It seems that the reception of Conrad Hal Waddington’s work never really gathered speed in mainstream biology. This paper, offering a transdisciplinary survey of approaches using his epigenetic landscape images, argues that (i) Waddington’s legacy is much broader than is usually recognized—it is widespread across the life sciences (e.g. stem cell biology, developmental psychology and cultural anthropology). In addition, I will show that (ii) there exist as yet unrecognized heuristic roles, especially in model building and theory formation, which (...) Waddington’s images play within his work. These different methodological facets envisioned by Waddington are used as a natural framework to analyze and classify the manners of usage of epigenetic landscape images in post-Waddingtonian ‘landscape approaches’. This evaluation of Waddington’s pictorial legacy reveals that there are highly diverse lines of traditions in the life sciences, which are deeply rooted in Waddington’s methodological work. (shrink)

The Neo‐Darwinian concept of natural selection is plausible when one assumes a straightforward causation of phenotype by genotype. However, such simple 1:1 mapping must now give place to the modern concepts of gene regulatory networks and gene expression noise. Both can, in the absence of genetic mutations, jointly generate a diversity of inheritable randomly occupied phenotypic states that could also serve as a substrate for natural selection. This form of epigenetic dynamics challenges Neo‐Darwinism. It needs to incorporate the non‐linear, (...) stochastic dynamics of gene networks. A first step is to consider the mathematical correspondence between gene regulatory networks and Waddington's metaphoric ‘epigenetic landscape’, which actually represents the quasi‐potential function of global network dynamics. It explains the coexistence of multiple stable phenotypes within one genotype. The landscape's topography with its attractors is shaped by evolution through mutational re‐wiring of regulatory interactions – offering a link between genetic mutation and sudden, broad evolutionary changes. (shrink)

Recent philosophical analyses of the epistemic dimension of images in the sciences show a certain trend in acknowledging potential roles of these images beyond their merely decorative or pedagogical functions. We argue, however, that this new debate has yet paid little attention to a special type of pictures, we call ‘visual metaphor’, and its versatile heuristic potential in organizing data, supporting communication, and guiding research, modeling, and theory formation. Based on a case study of Conrad Hal Waddington’s epigenetic (...) class='Hi'>landscape images in biology, we develop a descriptive framework applicable to heuristic roles of various visual metaphors in the sciences. (shrink)

Recent philosophical analyses of the epistemic dimension of images in the sciences show a certain trend in acknowledging potential roles of these images beyond their merely decorative or pedagogical functions. We argue, however, that this new debate has yet paid little attention to a special type of pictures, we call ‘visual metaphor’, and its versatile heuristic potential in organizing data, supporting communication, and guiding research, modeling, and theory formation. Based on a case study of Conrad Hal Waddington’s epigenetic (...) class='Hi'>landscape images in biology, we develop a descriptive framework applicable to heuristic roles of various visual metaphors in the sciences. (shrink)

A history of colonization inflicts psychological, physical, and structural disadvantages that endure across generations. For an increasing number of Indigenous Australians, environmental epigenetics offers an important explanatory framework that links the social past with the biological present, providing a culturally relevant way of understanding the various intergenerational effects of historical trauma. In this paper, we critically examine the strategic uptake of environmental epigenetics by Indigenous researchers and policy advocates. We focus on the relationship between epigenetic processes and Indigenous (...) views of Country and health—views that locate health not in individual bodies but within relational contexts of Indigenous ontologies that embody interconnected environments of kin/animals/matter/bodies across time and space. This drawing together of Indigenous experience and epigenetic knowledge has strengthened calls for action including state-supported calls for financial reparations. We examine the consequences of this reimagining of disease responsibility in the context of “strategic biological essentialism,” a distinct form of biopolitics that, in this case, incorporates environmental determinism. We conclude that the shaping of the right to protection from biosocial injury is potentially empowering but also has the capacity to conceal forms of governance through claimants’ identification as “damaged,” thus furthering State justification of biopolitical intervention in Indigenous lives. (shrink)

Recent trends in psychiatry involve a transition from categorical to dimensional frameworks, in which the boundary between health and pathology is understood as a difference in degree rather than as a difference in kind. A major tenet of dimensional approaches is that no qualitative distinction can be made between health and pathology. As a consequence, these approaches tend to characterize such a threshold as pragmatic or conventional in nature. However, dimensional approaches to psychopathology raise several epistemological and ontological issues. First, (...) we review major sources of evidence usually recruited in support of the dimensional trend (focusing on clinical observation and biological data), and we show that these are connected to different conceptualizations of how dimensional traits extend across health and pathology. Second, we criticize two unquestioned assumptions that stand at the core of the dimensional trend: a) that there is continuity from health to pathology at the symptomatic level; b) that such continuity reflects an underlying continuity in the genetic liability for pathological conditions. Third, we argue against the idea of a conventional threshold by showing that such a view implies a linear relationship between the genotype and the phenotype. Fourth, drawing on epigenetics and developmental biology, we offer a characterization of mental disorders as stable and dynamic constellations of multi-level variables that differ qualitatively from ‘healthy states’. We conclude by showing that our account has several theoretical advantages over both categorical and dimensional approaches. Notably, it provides crucial insights into psychological development over time and individual differences, with major implications in terms of intervention and clinical decision-making. (shrink)

Determinism and unpredictability are compatible since deterministic flows can produce, if sensitive to initial conditions, unpredictable behaviors. Within this perspective, the notion of scenario to chaos transition offers a new form of predictability for the behavior of sensitive to initial condition systems under the variation of a control parameter. In this paper I first shed light on the genesis of this notion, based on a dynamical systems approach and on considerations of structural stability. I then suggest a link to the (...) figure of epigenetic landscape, partially inspired by a dynamical systems perspective, and offering a theoretical framework to apprehend developmental noise. (shrink)

This article develops a media philosophical framework for addressing the intersection of epigenetics and complex dynamical systems in theoretical biology. In particular, it argues that the theoretical humanities need to think critically about the computability of epigenomic regulation, as well as speculatively about the possibility of an epigenomics beyond complexity. The fact that such a conceptual framework does not exist suggests not only a failure to engage with the mathematics of complexity, but also a failure to engage with (...) its history. Both epigenetics and the application of complex dynamical systems to biology originate in the mid-twentieth-century work of Conrad Hal Waddington. The article demonstrates how this genealogy of epigenetic complexity reveals the need for a speculative conception of epigenomic mediation beyond mathematical complexity. Using Whitehead’s philosophy as a conceptual anchor, the “epimedial landscape” serves as a first pass at a media philosophical revision of the complex dynamical systems view of the epigenetic landscape. (shrink)

This article develops a media philosophical framework for addressing the intersection of epigenetics and complex dynamical systems in theoretical biology. In particular, it argues that the theoretical humanities need to think critically about the computability of epigenomic regulation, as well as speculatively about the possibility of an epigenomics beyond complexity. The fact that such a conceptual framework does not exist suggests not only a failure to engage with the mathematics of complexity, but also a failure to engage with (...) its history. Both epigenetics and the application of complex dynamical systems to biology originate in the mid-twentieth-century work of Conrad Hal Waddington. The article demonstrates how this genealogy of epigenetic complexity reveals the need for a speculative conception of epigenomic mediation beyond mathematical complexity. Using Whitehead’s philosophy as a conceptual anchor, the “epimedial landscape” serves as a first pass at a media philosophical revision of the complex dynamical systems view of the epigenetic landscape. (shrink)

The stunning possibility of “reprogramming” differentiated somatic cells to express a pluripotent stem cell phenotype (iPS, induced pluripotent stem cell) and the “ground state” character of pluripotency reveal fundamental features of cell fate regulation that lie beyond existing paradigms. The rarity of reprogramming events appears to contradict the robustness with which the unfathomably complex phenotype of stem cells can reliably be generated. This apparent paradox, however, is naturally explained by the rugged “epigenetic landscape” with valleys representing “preprogrammed” attractor (...) states that emerge from the dynamical constraints of the gene regulatory network. This article provides a pedagogical primer to the fundamental principles of gene regulatory networks as integrated dynamic systems and reviews recent insights in gene expression noise and fate determination, thereby offering a formal framework that may help us to understand why cell fate reprogramming events are inherently rare and yet so robust. (shrink)

From the 1930s through the 1970s, C. H. Waddington attempted to reunite genetics, embryology, and evolution. One of the means to effect this synthesis was his model of the epigenetic landscape. This image originally recast genetic data in terms of embryological diagrams and was used to show the identity of genes and inducers and to suggest the similarities between embryological and genetic approaches to development. Later, the image became more complex and integrated gene activity and mutations. These revised (...) epigenetic landscapes presented an image of how mutations could alter developmental pathways to yield larger phenotypic changes. These diagrams became less important as the operon became used to model differential gene regulation. (shrink)

Conrad Hal Waddington was a British developmental biologist who mainly worked in Cambridge and Edinburgh, but spent the late 1930s with Morgan in California learning about Drosophila. He was the first person to realize that development depended on the then unknown activities of genes, and he needed an appropriate model organism. His major experimental contributions were to show how mutation analysis could be used to investigate developmental mechanisms in Drosophila, and to explore how developmental mutation could drive evolution, his other (...) deep interest. Waddington was, however, predominantly a thinker, and set out to provide a coherent framework for understanding the genetic bases of embryogenesis and evolution, developing his ideas in many books. Perhaps his best-known concept is the epigenetic landscape: here a ball rolls down a complex valley, making path choices. The rolling ball represents a cell’s development over time, while the topography represents the changing regulatory environment that controls these choices. In its later forms, the role of each feature in the landscape was controlled by the effects of sets of interacting genes, an idea underpinning contemporary approaches to systems biology. Waddington was the first developmental geneticist and probably the most important developmental biologist of the pre-molecular age. (shrink)

In eukaryotic cells, heterochromatin is typically composed of tandem DNA repeats and plays crucial roles in gene expression and genome stability. It has been reported that silencing at individual units within tandem heterochromatin repeats exhibits a position‐dependent variation. However, how the heterochromatin is organized at an individual repeat level remains poorly understood. Using a novel genetic approach, our recent study identified a conserved protein Rex1BD required for position‐dependent silencing within heterochromatin repeats. We further revealed that Rex1BD interacts with the 14‐3‐3 (...) protein to regulate heterochromatin silencing by linking RNAi and HDAC pathways. In this review, we discuss how Rex1BD and the 14‐3‐3 protein coordinate to modulate heterochromatin organization at the individual repeat level, and comment on the biological significance of the position‐dependent effect in heterochromatin repeats. We also identify the knowledge gaps that still need to be unveiled in the field. (shrink)

The notion that genetics, through natural selection, determines innate traits has led to much debate and divergence of thought on the impact of innate traits on the human phenotype. The purpose of this synthesis was to examine how innate theory informs genetic research and how understanding innate theory through the lens of Martha Rogers’ theory of unitary human beings can offer a contemporary view of how innate traits can inform epigenetic and genetic research. We also propose a new conceptual (...) model for genetic and epigenetic research. The philosophical, theoretical, and research literatures were examined for this synthesis. We have merged philosophical and conceptual phenomena from innate theory with the theory of unitary beings into the University of Illinois at Chicago model for genetic and epigenetic research. Innate traits are the cornerstone of the framework but may be modified epigenetically by biological, physiological, psychological, and social determinants as they are transcribed. These modifiers serve as important links between the concept of innate traits and epigenetic modifications, and, like the theory of unitary human beings, the process is understood in the context of individual and environmental interaction that has the potential to evolve as the determinants change. (shrink)

This chapter offers a brief review of theories on mirror neuron development, highlighting different models. These models focus on either the role of genetic mechanisms or the contributions of experience and of learning processes in shaping the brain circuits involved in action–perception coupling. As an alternative, the chapter proposes an epigenetic model for mirror neuron development, explaining how such a model can help to elucidate, within a unifying explanatory framework, the emergence, diversity, and functional reuse of mirror neurons. (...) Lastly, a related evolutionary scenario is sketched in which epigenetic regulation, genetic assimilation/the Baldwin effect, and niche construction play crucial roles in mirror neuron evolution. (shrink)

Recent findings in epigenetics have been attracting much attention from social scientists and bioethicists because they reveal the molecular mechanisms by which exposure to socioenvironmental factors, such as pollutants and social adversity, can influence the expression of genes throughout life. Most surprisingly, some epigenetic modifications may also be heritable via germ cells across generations. Epigenetics may be the missing molecular evidence of the importance of using preventive strategies at the policy level to reduce the incidence and prevalence of common (...) diseases. But while this “policy translation” of epigenetics introduces new arguments in favor of public health strategies and policy-making, a more “clinical translation” of epigenetics is also emerging. It focuses on the biochemical mechanisms and epigenetic variants at the origin of disease, leading to novel biomedical means of assessing epigenetic susceptibility and reversing detrimental epigenetic variants. In this paper, we argue that the impetus to create new biomedical interventions to manipulate and reverse epigenetic variants is likely to garner more attention than effective social and public health interventions and therefore also to garner a greater share of limited public resources. This is likely to happen because of the current biopolitical context in which scientific findings are translated. This contemporary neoliberal “regime of truth,” to use a term from Michel Foucault, greatly influences the ways in which knowledge is being interpreted and implemented. Building on sociologist Thomas Lemke's Foucauldian “analytics of biopolitics” and on literature from the field of science and technology studies, we present two sociological trends that may impede the policy translation of epigenetics: molecularization and biomedicalization. These trends, we argue, are likely to favor the clinical translation of epigenetics—in other words, the development of new clinical tools fostering what has been called “personalized” or “precision” medicine. In addition, we argue that an overemphasized clinical translation of epigenetics may further reinforce this biopolitical landscape through four processes closely related to neoliberal pathways of thinking: the internalization and isolation of socioenvironmental determinants of health and increased opportunities for commodification and technologicalization of health care interventions. (shrink)

Environmental epigenetics is increasingly employed to understand the health outcomes of communities who have experienced historical trauma and structural violence. Epigenetics provides a way to think about traumatic events and sustained deprivation as biological “exposures” that contribute to ill-health across generations. In Australia, some Indigenous researchers and clinicians are embracing epigenetic science as a framework for theorising the slow violence of colonialism as it plays out in intergenerational legacies of trauma and illness. However, there is dispute, contention, and (...) caution as well as enthusiasm among these research communities.In this article, we trace strategies of “refusal” (Simpson, 2014) in response to epigenetics in Indigenous contexts. Drawing on ethnographic fieldwork conducted in Australia with researchers and clinicians in Indigenous health, we explore how some construct epigenetics as useless knowledge and a distraction from implementing anti-colonial change, rather than a tool with which to enact change. Secondly, we explore how epigenetics narrows definitions of colonial harm through the optic of molecular trauma, reproducing conditions in which Indigenous people are made intelligible through a lens of “damaged” bodies. Faced with these two concerns, many turn away from epigenetics altogether, refusing its novelty and supposed benefit for Indigenous health equity and resisting the pull of postgenomics. (shrink)

Genomic function is dictated by a combination of DNA sequence and the molecular mechanisms controlling access to genetic information. Access to DNA can be determined by the interpretation of covalent modifications that influence the packaging of DNA into chromatin, including DNA methylation and histone modifications. These modifications are believed to be forms of “epigenetic codes” that exist in discernable combinations that reflect cellular phenotype. Although DNA methylation is known to play important roles in gene regulation and genomic function, its (...) contribution to the encoding of epigenetic information is just beginning to emerge. Here we discuss paradigms associated with the various components of DNA methylation/demethylation and recent advances in the understanding of its dynamic regulation in the genome, integrating these mechanisms into a framework to explain how DNA methylation could contribute to epigenetic codes. (shrink)

Epigenetic research has brought several important technological achievements, including identifying epigenetic clocks and signatures, and developing epigenetic editing. The potential military applications of such technologies we discuss are stratifying soldiers’ health, exposure to trauma using epigenetic testing, information about biological clocks, confirming child soldiers’ minor status using epigenetic clocks, and inducing epigenetic modifications in soldiers. These uses could become a reality. This article presents a comprehensive literature review, and analysis by interdisciplinary experts of the (...) scientific, legal, ethical, and societal issues surrounding epigenetics and the military. Notwithstanding the potential benefit from these applications, our findings indicate that the current lack of scientific validation for epigenetic technologies suggests a careful scientific review and the establishment of a robust governance framework before consideration for use in the military. In this article, we highlight general concerns about the application of epigenetic technologies in the military context, especially discrimination and data privacy issues if soldiers are used as research subjects. We also highlight the potential of epigenetic clocks to support child soldiers’ rights and ethical questions about using epigenetic engineering for soldiers’ enhancement and conclude with considerations for an ethical framework for epigenetic applications in the military, defense, and security contexts. (shrink)

Both landscape and aesthetics are all too often considered disengaged categories associated with leisure and contemplation. This book establishes landscape as a key concept in contemporary thought and rethinks aesthetics in political and activist terms. In order to do so, it challenges the dualism of "the environment" as the space inhabited by humans and the province of the natural sciences about which philosophy has little to say. (This separation is evident even in the name of the recent field (...) of environmental humanities.) In a holistic view, landscapes are at the intersection of environment and human, place and people, and nature and culture, and aesthetics provide an immersive and engaged approach to them. Landscapes are ways of being in the world and aesthetics practical means of inhabiting them. Utilizing a pragmatist, antiessentialist lens, Alberto L. Siani characterizes landscapes (as opposed to environments and territories) as concrete, experienced habitats, performative ways of making sense of the world, while aesthetics (following Dewey) identify values and ordering criteria that permeate them. He addresses issues such as temporality, environmentalism, justice, education, and interdisciplinarity within this framework and in conversation with scientific positions. A coda gives three phenomenological accounts of intensely experienced and inhabited landscapes. (shrink)

In this paper we address a frontier topic in the humanities, namely how the cultural and natural construction that we call landscape affects well-being and health. Following an updated review of evidence-based literature in the fields of medicine, psychology, and architecture, we propose a new theoretical framework called “processual landscape,” which is able to explain both the health-landscape and the medical agency-structure binomial pairs. We provide a twofold analysis of landscape, from both the cultural and (...) naturalist points of view: in order to take into account its relationship with health, the definition of landscape as a cultural product needs to be broadened through naturalization, grounding it in the scientific domain. Landscape cannot be distinguished from the ecological environment. For this reason, we naturalize the idea of landscape through the notion of affordance and Gibson’s ecological psychology. In doing so, we stress the role of agency in the theory of perception and the health-landscape relationship. Since it is the result of continuous and co-creational interaction between the cultural agent, the biological agent and the affordances offered to the landscape perceiver, the processual landscape is, in our opinion, the most comprehensive framework for explaining the health-landscape relationship. The consequences of our framework are not only theoretical, but ethical also: insofar as health is greatly affected by landscape, this construction represents something more than just part of our heritage or a place to be preserved for the aesthetic pleasure it provides. Rather, we can talk about the right to landscape as something intrinsically linked to the well-being of present and future generations. (shrink)

This article compares two different bodies of theories concerning the role of the genome in life processes. The first group of theories can be indicated as referring to the gene-centric paradigm. Dominated by an informational myth and a mechanistic Cartesian body/mind and form/substance dualism, this considers the genome as an ensemble of discrete units of information governing human body and behavior, and remains hegemonic in life sciences and in the public imagination. The second body of theories employs the principle of (...) the extraordinary plasticity of the (body-)organism and emphasizes the value of the (body-)organism-environment mutual interchange, known as ‘the epigenetic approach’. This approach is outlined, showing a gradual, paradigmatic shift from the genecentric towards an epigenetic approach can be observed in the ‘scientific landscape’ over the last 20 years. The article concludes by formulating the argument that this ‘epigenetic turn’ in life sciences has some important implication for renewing epistemological basis of social sciences. (shrink)

Evolution is frequently concentrated in bursts of rapid morphological change and speciation followed by long‐term stasis. We propose that this pattern of punctuated equilibria results from an evolutionary tug‐of‐war between host genomes and transposable elements (TEs) mediated through the epigenome. According to this hypothesis, epigenetic regulatory mechanisms (RNA interference, DNA methylation and histone modifications) maintain stasis by suppressing TE mobilization. However, physiological stress, induced by climate change or invasion of new habitats, disrupts epigenetic regulation and unleashes TEs. With (...) their capacity to drive non‐adaptive host evolution, mobilized TEs can restructure the genome and displace populations from adaptive peaks, thus providing an escape from stasis and generating genetic innovations required for rapid diversification. This “epi‐transposon hypothesis” can not only explain macroevolutionary tempo and mode, but may also resolve other long‐standing controversies, such as Wright's shifting balance theory, Mayr's peripheral isolates model, and McClintock's view of genome restructuring as an adaptive response to challenge. (shrink)

Epigenetic changes are implicated in aging and cancer. Sometimes, it is clear whether the causing agent of the condition is a genetic factor or epigenetic. In other cases, the causative factor is unclear, and could be either genetic or epigenetic. Is there a general role for epigenetic changes in cancer and aging? Here, I present the paradigm of causative roles executed by epigenetic changes. I discuss cases with clear roles of the epigenome in cancer and (...) aging, and other cases showing involvement of other factors. I also present the possibility that sometimes causality is difficult to assign because of the presence of self‐reinforcing loops in epigenetic regulation. Such loops hinder the identification of the causative factor. I provide an experimental framework by which the role of the epigenome can be examined in a better setting and where the presence of such loops could be investigated in more detail. (shrink)

The rise of molecular epigenetics over the last few years promises to bring the discourse about the sociality and susceptibility to environmental influences of the brain to an entirely new level. Epigenetics deals with molecular mechanisms such as gene expression, which may embed in the organism “memories” of social experiences and environmental exposures. These changes in gene expression may be transmitted across generations without changes in the DNA sequence. Epigenetics is the most advanced example of the new postgenomic and context-dependent (...) view of the gene that is making its way into contemporary biology. In my article I will use the current emergence of epigenetics and its link with neuroscience research as an example of the new, and in a way unprecedented sociality of contemporary biology. After a review of the most important developments of epigenetic research, and some of its links with neuroscience, in the second part I reflect on the novel challenges that epigenetics presents for the social sciences for a re-conceptualization of the link between the biological and the social in a postgenomic age. Although epigenetics remains a contested, hyped, and often uncritical terrain, I claim that especially when conceptualized in broader non-genecentric frameworks,. (shrink)

Emerging fields of science often create new challenges for ethics and law. In assessing the broader societal implications of scientific discoveries, a reasonable analytical starting point is determining how the discoveries compare with existing science. If the new field is substantially similar to an established one, then the ethical and legal analyses are likely to be comparable. On the other hand, if the new scientific developments are extraordinary in kind or degree, then a new analytical framework and new approaches (...) to ethics and law may be necessary. (shrink)

Epigenetic markers could potentially be used for risk assessment in risk-stratified population-based cancer screening programmes. Whereas current screening programmes generally aim to detect existing cancer, epigenetic markers could be used to provide risk estimates for not-yet-existing cancers. Epigenetic risk-predictive tests may thus allow for new opportunities for risk assessment for developing cancer in the future. Since epigenetic changes are presumed to be modifiable, preventive measures, such as lifestyle modification, could be used to reduce the risk of (...) cancer. Moreover, epigenetic markers might be used to monitor the response to risk-reducing interventions. In this article, we address ethical concerns related to personal responsibility raised by epigenetic risk-predictive tests in cancer population screening. Will individuals increasingly be held responsible for their health, that is, will they be held accountable for bad health outcomes? Will they be blamed or subject to moral sanctions? We will illustrate these ethical concerns by means of a Europe-wide research programme that develops an epigenetic risk-predictive test for female cancers. Subsequently, we investigate when we can hold someone responsible for her actions. We argue that the standard conception of personal responsibility does not provide an appropriate framework to address these concerns. A different, prospective account of responsibility meets part of our concerns, that is, concerns about inequality of opportunities, but does not meet all our concerns about personal responsibility. We argue that even if someone is responsible on grounds of a negative and/or prospective account of responsibility, there may be moral and practical reasons to abstain from moral sanctions. (shrink)

Two types of formal models - landscape search tasks and two-armed bandit models - are often used to study the effects that various social factors have on epistemic performance. I argue that they can be understood within a single framework. In this unified framework, I develop a model that may be used to understand the effects of functional and demographic diversity and their interaction. Using the unified model, I find that the benefit of demographic diversity is most (...) pronounced in a functionally homogeneous group, and decreases with the increase of functional diversity. (shrink)

As genetic knowledge continues to strengthen notions of identity in Euro-American societies and beyond, epigenetic knowledge is intervening in these legitimation frameworks. I explore these interventions in the realm of assisted reproduction—including adoption, donor conception, and gestational surrogacy. The right to identity is protected legally in many states and receives due attention in public and private international law. Originating from the context of adoption, donor-conceived and surrogacy-born persons have recently demanded the same protections and focused on the right to (...) genetic knowledge. This article explores possible implications of epigenetic knowledge on identity. I start by articulating the deep influence of genetics on the notion of identity, and how this unfolds in legal contexts. Next, I examine how epigenetic findings that stress the importance of seeing biological life as situated and embedded in environments can challenge how adoption, donor conception, and gestational surrogacy are experienced and understood. While I argue that epigenetic knowledge can reify identity with the same determinism underpinning genetics, it can also allow for more biosocial understandings of identity that consider history and experience as entangled with biology. (shrink)

Approaches to induce tumor differentiation often result in manageable and therapy‐naïve cellular states in cancer cells. This transformation is achieved by activating pathways that drive tumor cells away from plasticity, a state that commonly correlates with enhanced aggression, metastasis and resistance to therapy. Here, we discuss signaling pathways, epigenetics and non‐coding RNAs as three main regulatory levels with the potential to drive tumor differentiation and hence as potential targets in differentiation therapy approaches. The success of an effective therapeutic regimen in (...) one cancer, however, does not necessarily sustain across cancer types; a phenomenon largely resulting from heterogeneity in the genetic and physiological landscapes of tumor types necessitating an approach designed for each cancer's unique genetic and phenotypic build‐up. (shrink)

Andean philosophy of nature or pachasophy results from topography and mode of production that, merged together, have produced an integrated and interacting worldview that blurs the line between culture and nature. Respecting Pacha, or the interconnectedness of life and geography, maintaining complementarity and equilibrium through symbolic interactions, and caring for Pachamama, the feminine presence of Pacha manifested mainly as cultivable soil are the basis of Andean environmental and social ethics. Reciprocity or ayni is the glue that holds everything together. This (...) weaving of traditional beliefs, customs, and ecologi­cal knowledge is rooted in the landscape and has sustained Quechua and Aymara societies during many millennia of knowing, using, and transforming the varied environments of the central Andes of South America. Any environmental ethics that influences people’s lives and promotes respectful and sustainable relationships with nature will be framed by already held worldviews. In Bolivia indigenous intellectuals are drawing on the ancient tradition of Pacha to trace an environmental ethics of pacha qamaña or the harmonious and integral well-being of life, the Earth, and the cosmos, and the ethics of suma qamaña as an all em­bracing ethical framework for the “good life” or “living well.” Although pacha qamaña and suma qamaña are rooted in the Andean mythological worldview, they will interest Western philosophers because the values they promote can be correctives for Western cultural traits that see little more than instrumental value in nature. In this sense, pacha qamaña and suma qamaña contribute to the broader discussion of environmental ethics. (shrink)

The article discusses the features of landscape philosophy, as well as the prospects of its practical application to analyze the crises of modern society associated with the scientific and technological revolution, globalization and the massification of culture. The concept of landscape becomes particularly important in connection with the urban turn in philosophy. The analysis given in this article has shown that landscape philosophy explains the negative characteristics of colonial cognition. The interpretation of the concept of space in (...) landscape philosophy is considered. Following S. Goryainov, we consider landscape philosophy as a philosophy of crisis. Our analysis has shown that landscape philosophy contributes to the approbation of models for solving the crisis of language and mind. Landscape philosophy and philosophical anthropology reveal existential problems. The works of M. de Unamuno, M. Scheler, M. Foucault and V. Podoroga were analyzed in this context. The significance of Unamuno's philosophy for the analysis of the role of individual creative space in the contemporary world is revealed. The applicability of Scheler's concept of spirit for the analysis of the problems of landscape philosophy is revealed. It is proved that within the framework of Podoroga's landscape philosophy, the problem of the correlation of politics and political. Using the concepts of utopia, atopia, and heterotopia, various aspects of the crisis of contemporary man man associated with the transformation of the subject's identity, the fragmentation of meanings and significance are studied. Thus, Podoroga's works are valuable for crisis philosophy because they analyze both spatial and political aspects of the crisis of contemporary society. Podoroga's works make it possible to reflect the contradictions of contemporary society, which ensures the prospects of their application for the analysis of changes in the contemporary social space. (shrink)

There has been considerable debate in the literature as to whether work in experimental philosophy actually makes any significant contribution to philosophy. One stated view is that many X-Phi projects, notwithstanding their focus on topics relevant to philosophy, contribute little to philosophical thought. Instead, it has been claimed the contribution they make appears to be to cognitive science. In contrast to this view, here we argue that at least one approach to X-Phi makes a contribution which parallels, and also extends, (...) historically salient forms of philosophical analysis, especially contributions from Immanuel Kant, William James, Peter F. Strawson and Thomas Nagel. The framework elaborated here synthesizes philosophical theory with empirical evidence from psychology and neuroscience and applies it to three perennial philosophical problems. According to this account, the origin of these three problems can be illuminated by viewing them as arising from a tension between two distinct types of cognition, each of which is associated with anatomically independent and functionally inhibitory neural networks. If the parallel we draw, between an empirical project and historically highly influential examples of philosophical analysis, is viewed as convincing, it follows that work in the cognitive sciences can contribute directly to philosophy. Further, this conclusion holds whether the empirical details of the account are correct or not. (shrink)

Since the Millennium Ecosystem Assessment in 2005, interest has increased in cultural ecosystem services (CESs) research to understand the complexity of the non-material benefits that people obtain from ecosystems. The intangible and interactive characteristics of CESs present many challenges regarding how to approach, quantify and even define CESs. In this paper, we suggest looking at CESs through the lens of embodied and situated cognition theories. We advocate that such an approach should be applied to the development stage of CES research (...) projects, as the embodied and situated experience of the site aids the development of research questions and future interventions. We described a case study—namely, the Environmental Empathy Research Challenge, which took place during the ColLaboratoire 2020 Research Residency in the Philippines. This case shows how interactive, embodied and situated workshops, such as Embodied Empathy and Walking Maps, contributed to developing a research proposal and a novel research framework, ecological embodied cognition (EEC). EEC focuses on the concept of environmental empathy to redefine the human-environment relationship. Further, based on an example of a participatory research activity, Sensing-Playing-Moving, we examined how interventions founded upon EEC principles enhance environmental empathy. (shrink)

For more than 35 years, James Welling has explored the material and conceptual possibilities of photography. Diary/Landscape - the first mature body of work by this important contemporary artist - set the framework for his subsequent investigations of abstraction and his fascination with nineteenth- and twentieth-century New England. In July 1977, Welling began photographing a two-volume travel diary kept by his great-grandmother Elizabeth C. Dixon, as well as landscapes in southern Connecticut. A beautiful and moving meditation on family, (...) history, memory, and place, the work reintroduced history and private emotion as subjects in high art, while also helping to usher in the centrality of photography and theoretical questions about originality that mark the epochal Pictures Generation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 36.2 (2003) 148-167 [Access article in PDF] Disciplinary Landscaping, or Contemporary Challenges in the History of Rhetoric Jacqueline Jones Royster Imagine that we have the privilege of viewing a terrain with its mountains, valleys, rivers and streams, with its flora and fauna, with its creatures that fly, walk, swim, and slither. What does it mean to understand such a geographical space in a richly textured, full-bodied (...) way and to recognize the many ways that we might appreciate and showcase dimensions of that view? What we choose to showcase depends materially on where on the landscape we stand and what we have in mind. The imperative is to recognize that the process of showcasing space is an interpretive one, one that acknowledges a view and often re-scopes that view in light of aesthetic sensibilities—values, preferences, beliefs. We landscape. We select, focus, and develop, bringing more clearly and vibrantly into view particular features that we frame and foreground, while simultaneously disregarding or minimizing other features and dimensions that we might have selected, developed, and showcased instead.Highlighting landscaping as an interpretive process underscores the extent to which interpretive enterprises are contingent more generally on perception and more specifically on the limitations of perception. In order to make sense of what is before us, we select, focus, and fine-tune the view that we are perceiving or imagining, and we assign to those perceptions value and meaning. We are limited by the choices we make and by the mechanisms and processes we use in shaping them into something that we care about and can persuade others to care about as well.Using landscaping as a metaphor for disciplinary knowledge-making offers a mechanism for understanding two provocative challenges. One is to recognize that whatever we currently know about rhetorical history as a disciplinary landscape is situated on a larger terrain of developed and undeveloped possibilities. A second challenge is to understand on an operational [End Page 148] level, rather than just a theoretical one, that knowledge is less truth for all time, space, and conditions than it is interpretation. In other words, scholars such as Burke, Foucault, Geertz, 1 and so on have helped us to see more clearly over the last few decades that we actually create and filter meaning from more elaborate perceptive possibilities, making sense of what we see based on ideological frameworks and social practices. In recognizing knowledge as an interpretive enterprise, a social construction, the imperative becomes the task of connecting theory with scholarly action in order to both theorize and engage in other scholarly activities more systematically. We are well challenged, thereby, to articulate the limitations of historical and current practices and the scholarship produced by such practices; to sustain perspectives that assume, rather than minimize, a fuller terrain where other views participate kaleidoscopically in the knowledge-making process; and to establish a more generous accreditation system capable of accounting for a more richly endowed rhetorical landscape and for more dynamic possibilities for understanding that landscape.How do we demonstrate in the history of rhetoric that we are cognizant of and informed by the knowledge that a territory, even an abstracted and often stylized domain of an intellectual territory, is endowed by various contingencies, as well as various dimensions of materiality? How do we make evident an understanding that the textures created by such variability can be brought to dynamic relief, enhanced, appreciated, and flexibly configured and reconfigured in valuation processes and in knowledge-making processes? Further, how do we bring such an understanding to bear in an academic domain such as rhetorical history where there is a deeply entrenched habit of standing in one place (that is, in territories deemed Western), shaping inquiries with a particular set of interests in mind (for example, the desires and experiences of elite males), and interestingly disregarding some features even within its own scope (for example, the desires and experiences of women or people from non-elite classes)? How do we engage in such endeavors with Western rhetorics, when these traditions of theory and... (shrink)

Connolly draws on the recent changes in the Malaysian state of Penang to open up new perspectives on urban development, governance and the politics of place. Reviewing the role of residents, activists, planners and other experts in socio-natural changes and urban regeneration, it builds an important new framework of landscape political ecology.

Big data has brought about opportunities for landscape architecture, changing the design thinking of layout optimization simulation, expanding the platform for public participation in layout optimization simulation design, reflecting social and humanistic care, and promoting the integration of discipline cooperation and data. At the same time, it also brings about challenges. The proposal of data theory, the acquisition and analysis of data, and the protection of privacy are all issues that we need to face and solve. First, build a (...) layout optimization simulation program under the background of big data. Follow the procedures of conventional layout optimization simulation, add big data analysis technology to the preliminary analysis, layout optimization simulation design, and later evaluation management, introduce new data processing methods, and build a theoretical framework of landscape optimization simulation methods that integrate new and traditional data. Second, studying the evolution of the landscape image layout of the three-dimensional pastoral complex is different: the overall landscape image layout of the three-dimensional pastoral complex shows a trend of fragmentation and heterogeneity. Among them, the arable land is gradually fragmented, the wetland and water area are simplified in form, the woodland and grassland patches are gradually distributed, the fragmentation is reduced by 76.19%, and the connectivity index is gradually increased. From a spatial perspective, the edge area outside the Fourth Ring Road becomes the most obvious area of fragmentation tendency. Finally, by introducing big data into the landscape layout optimization simulation, a layout optimization simulation method based on big data is constructed and used in the layout optimization simulation of the landscape image layout of the three-dimensional pastoral complex to guide the participatory layout optimization simulation. (shrink)

In a development of the ecosemiotic vivo-scape concept, a ‘safety eco-field’ is proposed as a model of a species response to the safety of its environment. The safety eco-field is based on the ecosemiotic approach which considers environmental safety as a resource sought and chosen by individuals to counter predatory pressure. To test the relative safety of different locations within a landscape, 66 bird feeders (BF) were deployed in a regular 15 × 15 m grid in a rural area, (...) surrounded by shrubs, small trees, hedgerows, and buildings. On each of 48 days in November 2021 and February and March 2022, dried mealworms were placed on each BF and counts of larvae at each BF were made at noon and dusk. The European robin (Erithacus rubecula) and the great tit (Parus major) were the most regular visitors to the BFs. Land cover at each BF was recorded. Bird behaviour at the BFs was noted from direct video recordings of the birds at nine selected BFs, totalling 32 daily sessions in March. The different behaviours of the European robin and the great tit were observable. The safety eco-field changed according to the month and the time of day. The distance of the BF from the woodland edges seemed to be important only in the morning. In the afternoon, BFs that were more distant from the woodland edges received the highest number of visits. Weather conditions were found to influence the number of mealworms removed, but this requires further investigation. A significant relationship between land cover and the number of mealworm larvae removed from the BFs was observed. Within the grid of BF, three regions were distinguishable which were related to land cover in the safety eco-field process. The experimental framework confirms the adequacy, at least for birds that have cryptic predators, to map the landscape as a proxy of safety resource. From the video recordings it was noted that the European robin visits were distributed throughout the day without apparent temporal preferences, while the great tit visits were concentrated in the central part of the day. This result has the limitation of the short period of observation (March) and should be extended to the entire period of the experiment to eventually capture seasonal variation. The experimental evidence obtained confirms that the ecosemiotic-based models of safety eco-field are an efficient approach to explain bird feeding preferences and behaviours. (shrink)

Following the suggestion expressed in the title of this essay, I deal with the idea which allows for considering landscape garden as a paradigmatic indicator of our relationship with nature. Focusing on the idea of landscape garden and its aesthetics I analyze two aesthetic notions: the picturesque and sublime, which are the background of the kind of experience accompanying a perception and participation of and in the landscape and environment. I analyse the kind of experience, which captures (...) all the aspects that situate the human in the environment instead of opposing it. The analysis will be conducted within the framework of aesthetics. (shrink)

Debates over adaptationism can be clarified and partially resolved by careful consideration of the ‘grain’ at which evolutionary processes are described. The framework of ‘adaptive landscapes’ can be used to illustrate and facilitate this investigation. We argue that natural selection may have special status at an intermediate grain of analysis of evolutionary processes. The cases of sickle-cell disease and genomic imprinting are used as case studies.