness. (shrink)

How making up our minds and the makeup of our minds can help us live better and die better. We live in a climate where feelings trump reason and evidence. Lies are treated as "alternative facts." At the same time, it seems our culture does not want us to treat altered or higher states of consciousness seriously. Focusing both on evidence and on such states of consciousness can reorient our attitudes. Jack Crittenden asks the reader to think about life after (...) death, about the basis of morality and the essence of spirituality, about the meaning of happiness, about the path of dying, and about the proper role of work in our lives and how education connects to that role. What if our memories, thoughts, and whole personality lived on after we died? What if morality were based on reasons and evidence and not on God and sacred texts? What if happiness lies not in what we think, how we feel, and what we long for, but in living in the present and in the dying of the self itself? Experiences of and the evidence on altered and higher states of consciousness can lead us to better lives and better deaths. (shrink)

Takes up Kripke's theory of reference for proper names and natural kind words. Advocates investigation by means of ordinary language examples. Finds the problem for which Kripke's theory is offered as an answer seems to rest on an implausible picture of language.

"A rough spade for a rugged landscape" : on savage selves and more civil places -- "What remains of the harvest when the fence grazes the crop?" : on the proper violence of agrarian citizenship -- "The life of the thief leaves the belly always boiling" : on the nature and restraint of the criminal animal -- "Millets sown yield millets, evil sown yields evil" : on the moral returns of agrarian toil -- "Let the water for the paddy also (...) irrigate the grass" : on the sympathies of an aqueous self. (shrink)

Recent evidence indicates that inhibition of protein translation may be a common pathogenic mechanism for peripheral neuropathy associated with mutant tRNA synthetases (aaRSs). aaRSs are enzymes that ligate amino acids to their cognate tRNA, thus catalyzing the first step of translation. Dominant mutations in five distinct aaRSs cause Charcot‐Marie‐Tooth (CMT) peripheral neuropathy, characterized by length‐dependent degeneration of peripheral motor and sensory axons. Surprisingly, loss of aminoacylation activity is not required for mutant aaRSs to cause CMT. Rather, at (...) least for some mutations, a toxic‐gain‐of‐function mechanism underlies CMT‐aaRS. Interestingly, several mutations in two distinct aaRSs were recently shown to inhibit global protein translation in Drosophila models of CMT‐aaRS, by a mechanism independent of aminoacylation, suggesting inhibition of translation as a common pathogenic mechanism. Future research aimed at elucidating the molecular mechanisms underlying the translation defect induced by CMT‐mutant aaRSs should provide novel insight into the molecular pathogenesis of these incurable diseases. (shrink)

Such activities as tracking, watching, and photographing animals are frequently presented as morally superior alternatives to hunting, but could they themselves be morally problematic? In this paper I argue that, despite certain differences from the stalking of humans, a strong case can be made for the prima facie wrongness of stalking sentient animals. The chief harm of stalking is the fear and altered patterns of behavior which it forces upon its victims.

After thirty years of the current “imagery debate,” it appears far from resolved, even though there seems to be a growing acceptance that a cortical display cannot be identified directly with the experienced mental image, nor can it account for the experimental findings on imagery, at least not without additional ad hoc assumptions. The commentaries on the target article range from the annoyed to the supportive, with a surprising number of the latter. In this response I attempt to correct some (...) misreadings of the target article and discuss some of the ideas and evidence introduced by the commentators – much of which I found helpful, even though they do not alter my basic thesis. I also further develop the idea that the spatial character of images may come from the way they are connected to our immediate or immediately-recalled environment (by attention or by visual indexes) and towards which we may orient while we are imaging, thus leaving the alleged spatial properties of images outside the head and freeing image-representations from having to be displayed on any surface. (shrink)

Much stalking consists in behavior which would normally be permissible; indeed, many stalking behaviors are protected liberties. How, then, does the stalker wrong the victim? I consider and reject different answers as failing to identify the essential wrong of stalking: stalking perpetuates gender oppression; it threatens or coerces, disrespects autonomy, or violates privacy. I argue that the stalker forces a personal relationship on the target and that our interest in being able to refuse such relationships is strong enough to ground (...) a right. It is a benefit if my account changes the standards of which intimacy-seeking behaviors we consider permissible. (shrink)

I have not attempted to provide here an analysis of the methodology of molecular biology or molecular genetics which would demonstrate at what specific points a more reductionist aim would make sense as a research strategy. This, I believe, would require a much deeper analysis of scientific growth than philosophy of science has been able to provide thus far. What I have tried to show is that a straightforward reductionist strategy cannot be said to be follwed in important cases of (...) theory development in molecular biology, and that in at least one important case, the Jacob-Monod operon theory, the methodology followed was more biological than chemical. It should be noted in closing, however, that since biological systems are thought by molecular biologists to be nothing but chemical systems, in the long run detailed investigations of such systems will be in full accord with the dictates suggested by the general reduction model. (shrink)

This article proposes an ecophilosophy of the cinema. It builds on Martin Heidegger’s articulation of art as ‘world-disclosing,’ and on a Whiteheadian and Deleuzian understanding of the universe as a lively and eventful place in which subjects and objects are persistently coming into being, jointly constituted in the process of their becoming. Accordingly, it proposes that cinema be considered a machine that produces or discloses worlds. These worlds are, at once, anthropomorphic, geomorphic, and biomorphic, with each of these registers mapping (...) onto the ‘three ecologies,’ in Felix Guattari’s terms, that make up the relational ontology of the world: the social, the material, and the mental or perceptual. Through an analysis of Andrei Tarkovsky’s Stalker (1979), I suggest that cinema ‘stalks’ the world, and that our appreciation of its potentials should similarly involve a kind of ‘stalking’ of its effects in the material, social, and perceptual dimensions of the world from which cinema emerges and to which it returns. (shrink)

I argue that Husserl’s account of passive synthesis can be developed into a phenomenology of peripheral experience. Peripheral experiences are not defined by their location in visual space but by their phenomenal and intentional character, by what these experiences are like and how they present things in the world. Further, I argue that peripheral experience is of a piece with our most basic background convictions about the world. As such, the periphery is epistemically neutral, but not therefore (...) empty of meaning. It is meaningful as holding open the possibility of further activity, both practical and intellectual. I explore these ideas by focusing on peripheral color experience. Husserl’s discussions of associative synthesis, affection, and doxic and nondoxic forms of attention prove key to detailing peripheral color experience. I end by arguing that at the periphery, intentional content and phenomenal content come apart. (shrink)

This article examines the study of natural history on the imperial periphery in late colonial Spanish America. It considers the problems that afflicted peripheral naturalists—lack of books, instruments, scholarly companionship, and skilled technicians. It discusses how these deprivations impacted upon their self-confidence and credibility as men of science and it examines the strategies adopted by peripheral naturalists to boost their scientific credibility. The article argues that Spanish American savants, deprived of the most up-to-date books and sophisticated instruments, emphasised (...) instead their sustained experience of local nature and their familiarity with indigenous knowledge. It details how some creole naturalists, such as the Mexican José Antonio Alzate, questioned the applicability of European classificatory systems to American fauna and flora, and it analyses the complex relationship between natural science and creole patriotism. (shrink)

While reading philosophical literature, once in a while I come across passages which say that a particular essay or book is very good, and sometimes an additional remark is made that it is neglected. While reading such passages, I say to myself that I should take a look at this essay or book -- but then I forget to do so, or don't remember who or what was mentioned. Well, I have decided to start keeping..

Oersted has been a puzzle for historians of science. Unflatteringly regarded by contemporaries in Britain and France as a metaphysician, he astonished and galvanised the learned world in 1820 with his discovery of electromagnetism. Suddenly famous, he was belatedly honoured; but, like Röntgen with X-rays, did no more serious work on the discovery that brought him renown, leaving that to Ampère and Faraday while he concentrated on an aesthetics that would bridge arts and sciences, and on building up scientific institutions (...) at home in Denmark in the wake of the Napoleonic wars and the British bombardment of Copenhagen. He lived in exciting times under the last absolutist monarchy in western Europe; and as he lay dying, his country was lapsing into civil war over the Schleswig–Holstein question, following the 1848 revolutions all over Europe. Although not geographically remote, Denmark was peripheral as far as science was concerned and was a very small country in which the int .. (shrink)

The present study employed the gaze-contingent window paradigm to investigate parafoveal and peripheral cueing and masking effects on saccadic selectivity in a triple-conjunction visual search task. In the cueing conditions, the information shown outside the gaze-contingent window was restricted to the feature or feature pair shared between the target and a particular distractor type. In the masking conditions, no stimulus features were shown outside the window. Significant cueing and masking effects on saccadic selectivity were observed for saccades directed at (...) items within the window, where all features were visible across experimental conditions. Cueing a particular feature or feature pair biased saccadic selectivity towards this feature or feature pair, while masking generally reduced saccadic selectivity. These findings support the concept of visual guidance being a preattentive process that operates in parallel across the display. © 2001 Published by Elsevier Science Ltd. (shrink)

dickenson briefly mentions that peripheral opioid receptors somehow become active following inflammation and that the appearance of endogenous opioid peptides at the injury site may be related to immune cell proliferation. Recent findings elucidate the underlying mechanisms in more detail and provide an incentive for the development of a novel generation of analgesics devoid of typical central opioid side effects.

Stalking the elusive physicalist thesis Content Type Journal Article Pages 1-5 DOI 10.1007/s11016-011-9528-2 Authors D. Gene Witmer, Department of Philosophy, University of Florida, P. O. Box 118545, Gainesville, FL 32611-8545, USA Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.

This target article examines the clinical and experimental evidence for a role of peripheral and central hyperexcitability in persistent pain in four key areas: cutaneous hyperalgesia, referred pain, neuropathic pain, and postoperative pain. Each suggests that persistent pain depends not only on central sensitization, but also on inputs from damaged peripheral tissue. It is instructive to think of central sensitization as comprised of both an initial central sensitization and an ongoing central sensitization driven by inputs from peripheral (...) sources. Each of these factors, initial sensitization, ongoing central sensitization, and inputs from peripheral sources, contributes to the net activity in dorsal horn neurons and thus influences the expression of persistent pain or hyperalgesia. Since each factor, peripheral inputs and central sensitization (initial or ongoing), can contribute to both the initiation and maintenance of persistent pain, therapies should target both peripheral and central sources of pathology. (shrink)

In "Peripheralities: 'Minor' Literatures, Women's Literature, and Adrienne Orosz de Csicser's Novels" Steven Tötösy de Zepetnek discusses events surrounding Adrienne Orosz de Csicser's work. For the contextualization of the events Tötösy de Zepetnek employs his own framework of "comparative cultural studies" here applied to "minor literatures" and women's literature and Shunqing Cao's "variation theory." While Orosz's novels are not considered exceptional, the author achieved notoriety after locked up in a mental institution. In addition to three published novels, in an unpublished (...) novel Orosz narrates her love affair with a Roman Catholic bishop. Knowledge about her novel's contents resulted in the bishop orchestrating Orosz's commitment to a mental hospital. The context in which Orosz's texts are located in is the socio-political situation in Hungarian society prior to and shortly after the First World War. (shrink)

The ten largest food and beveragecorporations control over half of the food sales inthe United States and their share may be increasing.Using data from a range of secondary sources, weexamine these corporations and their boards ofdirectors. Social and demographic characteristics ofboard members gleaned from corporate reports, thebusiness press, and elsewhere are presented.Information on interlocking corporate directorates andother common ties among members of the boards ofdirectors show that US based food and beveragecorporations are tied together through a web ofindirect interlocks.

The aim of this article is to reclaim social class as a central concern within education, not in the traditional sense as a dimension of educational stratification, but as a powerful and vital aspect of both learner and wider social identities. Drawing on historical and present evidence, a case is made that social inequalities arising from social class have never been adequately addressed within schooling. Recent qualitative research is used to indicate some of the ways in which class is lived (...) in classrooms. The article also raises concerns about the ability of the education system to positively address social class in the classroom when contemporary initial teacher training rarely engages with it as a relevant concern within schooling. (shrink)

This paper seeks to identify the distinctive moral wrong of stalking and argues that this wrong is serious enough to criminalize. We draw on psychological literature about stalking, distinguishing types of stalkers, their pathologies, and victims. The victimology is the basis for claims about what is wrong with stalking. Close attention to the experiences of victims often reveals an obsessive preoccupation with the stalker and what he will do next. The kind of harm this does is best understood in relation (...) to the value of privacy and conventionally protected zones of privacy. We compare anti-stalking laws in different jurisdictions, claiming that they all fail in some way to capture the distinctive privacy violation that stalking involves. Further reflection on the seriousness of the invasion of privacy it represents suggests that it is a deeply personal wrong. Indeed, it is usually more serious than obtrusive surveillance by states, precisely because it is more personal. Where state surveillance genuinely is as intrusive as stalking, it tends to adopt the tactics of the stalker, imposing its presence on the activist victim at every turn. Power dynamics —whether rooted in the power of the state or the violence of a stalker —may exacerbate violations of privacy, but the wrong is distinct from violence, threats of violence and other aggression. Nor is stalking a simple expression of a difference in power between stalker and victim, such as a difference due to gender. (shrink)