When the history of life on earth is viewed as a history of cell division, all of life becomes a single cell lineage. The growth and differentiation of this lineage in reciprocal interaction with its environment can be viewed as a developmental process; hence the evolution of life on earth can also be seen as the development of life on earth. Here, in reviewing this field, some potentially fruitful research directions suggested by this change in perspective are highlighted. (...) Variation and selection become, for example, bidirectional information flows between scales, while the notions of “cooperation” and “competition” become scale relative. The language of communication, inference, and information processing becomes more useful than the language of causation to describe the interactions of both homogeneous and heterogeneous living systems at any scale. Emerging scale‐free theoretical frameworks such as predictive coding and active inference provide conceptual tools for reconceptualizing biology as the study of a unified, multiscale dynamical system. (shrink)

Population-based research is enhanced by biological measures, but biological sampling raises complex ethical issues. The third British National Survey of Sexual Attitudes and Lifestyles (Natsal-3) will estimate the population prevalence of five sexually transmitted infections (STIs) (Chlamydia trachomatis, Neisseria gonorrhoeae, human papillomavirus (HPV), HIV and Mycoplasma genitalium) in a probability sample aged 16–44 years. The present work describes the development of an ethical approach to urine testing for STIs, including the process of reaching consensus on whether to (...) return results. The following issues were considered: (1) testing for some STIs that are treatable and for which appropriate settings to obtain free testing and advice are widely available (Natsal-3 provides all respondents with STI and healthcare access information), (2) limits on test accuracy and timeliness imposed by survey conditions and sample type, (3) testing for some STIs with unknown clinical and public health implications, (4) how a uniform approach is easier to explain and understand, (5) practical difficulties in returning results and cost efficiency, such as enabling wider STI testing by not returning results. The agreed approach, to perform voluntary anonymous testing with specific consent for five STIs without returning results, was approved by stakeholders and a research ethics committee. Overall, this was acceptable to respondents in developmental piloting; 61% (68 of 111) of respondents agreed to provide a sample. The experiences reported here may inform the ethical decision making of researchers, research ethics committees and funders considering population-based biological sampling. (shrink)

A number of philosophers :171–187, 2011; Arnold 2011, in Ethics Politics XV:101–138, 2013) have argued that agent-based, evolutionary game theory models of the evolution of cooperation fail to provide satisfying explanations of cooperation because they are too disconnected from actual biology. I show how these criticisms can be answered by employing modeling approaches from the situated cognition research program that allow for more biologically detailed models. Using cases drawn from recent situated cognition modeling research, I show how agent-based (...) models of the evolution of cooperation can become more empirically-informed and relevant to explaining the evolution of cooperation in real populations. I argue that because situated cognition models allow for more detailed representations of not just agents’ brains but bodies and environments as well, they can be informed by a much wider breadth of empirical research than traditional agent-based models. Moreover, because the simulated bodies of these agents exhibit particular behaviors, they can be more readily compared to the behaviors of actual organisms. I conclude that employing situated cognition approaches to modeling the evolution of cooperation is a more promising way to investigate the evolution of cooperation than more traditional agent-based evolutionary game theory models. (shrink)

Doctoral programs at U.S. universities play a critical role in the development of human resources both in the United States and abroad. This volume reports the results of an extensive study of U.S. research-doctorate programs in five broad fields: physical sciences and mathematics, engineering, social and behavioral sciences, biological sciences, and the humanities. Research-Doctorate Programs in the United States documents changes that have taken place in the size, structure, and quality of doctoral education since the widely used (...) 1982 editions. This update provides selected information on nearly 4,000 doctoral programs in 41 subdisciplines at 274 doctorate-granting institutions. This volume also reports the results of the National Survey of Graduate Faculty, which polled a sample of faculty for their views on the scholarly quality of program faculty and the effectiveness of doctoral programs in preparing research scholars/scientists. This much-anticipated update of such an essential reference will be useful to education administrators, university faculty, and students seeking authoritative information on doctoral programs. (shrink)

There is a trend within philosophy of biology to concentrate on questions that are strongly related to particular biological research programs rather than on the general scope of the field and its relation to other sciences. Projects of the latter kind, of course, are followed as well but will not be the topic of this review. Shifting the focus to particular research programs reflects philosophers’ increased interest in knowledge of, and contribution to, actual biological (...) class='Hi'>research, which is organized in such programs. It is accompanied by the increasing enthusiasm of biologists to involve philosophers in the conceptual work of theoretical biology. I concentrate on the philosophies of four biological research programs, three of which are devoted to evolutionary biology, which is still the main field of interest among philosophers of biology: adaptationism, EvoDevo, and the developmental systems approach. In addition, a short sketch of the newly emerging philosophy of systems biology is given. Several lines of philosophical inquiry can be found in all of the fields considered here: philosophy contributes to the conceptual development of biological research programs, it analyzes structures and delineations of particular research programs, and sometimes it is involved in a comparative assessment of biological programs as well. Philosophical projects that start from the level of a particular research program may give rise to a bottom-up perspective on biology and allow for an integrative view of biological research. This may open up the opportunity to tackle “larger” questions again in an altered and fruitful manner. (shrink)

Science is about conceptualizing the natural world in a way that can be understood by human beings while at the same time reflecting as much as possible what we can empirically infer about how the world actually is. Among the crucial tools that allow scientists to formulate hypotheses and to contribute to a progressive understanding of nature are the use of imagery and metaphors, on the one hand, and the ability to assume certain starting points on which to build new (...) avenues of inquiry on the other hand. The premise of this work is that, in the words of philosopher of science Daniel Dennett, "There is no such thing as philosophy-free science; there is only science whose philosophical baggage is taken on board without examination." The purpose here is precisely to examine some of this philosophical baggage, and to see where such analysis may lead us. Obviously, it is not possible for a single project to take on science as a whole, or even an entire discipline such as physics, or ecology. Therefore, the core of this work is constituted by a series of eight case studies drawn from the field of evolutionary biology, with which I am particularly familiar as a practicing biologist. The hope is that combining expertise in both philosophy and science in one person, the resulting insights might be useful for the practicing scientist as well as because of their value as philosophical inquires. The dissertation is a combination of conceptual analysis and science criticism applied to specific questions in organismal biology, largely of an evolutionary nature, with the eight case studies grouped into three broad categories: Unexamined Baggage, Bad Habits, and Good and bad metaphors. (shrink)

In many fields of biology, researchers explain a phenomenon by characterizing the responsible mechanism. This requires identifying the candidate mechanism, decomposing it into its parts and operations, recomposing it so as to understand how it is organized and its operations orchestrated to generate the phenomenon, and situating it in its environment. Mechanistic researchers have developed sophisticated tools for decomposing mechanisms but new approaches, including modeling, are increasingly being invoked to recompose mechanisms when they involve nonsequential organization of nonlinear operations. The (...) results often are dynamical mechanistic explanations. The steps in mechanistic research are illustrated using research on circadian rhythms. (shrink)

Synthetic genomics is a new field of research in which small DNA pieces are assembled in a series of steps into whole genomes. The highly reduced genomes of host‐associated bacteria are now being used as models for de novo synthesis of small genomes in the laboratory. Bacteria with the smallest genomes identified in nature provide nutrients to their hosts, such as amino acids, co‐factors and vitamins. Comparative genomics of these bacteria enables predictions to be made about the gene (...) sets required for core cellular functions and the associated metabolic network for the biosynthesis of host‐selected compounds. Synthetic biology may ultimately enable researchers to make customized cell‐specific organelles for the production and delivery of drugs to humans and domestic animals. Synthetic genomics may also become the method of choice for functional analyses of genes and genomes from bacteria that cannot be cultivated in the laboratory. (shrink)

Multilevel research strategies characterize contemporary molecular inquiry into biological systems. We outline conceptual, methodological, and explanatory dimensions of these multilevel strategies in microbial ecology, systems biology, protein research, and developmental biology. This review of emerging lines of inquiry in these fields suggests that multilevel research in molecular life sciences has significant implications for philosophical understandings of explanation, modeling, and representation.

According to the working definition of the International Big History Association, ‘Big History seeks to understand the integrated history of the Cosmos, Earth, Life and Humanity, using the best available empirical evidence and scholarly methods’. In recent years Big History has been developing very fast indeed. Big History courses are taught in the schools and universities of several dozen countries. Hundreds of researchers are involved in studying and teaching Big History. The unique approach of Big History, the interdisciplinary genre of (...) history that deals with the grand narrative of 13.8 billion years, has opened up a vast amount of research agendas. Big History brings together constantly updated information from the scientific disciplines and merges it with the contemplative realms of philosophy and the humanities. It also provides a connection between the past, present, and future. Big History is a colossal and extremely heterogeneous field of research encompassing all the forms of existence and all timescales. Unsurprisingly, Big History may be presented in very different aspects and facets. In this volume the Big History is presented and discussed in three different ways. In its first part, Big History is explored in terms of methodology, theories of knowledge, as well as showcasing the personal approach of scholars to Big History. The second section comprises such articles that could clarify Big History's main trends and laws. The third part of this book explores the nature of teaching Big History as well as profiling a number of educational methods. This volume will be useful both for those who study interdisciplinary macroproblems and for specialists working in focused directions, as well as for those who are interested in evolutionary issues of Astrophysics, Geology, Biology, History, Anthropology, Linguistics and other areas of study. (shrink)

Two overriding considerations shaped the development of early research on the biological effects of microwave radiation—possible medical application and uncertainty about the hazards of exposure to radar. Reports in the late 1940s and early 1950s of hazards resulting from microwave exposure led to the near abandonment of medical research related to microwave diathermy at the same time that military and industrial concern over hazards grew, culminating in the massive research effort known as ‘the Tri-Service program’ . (...) Both the early focus on medical application and the later search for hazards played important roles in dictating how this field of research developed as a science. (shrink)

The ability of powerful and well-funded interest groups to steer scientific research in directions that advance their goals has become a significant social concern. This ability is increasingly being recognized in the peer-reviewed literature and in the findings of deliberative expert consensus committees. For example, there is increasing recognition that efforts to address climate change have been stymied in part by a powerful network of conservative foundations, which fund think tanks and other organizations that constitute a “climate change counter (...) movement”. Sociologist Robert Brulle recently found that the total annual income for 91 powerful.. (shrink)

The crisis of confidence in the social sciences has many corollaries which impact our research practices. One of these is a push towards maximal and mechanical objectivity in quantitative research. This stance is reinforced by major journals and academic institutions that subtly yet certainly link objectivity with integrity and rigor. The converse implication of this may be an association between subjectivity and low quality. Subjectivity is one of qualitative methodology’s best assets, however. In qualitative methodology, that subjectivity is (...) often given voice through reflexivity. It is used to better understand our own role within the research process, and is a means through which the researcher may oversee how they influence their research. Given that the actions of researchers have led to the poor reproducibility characterising the crisis of confidence, it is worthwhile to consider whether reflexivity can help improve the validity of research findings in quantitative psychology. In this report, we describe a combination approach of research: the data of a series of interviews helps us elucidate the link between reflexive practice and quality of research, through the eyes of practicing academics. Through our exploration of the position of the researcher in their research, we shed light on how the reflections of the researcher can impact the quality of their research findings, in the context of the current crisis of confidence. The validity of these findings is tempered, however, by limitations to the sample, and we advise caution on the part of our audience in their reading of our conclusions. (shrink)

Este artículo tiene por objetivo general indagar acerca de los procesos de institucionalización de una nueva disciplina científica. En particular, se analizan los desplazamientos que se producen entre disciplinas al emerger una nueva: la biología molecular. Se presenta en este artículo el caso del Instituto Nacional de Tecnología Agropecuaria (INTA) de Argentina, institución creada en 1956 para realizar investigaciones, innovaciones y extensionismo para el sector agropecuario. De esa manera, el trabajo presenta los cambios en las disciplinas de las que provienen (...) los investigadores del INTA, desde su creación en 1956 hasta 2010. La investigación que se presenta se centra en un análisis cuantitativo en relación a las disciplinas de origen de los investigadores que se incorporaron a la institución. Al mostrar los desplazamientos entre disciplinas, este artículo pretende contribuir al estudio sobre los conflictos entre las mismas. Pues se sugiere que la emergencia de una nueva disciplina no implica solamente la apertura de nuevas profesiones, instituciones, temas y técnicas de investigación, sino también el desplazamiento de otras anteriormente instaladas, y que tales desplazamientos estarían en la raíz de las tensiones que se registran en la institucionalización de una nueva disciplina. This article aims to investigate the process of institutionalization of a new scientific discipline. In particular, the displacements that occur between disciplines with the emergence of a new one: molecular biology. The case presented in this article is the National Institute of Agricultural Technology (INTA) of Argentina, institution created in 1956 for research, innovation and extension to the agricultural sector. Thus, the paper presents the changes in the disciplines from which INTA's researchers come, since its inception in 1956 until 2010. The research presented in this article focuses on a quantitative analysis in relation to the disciplines of origin of the researchers who joined the institution. By showing the displacements between disciplines, this article aims to contribute to the study of the conflicts between them. For it suggests that the emergence of a new discipline involves not only the opening of new professions, institutions, research subjects and techniques, but also the displacement of other previously installed. These displacements would be at the root of the tensions that occur in the institutionalization of a new discipline. (shrink)

Meaning has traditionally been regarded as a problem for philosophers and psychologists. Advances in cognitive science since the early 1960s, however, broadened discussions of meaning, or more technically, the semantics of perceptions, representations, and/or actions, into biology and computer science. Here, we review the notion of “meaning” as it applies to living systems, and argue that the question of how living systems create meaning unifies the biological and cognitive sciences across both organizational and temporal scales.

Students often have difficulty connecting theoretical and text-based scholarship to the real world. When teaching in Asia, this disconnection is exacerbated by the European/American focus of many canonical texts, whereas students' own experiences are primarily Asian. However, in my discipline of political philosophy, this problem receives little recognition nor is it comprehensively addressed. In this paper, I propose that the problem must be taken seriously, and I share my own experiences with a novel pedagogical strategy which might offer a possible (...) path forward. Recent scholarship has championed an active learning approach, where students engage in their own research, and deliver outward-facing products that have a meaning and purpose beyond the confines of the student-professor relationship. In this spirit, I have put into practice a strategy of course design, where active learning is used to overcome students' disconnection with the course content. In particular, as a major component of course assessment, students are required to write an 'opinion piece', which is then showcased on a public website. The opinion piece must address a real-world issue which the student himself or herself selects and deems important; furthermore, it must build on the theoretical tools of the course and be written in a style which makes it accessible to a wider audience. I discuss the implementation of this strategy in two political philosophy courses, including strategies to avoid 'dumbing down' and ‘diluting’ the process of critical thinking. While no formal analysis of impact of the strategy on learning outcomes has been conducted, an anonymous pedagogical survey has yielded an overwhelmingly positive response for students' self-reported perceptions of the curricular innovations. (shrink)

Eleven interdisciplinary essays investigate embodiment in contexts including epistemology, medicine and psycho-therapeutics, language, and art. An excellent resource for education in medicine, psychology, and other healing arts, as well as for researchers and others concerned with the body. Each essay opens meanings in the increasingly active field of philosophy of body. Western and non-Western sources contribute to "a metaphysics that upholds the truths of experience.".

Distinguished feminist philosophers consider the future of their field and chart its political and ethical course in this forward-looking volume. Engaging with themes such as the historical trajectory of feminist phenomenology, ways of perceiving and making sense of the contemporary world, and the feminist body in health and ethics, these essays affirm the base of the discipline as well as open new theoretical spaces for work that bridges bioethics, social identity, physical ability, and the very nature and boundaries of (...) the female body. Entanglements with thinkers such as Heidegger, Merleau-Ponty, Beauvoir, and Arendt are evident and reveal new directions for productive philosophical work. Grounded in the richness of the feminist philosophical tradition, this work represents a significant opening to the possible futures of feminist phenomenological research. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data (...) sets them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Religious therapeutics is the term I use to designate relations between health and spirituality, and medicine and religion. Dimensions of religious therapeutics include religious meanings that inform medical theory, religious means of healing, health as part of religious life, and religion as a remedy for human suffering. Classical Yoga is analyzed to establish an initial matrix of religious therapeutics with 5 branches: philosophical foundations, soteriology, value theory, physical practice, and cultivation of consciousness. Through comparative criticism of classical Yoga, the study (...) presents a heuristic of religious therapeutics: a model for interpreting relations among healing and liberative functions in world religions. ;Body and health are of instrumental but not ultimate value in classical Yoga: the body is used to transcend itself for attainment of Yoga's soteriological goal, realization of self as pure consciousness. Yoga's Samkhya-based metaphysics contains an unreconciled dualism, and while practice of Yoga is paradigmatic of mind/body holism, Yoga prescribes realization of a spiritual self, independent of material and psychological nature. The study rehabilitates the body in respect of the compatibility of embodiedness with religiousness. ;Other Indian and world traditions suggest dimensions of religious therapeutics both resonant with classical Yoga and lacking from it. India's Ayurvedic medicine represents the sixth branch of religious therapeutics: medical therapeutics. I distill from Ayurvedic and Western sources a set of determinants of health: biological, medical/psychological, cultural, and metaphysical. Significant determinants of health are wholeness, self-identity, and freedom; these are incorporated in discussion of the complementary functions of medicine and religion, grounding the claim that in classical Yoga, liberation is healing in an ultimate sense. ;Tantric yogas utilize material nature for human spiritual progress, and unlike classical Yoga, esteem nature, body/mind, the feminine, and relationality. Tantra provides another branch of religious therapeutics: aesthetic therapeutics. The study anticipates elements of health/medicine in western religions, Buddhism, and Lakota religious philosophy. Sacred speech and song are explored to demonstrate comparative inquiry into religious therapeutics; some Native American Indian and Hindu applications of sacred language are considered. Finally, the model of religious therapeutics is supplemented with community, embracing ecological, social, and religious relationality and communication. (shrink)

Distinguished feminist philosophers consider the future of feminist phenomenology and chart its political and ethical future in this forward-looking volume. Engaging with themes such as the historical trajectory of feminist phenomenology, ways of perceiving and making sense of the contemporary world, and the feminist body in health and ethics, these essays affirm the base of the discipline as well as open new theoretical spaces for work that bridges bioethics, social identity, physical ability, and the very nature and boundaries of the (...) female body. Entanglements with thinkers such as Arendt, Beauvoir, Merleau-Ponty, Heidegger and Deleuze are evident as they reveal new directions for productive philosophical work. Grounded in the richness of the feminist philosophical tradition, this lively volume represents a significant opening to the possible futures of feminist phenomenological research. (shrink)

In developing a framework for assessing privacy risks, Dupras and Bunnik’s “Toward a framework for assessing privacy risks in multi-omic research and databases” considers the question of whe...

I use a recent ‘experimental philosophy’ study of the concept of the gene conducted by myself and collaborators to discuss the broader epistemological framework within which that research was conducted, and to reflect on the relationship between science, history and philosophy of science, and society.Keywords: Experimental philosophy; Biohumanities; Representing Genes Project; Gene concept; Science criticism; Conceptual ecology.

The relationship between philosophy and research on artificial intelligence (AI) has been difficult since its beginning, with mutual misunderstanding and sometimes even hostility. By contrast, we show how an approach informed by both philosophy and AI can be productive. After reviewing some popular frameworks for computation and learning, we apply the AI methodology of “build it and see” to tackle the philosophical and psychological problem of characterizing perception as distinct from sensation. Our model comprises a network of very simple, (...) but interacting agents which have binary experiences of the “yes/no”-type and communicate their experiences with each other. When does such a network refer to a single agent instead of a distributed network of entities? We apply machine learning techniques to address the following related questions: i) how can the model explain stability of compound entities, and ii) how could the model implement a single task such as perceptual inference? We thereby find consistency with previous work on “interface” strategies from perception research. While this reflects some necessary conditions for the ascription of agency, we suggest that it is not sufficient. Here, AI research, if it is intended to contribute to conceptual understanding, would benefit from issues previously raised by philosophy. We thus conclude the article with a discussion of action-selection, the role of embodiment, and consciousness to make this more explicit. We conjecture that a combination of AI research and philosophy allows general principles of mind and being to emerge from a “quasi-empirical” investigation. (shrink)

In many experimental sciences, like particle physics or molecular biology, the proper place for establishing facts is the laboratory. In the sciences of population biology, however, the laboratory is often seen as a poor approximation of what occurs in nature. Results obtained in the field are usually more convincing. This raises special problems: it is much more difficult to obtain stable, repeatable results in the field, where environmental conditions vary out of the experimenter’s control, than in the laboratory. (...) We examine here how this problem affected an influential experimental research tradition in community ecology, the study of the ecology of the rocky seashores. In the 1960s, a handful of North-American ecologists, most notably Joseph Connell, Robert Paine and Paul Dayton, made the rocky seashores a model study system for experimenting in the field. Their experiments were deceptively simple: they removed species living on the seashore and described the resulting effects on the local ecology. These experiments exerted a deep influence on community ecology. They provided evidence for speculative developments concerning the theory of interspecific competition, the factors responsible for species richness and the ecology of food webs. They also stimulated novel conceptual developments. In particular, Paine developed the predation hypothesis, which states that the presence of predators can favour species richness, before introducing the keystone species concept, according to which some species exert disproportionate effects on ecological systems. More broadly, these experiments gave support to a methodological trend in favour of field experimentation. Only controlled perturbations in the field, it seemed, provided a reliable method to get insights into the structure of ecological communities. However, as experiments were continued in time and repeated in different sites, divergent results appeared. We analyse here how intertidal researchers coped with the variability of environmental conditions and tried to stabilize their results. In the process, they reconsidered not only their early conclusions, but also the exclusive status given to field experiments. Expanding on this case study, we discuss some significant differences between laboratory and field experiments. (shrink)

This paper reviews the location of Responsible Research and Innovation approaches within the access and benefit sharing policy spaces of the Convention on Biological Diversity and Nagoya Protocol. We describe how a range of dialogues on ethical research practices found a home, almost inadvertently, within the ABS policy process. However, more recent RRI dialogues around emerging technologies have not been similarly absorbed into ABS policy, due in part to the original framing of ABS and associated definitional and (...) scope issues. Consideration is given to the challenges posed to these policy processes by the transformative and rapid nature of scientific and technological change today, including the emerging field of synthetic biology. Drawing on experiences from regulating ABS, we emphasize that the integration of RRI into policies for new, emerging, or poorly understood activities such as synthetic biology faces deficiencies such as limits to government capacity, jurisdictional confusion, shortages in funds, and an absence of strategic approaches. We conclude that a coordinated combination of diverse policy processes within the CBD might provide an invaluable space for RRI dialogues on social justice, sustainability, biosafety, and other issues raised by emerging technologies. (shrink)

Scholarship in education beyond school has developed largely outside university departments of education, and has rarely engaged systematically with the study of education in schools. The paper concentrates on three areas: adult education, higher education, and further education. The development of the extra-mural tradition meant that adult education was less an object of scholarly study than a means of spreading scholarship to the wider population, with important exceptions such as historical studies. Since the 1970s, the volume of research and (...) postgraduate education in adult education in British universities has grown considerably. The study of higher education was marginal until the 1960s; its subsequent development was relatively slow until the 1990s, when the quality of university teaching came under wider external scrutiny. The study of further education and vocational training is characterised by disciplinary fragmentation, with much activity taking place in departments of psychology, economics, sociology and management, as well as in those former polytechnics that specialised in training further education teachers. The rise of integrative concepts such as lifelong learning suggest greater potential for cross-disciplinary scholarship that can engage the diverse body of those interested in teaching and research about this field. (shrink)

Although there has been much research on the connection between nonhuman animal cruelty/ abuse and domestic violence, the link between nonhuman animal care and domestic violence has received less attention. This study, based on responses from 477 college students in New Provi-dence, The Bahamas, indicates that the presence of domestic violence in homes is linked with the level of care and the prevalence of negative interactions with dogs. Dogs received 10 or more of 11 components of essential care in (...) 58.0% of homes without domestic violence compared with 43.7% in homes with domestic violence. A dog was reported being physically injured in 6.8% of homes when domestic violence was absent and in 13.6% of homes when domestic violence was present. The study suggests that in homes with domestic violence, dogs as well as people are at higher risk of intentional harm and/or neglect. (shrink)

Questions surrounding the evolution of cooperation, especially human cooperation, have driven research in many disciplines. Two key methodologies used to research and explain the evolution of cooperation are modeling and narrative construction. A number of scientists and philosophers have suggested that advancing research on the evolution of cooperation will require integrating models and narratives. But, relatively little has been said about what challenges exist to integrating models and narratives, how to go about integrating models and narratives, and (...) what particular benefits might be gained by accomplishing such integration. In this dissertation project, I address these questions in order to show how models and narratives can be integrated to produce better research on and explanations of the evolution of cooperation. The major challenge to integrating models and narratives concerning the evolution of cooperation that I address in this dissertation stems from the criticisms that such models and narratives lack empirical support. I answer this challenge by defending models and narratives from these criticisms. In the case of models, I argue both that at least some models of the evolution of cooperation have stronger empirical support than supposed by critics and that evolutionary robotics modeling approaches can be used to create even better models. In the case of narratives, I argue that several means of defending narratives from evidential challenges already developed by philosophers can be used to defend narratives about the evolution of cooperation as well. To show how narratives and models can be integrated to better research and explain the evolution of cooperation, I first establish an account of integration by drawing on the work of other philosophers. I then argue that models and narratives can provide certain benefits to each other via integration. Models can benefit from integration with narratives by using the narratives as sources of information as well as hypotheses to test. Indeed, as models are used to test such hypotheses, they also gain explanatory power. Narratives can benefit from integration with models by using the models as sources of support and constraint. Moreover, models can help deepen the understanding of historical contingency provided by narratives. (shrink)

We would first of all like to thank Thor Grünbaum and Andrea Raballo for their thoughtful and lively commentary on our work. We would also like to thank Daniel Rubin for taking this opportunity to describe in detail some of the research carried out in this domain since our paper was first written. Although their commentaries may seem to fall on opposite ends of the critical scale, so to speak, taken together they provide an opportunity to take stock of (...) the progress that has been made in this endeavor as well as some of the challenges that remain to be overcome. In this short response, we focus primarily on what we believe to be the most serious of Grünbaum and Raballo's criticisms to our work, arguing that our .. (shrink)

This exploratory paper considers the concept of generation in the context of learning across the life course. Although researchers have often found considerable inequalities in participation by age, as well as strongly articulated attitudinal differences, there have so far been only a handful of studies that have explored these patterns through the perspective of generational formations. The paper is primarily conceptual, exploratory and reflective, setting out a number of approaches to the concept of generations, most of which derive largely from (...) debates with the ghost of Karl Mannheim; it then considers how these concepts of generation have been applied to understandings of educational inequalities in recent research in Germany and the Nordic nations. It then examines the dynamics of inter-generational relations in learning, drawing on research undertaken as part of the Teaching and Learning Research Programme. The paper argues that although inter-generational dynamics are a relatively neglected dimension of Anglophone research on life chances and learning, there is a strong case for understanding their dual roles in both inequality and cohesion. It concludes by outlining some themes and areas for further investigation in the future. (shrink)

In science policy, public controversy around synthetic biology has often been presented as a major risk because it could deter innovation. The following inter-related strategies for avoiding contestation have been observed: There have been attempts to close down debates by alluding to the importance and legitimacy of reliance on scientific evidence as input to regulatory processes. Scientific policy advice has stressed sufficiency of existing regulation, economic risks of additional regulation and/or suggestions for monitoring that are limited in scope. Initiatives for (...) self-governance have narrowed the scope of topics for consideration. Engagement with humanities, social sciences and arts has been co-opted for legitimisation and science communication. Although such agendas are of course not ubiquitous, in this paper, I criticise that instrumentally motivated engagement has been supported not only by the scientific community but also by policy institutions and funding bodies. I argue that it is good that this now seems to fuel controversy in the academic and policy realms. As synthetic biology is not the only technoscientific field to see such dynamics, this is also part of the broader context of debate about the governance of science, especially the concept of “responsible research and innovation” currently promoted in the EU. (shrink)

Heart disease is the leading cause of death amongst adult Americans and has recently become a top killer worldwide. The direct costs of cardiovascular disease are projected to triple in the next 20 years, from $272.5 billion to $818.1 billion (Heidenreich et al. 2011). Although there has been a decreased incidence and prevalence of ischemic heart disease over the past several decades in the United States, heart failure remains a major cause of morbidity and mortality. In the United States, approximately (...) 500,000 to 700,000 new cases are identified each year (Lloyd-Jones et al. 2009). Heart failure is now the number one diagnosis leading to hospitalization. As such, it is an increasingly heavy economic burden on .. (shrink)

Twentieth-century action theory has concentrated on the relationship of intention to action, and thereby the relationship of belief as an occurrent state of the agent to the agent’s action. This stress on belief appears to be predicated on the view that our actions are primarily guided by our understanding of the relevant conditions of action, a view encouraged by the fact that we can and do attribute beliefs to ourselves and others to explain instances of the failure of an action (...) toachieve a desired outcome. I argue that, to the contrary, there is no compelling reason to conclude that such attributions imply that our actions are guided by occurrent beliefs. The alternative view offered is that our actions are typically guided by habit, but in cases of pragmatic failure we attribute putative prefailurebeliefs on the basis of the overall intention of action and relevant background understanding. (shrink)

Human brain organoids are three-dimensional masses of tissues derived from human stem cells that partially recapitulate the characteristics of the human brain. They have promising applications in many fields, from basic research to applied medicine. However, ethical concerns have been raised regarding the use of human brain organoids. These concerns primarily relate to the possibility that brain organoids may become conscious in the future. This possibility is associated with uncertainties about whether and in what sense brain organoids could have (...) consciousness and what the moral significance of that would be. These uncertainties raise further concerns regarding consent from stem cell donors who may not be sufficiently informed to provide valid consent to the use of their donated cells in human brain organoid research. Furthermore, the possibility of harm to the brain organoids raises question about the scope of the donor’s autonomy in consenting to research involving these entities. Donor consent does not establish the reasonableness of the risk and harms to the organoids, which ethical oversight must ensure by establishing some measures to mitigate them. To address these concerns, we provide three proposals for the consent procedure for human brain organoid research. First, it is vital to obtain project-specific consent rather than broad consent. Second, donors should be assured that appropriate measures will be taken to protect human brain organoids during research. Lastly, these assurances should be fulfilled through the implementation of precautionary measures. These proposals aim to enhance the ethical framework surrounding human brain organoid research. (shrink)

Culture can be said to be about the business of 'self-replication'. From the moment of conception, it impresses its patterns and rhythms on the developing, infinitely plastic neuronal substrate of the fetal organism. It shapes this substrate to become preferentially sensitive to its patterns and thus to seek to replicate them as an adult. This process of neural shaping continues throughout life as the capacity of the brain to reorganize itself according to the uses to which it addresses itself never (...) ceases. The extraordinary capacity of culture to extract different abilities from the biological form is clearly manifest in the lexical, vocal, tool manufacture, and writing capabilities emerging in bonobos raised in a Pan/Homo culture. These findings render moot old questions regarding the innate limits of the ape brain. They raise instead far more productive questions about the form and function of the perpetual dance that is constantly taking place between plastic neuronal systems and their external culturally devised ways of being. (shrink)

In this review, I discuss the justifications for focussing on Hobbes's On the Citizen (De Cive), the middle recension of his political philosophy, separately from his better known Leviathan. I provide an overview of the collection's chapter contents, and I close by calling for further research regarding the impact of this text on later European political philosophy (such as Spinoza, Rousseau, Kant).

Tim Maudlin’s Truth and Paradox is terrific. In some sense its solution to the paradoxes is familiar—the book advocates an extension of what’s called the Kripke-Feferman theory. Nonetheless, the perspective it casts on that solution is completely novel, and Maudlin uses this perspective to try to make the prima facie unattractive features of this solution seem palatable, indeed inescapable. Moreover, the book deals with many important issues that most writers on the paradoxes never deal with, including issues about the application (...) of the Gödel theorems to powerful theories that include our theory of truth. The book includes intriguing excursions into general metaphysics, e.g. on the nature of logic, facts, vagueness, and much more; and it’s lucid and lively, a pleasure to read. It will interest a wide range of philosophers. (shrink)

Scientific data are often subjected to two contradictory over-simplifications. People who have no personal experience in science often say that a certain idea has been scientifically established and feel that the question is therewith settled. They do not distinguish among methods, or generalizations in different fields. This implies that all science is infallible. The other oversimplification comes from the specialist; he may dismiss the work of men who study the problems approaching his own but who use methods different from his. (...) This view implies that only one type of scientific investigation is really sound. Both groups are wrong, for science is neither infallible nor wholly untrustworthy. In fact, science as an abstract whole is nothing; it is the name given collectively to all methods which men have used to explore natural processes and the results obtained by the use of such methods. Some problems are sufficiently simple and accessible to be explored in detail while others can be treated only after a set of postulates have been set as a starting point. A mechanism must be established within which it is possible to deal with the problems at hand. In other words, there are levels of scientific research which may be arranged in a series based on increasing assumptions. The more complex levels are formed by assuming the data and methods of those simpler and adding to them a new set of assumptions with the aid of which it is possible to treat the phenomena to be studied. Material cannot be carried directly from one level to another unless attention is given to the premises on which the conclusions have been drawn. Since such attention is not always given, entire fields of research have sometimes been brought into suspicion on the part of those working in what they themselves style “a more fundamental field.” Yet there may be data available at a different level which, when properly used, would be of value in their own work. (shrink)

We analyzed stable patients’ views regarding synthetic biology in general, the medical application of synthetic biology, and their potential participation in trials of synthetic biology in particular. The aim of the study was to find out whether patients’ views and preferences change after receiving more detailed information about synthetic biology and its clinical applications. The qualitative study was carried out with a purposive sample of 36 stable patients, who suffered from diabetes or gout. Interviews were transcribed verbatim, translated and fully (...) anonymized. Thematic analysis was applied in order to examine stable patients’ attitudes towards synthetic biology, its medical application, and their participation in trials. When patients were asked about synthetic biology in general, most of them were anxious that something uncontrollable could be created. After a concrete example of possible future treatment options, patients started to see synthetic biology in a more positive way. Our study constitutes an important first empirical insight into stable patients’ views on synthetic biology and into the kind of fears triggered by the term “synthetic biology.” Our results show that clear and concrete information can change patients’ initial negative feelings towards synthetic biology. Information should thus be transmitted with great accuracy and transparency in order to reduce irrational fears of patients and to minimize the risk that researchers present facts too positively for the purposes of persuading patients to participate in clinical trials. Potential participants need to be adequately informed in order to be able to autonomously decide whether to participate in human subject research involving synthetic biology. (shrink)