The regulation of glucose dehydrogenase (GLD) in Drosophila illustrates the combinatorial aspects of gene regulation in development. Furthermore, the findings serve to point up a general question about cukaryotic structural gene control: is regulation of expression always optimal?

Starting from the assumption that working memory capacity is an important predictor of general fluid intelligence, we asked which aspects of working memory account for this relationship. Two theoretical stances are discussed. The first one posits that the important explanatory factor is storage capacity, roughly defined as the number of chunks possible to hold in the focus of attention. The second one claims that intelligence is explained by the efficiency of executive control, for instance, by prepotent response inhibition. We (...) investigated 96 children at the age between 10 and 13. They completed a version of the n-back task that allows assessment of both storage capacity and inhibitory control. They also completed Raven’s Progressive Matrices as the fluid intelligence test and the Test for Creative Thinking - Drawing Production, for control purposes. We found that Raven’s scores correlated negatively with the number of unnecessary responses to irrelevant stimuli but they did not correlate with the number of signal detections. We conclude that children’s fluid intelligence depends on inhibitory control, with no relationship with storage capacity. (shrink)

Receptor tyrosine kinases and integrins are activated by growth factors and extracellular matrix, respectively. Their activation leads to signal transduction cascades that control many aspects of cell phenotype, including progression through the G1 phase of the cell cycle. However, the signalling cassettes driven by growth factors and matrix do not work independently of each other. Integrin triggering is essential to facilitate kinase‐ and GTPase‐mediated signals and thereby drive efficient transfer of information through the growth factor–cyclin axis. A recent (...) study indicates that an additional type of player has a key role in adhesion‐regulated control of cell cycle, namely ubiquitin ligase.(1) BioEssays 24:17–21, 2002. © 2002 John Wiley & Sons, Inc. (shrink)

Employers seeking to control employee behavior outside of working hours is nothing new. However, recent developments have extended efforts to control employee behavior into new areas, with new significance. Employers seek to control legal behavior by employees outside of working hours, to have significant influence over employee’s health-related behavior, and to monitor and control employee’s social media, even when this behavior has nothing to do with the workplace. In this article, I draw on the work (...) of political theorists Jon Elster, Gerald Gaus and Michael Walzer, and privacy scholars Daniel Solove and Anita Allen, to show what is wrong with this extension of employer control of employee’s outside of work behavior. I argue that there are ethical limits on the controls that employers may put on their employees’ out of work behavior, and that many of these limits should be enshrined into legal protections which would prevent employers from conditioning employment on the regulations criticized. -/- (Please note that the version of this paper on SSRN is a pre-publication version. Please cite and refer to the published version when possible.). (shrink)

Contents: PART I BASIC ASPECTS AND VARIETIES OF CONTROL: - Emotion, Cognition, and Control: Limits of Intentionality - Self-Efficacy: The Foundation of Agency - The Orchestration of Selection, Optimization and Compensation: An Action-Theoretical Conceptualization of a Theory of Developmental Regulation - Freedom of the Will -- the Basis of Control. PART II CONSCIOUS, AUTOMATIC, AND CONTROLLED PROCESSES: - Automatic and Controlled Uses of Memory in Social Judgments - Are Controlled Processes Conscious? - Intuition and Levels of (...) class='Hi'>Control: The Non-Rational Way of Reacting, Adapting, and Creating. PART III PERCEPTION, KNOWLEDGE, MEMORY, AND LEARNING: - The Issue of Control in Sensory and Perceptual Processes: Attention Selects and Modulates the Visual Input - The Control of Knowledge Activation in Discourse Comprehension - Working Memory and Attentional Control - Problem-Oriented Learning: Facilitating the Use of Domain-Specific and Control Strategies through Modeling by an Expert - The Role of Cognitive Structure in the Development of Behavioral Control: A Dynamic Skills Approach. (shrink)

This work examines the development and performance of federal independent regulatory bodies in Canada in the period up to 1979, with particular attention to the operation of legislative schemes that include executive review and appeal powers. The author assesses the impact of the exercise of these powers on the administrative law process, and proposes new models for the generation, interpretation, implementation, review, and enforcement of regulatory policy. The study includes a series of representative case studies based on documentation and (...) extensive interviews with individuals drawn from government, agencies, and other parties, including counsel for public interest groups. This enables author, writing from her experience as a participant-observer embedded in the public interest legal sector, to draw on the experiences and perspectives of a broad range of participants in the regulatory process, including but not limited to those dealing with the regulated energy, transportation, communications, and foreign investment sectors. Legal principles identified as emergent in leading judicial decisions in administrative law are used to assess the powers and practices used in executive reviews and appeals. The author finds those powers and practices to be flawed and proposes changes. The proposed models are designed to accord with emerging legal principles and avoid flaws of the types identified in the review and appeal provisions. This work, written under contract with the Administrative Law Project of the Law Reform Commission of Canada, formed one part of a comprehensive study of administrative law at the federal level in Canada. (shrink)

In this paper, we delve into the significant impact of recent advancements in Artificial Intelligence (AI) on the future landscape of work. We discuss the looming possibility of mass unemployment triggered by AI and the societal repercussions of this transition. Despite the challenges this shift presents, we argue that it also unveils opportunities to mitigate social inequalities, combat global poverty, and empower individuals to follow their passions. Amidst this discussion, we also touch upon the existential question of the purpose (...) of human life in a world where machines predominantly perform work. Additionally, we explore the contentious issue of the moral status and rights of AI entities, contemplating the scenario where machines evolve to become sapient and sentient. The paper concludes with a call to action, emphasizing the necessity to acknowledge these potential outcomes and proactively seek solutions, as part of an inevitable journey through the evolution of human society shared with intelligent machines. (shrink)

Virtual enterprise is a dynamic alliance of businesses, in which multiple members undertake joint research, development, manufacturing, operation, etc. The complexity of the relationship between business members, coupled with many new technologies or methods applied in the alliance operation, leads to more uncertain factors and difficulties in the operation and risk management of the virtual enterprise. The distributed decision-making model is a fast and effective decision-making model, in which dispersed intellectual resources and information resources are dynamically integrated through virtual organization (...) forms and operating mechanisms, and the dynamic reorganization, result evaluation, and synthesis of the decision-making system are realized by certain control rules. On the basis of summarizing and analyzing previous research works, this paper expounded the research status and significance of the risk control of virtual enterprise; elaborated the development background, current status, and future challenges of distributed decision-making model; introduced the related works of decision-making variable calculation and constraint determination; constructed a risk control model for virtual enterprise based on distributed decision-making model; analyzed the multiobjective model and interval programming model of risk control; established a risk control approach for virtual enterprise based on distributed decision-making model; performed the optimal allocation of risk control funds and the selective optimization of backup allies; and finally conducted a case analysis. The study results show that, in view of the diversity of relationships between alliance businesses and the complexity of the distribution of cooperative areas, the distributed decision-making model can more reasonably describe the relationship between alliance members and accurately control the risks of virtual enterprise from multiple angles, which can effectively manage the risks of virtual enterprise. The study results of this paper provide a reference for further research on the risk control of virtual enterprise based on distributed decision-making model. (shrink)

The ability to perform movements is vital for our daily life. Our actions are embedded in a complex environment where we need to deal efficiently in the face of unforeseen events. Neural oscillations play an important role in basic sensorimotor processes related to the execution and preparation of movements. In this review, I will describe the state of the art regarding the role of motor gamma oscillations in the control of movements. Experimental evidence from electrophysiological studies has shown that (...) motor gamma oscillations accomplish a range of functions in motor control beyond merely signaling the execution of movements. However, these additional aspects associated with motor gamma oscillation remain to be fully clarified. Future work on different spatial, temporal and spectral scales is required to further understand the implications of gamma oscillations in motor control. (shrink)

Gray's neuropsychological model of consciousness uses a hierarchical feedback loop framework that has been extensively discussed by many others in psychology. This commentary therefore urges Gray to integrate with, or at least acknowledge previous models. It also points out flaws in his feedback model and suggests directions for further theoretical work.

In recent years, the phenomena of hormonal control, embryonic determination and pattern formation have been receiving intensive scrutiny from molecular biologists. In the following «Roots» contribution, Professor Sir Vincent B. Wigglesworth reviews some of the seminal work that he did on these subjects in the insect Rhodnius prolixus.

SummaryThis paper explicates a Constructivist Epistemology which underlies cybernetic models of perceiving and knowing. We focus on the recent work of W. T. Powers . Powers' model consists of hierarchially arranged negative feedback systems, is based on the claim that living organisms behave to control perceptions, and thus suggests that organisms construct their experiential world. We argue that this provides a basis for a modified scientific scepticism, a scepticism with a positive dimension gained by adding the notion of (...) cognitive construction. From this perspective, knowing and perceiving pertain to the construction of invariances in the living organism's experience.RésuméDans cet essai, nous exposons une épistémologie constructivistc qui sert de base pour des modèles cybernétiques de la perception et de la connaissancc. Nous nous référonts à l'œuvre de W. T. Powers qui a propose un modèle constitué par un arrangement hiérarchique de boucles rétroactives en partant de l'idée que tout comportement a pour but de contrôler les perceptions. Ce modèle suggère que le monde expérientiel est le produit d'une activité constructive. Nous défendons la thèse que cette orientation peut fournir le fondement d'un scepticisme scientifique qui acquiert un aspect positif par la notion de construction cognitive. De ce point de vue, connaissance et perception sont des activités qui construisent des invariances dans l'expérience d'un organisme.ZusammenfassungIn der vorliegenden Arbeit wird eine konstruktivistische Erkenntnistheorie entwickelt, die ihrerseits gewissen kybernetischen Modeller) der Wahrnehmurtg und Er‐kenntnis zugrundeliegt. Wir beziehen uns auf die Untersuchungen von W. T. Powers , dessen Modell aus hierarchisch angeordneten Rückkopplungssystemen besteht und auf der Annahme be‐ruht, dass das Verhalten von Lebewesen der Regelung von Wahrnehmungcn dicnt. Powers legt deshalb die Hypothese nahe, dass Organismen ihre Erlebenswelt konstru‐iren. Wir vertreten die Ansicht, dass diese die Grundlage für einen neuen wisscnschaftli‐chen Skeptizismus liefert, der auf Grund des Begriffes der kognitiven Konstruktion eine positive Dimension gewinnt. Von diesem Gesichtspunkt aus betrachtet betreffen Wissen und Wahrnehmung den aktiven Aufbau von Konstanten in der Erlebenswelt des Orga‐nismus. (shrink)

This paper offers a conceptual framework which (re)integrates goal-directed control, motivational processes, and executive functions, and suggests a developmentalpathway from situated action to higher level cognition. We first illustrate a basic computational (control-theoretic) model of goal-directed action that makes use of internalmodeling. We then show that by adding the problem of selection among multiple actionalternatives motivation enters the scene, and that the basic mechanisms of executivefunctions such as inhibition, the monitoring of progresses, and working memory, arerequired for this (...) system to work. Further, we elaborate on the idea that the off-line re-enactment of anticipatory mechanisms used for action control gives rise to (embodied)mental simulations, and propose that thinking consists essentially in controlling mental simulations rather than directly controlling behavior and perceptions. We concludeby sketching an evolutionary perspective of this process, proposing that anticipationleveraged cognition, and by highlighting specific predictions of our model. (shrink)

Reclamation is the phenomenon of an oppressed group repurposing language to its own ends. A case study is reclamation of slur words. Popa-Wyatt and Wyatt (2018) argued that a slurring utterance is a speech act which performs a discourse role assignment. It assigns a subordinate role to the target, while the speaker assumes a dominant role. This pair of role assignments is used to oppress the target. Here I focus on how reclamation works and under what conditions its benefits can (...) stabilise. I start by reviewing the data and describing preconditions and motivations for reclamation. Can reclamation be explained in the same basic framework as regular slurring utterances? I argue that it can. I also identify some features that must be a prediction of any theory of reclamation. I conclude that reclamation is an instance of a much broader class of acts we do with words to change the distribution of power: it begets power, but it also requires it. (shrink)

Prior research has identified age 9–11 as a critical period for the development of the control-of-variables strategy (CVS). We examine the stability of interindividual differences in children's CVS skills with regard to their precursor skills during this critical developmental period. To this end, we relate two precursor skills of CVS at age 9 to four skills constituting fully developed CVS more than 2 years later, controlling for children's more general cognitive development. Note thatN= 170 second- to fourth-graders worked on (...) multiple choice-assessments of their understanding of indeterminacy of evidence and of confounding. We find relations between these two precursor skills and children's CVS skills 2 years later at age 11 inplanning, identifying, andinterpretingcontrolled experiments, and in recognizing the inconclusiveness of confounded comparisons (understanding). In accordance with the perspective that both indeterminacy and confounding constitute critical, related yet distinct elements of CVS, both precursor skills contribute to the prediction of later CVS. Together, the two precursor skills can explain 39% of students' later CVS mastery. Overall, the understanding of indeterminacy is a stronger predictor of fully developed CVS than that of confounding. The understanding of confounding, however, is a better predictor of the more difficult CVS sub-skills of understanding the inconclusiveness of confounded comparisons, and of planning a correctly controlled experiment. Importantly, both precursor skills maintain interactive predictive strength when controlling for children's general cognitive abilities and reading comprehension, showing that the developmental dynamics of CVS and its precursor skills cannot be fully ascribed to general cognitive development. We discuss implications of these findings for theories about the development of CVS and broader scientific reasoning. (shrink)

The human masticatory system is a complex functional unit characterized by a multitude of skeletal components, muscles, soft tissues, and teeth. Muscle activation dynamics cannot be directly measured on live human subjects due to ethical, safety, and accessibility limitations. Therefore, estimation of muscle activations and their resultant forces is a longstanding and active area of research. Reinforcement learning (RL) is an adaptive learning strategy which is inspired by the behavioral psychology and enables an agent to learn the dynamics of an (...) unknown system via policy-driven explorations. The RL framework is a well-formulated closed-loop system where high capacity neural networks are trained with the feedback mechanism of rewards to learn relatively complex actuation patterns. In this work, we are building on a deep RL algorithm, known as the Soft Actor-Critic, to learn the inverse dynamics of a simulated masticatory system, i.e., learn the activation patterns that drive the jaw to its desired location. The outcome of the proposed training procedure is a parametric neural model which acts as the brain of the biomechanical system. We demonstrate the model’s ability to navigate the feasible three-dimensional (3D) envelope of motion with sub-millimeter accuracies. We also introduce a performance analysis platform consisting of a set of quantitative metrics to assess the functionalities of a given simulated masticatory system. This platform assesses the range of motion, metabolic efficiency, the agility of motion, the symmetry of activations, and the accuracy of reaching the desired target positions. We demonstrate how the model learns more metabolically efficient policies by integrating a force regularization term in the RL reward. We also demonstrate the inverse correlation between the metabolic efficiency of the models and their agility and range of motion. The presented masticatory model and the proposed RL training mechanism are valuable tools for the analysis of mastication and other biomechanical systems. We see this framework’s potential in facilitating the functional analyses aspects of surgical treatment planning and predicting the rehabilitation performance in post-operative subjects. (shrink)

Most accounts of mechanism discovery have focused on mechanisms that perform the work required to produce a phenomenon. These mechanisms are often subject to regulation by control mechanisms. Using the example of the molecular motor dynein, this paper examines one process by which such control mechanisms are discovered—the process by which researchers, after identifying additional components required to produce the phenomenon but not directly involved in the work of producing that phenomenon, investigate both how these components (...) act on the original mechanism and how they do so in response to measurements of conditions relevant to the operation of the controlled mechanism. (shrink)

This book constitutes the outcome of an international conference held at the Otto-Mobes-Volkswirtschaftsschule, Graz-Stifting( Austria), from June 16 to 22, 1974. The conference was initiated by a project group working on determinants and controls of social science development at the In stitute for Advanced Studies and Scientific Research in Vienna and or ganized by the editors of this volume. It was held under the auspices of the Austrian Ministry of Science and Research. The main topics of the conference were those (...) at the forefront of the 'state of argumentation' (to borrow from one of our contributors) in philosophy and sociology of science ever since the controversy between Thomas S. Kuhn and Sir Karl R. Popper has sharpened our awareness for the methodological and substantial presuppositions involved with questions of growth and development in science. Let us give two examples of those topics. The borderline between sociology of science and philo sophy of science has become more and more unclear; while the work of at least some philosophers of science comes to have an empirical flavour, sociologists of science are increasingly apt to include logical and methodo logical components of the research process as their objects of examina tion. Papers included in this volume testify to both tendencies. (shrink)

Journal of Social Philosophy, Volume 53, Issue 2, Page 221-238, Summer 2022.

The ability to reason independently from one's own goals or beliefs has long been recognised as a key characteristic of the development of formal operational thought. In this article we present the results of a study that examined the correlates of this ability in a group of 10-year-old children ( N = 61). Participants were presented with conditional and relational reasoning items, where the content was manipulated such that the conclusion to the arguments were either congruent, neutral, or incongruent with (...) beliefs, and either logically valid or logically invalid. Participants also received a measure of working memory capacity (the counting span task) and a measure of inhibitory control (the stop signal task). Indices of belief bias and logical reasoning on belief-based problems were predicted independently by both measures. In contrast logical reasoning on belief neutral problems was predicted by working memory alone. The findings suggest that executive functions play a key role in the development of children's ability to decontextualise their thinking. (shrink)

Due to the frequent occurrence of ethical transgressions and unethical employee behaviors, there has lately been an increasing interest in the ethical foundations of contemporary organizations. However, large-scale comprehensive analyses of organizational ethics are still comparatively limited. Our study contributes to both management control and business ethics literature by empirically examining potential antecedents as well as resulting effects of ethical work climates on organizational-level outcomes. Based on a cross-sectional survey among 295 large- and medium-sized companies, we find that (...) more informal means of control constitute important elements of a broader organizational control context that are strongly related to the emergence of coherent ethical work climates with an increased awareness of ethical issues. Moreover, our results show that the relationship between ethical work climates and organizational performance can be considered as rather indirect as it is fully mediated by increased mutual trust among employees. Overall, our study thus supports the particular importance of ethical work climates and identifies appropriate means to encourage ethical conduct. (shrink)

Can suggestion, particularly hypnotic suggestion, influence cognition? Addressing this intriguing question experimentally is on the rise in cognitive research, nowhere more prevalently than in the domain of cognitive control and attention. This may well rest on the intuitive connection between hypnotic suggestion and attention, where the hypnotist controls the subject’s attention. Particularly impressive has been the work of Raz and his colleagues demonstrating the modulation and even the complete elimination of classic Stroop color–word interference when subjects are given (...) a posthypnotic suggestion that words are meaningless. Overriding a highly practiced, possibly even automatic response like reading is testament to the attentional control that can be exerted under hypnotic suggestion. What else do we need to know—in the Stroop context and more broadly—to obtain a clear picture of how suggestion can orchestrate attention? (shrink)

We investigated the association between cognitive control and individual differences in cortisol response to stress in participants with generalised anxiety disorder and in never-disordered c...

Working memory (WM) is a cognitive system that allows us to select, organise, and integrate perceptual information with memories and current goal-directed intentions. As such, this system is central to day-to-day functioning and would be expected to be especially important in decision making and problem solving. We hypothesised that to the extent that individuals differ in WM capacity they would also be differentially vulnerable to the experience of depression and anxiety. Undergraduate students completed a computerised change detection task in which (...) storage capacity and filtering efficiency measures were obtained. It was found that low WM storage and poor filtering efficiency interacted to predict higher levels of emotional distress as measured by self-reported depressive symptoms, ruminative coping, and state anxiety. It was suggested that low capacity and a poor ability to ignore task-irrelevant information may lead to poorer problem solving, more extreme judgements of oneself and circumstances, increased rumination, and poorer emotional regulation. (shrink)

A number of studies have demonstrated pragmatic language difficulties in people with Schizophrenia Spectrum and Other Psychotic Disorders. However, research about how people with schizophrenia spectrum and other psychotic disorders understand scalar implicatures is surprisingly rare, since SIs have generated much of the most recent literature. Scalar implicatures are pragmatic inferences, based on linguistic expressions like some, must, or, which are part of a scale of informativeness. Logically, the less informative expressions imply the more informative ones, but pragmatically people usually (...) infer that the presence of a less informative term implies that the more informative term was not applicable. In one of the few existing studies with people with schizophrenia spectrum and other psychotic disorders, Wampers et al. observed that in general, people with schizophrenia spectrum and other psychotic disorders were less likely to derive SIs than controls. The current study has three main aims. First, we want to replicate the original finding with the scalar terms some-all. Second, we want to investigate how these patients deal with different scalar terms, that is, we want to investigate if scalar diversity is also observed in this clinical group. Third, we investigate the role of working memory, often seen as another important mechanism to enable inferring SIs. Twenty-one individuals with a psychotic disorder and 21 matched controls answered 54 under-informative statements, in which seven different pairs of scalar terms were used. In addition, working memory capacity was measured. Patients with schizophrenia spectrum and other psychotic disorders did not make more logical interpretations when processing quantifiers, disconfirming Wampers et al.. However, certain scalar scales elicited more pragmatic interpretations than others, which is in line with the scalar diversity hypothesis. Additionally, we observed only partial evidence for the role of working memory. Only for the scalar scale and-or, a significant effect of working memory was observed. The implications of these results for patients with schizophrenia spectrum and other psychotic disorders are discussed, but also the role of working memory for pragmatic inferences, as well as the place of SIs in experimental pragmatics. (shrink)

Immigrant nurses make up a large percentage of the Australian nursing workforce. Since the support in the workplace is expected to be inclusive for all nurses, the aim of this article is to explore how support and opportunities for professional growth, learning and development are distributed across different categories of nurses working in a neonatal intensive care unit (NICU). An ethnographic approach has opened an examination of the everyday workplace practices in the NICU to gain insight into how nurses made (...) sense of the social and power relations occurring between themselves and their senior colleagues and how they experienced the support and opportunities they received in their workplace. As today's workplaces such as the NICU are diverse in races, culture and experiences, the concepts of intersectionality and cultural safety assisted in identifying inequality and injustice related to such diversity. The results showed how patronage relations rendered nurses with immigrant status with major disadvantage and left them clinically and culturally vulnerable. Such inequity defeats the reasons for encouraging skilled migration of nurses and poses questions on the cultural competency of recruiting organisations. Considering how cultural safety might guide staff development offers opportunities for authentic support to culturally diverse nurses. (shrink)

Beyond the reaches of scholarly debates about how to define and value civility properly, social actors across various institutional domains routinely demarcate civil from uncivil behavior. Yet this everyday classification process remains understudied and undertheorized, despite being widespread and having significant stakes for the individuals and groups involved. This article begins to fill this gap by developing the concept of civility contests—practical efforts to draw symbolic boundaries between civil and uncivil individuals, groups, or behaviors. Through a focus on the realm (...) of political protest in the United States, this article demonstrates that civility contests involve a wide range of political actors (including institutionalized power holders, opposing movements, and the media) who engage in this boundary-work in order to justify the control or (de)legitimation of protest. It then highlights patterned disparities in the outcomes of these contests, demonstrating that the likelihood of being marked as uncivil and the extent to which this prompts negative social sanction is shaped by one’s social position. Overall, the article seeks to stimulate and guide future empirical research on civility contests and to deepen theoretical understandings of the relationship between symbolic and social boundaries and the role of symbolic boundary-work in the reproduction of political inequality. (shrink)

Investigation of joint torque constraint compliance is of significance for robot manipulators especially working in complex environments. A lot of which is attributed to that, on the one hand, it is beneficial to the improvement of both safety and reliability of the mission execution. On the other hand, the energy consumption required by the robot to complete the desired mission can be reduced. Most existing schemes do not take the joint torque limit and other inherent physical structure limits in a (...) manipulator into account at the same time. In addition, many unavoidable uncertainties such as the external environmental disturbance and/or electromagnetism interferences in the circuit system may influence the accuracy and effectiveness of the task execution for a robot. In this study, we cast light on the acceleration level control of redundant robot manipulators considering both four physical constraint limits and interference rejection. A robust unified quadratic-programming-based hybrid control scheme is proposed, where the joint torque constraints are converted as two inequality constraints based on the robots’ dynamics equation. A recurrent-neural-network-based controller is designed for solving the control variable. Numerical experiments performing in PUMA 560 manipulator and planer manipulator illustrate that a rational torque distribution is obtained among the joints and the considered physical structural vectors are all restricted to the respective constraint range. In addition, even disturbed by the noise, the manipulator still successfully tracks the desired trajectory under the proposed control scheme. (shrink)

The endocannabinoid system is the target of the main psychoactive component of the plant Cannabis sativa, the Δ9‐tetrahydrocannabinol (THC). This system is composed by the cannabinoid receptors, the endogenous ligands, and the enzymes involved in their metabolic processes, which works both centrally and peripherally to regulate a plethora of physiological functions. This review aims at explaining how the site‐specific actions of the endocannabinoid system impact on memory and feeding behavior through the cannabinoid receptors 1 (CB1R). Centrally, CB1R is widely distributed (...) in many brain regions, different cell types (e.g. neuronal or glial cells) and intracellular compartments (e.g. mitochondria). Interestingly, cellular and molecular effects are differentially mediated by CB1R according to their cell‐type localization (e.g. glutamatergic or GABAergic neurons). Thus, understanding the cellular and subcellular function of CB1R will provide new insights and aid the design of new compounds in cannabinoid‐based medicine.Also watch the Video Abstract. (shrink)

In a laboratory on a university campus in Santa Cruz, California, Ben Novak is doing everything he can to bring Ectopistes migratorius back from the dead. Using techniques now available in genome reading and gene synthesis, he and paleogenomicist Beth Shapiro hope that, by 2032, a flock of passenger pigeons ten thousand or more strong will have resumed an ecologically significant role in the mast forests of the Eastern United States. Novak knows—and the International Union for Conservation of Nature (IUCN) (...) affirms—that the challenges involved in making de‐extinction work are far from solely genetic. Novak is doing an ecological risk assessment of passenger pigeon reintroduction to figure out whether flocks of the resurrected species would pose any special hazards to ecosystems. Ecological harm is one of several worries attending the prospect of de‐extinction. Among other concerns are the possible harm that individuals born through this process might suffer and the possible introduction of disease vectors. But I want to step back from these immediate questions and think about some conceptual ones that operate in the background. Technology can be a grand shaper of cultural norms and expectations, and de‐extinction should be looked at in relation to a number of emerging technologies. This paper will examine the degree to which de‐extinction is part of a more widespread restructuring of ethical relationships to the surrounding world that are under way at the hands of emerging technologies. This restructuring is part of an ongoing shift in how to think about conservation in the new epoch of the Anthropocene. (shrink)

The target article by Bernard Baars presents a quick way of grasping the gist of his book In the Theater of Consciousness: The Workspace of the Mind, published recently . The metaphor of consciousness as a theatre has a long history. A prototype of the theatre model may be traced back to Plato's Allegory of the Cave, in which we are like prisoners living in a cave just observing the shadows of reality. The modern theatre model insists on consciousness being (...) under the control of attention by introducing a searchlight metaphor . The target article explores some evidence from the viewpoint of Global Workspace theory by using a method of ‘contrastive analysis’. According to this theory, GW works as the publicity organ of the brain and has a facility for accessing, disseminating, and exchanging information, and for exercizing global coordination and control . Baars describes his GW as a theatre. ‘As the house lights begin to dim and the audience falls silent, a single spotlight pierces the descending darkness, until only one bright spot, shining on stage, remains visible. You know that the audience, actors, stagehands, and spotlight operators are there, working together under invisible direction and guided by an unknown script, to present the flow of visible events on stage. As the house lights dim, only the focal contents of consciousness remain. Everything else is in darkness’ . According to GW theory, a theatre stage with a bright spot is just a working memory. So I would like to comment on some general characteristics of the working memory and related spotlight problem. (shrink)

This paper is devoted to the control problem of a nonlinear dynamical system obtained by a truncation of the two-dimensional Navier–Stokes equations with periodic boundary conditions and with a sinusoidal external force along the x-direction. This special case of the 2D N-S equations is known as the 2D Kolmogorov flow. Firstly, the dynamics of the 2D Kolmogorov flow which is represented by a nonlinear dynamical system of seven ordinary differential equations of a laminar steady state flow regime and a (...) periodic flow regime are analyzed; numerical simulations are given to illustrate the analysis. Secondly, an adaptive controller is designed for the system of seven ODEs representing the approximation of the dynamics of the 2D Kolmogorov flow to control its dynamics either to a steady-state regime or to a periodic regime; the value of the Reynolds number is determined using an update law. Then, a static sliding mode controller and a dynamic sliding mode controller are designed for the system of seven ODEs representing the approximation of the dynamics of the 2D Kolmogorov flow to control its dynamics either to a steady-state regime or to a periodic regime. Numerical simulations are presented to show the effectiveness of the proposed three control schemes. The simulation results clearly show that the proposed controllers work well. (shrink)

In previous works, I defined ourselves as informational organisms, or inforgs for short, who forage for, produce, cultivate, curate, process, and consume information (Floridi 2013). Yet, we may also be understood as interfaces, who inhabit and interact with, an environment also made up of data and computational processes. By describing ourselves in such terms, this paper argues that we can better understand several crucial phenomena that characterise our digital age, including marketing and the “marketisation” of political communication. The article concludes (...) by discussing some of the implications for this in political theory. -/- . (shrink)

Whenever we grasp and lift an object, our tactile system provides important information on the contact location and the force exerted on our skin. The human brain integrates signals from multiple sites for a coherent representation of object shape, inertia, weight, and other material properties. It is still an open question whether the control of grasp force occurs at the level of individual fingers or whether it is also influenced by the control and the signals from the other (...) fingers of the same hand. In this work, we approached this question by asking participants to lift, transport, and replace a sensorized object, using three- and four-digit grasp. Tactile input was altered by covering participant's fingertips with a rubber thimble, which reduced the reliability of the tactile sensory input. In different experimental conditions, we covered between one and three fingers opposing the thumb. Normal forces at each finger and the thumb were recorded while grasping and holding the object, with and without the thimble. Consistently with previous studies, reducing tactile sensitivity increased the overall grasping force. The gasping force increased in the covered finger, whereas it did not change from baseline in the remaining bare fingers. Digit placement and object tilt were not systematically affected by rubber thimble conditions. Our results suggest that, in each finger opposing thumb, digit normal force is controlled locally in response to the applied tactile perturbation. (shrink)