This paper is devoted to the concepts of consequence and rejection, formulated as operators on a nonempty set of sentences, which may initially be unstructured. One of the issues that we pay attention to is the “cyclicity” of these concepts when they are defined one through the other. In addition, we explore this cyclicity, when the set of all sentences acquires some structure, or we can assume some structure of sentences in the sense that the operation of (...) substitution can be applied to them. (shrink)

In this thesis, Semantics, Meta-Semantics, and Ontology, I provide a critique of the method of truth in metaphysics. Davidson has suggested that we can determine the metaphysical nature and structure of reality through semantic investigations. By contrast, I argue that it is not semantics, but meta-semantics, which reveals the metaphysically necessary and sufficient truth conditions of our claims. As a consequence I reject the Quinean criterion of ontological commitment. In Part I, chapter 1, I argue that the metaphysically primary (...) truth bearers are not propositions, but rather concrete representations, either beliefs or sentences. I show, in chapter 2, that we can give sense to a truth predicate applying to sentences, given a truth operator and quantification into sentence position. I argue that this strategy does not commit us to the existence of propositions serving as truth bearers. In Part II I argue that although we must assign semantic values to sentences and/or predicates, the meaningfulness of these expressions is not thereby explained. In chapter 3 I articulate Davidson’s problem of predication and his solution, but argue that he was wrong to attribute this solution to Tarski. In chapter 4 I examine the semantics of modal languages; I conclude that although they require semantic values for predicates and/or sentences we should be instrumentalists about these theories. In Part III I consider the relationship between truth and existence. In chapter 5, I defend Pluralism about truth: in some domains of discourse, I claim, semantic reference plays a merely instrumental role in explaining truth. In chapter 6, I show that Hume’s Principle, which is committed by the Quinean criterion to the existence of numbers, can be true even though numbers do not exist. In doing so, I appeal to meta-semantic and diachronic considerations. In the conclusion I compare my views on ontology and commitment to Jody Azzouni’s; and in the appendix I suggest how one might pursue diachronic linguistics. (shrink)

In the paper, the authors discuss two kinds of consequence operations characterized axiomatically. The first one are consequence operations of the type Cn + that, in the intuitive sense, are infallible operations, always leading from accepted (true) sentences of a deductive system to accepted (true) sentences of the deductive system (see Tarski in Monatshefte für Mathematik und Physik 37:361–404, 1930, Comptes Rendus des Séances De la Société des Sciences et des Lettres de Varsovie 23:22–29, 1930; Pogorzelski and Słupecki (...) in Stud Logic 9:163–176, 1960, Stud Logic 10:77–95, 1960). The second kind are dual consequence operations of the type Cn − that can be regarded as anti-infallible operations leading from non-accepted (rejected, false) sentences of a deductive system to non-accepted (rejected, false) sentences of the system (see Słupecki in Funkcja Łukasiewicza, 33–40, 1959; Wybraniec-Skardowska in Teoria zdań odrzuconych, 5–131, Zeszyty Naukowe Wyższej Szkoły Inżynierskiej w Opolu, Seria Matematyka 4(81):35–61, 1983, Ann Pure Appl Logic 127:243–266, 2004, in On the notion and function of rejected propositions, 179–202, 2005). The operations of the types Cn + and Cn − can be ordinary finitistic consequence operations or unit consequence operations. A deductive system can be characterized in two ways by the following triple: $$\begin{array}{ll}{\rm by\,the\,triple}:\hspace{1.4cm} (+ , -)\hspace{0,6cm} \\ {\rm or\,by\,the\,triple}:\hspace{1.0cm} (-, +)\hspace{0,6cm} .\end{array}$$ We compare axiom systems for operations of the types Cn + and Cn −, give some methodological properties of deductive systems defined by means of these operations (e.g. consistency, completeness, decidability in Łukasiewicz’s sense), as well as formulate different metatheorems concerning them. (shrink)

. In this paper, the significance of using general logic-systems and finite consequence operators defined on non-organized languages is discussed. Results are established that show how properties of finite consequence operators are independent from language organization and that, in some cases, they depend only upon one simple language characteristic. For example, it is shown that there are infinitely many finite consequence operators defined on any non-organized infinite language L that cannot be generated from any finite logic-system. On (...) the other hand, it is shown that for any nonempty language L, a set map is a finite consequence operator if and only if it is defined by a general logic-system. Simple logic-system examples that determine specific consequence operator properties are given. (shrink)

Tarski presented his definition of consequence operator to explain the most important notions which any logical consequence concept must contemplate. A Tarski space is a pair constituted by a nonempty set and a consequence operator. This structure characterizes an almost topological space. This paper presents an algebraic view of the Tarski spaces and introduces a modal propositional logic which has as a model exactly the closed sets of a Tarski space.

Tarski presented his definition of consequence operator to explain the most important notions which any logical consequence concept must contemplate. A Tarski space is a pair constituted by a nonempty set and a consequence operator. This structure characterizes an almost topological space. This paper presents an algebraic view of the Tarski spaces and introduces a modal propositional logic which has as a model exactly the closed sets of a Tarski space. • DOI:10.5007/1808-1711.2010v14n1p47.

Tarski apresentou sua definição de operador de consequência com a intenção de expor as concepções fundamentais da consequência lógica. Um espaço de Tarski é um par ordenado determinado por um conjunto não vazio e um operador de consequência sobre este conjunto. Esta estrutura matemática caracteriza um espaço quase topológico. Este artigo mostra uma visão algébrica dos espaços de Tarski e introduz uma lógica proposicional modal que interpreta o seu operador modal nos conjuntos fechados de algum espaço de Tarski. DOI:10.5007/1808-1711.2010v14n1p47.

The book questions two key dichotomies: that of the apparent and real, and that of the internal and external. This leads to revised notions of the structure of experience and the object of knowledge. Our world is experienced as possibilities of action, and to know is to know what to do. A further consequence is that the mind is best considered as a property of organisms' interactions with their environment. The unit of analysis is the loop of action and (...) perception, and the central concept is the notion of habit of action, which provides the embodied basis of cognition as the anticipation of action. This holds for non-linguistic tacit meanings as well as for linguistic meanings. Habit of action is a teleological notion and thus opens a possibility for defining intentionality and normativity in terms of the soft naturalism adopted in the book. The mind is embodied, and this embodiment determines our physical perspective on the world. Our sensory organs and other instruments give us instrumental access to the world, and this access is epistemic in character. The distinction between the physical and conceptual viewpoint allows us to define truth as the correspondence with operational fit. This embodied epistemic truth is however not a sign of antirealism, as the instrumentally accessed theoretical objects are precisely those objects that experimental science deals with.. (shrink)

It’s commonly thought that, in conversation, speakers accept and reject propositions that have been asserted by others. Do speakers accept and reject questions as well? Intuitively, it seems that they do. But what does it mean to accept or reject a question? What is the relationship between these acts and those of asking and answering questions? Are there clear and distinct classes of reasons that speakers have for acceptance and rejection of questions? This chapter seeks to address these issues. (...) Beyond their intrinsic interest to those working on the nature of questions, solutions to these problems may aid the extension of inferentialist approaches to logic and language. Inferentialists who think that inferences should be conceived in terms of the norms we are subject to in virtue of both the sentences we accept or assert as well as those we reject or deny are known as bilateralists. A coherent account of accepting and rejecting questions raises the prospects for a bilateralism that interprets question-involving or erotetic inferences according to these additional primitives. While a full-blown bilateralism for erotetic inferences and ultimately for question-forming operators themselves far exceeds this chapter’s scope, the work presented here does sketch the first steps in that direction. (shrink)

The intuitionistic consequence operation restricted to the language with (equivalence) and (negation) as the only connectives is axiomatized by means of a finite set of sequential rules of inference.

Background: The high disease burden of Africa, the emergence of new diseases and efforts to address the 10/90 gap have led to an unprecedented increase in health research activities in Africa. Consequently, there is an increase in the volume and complexity of protocols that ethics review committees in Africa have to review. Methods: With a grant from the Bill and Melinda Gates Foundation, the African Malaria Network Trust (AMANET) undertook a survey of 31 ethics review committees (ERCs) across sub-Saharan Africa (...) as an initial step to a comprehensive capacity-strengthening programme. The number of members per committee ranged from 3 to 21, with an average of 11. Members of 10 institutional committees were all from the institution where the committees were based, raising prima facie questions as to whether independence and objectivity could be guaranteed in the review work of such committees. Results: The majority of the committees (92%) cited scientific design of clinical trials as the area needing the most attention in terms of training, followed by determination of risks and benefits and monitoring of research. The survey showed that 38% of the ERC members did not receive any form of training. In the light of the increasing complexity and numbers of health research studies being conducted in Africa, this deficit requires immediate attention. Outcome: The survey identified areas of weakness in the operations of ERCs in Africa. Consequently, AMANET is addressing the identified needs and weaknesses through a 4-year capacity-building project. (shrink)

Problem: Is Niklas Luhmann’s theory of social systems based on a constructivist or on a realist epistemology? Luhmann’s own elaborations seem to oscillate between both standpoints. Method: The argumentation provided in this article starts with a detailed reconstruction of Luhmann’s epistemology and of Luhmann’s criticism towards radical constructivism and then examines the consequences for a comparison of systems theory and (radical) constructivism. Results: Although Luhmann’s operative constructivism can be distinguished from radical constructivism, the differences are not considered fundamental. Luhmann’s epistemology (...) is clearly nearer to constructivism than to realism and it shares most of constructivism’s key concepts, such as self-referential logic, a strict relation between observer and observed, and the relativism of reality construction. Implications: Luhmann’s criticism of radical constructivism must be understood in the context of his sociological background. Most of his arguments against radical constructivism can be considered apprehensions of misleading interpretations of radical constructivism rather than of substantial criticism. They may help to clarify a radical constructivist epistemology. Constructivist content: The paper attempts to check whether Luhmann’s theory of social theory is based on (radical) constructivist epistemology. (shrink)

Tracking theories of knowledge are widely known to have the consequence that knowledge is not closed. Recent arguments by Vogel and Hawthorne claim both that there are no legitimate examples of knowledge without closure and that the costs of theories that deny closure are too great. This paper considers the tracking theories of Dretske and Nozick and the arguments by Vogel and Hawthorne. We reject the arguments of Vogel and Hawthorne and evaluate the costs of closure denial for tracking (...) theories of knowledge. (shrink)

Inequality in the family is the most damaging of all forces in women’s lives. It is overtly preserved by religious, customary, and state laws that formally enshrine discrimination against women and is perpetuated by de facto lack of access to nominally protective systems and remedies. International law and its implementation mechanisms provide an arena for confronting resistance to gender equality in the family, calling states to account at the highest level as well as providing a platform for domestic advocacy. CEDAW (...) and the jurisprudence of its monitoring body, the Committee on the Elimination of Discrimination against Women, clearly state the paramount value of protecting the individual human rights of family members rather than maintaining family “protection” and privacy at the expense of the women within it. By ratifying, States theoretically commit themselves to this progressive position. However, the politics of state and community identity make for a more complex picture that includes multiple, sometimes overlapping, levels of acceptance and rejection. Taking as a case study the current initiative to adopt a new General Recommendation to address the economic consequences of family relations and their dissolution, this Article draws on the CEDAW Convention and the CEDAW Committee’s work to suggest a practical application of international standards to address the tangle of legal systems and identity that have disadvantaged women for centuries. Placing this initiative within the context of multiple family law regimes and the multicultural debate, the right to exit and the concept of freedom to associate and to disassociate are emphasized as crucial in confronting the phenomenon of discriminatory identitybased family legal regimes. The Article concludes with an illustration of the harmonization process required by the CEDAW Convention, taking the new General Recommendation as a model approach for meeting the international equality norms while preserving community or State identity. (shrink)

In this paper we exploit the notions of conjoined and iterated conditionals, which are defined in the setting of coherence by means of suitable conditional random quantities with values in the interval [0,1]. We examine the iterated conditional (B|K)|(A|H), by showing that A|H p-entails B|K if and only if (B|K)|(A|H) = 1. Then, we show that a p-consistent family F={E1|H1, E2|H2} p-entails a conditional event E3|H3 if and only if E3|H3= 1, or (E3|H3)|QC(S) = 1 for some nonempty subset S (...) of F, where QC(S) is the quasi conjunction of the conditional events in S. Then, we examine the inference rules And, Cut, Cautious Monotonicity, and Or of System P and other well known inference rules (Modus Ponens, Modus Tollens, Bayes). We also show that QC(F)|C(F) = 1, where C(F) is the conjunction of the conditional events in F. We characterize p-entailment by showing that F p-entails E3|H3 if and only if (E3|H3)|C(F) = 1. Finally, we examine Denial of the antecedent and Affirmation of the consequent, where the p-entailment of (E3|H3) from F does not hold, by showing that (E3|H3)|C(F) is not equal to 1. (shrink)

Transoral laser microsurgery applies to the piecemeal removal of malignant tumours of the upper aerodigestive tract using the CO2 laser under the operating microscope. This method of surgery is being increasingly popularised as a single modality treatment of choice in early laryngeal cancers (T1 and T2) and occasionally in the more advanced forms of the disease (T3 and T4), predomi- nantly within the supraglottis. Thomas Kuhn, the American physicist turned philosopher and historian of science, coined the phrase ‘paradigm shift’ in (...) his groundbreaking book The Structure of Scientific Revolutions. He argued that the arrival of the new and often incompatible idea forms the core of a new paradigm, the birth of an entirely new way of thinking. This article discusses whether Steiner and col- leagues truly brought about a paradigm shift in oncological surgery. By rejecting the principle of en block resection and by replacing it with the belief that not only is it oncologically safe to cut through the substance of the tumour but in doing so one can actually achieve better results, Steiner was able to truly revolutionise the man- agement of laryngeal cancer. Even though within this article the repercussions of his insight are limited to the upper aerodigestive tract oncological surgery, his willingness to question other peoples’ dogma makes his contribution truly a genuine paradigm shift. (shrink)

The International Federation of Gynecology and Obstetrics (FIGO) Committee for the Ethical Aspects of Human Reproduction and Women9s Health advises against tubal occlusion (TO) performed at the time of caesarean section (CS/TO) or following a vaginal delivery (VD/TO) if this sterilisation has not been discussed with the woman in an earlier phase of her pregnancy. This advice is neither in accordance with existing medical custom nor evidence based. Particularly in less-resourced locations, adherence to it would deny much wanted one-off sterilisation (...) opportunities to hundreds of thousands of women, many of whom have no reliable contraceptive alternative. To be sure, a well-timed discussion in pregnancy about a potential peripartum TO is preferable and, if conducted as a matter of course (as the Committee appears to promote), would represent an enormous improvement on current practice. Earlier counselling has the advantage that it results in fewer women who regret having rejected the CS/TO or VD/TO option. However, there is no evidence that earlier counselling leads to a smaller proportion of regretted sterilisations. Consequently, where early TO counselling has been impossible, forgotten or deliberately omitted on pronatalist, traditional, financial, cultural or religious grounds, offering a perinatal sterilisation belatedly and in an unbiased, culturally sensitive manner is often verifiably better than not presenting that option at all, notably where high parity and uterine scars are particularly dangerous. Belated counselling, as will be demonstrated in this paper, saves many lives. The Committee9s blanket rejection of belated counselling on perinatal sterilisation is therefore unjustified. (shrink)

The partitions of a given set stand in a well known one-to-onecorrespondence with the equivalence relations on that set. We askwhether anything analogous to partitions can be found which correspondin a like manner to the similarity relations (reflexive, symmetricrelations) on a set, and show that (what we call) decompositions – of acertain kind – play this role. A key ingredient in the discussion is akind of closure relation (analogous to the consequence relationsconsidered in formal logic) having nothing especially to (...) do with thesimilarity issue, and we devote a final section to highlighting some ofits properties. (shrink)

We examine the notion of inquiry and argue that philosophic inquiry is a transcendental activity. Activities, viewed as conforming to intelligible canons, applying to appropriate contexts, and directed to specifiable ends, are contrasted with their empirical descriptions. Inquiry, characterized as an internalized, continuous activity directed to an intrinsic end, and fundamentally presupposed by other activities, is considered at the levels of (1) science, (2) philosophy and (3) transcendental philosophy. We argue that (2) is a transcendental activity which determines non-empirical concepts (...) and is presupposed by (1). Alternative philosophic frameworks are grounded on hypothetical canons conceived by intelligence itself, which imply interpretations of objectivity and universality claiming validity for the community of inquirers, but they can always be rejected. We consider the possibility of categorical canons operating as second-order rules necessarily presupposed for the formulation of alternative philosophic frameworks, and (3) would be the activity of identifying, justifying and applying such transcendental canons of inquiry in general. Finally, we suggest that the only possible justification of such categorical canons would be a kind of ontological proof. Thus, a given philosophic approach reflects the transcendental activity of determining non-empirical concepts through the implementation of its fundamental regulative norms; but transcendental philosophy would determine the concept of philosophy itself through implementation of the categorical canons of inquiry in the construction of philosophic systems. (shrink)

The term fuzzy logic is used in this paper to describe an imprecise logical system, FL, in which the truth-values are fuzzy subsets of the unit interval with linguistic labels such as true, false, not true, very true, quite true, not very true and not very false, etc. The truth-value set, , of FL is assumed to be generated by a context-free grammar, with a semantic rule providing a means of computing the meaning of each linguistic truth-value in as a (...) fuzzy subset of [0, 1].Since is not closed under the operations of negation, conjunction, disjunction and implication, the result of an operation on truth-values in requires, in general, a linguistic approximation by a truth-value in . As a consequence, the truth tables and the rules of inference in fuzzy logic are (i) inexact and (ii) dependent on the meaning associated with the primary truth-value true as well as the modifiers very, quite, more or less, etc. (shrink)

Abstract There is one assumption that is shared by practically all popular religious and philosophic systems, ancient and modern, Eastern and Western. In truth it may well be that it is this single assumption which makes such ?systems? possible. That shared assumption is the belief in a ?just universe?, i.e. ?just? in the sense of morally ordered, morally predictable and morally explainable. This assumption rests, as most assumptions must, on pragmatic grounds; that is to say, the assumption is retained or (...) used because it gets the users where they want to go, i.e. the assumption works. But if it could be shown that this assumption, aside from being useful, leads to insuperable logical or empirical problems, then this might be prima facie grounds for rejecting the assumption. Part I examines the historical roots of the assumption of a just universe. Part II, examines three implications that would seem to follow from the assumption that the universe, the world, is a just place in which to live. Part III explores the unacceptable consequences that are found in and that follow from these three implications and that necessitate the rejection of the assumption of the just universe of Part I. (shrink)

I argued in Karl Marx's Theory of History that the central claims of historical materialism are functional explanations, and I said that functional explanations are consequence explanations, ones, that is, in which something is explained by its propensity to have a certain kind of effect. I also claimed that the theory of chance variation and natural selection sustains functional explanations, and hence consequence explanations, of organismic equipment. In Section I I defend the thesis that historical materialism offers functional (...) or consequence explanations, and I reject Jon Elster's contention that game theory can, and should, assume a central role in the Marxist theory of society. In Section II I contrast functional and consequence explanation, thereby revising the position of Karl Marx's Theory of History, and I question whether evolutionary biology supports functional explanations. Section III is a critique of Elster's views on functional explanation, and Sections IV and V defend consequence explanation against metaphysical and epistemological doubts. A concluding section summarizes my present understanding of the status of historical materialist explanations. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 36.3 (2003) 177-188 [Access article in PDF] Chaïm Perelman's "First Philosophies and Regressive Philosophy":Commentary and Translation David A. Frank Michelle K. Bolduc Chaïm Perelman's 1949 article, "First Philosophies and Regressive Philosophy," has remained unavailable to readers unable to read French. Our commentary and translation is intended to provide English readers access to the context, influences, and themes that make the article an extraordinarily important work in (...) the history of twentieth-century rhetoric. In this article, Perelman offers a powerful critique of first philosophies and anticipates the problems of radical postmodernity. "First Philosophies" remains a strikingly elegant attempt to foil what Foucault (1984, 41-42) has called the "Enlightenment blackmail of reason," the assumption held by logical positivists and radical skeptics that if reason does not yield absolute and eternal Enlightenment knowledge, there can be no knowledge.Perelman and Lucie Olbrechts-Tyteca's New Rhetoric project avoids Enlightenment blackmail by charting a third way between logical positivism and radical relativism, and "First Philosophies" sets forth the project's philosophical blueprint. Commencing in 1947 and culminating in 1958 with the publication of Traité de l'argumentation: La nouvelle rhétorique, Perelman and Olbrechts-Tyteca sought, discovered, and developed a philosophical system designed as a rapprochement between dialectic (reason and logic) and rhetoric (the art of adapting arguments to audiences). Historians of rhetoric judge the work a "grand revolution" (Meyer 1999, 259), believing it marks a rhetorical renaissance in Europe, and suggest nothing like it will appear for another 100 years after its publication (Johnstone 1971). The New Rhetoric project influenced Gadamer and a host of post-war European and American thinkers (Mootz 1998). Michael Leff calls the 1970 English translation of Traité a "bombshell" (1994, 510). Beyond its historical importance, Crosswhite suggests that the New Rhetoric project is "the single most important event in contemporary rhetorical theory" (1996, 35)and "First Philosophies" marks Perelman's turn from logical [End Page 177] positivism to rhetoric, offering prescient answers to the post-World War II crises of reason, and the ideas in the article provide the Traité'sphilosophical glue (see in particular the English translation, 62).Perelman joined many post-war theorists, including Horkheimer and Adorno (1972), in the resistance to the reign of a disembodied Enlightenment rationality. However, Perelman identified what Habermas (1987, 119) would later call the "performative contradiction" in the conclusion that radical skepticism was the only alternative to Enlightenment rationality. In "First Philosophies," Perelman responds directly to Sartre's 1943 Being and Nothingness (198; see translation below) by exposing the failure of radical skeptics to see that they had been held hostage by Enlightenment blackmail in accepting the Enlightenment criterion for truth, rejecting it, and then making skepticism an absolute. Indeed, "First Philosophies" navigates from this performative contradiction to chart a third way between Enlightenment rationality and radical skepticism with an approach that he labels regressive philosophy. Regressive philosophy, Perelman argues, provides the human community with a mode of philosophical reasoning located between the extremes of Enlightenment rationality and radical skepticism. In this space between extremes, Perelman identifies contingent truths and values dependent on a rhetorical mode of reasoning, one making moral judgments possible.To best understand "First Philosophies," we recognize the importance of historical context in the development of social theories of knowledge (see Delacampagne 1999; Kennedy 1999). The intellectual networks in which philosophers operate also influence the development of philosophical systems, as Randall Collins has aptly documented. In addition to historical context and intellectual networks, Frederick Beiser has recently noted: "[t] he best introduction to any philosophy is the biography of the person who created it" (1999, 5). He argues that textual analysis alone cannot illuminate the motivation or meaning of a philosophy. A sense of Perelman's biography and the cultural influences that gave rise to "First Philosophies" are necessary for a proper understanding of its themes. For Perelman, the primary intellectual exigencies of the post-war period were the interrelated crises of justice, philosophical reasoning, and responsibility to which "First Philosophies" is a... (shrink)

The logic TK was introduced as a propositional logic extending the classical propositional calculus with a new unary operator which interprets some conceptions of Tarski’s consequence operator. TK-algebras were introduced as models to TK. Thus, by using algebraic tools, the adequacy of TK relatively to the TK-algebras was proved. This work presents a neighbourhood semantics for TK, which turns out to be deductively equivalent to the non-normal modal logic EMT4.

1. The sequence of the organisation levels is regarded as originating from a sequence of symmetry breakings. Each breaking generates a more improbable structure. In addition to the Euclidian symmetries, homogeneity, isotropy, translation, rotation, helix displacement, neutrality and even indiscernibility can be broken. Here are considered the initial and the subatomic breaking molecular morphogenesis and other higher breakings.2.1 HOMOGENEITY BREAKING OF THE VACUUM SPACE. We studied this as a new model of wave-corpuscle relation. Every noticeable point breaks the space homogeneity. (...) Directed by a momentum this breaking operates as a fissure.2. Postulate of the corpuscle. The quantum mechanical corpuscle is the end of a fissure, the momentum of which characterises direction and velocity.2.2. Postulate of the wave. The associate wave comes from the end of the fissure and works to split the medium.2.3. Corollary to the trajectory. The fissure prefers continuity and a straight line. Nevertheless the fissure can stop at a point and then start from an other point. This discontinuity and any momentum possible discontinuity are limited only by uncertainty relationships; frequency of discontinuity is limited by the first one. Vacuum has no memory of the fissures. 2.4.Corollary to the localisation. The fissure diminishes the medium constraints and allows the medium to vibrate in a domain surrounding the end of the fissure.2.5. Physical analogies. – - Photo-elastic studies of the fissuration of solids show a little sphere and a wavelike perturbation at the end of the fissure. – - A fragile and resonating object can be broken by a sound wave. This crack emits a sound wave. Here we consider one associated wave, emitted and absorbed. – - Broken panes picture an emission of rays. li]2.6. Consequences of the fissure model. (shrink)

The vast majority of contributions to the literature on spirituality in nursing make extravagant claims about transcendence, eternity, the numinous, higher powers, higher levels of existence, invisible forces, cosmic unity, the essence of humanity, or other supernatural concepts. Typically, these assertions are made without the support of argument or evidence; and, as a consequence, alternative ways of theorizing ‘spirituality’ have been closed off, while the lack of consistent scholarship has turned the topic into a metaphysical backwater. In this paper, (...) I adopt a different premise, rejecting unsupported claims, and surveying the ‘spirituality’ terrain from a naturalistic and reductionist perspective. I argue that, if we rid ourselves of non‐naturalistic assumptions, we will discover theoretical and clinical resources in health psychology, social psychology, neuropsychology, and pharmacopsychology – resources which confirm that it is possible to conceptualize the study of existential concerns, and how health professionals might respond to them, in a properly scientific manner. In order to illustrate the potential usefulness of these resources, I will take palliative care as an example. (shrink)

One of the ethical issues that has been raised recently regarding emerging neurotherapies is that people will be coerced explicitly or implicitly in the workplace or in schools to take cognitive enhancing drugs. This article builds on this discussion by showing how the law may pressure people to adopt emerging neurotherapies. It focuses on a range of private law doctrines that, unlike the criminal law, do not come up very often in neuroethical discussions. Three doctrines—the doctrine of mitigation, the standard (...) of care in negligence, and child custody determinations in family law—are addressed to show how the law may pressure people to consent to treatment by offering a choice between accepting medical treatment and suffering a legal disadvantage. The doctrines considered in this article apply indirect pressure to submit to treatment, unlike court-ordered medical treatment, which applies direct pressure and is not addressed here. The outcome of this discussion is to show that there is a greater range of social pressures that may encourage the uptake of novel neurotherapies than one might initially think. Once treatments that were developed and offered with therapeutic benefits in mind become available, their existence gives rise to unintended legal consequences. This certainly does not mean we should cease developing new therapies that may be of tremendous benefit to patients, but it does raise some questions for physicians and for legal policy-makers. How should physicians, who are required by medical ethical principles to obtain valid consent to treatment, react to a patient’s reluctant consent that is driven by legal pressure? From the legal policy perspective, are our legal doctrines satisfactory or should they be changed because, for example, they unduly promote the collective interest over individual freedom to reject medical treatment or because they channel us toward economically efficient treatments to the detriment of more costly but potentially superior approaches of dealing with behavioural problems? (shrink)

The logic TK was introduced as a propositional logic extending the classical propositional calculus with a new unary operator which interprets some conceptions of Tarski’s consequence operator. TK-algebras were introduced as models to TK . Thus, by using algebraic tools, the adequacy (soundness and completeness) of TK relatively to the TK-algebras was proved. This work presents a neighbourhood semantics for TK , which turns out to be deductively equivalent to the non-normal modal logic EMT4 . DOI:10.5007/1808-1711.2011v15n2p287.

In lieu of an abstract, here is a brief excerpt of the content:372 THE ROLE OF REASON IN HUME'S THEORY OF BELIEF Much has been written on Hume's theory of belief, yet problems of interpretation remain as serious as ever. The most pervasive and persistent problem relates to the role reason plays in Hume's conception of belief. When Hume says that belief is a matter of feeling, does he mean to say that reason has nothing to do with it, or (...) that belief is not a matter of choice? Does he imply that one cannot be blamed for believing as one does? The view that belief is unavoidable and not a matter of choice, and its implication, seem counter-intuitive, if not drastic. Are there grounds for attributing such a view to Hume? There is indeed a tendency to interpret Hume as saying that reason plays no role, not just in the moral sphere, but in the understanding as well. Thus, Barry Stroud claims that "in Hume's hands the denigration of the role of reason and the corresponding elevation of feeling and sentiment is generalized into a total theory of man." Elsewhere I have argued against this view insofar as it relates 2 to Hume's moral theory. But the dismay at Hume's (alleged) denigration of reason is even greater in the case of belief. For instance, Antony Flew considers Hume's view that belief is "a species of natural instincts, which no reason or process of the thought and understanding is able either to produce or to prevent" as a "drastic and disastrous conclusion." According to Flew, one drastic and disastrous consequence of such a view is that "insofar as belief really is necessary and unavoidable we can neither criticize others for the irrationality of their convictions nor retain any 4 confidence about the rationality of our own." 373 In a more sympathetic reading of Hume, J. A. Passmore has cited evidence to show that Hume acknowledges that belief can be a matter of choice, 5 and thus there can be an ethics of belief. However, in doing so Passmore presents an inconsistency in Hume's view of belief, and does nothing to account for this inconsistency. Barbara Winters also sees inconsistencies, or paradoxes, in Hume's treatment, not only within Book I of the Treatise, but also between it and the other two Books (and between the Enquiries). Her resolution of the paradox is the suggestion that there are two conceptions of reason in Hume, the "traditional" and the "naturalistic," the former "plays no role in our acquisition of fundamental beliefs," and the latter is such that we do indeed "arrive at our beliefs through reasoning." In this paper I wish to argue that there are no inconsistencies, or paradoxes, in Hume's treatment of belief, and that his view is neither drastic nor disastrous. I wish to show that there is no 'denigration' of reason, " and that while belief is a matter of feeling, it is also, to an important degree, a matter of choice. In promoting the "undoubted truth, that belief is nothing but a peculiar feeling," Hume does write in such a way as to encourage the interpretation that he subordinates the role of reason to feelings (or sentiments, or passions), or worse, that he denigrates the role of reason. He tells us that belief is not "some new idea, such as that of reality or existence, which we join to the simple conception of an object" (T 623). If it were, "it wou'd be in a man's power to believe what he 374 pleas 'd" (T 624), as the mind can mix or join any two ideas. Hume tells us that we can easily "discover by experiments" that belief "arises immediately, without any new operation of the reason or imagination" (T 102). The widely quoted sentence is the following: "When the mind... passes from the idea or impression of one object to the idea or belief of another, it is not determin'd by reason..." (T 92). These and other statements clearly encourage the interpretation that belief does not arise from reason, or indeed that reason has nothing to do with belief. Depending on how far one sees the... (shrink)

Wittgenstein's conception of the general form of a truth function given in thesis 6 can be presented as a sort of a trade-off: the author of the Tractatus is unable to reconcile the simplicity of his original idea of a series of forms with the simplicity of his generalisation of Sheffer's stroke; therefore, he is forced to sacrifice one of them. As we argue in this paper, the choice he makes – to weaken the logical constraints put on the concept (...) of a series of forms, thus effectively metaphorising that concept for the sake of upholding the N-operation's role of generating the series – is unfortunate. An actual expansion of a series of truth functions as defined in 6 would require either making decisions at each step (Anscombe) or outwardly rejecting the concept of a series (Sundholm). However, neither is faithful to Wittgenstein's own fundamental intuitions regarding the nature of logic. For this reason, a different trade-off that prioritises upholding the basic features of a series of forms over the simplicity of the operation that generates that series seems to be much more reasonable. We offer such a trade-off by developing the schema already present in the Tractatus (5.101). The key element of our alternative solution is the construction of an operation that can perform the task of producing all consecutive truth functions of a given collection of atomic propositions as an invariant difference between any base and its successor throughout the series. We define it as a composition of three functions (in an algebraic sense): the first turns a symbol of a given truth function into a binary number, the second increments that number, the third turns the result back into a symbol of another truth function. We also show how the operation can be defined by means of a different notation without invoking binary arithmetic. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Imagining Karma, Ethical Transformation in Amerindian, Buddhist, and Greek RebirthA. L. HermanImagining Karma, Ethical Transformation in Amerindian, Buddhist, and Greek Rebirth. By Gananath Obeyesekere. Berkeley: University of California Press, 2002. 448 pp.Gananath Obeyesekere, professor emeritus of anthropology at Princeton University, is probably one of the world's greatest living anthropologists. The proof of that assertion lies in this his latest work on comparative anthropology, a study of the concept (...) and practice of rebirth—"reincarnation" as he calls it—from ancient Greece and India to modern West Africa, Melanesia, and North America. In what follows let me briefly set forth what I understand his central thesis to be, the evidence for it, and the conclusions to be drawn from it. I will end with two very modest problems connected with this altogether intriguing and brilliant investigation into the doctrine of rebirth.As a modified structural anthropologist, Gananath Obeyesekere rejects the rationalist model structuralism of Claude Levi-Strauss. He follows instead the lead of two of his empiricist predecessors, Max Weber and Fernand Braudel, pointing out that structures, types, or models "are constructions of scholars, not universals waiting to be discovered" (p. 351). Consequently, as this book aptly proves, Obeyesekere's own "imagined" models are based on parole data following the actual language of the cultures being studied.Obeyesekere thus begins his book with an elementary rebirth structure based on such parole. He refers to this primitive, first structure as "rebirth eschatology," which entails the rebirth of a deceased's soul into the body of a newborn relative of the deceased but without any determining ethical component as found in the more sophisticated and complex "karmic eschatologies." Such ethically neutral kin group rebirths are found among certain small-scale societies in West Africa, the Trobriand Islands, the Northwest American coast tribes, and the Inuits (Eskimos). Obeyesekere [End Page 303] draws extensively on field studies of these groups to bolster his conclusions about them. This simple rebirth eschatology is non-Indic in origin, Obeyesekere claims, since no evidence of influences have been found between these practitioners of rebirth eschatology and work relating to the Indic religions (Hinduism and Buddhism). The entry of the soul into postdeath life, either in this world or the world of the ancestors, depends not at all, consequently, on one's this-worldly behavior such that "morality does not affect the fate of the soul after death" (p. 74).Obeyesekere turns next to the "transformation" of this rebirth eschatology. It occurs with the introduction of the concept of ethicization, "the processes whereby morally right or wrong action becomes a religiously right or wrong action that in turn affects a person's destiny after death" (p. 75). It is Obeyesekere's contention that when ethicization is systematically introduced into any rebirth eschatology the latter must logically transform itself into a so-called "karmic eschatology." In other words, this second topological model or conceptual structure, karmic eschatology, the new ethicized rebirth eschatology, says that the otherworld for the dead is not simply a way station for departed souls waiting to be reborn, but rather that otherworld is now a place of retribution and punishment. Kinship affiliation alone no longer determines who goes where after death but moral action does. My own guess is that rebirth eschatology was introduced to answer the question of why the grandchild resembles the deceased grandparent. Karmic eschatology, on the other hand, was probably introduced to solve a more complex and sophisticated puzzle: Why is it, if there really is justice in the universe, that the wicked never get appropriately punished and the good never get sufficiently rewarded? At this stage of transformation, the law of karma, or some other principle of universal justice, now says that everyone gets what's coming to them, either in this life or the next, and that rebirth is necessary to make that principle of justice workable.1 In arguing that "rebirth cannot be divorced from ethics; it looks as if it is generated from ethics" (p. 82), Obeyesekere would seem to concur that karmic eschatology was introduced to answer the question: Why do the wicked seem to prosper and the good appear to suffer?Following... (shrink)

This paper contends that eating shapes the self; that is, our practices and understandings of eating can cultivate, reinforce, or diminish important aspects of the self, including agency, values, capacities, affects, and self-understandings. I argue that these self-shaping effects should be included in our ethical analyses and evaluations of eating. I make a case for this claim through an analysis and critique of the hypothesis that young women’s vegetarianism is a risk, sign, or “cover” for eating disorders or disordered eating. (...) After outlining the relevant empirical literature, I suggest that the evidence for this hypothesis is inconclusive. Given this uncertainty, we should consider the risks of making a mistake when accepting or rejecting this understanding of young women’s eating. I argue that these risks importantly include negative effects on the self, such as damage to moral and epistemic agency. Along with other potential consequences of mistakenly accepting the hypothesis, these effects give us reason to reject it pending more conclusive research. Overall, this paper offers a philosophical intervention into the debate over the relationship between vegetarianism and eating disorders while illustrating the ethical importance and relevance of eating as a self-shaping activity. (shrink)

Disease transmission is a fruitful domain in which to examine how scientific and folk theories interrelate, given laypeople’s access to multiple sources of information to explain events of personal significance. The current paper reports an in-depth survey of U.S. adults’ causal reasoning about two viral illnesses: a novel, deadly disease that has massively disrupted everyone’s lives, and a familiar, innocuous disease that has essentially no serious consequences. Participants received a series of closed-ended and open-ended questions probing their reasoning about disease (...) transmission, with a focus on causal mechanisms underlying disease contraction, transmission, treatment, and prevention; non-visible biological processes; and ontological frameworks regarding what kinds of entities viruses are. We also assessed participants’ attitudes, such as their trust in scientific experts and willingness to be vaccinated. Results indicated complexity in people’s reasoning, consistent with the co-existence of multiple explanatory frameworks. An understanding of viral transmission and viral replication existed alongside folk theories, placeholder beliefs, and lack of differentiation between viral and non-viral disease. For example, roughly 40% of participants who explained illness in terms of the transmission of viruses also endorsed a non-viral folk theory, such as exposure to cold weather or special foods as curative. Additionally, participants made use of competing modes of construal when explaining how viruses operate, such as framing the immune system response as cells trying to fight off the virus. Indeed, participants who displayed greater knowledge about viral transmission were significantly more likely to anthropomorphize bodily processes. Although comparisons of COVID-19 and the common cold revealed relatively few differences, the latter, more familiar disease elicited consistently lower levels of accuracy and greater reliance on folk theories. Moreover, for COVID-19 in particular, accuracy positively correlated with attitudes, self-protective behaviors, and willingness to be vaccinated. For both diseases, self-assessed knowledge about the disease negatively predicted accuracy. The results are discussed in relation to challenges for formal models of explanatory reasoning. (shrink)

It is argued that the current confusion about the role and purpose of the British nurse is a consequence of the modern rejection and consequent fragmentation of the inherited nursing tradition. The nature of this tradition, in which nurses were inducted into the moral virtues of care, is examined and its relevance to patient welfare is demonstrated. Practical suggestions are made as to how this moral tradition might be reappropriated and reinvigorated for modern nursing.

The review of activity of local governments of Leningrad on the solution of social problems is presented in article in the period of the Great Patriotic War and restoration of municipal economy during the post-war period. The considerable attention is paid to questions of ensuring activity of the population and the main directions of social policy. Consequences of the public regress caused by war, which detained for many decades development of the social sphere in the country, are not studied yet. (...) In this regard, the judgment of process of overcoming of these consequences, research of the principles of work, methods and forms of administrative activities for the organization of full-fledged life of citizens during the recovery post-war period and in the next decades is of special interest. Completion of World War II entailed changes in a control system of the country - as it is known, extraordinary bodies of authority and management of a wartime in the capital and on places were abolished. Management of restoration and maintenance of full functioning life support system of the cities and areas transferred to local governments of the Soviet power - to city and regional councils of deputies and their constantly operating executive committees. The role of the social sphere in modern conditions more and more increases in improvement of economy, development of democratic processes. The scientific analysis of activity of the central and local authorities for protection and providing the population in years of war and the post-war period gives more deep understanding of role and importance of social questions in life of society. It reveals historical experience of creation, development and implementation of effective mechanism of such activity, that experience is useful for modern management practice of state and local authorities. The considerable case of sources, among which analytical and research works of applied and theoretical character is analyzed. (shrink)

Morgan has argued that attitudes to the medicalisation of sports are historically conditioned.While the history of doping offers contested versions of when the sports world turned againstconservative forces, Morgan has argued that these attitudes are out of step with prevailingnorms and that the World Anti Doping Agency's policy needs to be modified to better reflectthis. As an advocate of critical democracies in sports, he argues that anti-doping policy mustacknowledge and reflect these shifts in order to secure their legitimacy. In response, (...) wecritically present the World Anti-Doping Agency's policy that incorporates the Prohibited Listof Substances and Methods for athletes. We evaluate the validity of the therapy-enhancementdistinction in relation to its role in both justifying and sustaining the operation of theProhibited List. In particular, we focus on the case of thyroxine, which has been the subjectof controversy in athletic doping. While thyroxine is not currently banned, critics haveclaimed that its use in the absence of a relevant pathology is tantamount to doping. Wechallenge Morgan's claim that a conventionalist defence of the therapy-enhancementdistinction is the best available, and his conclusion that this properly supports a morepermissive stance towards performance-enhancing drug use. Furthermore, we reject hisconventionalist support for democratic line drawing in relation to doping and in particular thestatus of thyroxine with regard to the prohibited list. We offer a modified defence of the statusquo, a qualified, naturalist account of health and disease, where athletes may be prescribeddrugs that are genuine responses to medical necessity that do not, or do not typically, threatenthe goods of athletic excellence. (shrink)

The extent to which the scientific method has yielded to analysis in recent years serves only to emphasize by contrast the presence within that method of an irrational element. For it is becoming increasingly evident that whatever one may say of the logical and psychological character of the pre-inductive operations, of the formal processes involved in deducing the consequences of a given theory, of the technique of experimental corroboration, and of certain other aspects of the scientific method, there is one (...) phase of the movement which remains a surd. This is the act of the creative imagination through which hypotheses and theories are called into being. Its mysterious character is exhibited in the terminology which is employed in describing it, in the variety and inconstancy of the conditions which give rise to it, in the apparent impossibility of controlling it, and in the impossibility of recognizing completely the adequacy of its results when it does occur. It is variously described as an act of intuition, mystic revelation, divine insight, a flash of understanding; it arises out of the greatest variety of conditions: acute and prolonged attention to the data in the confinement of the laboratory, or the complete relaxation of a walk in the country, or the intense mental effort upon a problem in a wholly unrelated field; it forbids direction, in fact it seems to arise most readily when the element of effort and control is conspicuously absent; it cannot even be certainly identified, for many supposed acts of discovery prove later to have produced only groundless fancies and absurd creations of the unguided imagination. (shrink)

The pertinence of questions of social forecasting increases in connection with the development of the revolution in science and technology and with the pressing need to predict its social consequences. The growing attention to these questions in contemporary bourgeois sociology is to be explained, on the one hand, by the need for a theoretical validation of what is termed "social programming" under the conditions of state-monopoly capitalism, by the requirements for a practical elaboration of a technique for predicting the state (...) of the economy and political situations of the future, and, on the other hand, by the effort of bourgeois ideologists to reject the very possibility of any social and historical forecasting requiring recognition of objective laws in history. (shrink)

Accidents involving large trucks result in significant economic and social costs. As technological solutions have improved, behavioral factors contributing to accidents have risen in importance. The purpose of this research is to investigate how norms, consequences, and personal attitudes influence safety-related ethical judgments and behavioral intentions. The Hunt–Vitell’s theory of ethical decision-making is adapted to test how these factors influence truck drivers’ decisions containing ethical content. Professional truck drivers evaluated decisions presented in two scenarios that included the situation, the decision, (...) and the results. The research found that drivers rely heavily on evaluations of safety norms when forming ethical judgments and behavioral intentions. Further, drivers’ attitudes toward compliance and the effectiveness of safety regulations also influenced decision-making to an extent. Overall, evidence of a refutation of the assumption that a tradeoff exists between operational productivity and safety was discovered. Drivers in this study intended to behave in a certain manner irrespective of time or money pressures. The perceived ethical component of the decision outweighed regulatory and economic consequences under a range of parameters. (shrink)

Historians of the Roman Empire have been nearly unanimous in giving the ill-fated Caesar whom Hadrian designated as his successor the cognomen Verus ascribed to him by Spartianus.2 Following the same biographer Annalists have given the names Aurelius and Annius to his father and grandfather. Noris in his Epistola Consularis3 maintained against Pagi that the original names of this prince were Lucius Ceionius Commodus, that neither he nor any of his family bore the names Aurelius, Annius, or Verus ascribed to (...) them in the Historia Augusta, but that the name Verus has been mistakenly reflected upon him from his more famous son L. Verus Augustus the colleague of M. Aurelius Antoninus. De Tillemont4 rejected Noris’ opinion on purely literary grounds, saying, ‘il est bien difficile de croire qu'un auteur ait esté assez ignorant et assez malheureux pour nommer toujours un prince, mesme en faisant exprès son histoire, d'un nom qu'il n'a jamais eu.’ By consequence the mistake, if mistake it be, is become inveterate and is repeated5 down to our own day. Klebs6 alone rejects the jiame, and the error is not corrected in Dr. Bury's edition of Gibbon. (shrink)

Some commentaries suggest that the attention-deficit/hyperactivity disorder (ADHD) theory of this condition does not explain enough. Because the theory includes parameters of the delay gradient that vary across individuals and developmental modulation of behavioral outcomes by different environments, it accommodates a wide range of manifestations of ADHD symptoms. Thus, the argument could instead be made that the theory allows too many degrees of freedom. For many purposes, behavior is better defined in terms of function (e.g., consequences) than in terms of (...) structure (e.g., muscle movements), so cognition is treated here as a variety of behavior rather than as a different category of phenomena. The commentaries are discussed in the context of these and other distinctions, including those between association and selection, between operant and respondent behavior, and between fundamental processes and those that are derivative. Other issues include: prosthetic environments, rapidity of developmental change, the concept of inhibition, the form of the delay gradient, and possible directions for experimental research. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Against Ethical CriticismRichard A. PosnerOscar Wilde famously remarked that “there is no such thing as a moral or an immoral book. Books are well written, or badly written. That is all.” He was echoed by Auden, who said in his poem in memory of William Butler Yeats that poetry makes nothing happen (though the poem as a whole qualifies this overstatement), by Croce, and by formalist critics such as (...) Cleanth Brooks, a doyen of the New Critics, who insisted that edification was the function of religion but not of poetry. 1 George Orwell, though himself a didactic novelist, was of this view as well, 2 and it is one that most critics adopt when the issue is censorship. I accept Wilde’s thesis—the creed of aestheticism, of art for art’s sake—if understood to mean that the moral content and consequences of a work of literature are irrelevant to its value as literature; or as the critic Helen Vendler has put it, that “treating fictions as moral pep-pills or moral emetics is repugnant to anyone who realizes the complex psychological and moral motives of a work of art.” 3 This is not to deny that reading can have consequences, including moral and political ones. Information affects people’s outlook and behavior, and reading is a source of information. Imaginative literature conveys ideas, opinions, and information, often with great power. Think of the role that novels by Turgenev (Fathers and Sons), Dostoevsky (The Possessed), Conrad (The Secret Agent, Under Western Eyes), Koestler (Darkness at Noon), Orwell (Animal Farm, Nineteen Eighty-Four), and, of course, Solzhenitsyn played in exposing the horrors of anarchism and communism. Of A Passage to India it has been said that “as an account of the social conditions of British India it was powerful enough to have influenced events.” 4 Upton Sinclair’s novel The Jungle is thought to have incited federal regulation of food processing; and few doubt the effect of Uncle Tom’s Cabin (1852) on the abolitionist cause. [End Page 1]At the core of the aesthetic tradition, which I shall be defending in this essay particularly against its opponents in the “law and literature” movement, are three theses. First, immersion in literature does not make us better citizens or better people. One might be able to pick out some works of literature that would have such an effect because of the information they convey or the emotional state they induce, but they would constitute a skewed sample of literary works. Second, we should not be put off by morally offensive views encountered in literature even when the author appears to share them. A work of literature is not to be considered maimed or even marred by expressing unacceptable moral views; by the same token, a mediocre work of literature is not redeemed by expressing moral views of which we approve. The proper criteria for evaluating literature are aesthetic rather than ethical. Third, authors’ moral qualities or opinions should not affect our valuations of their works.The insistence, in short, is on the separation of the moral from the aesthetic—but with two qualifications. Some literature has little interest or value apart from the didactic and for it the proper criticism is didactic. And the separation of moral from aesthetic values is not a rejection of the former. The aesthetic outlook is a moral outlook, one that stresses the values of openness, detachment, hedonism, curiosity, tolerance, the cultivation of the self, and the preservation of a private sphere—in short, the values of liberal individualism.The counter tradition in literary criticism to the aesthetic originates with Plato and insists upon the importance, in some versions to the near or even total exclusion of anything else, of the ethical or political content and effects of works of literature, and less commonly of the author’s own morality. Martha Nussbaum, for example, deems Greek tragedies and Anglo-American realistic novels a part of moral philosophy. 5 Reading novels, she argues, “develops moral capacities without which citizens will not succeed in making reality out of the normative conclusions of any moral or political theory, however excellent.” 6 Wayne Booth, disagreeing with his illustrious... (shrink)

Chad A Witt, Ramsey R Hachem Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, MO, USA: The role of donor-specific antibodies to human leukocyte antigens and the burden of antibody-mediated rejection in lung transplantation remain enigmatic. Over the past several years, evidence has been emerging that humoral immunity plays an important role in the development of both acute and chronic lung allograft dysfunction. Multiple case reports and case series have (...) identified lung allograft recipients with clinical findings consistent with acute AMR. However, there is currently no widely accepted definition for AMR in lung transplantation, and this has been a significant barrier to furthering our understanding of this form of rejection. Nonetheless, the development of DSA after transplantation has consistently been identified as an independent risk factor for persistent and high-grade acute cellular rejection and CLAD. This has raised the possibility that chronic AMR may be a distinct phenotype of CLAD although evidence supporting this paradigm is still lacking. Additionally, antibodies to lung-restricted self-antigens have been associated with primary graft dysfunction early and the development of CLAD late after transplantation, and emerging evidence underscores significant interactions between autoimmunity and alloimmunity after transplantation. There is currently an active International Society for Heart and Lung Transplantation working group that is developing an operational definition for AMR in lung transplantation. This will be critical to improve our understanding of this form of rejection and conduct clinical trials to identify optimal treatment strategies. This review will summarize the literature on DSA and AMR in lung transplantation and discuss the impact of antibodies to self-antigens on lung allograft dysfunction. Keywords: antibody-mediated rejection, donor-specific antibodies, lung transplantation. (shrink)

According to the received view the later Wittgenstein subscribed to the thesis that speaking a language requires being guided by rules (thesis RG). In this paper we question the received view. On its most intuitive reading, we argue, (RG) is very much at odds with central tenets of the later Wittgenstein. Giving up on this reading, however, threatens to deprive the notion of rule-following of any real substance. Consequently, the rule-following considerations cannot charitably be read as a deep and subtle (...) defense of (RG) against the threat of paradox, as proponents of the received view are wont to do. Instead, we argue, the rule-following considerations provide Wittgenstein's deep and subtle reasons for rejecting the very idea that speaking a language involves rule-guidance. Although Wittgenstein subscribed to (RG) during his middle period writings, his later remarks on rules, far from being a clarification and elaboration of his earlier views, are directed against the claim of the middle period that speaking a language is an essentially rule-guided activity. (shrink)

In this paper we develop an abstract theory of adequacy. In the same way as the theory of consequence operations is a general theory of logic, this theory of adequacy is a general theory of the interactions and connections between consequence operations and its sound and complete semantics. Addition of axioms for the connectives of propositional logic to the basic axioms of consequence operations yields a unifying framework for different systems of classical propositional logic. We present an (...) abstract model-theoretical semantics based on model mappings and theory mappings. Between the classes of models and theories, i.e., the set of sentences verified by a model, it obtains a connection that is well-known within algebra as Galois correspondence. Many basic semantical properties can be derived from this observation. A sentence A is a semantical consequence of T if every model of T is also a model of A. A model mapping is adequate for a consequence operation if its semantical inference operation is identical with the consequence operation. We study how properties of an adequate model mapping reflect the properties of the consequence operation and vice versa. In particular, we show how every concept of the theory of consequence operations can be formulated semantically. (shrink)

William James and Alfred North Whitehead strongly rejected materialism as a metaphysical option. While James lived and wrote only up to the beginning of the revolution in physics that brought to the fore fundamentally different theories such as quantum theory and the special and general theories of relativity, Whitehead, as an accomplished mathematician, was readily conversant with these new developments. Since their respective times, however, much innovation and refinement of theories in physics and other natural sciences has taken place. With (...) these later developments, conceptions of matter and its capabilities have undergone far-reaching explicit and implicit changes. A consequence of these... (shrink)

By the mid-1960s the sexual revolution was in full swing. The persuasive rhythms of the Beatles and the Rolling Stones urged new personal freedoms, Carl Djerassi’s Pill was introduced to widespread acclaim, and feminists were setting their underwear ablaze. Most Christian denominations had long ago overturned their previous teaching on contraception. John Calvin, had at one time, called the act "condemned" and "doubly monstrous", while John Wesley had said contraception was "very displeasing to God", and the "evidence of vile affections." (...) Those who used them he regarded as "logs", "stock" and "swine". But most Protestants had by now abandoned this instruction. Indeed, the Church of England had as far back as 1930 up-ended its once entrenched rejection of contraception as “demoralizing to character and hostile to national welfare.” Into this unlikely and tempting climate came the explosive Humanae Vitae. The Roman Catholic Church, alone among religions, publicly reaffirmed its traditional teaching prohibiting contraception. The encyclical warned of the need to maintain the connection between sex and babies – and this, despite the Rockefeller offer of cash for favourable encyclicals in the summer of ’65. Pope Paul VI warned that contraception would lead to promiscuity, loss of respect for life, marriage and the family, and breakdown of essential social structures. Laing suggests that there is reason to think this fear for the likely effects of separating sex from babies well founded. (shrink)

There is a small but growing community of researchers spanning a spectrum of disciplines which are united in rejecting the still dominant computationalist paradigm in favor of the enactive approach. The framework of this approach is centered on a core set of ideas, such as autonomy, sense-making, emergence, embodiment, and experience. These concepts are finding novel applications in a diverse range of areas. One hot topic has been the establishment of an enactive approach to social interaction. The main purpose of (...) this paper is to serve as an advanced entry point into these recent developments. It accomplishes this task in a twofold manner: it provides a succinct synthesis of the most important core ideas and arguments in the theoretical framework of the enactive approach, and it uses this synthesis to refine the current enactive approach to social interaction. A new operational definition of social interaction is proposed which not only emphasizes the cognitive agency of the individuals and the irreducibility of the interaction process itself, but also the need for jointly co-regulated action. It is suggested that this revised conception of `socio-cognitive interaction' may provide the necessary middle ground from which to understand the confluence of biological and cultural values in personal action. (shrink)

The Mind Argument is an argument for the incompatibility of indeterminism and anyone's having a choice about anything that happens. Peter van Inwagen rejects the Mind Argument not because he is able to point out the flaw in it, but because he accepts both that determinism is incompatible with anyone's having a choice about anything that happens and that it is possible for someone to have a choice about something that happens. In this paper I first diagnose and clear up (...) a confusion in recent discussions of the Mind Argument and then go on to show why it is a bad argument. (shrink)