Objective: The objectives of this study are to understand the current functions, structure and operation of hospital ethics committees (HECs) in Shanghai and to facilitate their improvement. Methods: (1) A questionnaire survey, (2) interviews with secretaries and (3) on-site document reviews of HECs in Shanghai were used in the study, which surveyed 33 hospitals. Results: In Shanghai, 57.56% of the surveyed hospitals established HECs from 1998 to 2005. Most HECs used bioethical review of research involving human subjects as well (...) as bioethical review or consultation regarding medical care services and administrative decision- making. Of the surveyed HECs, 14.3% did not provide any formal bioethical training to the HECs’ members and many HECs had no standard operating procedures. Some HECs had no clear definition of what was “conflict of interest” that should be considered by the HECs, while 44.4% of the HECs did not perform continuing review. Discussion: After the issues of related national regulations, more and more hospitals established HECs in Shanghai, but the functions of HECs need to be further developed and formal training on bioethics should be provided to HEC members. To assure the independence and good performance of HECs, the conflict of interest procedure, the standard operating procedures and bioethical review should be improved. Conclusion: HECs in Shanghai had developed in the preceding 10 years and they played great roles in protecting the rights and welfare of human subjects and patients; some areas need improvement. (shrink)

In their attempt to connect the workings of the human mind with their neural realizers, cognitive neuroscientists often bracket out individual differences to build a single, abstract model that purportedly represents (almost) every human being’s brain. In this paper I first examine the rationale behind this model, which I call ‘Platonic Brain Model’. Then I argue that it is to be surpassed in favor of multiple models allowing for patterned inter-individual differences. I introduce the debate on legitimate (and illegitimate) ways (...) of mapping neural structures and cognitive functions, endorsing a view according to which function-structure mapping is context-sensitive. Building on the discussion of the ongoing debate on the function(s) of the so-called Fusiform “Face” Area, I show the necessity of indexing function-structure mappings to some populations of subjects, clustered on the basis of factors such as their expertise in a given domain. (shrink)

The human body is a system made of systems. The body is divided into bodily systems proper, such as the endocrine and circulatory systems, which are subdivided into many sub-systems at a variety of levels, whereby all systems and subsystems engage in massive causal interaction with each other and with their surrounding environments. Here we offer an explicit definition of bodily system and provide a framework for understanding their causal interactions. Medical sciences provide at best informal accounts of basic notions (...) such as system, process, and function, and while such informality is acceptable in documentation created for human beings, it falls short of what is needed for computer representations. In our analysis we will accordingly provide the framework for a formal definition of bodily system and of associated notions. (shrink)

This paper claims that how economists actually treat the consumption function, both theoretically and empirically, seems to be at odds with traditional structural realism. While economics aims to find out the way the world actually is, economic theory – including theoretical staples such as the consumption Euler equation – do not always state literal truths. Yet, such methods persist. Our investigation will reveal that the Euler equation is deployed as part of a realist methodology to identify scale-dominant behaviors. These analyses (...) permit the economist to conduct counterfactual reasoning and sometimes (via policy) to intervene on the world itself; the implication is when this is successful, the economist has uncovered real structure. (shrink)

Abstract The tshogs zhing, or field of assembly, is an important subject in Tibetan religious art. Typically, it focuses on one's own guru, seated at the crest of a great tree, with the gurus preceding him ranged in the sky above him and the deities of one's tradition ranged on the tree below him. The tshogs zhing is an object of visualisation in Tibetan guru yoga practices, and serves as both a ?map? of the Tibetan sacred cosmos and as an (...) index of the guru's crucial role in the tradition as a mediator between the practitioner on the one hand and the diachronic lineage of teachers and the synchronie pantheon of deities, on the other. (shrink)

A distinction between different notions of “structure” and “function” is suggested for interpreting the overwhelming amount of data on microbiome structure and function. Sequence data, biochemical agents, interaction networks, taxonomic communities, and their dynamics can be linked to potential or actual biochemical activities, causal roles, and selected effects, respectively. This conceptual clarification has important methodological consequences for how to interpret existing data and approach open questions in contemporary microbiome research practice. In particular, the field will have to start (...) thinking about notions of function more directly. Also see the video abstract here https://youtu.be/j5pq5uGld1k. (shrink)

In this paper functional completeness results are obtained for certain positive and constructive propositional logics associated with a Tarski-type structured consequence relation as defined by Gabbay.

In this paper we present an action-theoretic account of artefact using and designing and describe our ICE-theory of function ascriptions to technical artefacts. By means of this account and theory we analyse the thesis of the dual nature of technical artefacts according to which descriptions of technical artefacts draw on structural and intentional conceptualisations. We show that the ascription of technical functions to technical artefacts can connect the intentional and structural parts of descriptions of artefacts, but also separate these parts. (...) Our conclusion is that the concept of technical functions forms a ‘conceptual drawbridge’ between the intentional and structural natures of technical artefacts.Keywords: Intentional and structural descriptions; Technical artefacts; Function theory; Action theory; Use; Design. (shrink)

One way social scientists explain phenomena is by building structural models. These models are explanatory insofar as they manage to perform a recursive decomposition on an initial multivariate probability distribution, which can be interpreted as a mechanism. Explanations in social sciences share important aspects that have been highlighted in the mechanisms literature. Notably, spelling out the functioning the mechanism gives it explanatory power. Thus social scientists should choose the variables to include in the model on the basis of their function (...) in the mechanism. This paper examines the notion of ‘function’ within structural modelling. We argue that ‘functions’ ought to be understood as the theoretical underpinnings of the causes, namely as the role that causes play in the functioning of the mechanism. (shrink)

This article presents a new framework for the analysis of experimental control. The framework highlights different functions for experimental controls in the realization of an experiment: experimental controls that serve as tests and experimental controls that serve as probes. The approach to experimental control proposed here can illuminate the constitutive role of controls in knowledge production, and it sheds new light on the notion of exploratory experimentation. It also clarifies what can and what cannot be expected from reviewers of scientific (...) journal articles giving feedback on experimental controls. (shrink)

The core structures of d 111 ¢ screw dislocations in bcc metals are studied using density functional theory in the local-density approximation. For Mo and Fe, direct calculations of the core structures show the cores to be symmetric with respect to 180° rotations around an axis perpendicular to the dislocation line. The magnetic moment in the Fe core is shown to be reduced relative to the bulk value. Calculations of n surfaces and the elastic constants B , C ' (...) and c 44 are reported for Fe and all group VB and VIB metals. Using a criterion suggested by Vitek and Duesbery the calculations point to symmetric core structures for all the studied metals. (shrink)

Professor Robinson provides a new critique of the often neglected problem of classification within the criminal law. He presents a discussion of the present conceptual framework of the law, and offers explanations of how and why formal structures do not match the operation of law in practice. In this scholarly exposition of applied criminal theory, Robinson argues that the current operational structure of the criminal law fails to take account of its different functions. He goes on to suggest new (...) sample codes of criminal conduct and criminal adjudication which mark a real departure from the pragmatic approach which presently dominates code-making. This rounded exploration of the structure of systems of criminal law is an important work for law teachers and policy makers world-wide. (shrink)

Professor Robinson provides a new critique of the often neglected problem of classification within the criminal law. He presents a discussion of the present conceptual framework of the law, and offers explanations of how and why formal structures do not match the operation of law in practice. In this scholarly exposition of applied criminal theory, Robinson argues that the current operational structure of the criminal law fails to take account of its different functions. He goes on to suggest new (...) sample codes of criminal conduct and criminal adjudication which mark a real departure from the pragmatic approach which presently dominates code-making. This rounded exploration of the structure of systems of criminal law is an important work for law teachers and policy makers world-wide. (shrink)

This paper considers two recent arguments that structure should not be regarded as the fundamental individuating property of proteins. By clarifying both what it might mean for certain properties to play a fundamental role in a classification scheme and the extent to which structure plays such a role in protein classification, I argue that both arguments are unsound. Because of its robustness, its importance in laboratory practice, and its explanatory centrality, primary structure should be regarded as the (...) fundamental distinguishing characteristic of protein taxonomy. (shrink)

In this work we show that every structure [MATHEMATICAL SCRIPT CAPITAL A] can be expanded to a partial structure [MATHEMATICAL SCRIPT CAPITAL A]* with universal functions for the class of polynomials on [MATHEMATICAL SCRIPT CAPITAL A]*. We can embed [MATHEMATICAL SCRIPT CAPITAL A]* monomorphically in a total structure [MATHEMATICAL SCRIPT CAPITAL A]º that preserves universal functions of [MATHEMATICAL SCRIPT CAPITAL A]* and that is universal among such structures, i.e. [MATHEMATICAL SCRIPT CAPITAL A]º can be homomorphically embedded in (...) every total structure that preserves universal functions of [MATHEMATICAL SCRIPT CAPITAL A]*. Universal functions are the starting point for developing recursion theoretic tools in an [MATHEMATICAL SCRIPT CAPITAL A]* that satisfies some simple additional conditions. (shrink)

The process of assessing executive functions through behavioral observation scales is still under theoretical and empirical construction. This article reports on the analysis of the factorial structure of the EOCL-1 scale that assesses executive functions, as proposed by the theory developed by Luria, which has not been previously considered in this type of evaluation. In this scale, the executive functions taken into account are error correction, internal behavioral and cognition regulatory language, limbic system conscious regulation, decision making, future consideration (...) of consequences of actions, goal-directed behavior, inhibitory control of automatic responses, creation of new behavioral repertoires, and cognitive–behavioral activity verification. A variety of validity and reliability analyses were carried out, with the following results: an adequate internal consistency level of executive functions between α = 0.70 and α = 0.83, significant convergent validity with a scale that assesses frontal deficits between r = −0.07 and r = 0.28, and the scale’s construct validity that proposes a model with an executive central factor comparative fit index = 0.93, root mean square error of approximation = 0.04, standardized root mean square residual = 0.04, and x2 = 789.29, p = 0.001. The findings are discussed based on previous literature reports and in terms of the benefits of using a scale to assess the proposed executive functions. (shrink)

The eukaryotic nucleosome, the basic unit of chromatin, is thermodynamically stable and plays critical roles in the cell, including the maintenance of DNA topology and regulation of gene expression. At its C2 axis of symmetry, the nucleosome exhibits a domain that can coordinate divalent metal ions. This article discusses the roles of the metal‐binding domain in the nucleosome structure, function, and evolution.

The history of biology is mottled with disputes between two distinct approaches to the organic world: structuralism and functionalism. Their persistence across radical theory change makes them difficult to characterize: the characterization must be abstract enough to capture biologists with diverse theoretical commitments, yet not so abstract as to be vacuous. This Element develops a novel account of structuralism and functionalism in terms of explanatory strategies (Section 2). This reveals the possibility of integrating the two strategies; the explanatory successes of (...) evolutionary-developmental biology essentially depend on such integration (Section 3). Neither explanatory strategy is universally subordinate to the other, though subordination with respect to particular explanatory tasks is possible (Section 4). Beyond structuralism and functionalism, philosophical analysis that centers explanatory strategies can illuminate conflicts within evolutionary theory more generally (Section 5). (shrink)

The purpose of this paper is to clarify the relationship between various conditions implying essential undecidability: our main result is that there exists a theory T in which all partially recursive functions are representable, yet T does not interpret Robinson’s theory R. To this end, we borrow tools from model theory — specifically, we investigate model-theoretic properties of the model completion of the empty theory in a language with function symbols. We obtain a certain characterization of ∃∀ theories interpretable in (...) existential theories in the process. (shrink)

This paper approaches the question of how to describe the higher-level internal structures and representations of cognitive systems across various kinds of nonhuman (neuro)cognitive systems. While much research in cognitive (neuro)science and comparative cognition is dedicated to the exploration of the (neuro)cognitive mechanisms and processes with a focus on brain-behavior relations across different non-human species, not much has been done to connect (neuro)cognitive mechanisms and processes and the associated behaviors to plausible higher-level structures and representations of distinct kinds of cognitive (...) systems in non-humans. Although the study of (neuro)cognitive mechanisms and processes can certainly be revealing, (neuro)cognitive mechanisms and processes are underspecified with respect to internal structures and representations of non-human cognitive systems because multiple such mechanisms can target, or be mapped onto, the same internal structure or vice versa. This paper outlines a biosemiotic approach to this linking problem in order to bridge the gap between functions of (neuro)cognitive systems in different species and the higher-level cognitive structures and representations. It is contended that the higher-level internal structures and representations of various cognitive systems are biosemiotic constraints on the (biological) functions of (neuro)cognitive systems that serve to restrict the range of functions (neuro)cognitive systems have or are selected for. This turns out to have implications for issues on the convergent evolution of cognitive traits. (shrink)

Laboratory-based studies of problem solving suggest that transfer of solution principles from an analogue to a target arises only minimally without the presence of directive hints. Recently, however, real-world studies indicate that experts frequently and spontaneously use analogies in domain-based problem solving. There is also some evidence that in certain circumstances domain novices can draw analogies designed to illustrate arguments. It is less clear, however, whether domain novices can invoke analogies in the sophisticated manner of experts to enable them to (...) progress problem solving. In the current study groups of novices and experts tackled large-scale management problems. Spontaneous analogising was observed in both conditions, with no marked differences between expertise levels in the frequency, structure, or function of analogising. On average four analogies were generated by groups per hour, with significantly more relational mappings between analogue and target being produced than superficial object-and-attribute mappings. Analogising served two different purposes: problem solving (dominated by relational mappings), and illustration (which for novices was dominated by object-and-attribute mappings). Overall, our novices showed a sophistication in domain-based analogical reasoning that is usually only observed with experts, in addition to a sensitivity to the pragmatics of analogy use. (shrink)

Aristotle is sometimes committed to a pattern of inference that moves from complexity offunctioning to complexity in the entity's metaphysical structure. This article argues that Aristotle rejects this inference in the case of the basic essence, the ultimate differentia that determines the kind to which the entity belongs. Specifically, the functional difference between active and passive reasoning in humans is not matched in the structure of the basic human essence. The basic essence is an immediate unity in (...) the strong sense that it is wholly without structural parts. Complex rational functioning emerges from a metaphysically simple basic essence. (shrink)

I explored the association between components constituting the basis for moral and optimal human functioning, i.e., moral reasoning, moral identity, empathy, and purpose, via network analysis. I employed factor scores instead of composite scores that most previous studies used for better accuracy in score estimation in this study. Then, I estimated the network structure among collected variables and centrality indicators. For additional information, the structure and indicators were compared between two groups, participants who engaged in civic activities highly (...) versus lowly. The results demonstrated significant intra- and inter-scale associations in the network. The network structure was invariant across the two groups. Despite the network invariance, I found that the global connectivity between and centrality indicators of examined factors were higher among the high civic engagement group in general. I discussed the implications of the findings in research on moral functioning based on moral psychology and virtue ethics. (shrink)

The list of Italian forces1 with which Virgil concluded Aeneid 7 was a piece of the ‘machinery’ of epic, that is to say an expected part of the content of an epic poem, established by Homer and expected of his successors; cf. Apollonius 1. 20–228, Silius 3. 222 f., Statius, Th. 4. 32 f., Milton, P.L. 1. 376 f. The straightforward enumeration of Homer was naturally appropriate in the Iliad both because oral technique sought this kind of directness and because (...) of the immediate relationship of the subject-matter to a heroic community. But Virgil was well aware that the Homeric manner would not fit satisfactorily into the sophisticated and elaborate structure of literary and contemplative epic. Two essential requirements had to be met in the transplanting of such ‘machinery’ into a new milieu. The first was one of function: the piece should blend with the whole intricate pattern of theme and tone which a poem like the Aeneid possesses. The second was one of structure: it must possess within itself artistic symmetries and designs of a carefully organized kind. (shrink)

The target article fails to disentangle the functional description from the structural description of the two somatosensory streams. Additional evidence and thorough reconsideration of the evidence cited argue for a functional distinction between the how processing and the what processing of somatosensory information, while questioning the validity and usefulness of the equation of these two types of processing with structural streams. We propose going one step further: to investigate how the distinct functional streams are coordinated via attention.

Molecular cloning of the genes encoding the muscarinic acetylcholine receptors has shwon that receptor subtypes classified on the basis of pharmacological properties are related polypeptides encoded by distinct genes. These studies have laso revealed the existence of novel muscarinic receptor subtypes. Functional analysis of each of the subtypes expressed in mammalian cells indicates that the different subtypes activate distinct biochemical pathways, a finding that explains the tissue‐specific physiological response elicited by the neurotransmitter, acetylcholine.

Sarco/endoplasmic reticulum Ca2+ ATPase 2b (SERCA2b), a member of the SERCA family, is expressed ubiquitously and transports Ca2+ into the sarco/endoplasmic reticulum using the energy provided by ATP binding and hydrolysis. The crystal structure of SERCA2b in its Ca2+‐ and ATP‐bound (E1∙2Ca2+‐ATP) state and cryo‐electron microscopy (cryo‐EM) structures of the protein in its E1∙2Ca2+‐ATP and Ca2+‐unbound phosphorylated (E2P) states have provided essential insights into how the overall conformation and ATPase activity of SERCA2b is regulated by the transmembrane helix 11 (...) and the subsequent luminal extension loop, both of which are specific to this isoform. More recently, our cryo‐EM analysis has revealed that SERCA2b likely adopts open and closed conformations of the cytosolic domains in the Ca2+‐bound but ATP‐free (E1∙2Ca2+) state, and that the closed conformation represents a state immediately prior to ATP binding. This review article summarizes the unique mechanisms underlying the conformational and functional regulation of SERCA2b. (shrink)

The Y‐box proteins are the most evolutionarily conserved nucleic acid binding proteins yet defined in bacteria, plants and animals. The central nucleic acid binding domain of the vertebrate proteins is 43% identical to a 70‐amino‐acid‐long protein (CS7.4) from E. coli. The structure of this domain consists of an antiparallel fivestranded β‐barrel that recognizes both DNA and RNA. The diverse biological roles of these Y‐box proteins range from the control of the E. coli cold‐shock stress response to the translational masking (...) of messenger RNA in vertebrate gametes. This review discusses the organization of the prokaryotic and eukaryotic Y‐box proteins, how they interact with nucleic acids, and their biological roles, both proven and potential. (shrink)

The structure and regulative function of the cognitive styles: a new theory The organization of human cognitive styles can be described as a kind of functional system or as an holon. In this framework it is possible to propose a new theoretical base for classifying the primary cognitive styles. The fundamental theoretical thesis is that for all styles there is one common mechanism of forming and scanning the perceptual and memory field induced by the situation, and by the (...) differences in the manner of carrying out the processes of field scanning /codes interfering depend on the range of conceptual equivalency and cognitive control of behavior. In the functional describing of the basic set of cognitive styles we must take into account three elements of the chain: neurobiological modules ® organization of cognitive holon ® behavioral manifestation of styles. (shrink)

Starting from R. K. Merton's now classic criticism of 'holistic' functionalism, i.e. of a functionalism which postulates social unity, universality and functional in-dispensability, the author stresses certain implications of this criticism more than they have been stressed hitherto. Classical and holistic functionalism) from H. Spencer, B. Malinowski, A. R. Radcliffe-Brown, etc to T. Parsons, postulates certain total unities (a global culture, an integrated system, etc.) in which each item (existence, actions, structures, etc.) is considered and defined on the grounds (...) of its consequences for the maintenance of the system as a whole; therefore holistic functionalism as a method is, in effect, the study of the consequences of the system on the items that compose it, since each of these items is defined within the sphere of the system and of its integrative functions. Merton's 'neo-functionalism', on the other hand, is remarkable not only in that it takes into account the 'dysfunctional' and 'nonfunctional' consequences of certain items on the system, but more especially because, within the context of functional analysis, it stresses the possible existence of structural substitutes and alternatives of functions, and therefore of latent structures which are foreign to objective functional consequences, as well as being able to deal with unanticipated and unexpected items and their consequences on the system. 'Neo-functionalism', which is susceptible of further development, is not limited to the study of the consequences of the system on its items: it can also reverse this scheme and study the consequences of certain items on the system. Merton's criticism of holistic functionalism therefore implies a broadening of the scientific resources of this method and a renewal of its interpretative scheme, thanks to which functional analysis ceases to appear as 'the* method of explaining sociology as a science, and becomes an interpretative method which complements the analysis of social structures and relations. Seen in this light the concept of structure becomes emancipated and independent of the concept of system and function; whereas, within the framework of universal functionalism, it was ancillary to the concept of function. Finally, latent structures and unconscious structures, conditions of possibility and subjective dispositions are favourable to social structures and social relations, not excluding those that are neither visible nor observable. This analysis, the author notes, is extremely meaningful and has great possibilities of development, especially in view of the structuralism recently to be noted in the human and social sciences: anthropology, history, linguistics, etc. (shrink)

The past decade has been marked by a series of global crises, presenting an opportunity to reevaluate the relationship between science and politics. The biological sciences are instrumental in understanding natural phenomena and informing policy decisions. However, scholars argue that current scientific expertise often fails to account for entire populations and long-term impacts, hindering efforts to address issues such as biodiversity loss, global warming, and pandemics. This article explores the structural challenges of integrating an evolutionary perspective, historically opposed to (...) class='Hi'>functional determinants of health and disease, into current biological science practices. Using data on Swiss biology professors from 1957, 1980, and 2000, we examine the structural power dynamics that have led to the division between these competing epistemologies, and how this division has influenced resource allocation and career trajectories. Our analysis suggests that this cleavage presents a significant obstacle to achieving fruitful reconciliations, and that increased academicization and internationalization may benefit functional biologists at the expense of evolutionary biologists. While evolutionary biologists have gained symbolic recognition in recent years, this has not translated into valuable expertise in the political domain. (shrink)

I will offer a conceptual analysis of different notions of structure and function of viral immunogens and of different structure-function relationships. My focus will then be on the mechanisms by which the desired immune response is induced and why strategies based on three-dimensional molecular antigen structures and their rational design are limited in their ability to induce the desired immunogenicity. I will look at the mechanisms of action of adjuvants (thus the wordplay with Janeway's "immunologist's dirty little secret"). (...) Strategies involving adjuvants and other (more successful) vaccination strategies rely on taking into account activities and functions ("what is going on"), and not just the structures involved ("who is there"), in binding in a "lock and key" fashion. Functional patterns as well as other organizational and temporal patterns, I will argue, are crucial for inducing the desired immune response and immunogenicity. The 3D structural approach by itself has its benefitsand its limits, which I want to highlight by this philosophical analysis, pointing out the importance of structure-function relationships. Different functional aspects such as antigenicity, immunogenicity, and immunity need to be kept separate and cannot be reduced to three-dimensional structures of vaccines. Taking into account different notions of structure and function and their relationships might thus advance our understanding of the immune system and rational HIV vaccine design, to which end philosophy can provide useful tools. (shrink)

The concept of structure, operation, and functionality, as they may be understood by clinicians or researchers using neural transplantation techniques, are briefly defined. Following Stein & Glasier, we emphasize that the question of whether an intracerebral graft is really functional should be addressed not only in terms of what such a graft does in a given brain structure, but also in terms of what it does at the level of the organism.

Understanding the organization of an organism by individuating meaningful parts and accounting for organismal properties by studying the interaction of bodily parts is a central practice in many areas of biology. While structures are obvious bodily parts and structure and function have often been seen as antagonistic principles in the study of organismal organization, my tenet is that structures and functions are on a par. I articulate a notion of function (functions as activities), according to which functions are bodily (...) parts just as structures are. Recognizing part-whole relations among an organism’s various structures and functions permits fruitful investigation and multilevel explanation of organismal properties and functioning, across both developmental and evolutionary time. I show how my perspective clarifies debates surrounding homology and evolutionary novelty that stem from an alleged structure-function dichotomy. My approach favors a pluralism about individuation, where the criteria of what counts as a meaningful bodily part depend on the particular epistemic aims pursued in a scientific context. (shrink)

Mucins are a family of high molecular weight, highly glycosylated glycoproteins found in the apical cell membrane of human epithelial cells from the mammary gland, salivary gland, digestive tract, respiratory tract, kidney, bladder, prostate, uterus and rete testis. Increased synthesis of the core protein and alterations in the carbohydrates attached to these glycoproteins are believed to play important roles in the function and proliferation of tumour cells. Aberrant glycosylation leads not only to the production of novel carbohydrate structures, but also (...) to the exposure of the core peptide. These novel epitopes may be candidates for diagnosis or therapy, by using either synthetic mucin fragments as vaccines, or monoclonal antibody‐based reagents which detect these structures. (shrink)