The building blocks and origins of life have fascinated scientists since the earliest of times. What is required for life to work in terms of building blocks? An outline of the building blocks that have to be present in living systems to allow the processes that are required for life is given. These building blocks have to be organised in a specific way to allow living processes to be functional, which are summarised in what is referred to as the seven (...) pillars of life. In essence, these are the fundamental characteristics of all living systems. Evidences of when and how living systems developed on the Earth shortly after the Earth established itself as a planet are discussed. This comes from the growing body of geological evidence of the age of rocks and rock formations in different places on the Earth. This review is concluded with the latest evidence of where on Earth living systems may have started. A large amount of uncertainty exists about these processes, but more and more consilient evidence is giving us important pointers as to the origins of life on the planet Earth.Contribution: As part of this special collection, the building blocks or origins of life give insights into the chemical principles and constituents of living organisms and how their interactions allow life to function on earth. (shrink)

Some uncertainty has always surrounded the translation of Thucydides made by Laurentius Valla in 1452 at the desire of the Humanist Pope, Nicolas V., because its source was unknown. It is recognized that the translation is of unequal value, because, excellent Latinist as Valla was, he was less at home in Greek, and often fails, even when the Greek is not particularly difficult; but his text, whatever its origin and history, is a primary authority. In the Oxford text of (...) Thucydides, edited by Principal Stuart Jones, I have counted sixteen places for which Valla is the only authority, and there are a few more which might perhaps well be added. The view both of the Principal and of Hude is that Valla's readings in these places were due to his own ingenuity. (shrink)

Richard Koch first made his appearance in the 1920s with works published on the foundations of medicine. These publications describe the character of medicine as an action and the status of medicine within the theory of science. One of his conclusions is that medicine is not a science in the original sense of the word, but a practical discipline. It serves a practical purpose: to heal the sick. All medical knowledge is oriented towards this purpose, which also defines the physician’s (...) role. One kind of knowledge is diagnosis, which is strictly understood in relation to therapy, and is at the core of medical thinking. Diagnosis is not the assignment of a term of a species to a patient’s disease: this would not do justice to the individuality of a clinical manifestation and would fail to provide a reason for individual therapy. Nevertheless, the terms assigned to diseases, although fictitious, are not useless, but assist in differentiating various phenomena. These conclusions carry ethical consequences. Because the task of helping the sick constitutes medicine, morals not only set ethical limits: medicine originates in a moral decision. If there are no diseases but only individual sick people, disease can not be defined as an abnormality. The individual benefit to the patient must not necessarily be the complete restoration of health. With its object being incalculable, medicine cannot guarantee its own success. Here the physician has to develop principles that allow for the best possible response to the challenges faced in varying situations of conduct. (shrink)

Much research has been done on the economic effects of self-employment, environmental conditions for entrepreneurial success, as well as attributes if the person him-/herself fits to this career path. To successfully run a business, however, is contingent on the health of the entrepreneur. In particular, small business owners (being solo self-employed without personnel) face financial uncertainties, a high workload, long working hours, and are often unable to call in sick. This study aimed at exploring the working situation considering resources (e.g., (...) autonomy), strain (e.g., dependency on contracts with clients) and health and career outcomes of small business owners. This study used a qualitative approach to comprehensively mirror the working situation. Participants who were 29 small business owners from Germany gave permission for recording expert interviews in which they reported, for example, on health complaints, recovery opportunities, obstacles and resources while running their businesses. The interviews emphasize the meaning of active actions and own responsibility for creating working conditions and enabling autonomy. Small business owners yet have to be able to use the autonomy. Besides personal preferences regarding the career path as being pulled into self-employment and not pushed by situational circumstances also marketability and flexibility played a role and explained health and career issues. Our findings underline that the social network is of utmost importance to small business owners and that social support – even or despite of being solo self-employed – is a key to sustaining health and satisfaction. As voluntariness played an essential role for selecting this specific career path those being pulled into self-employment as no other jobs are available should receive particular support through career counseling. One shortcoming of prior research is that the concrete working situation of small business owners and its impact on health and career has not adequately been taken into account. Based on work-related stress models we developed a frame model specific for the situation of small business owners which allows concrete hypotheses for further quantitative research. (shrink)

Objectives: To examine the experiences of spousal care givers of Alzheimer patients to disclosure of dementia diagnosis and subsequent care.Methods: A random sample of 1943 spousal care givers of people receiving medication for Alzheimer disease was sent a cross-sectional postal survey about their opinions on the disclosure of dementia and follow-up care. A smaller qualitative study included open-ended questions concerning their experiences of the same topics.Results: The response rate for the survey was 77%. Of the respondents, 1214 of 1434 acknowledged (...) themselves as their spouse’s care giver. The mean age of the care givers was 78.2 years, and that of demented spouses, 80.5 years. Of the care givers, 63% were women. The couples had long-lasting marriages. Of the care givers, 93% reported that dementia had been disclosed openly to their spouse; 97% also preferred that physicians openly inform the patients of the dementia diagnosis, although 55% of their spouses with AD had developed depressive symptoms after the disclosure. Of the care givers, 71% felt they had received sufficient information about dementia. However, only 50% estimated that their spouses’ follow-up care had been well organised. The responses in the qualitative study indicated that many care givers felt grief and anxiety. They also expressed feelings of loneliness and uncertainty about how to deal with follow-up care for dementia.Conclusions: Elderly spousal care givers were quite satisfied with the information given them about dementia. However, the support with regard to the follow-up care of care-giving families failed to meet their needs adequately. (shrink)

In this paper, we investigate the impact of economic policy uncertainty on the conditional dependence between China and U.S. stock markets by employing the Copula-mixed-data sampling framework. In the case of EPU, we consider the global EPU, the American EPU, and the China EPU. The empirical analysis based on the Shanghai Stock Exchange Composite index in China and the S&P 500 index in the U.S. shows that the tail dependence between China and U.S. stock markets is symmetrical, and the (...) t Copula outperforms alternative Copulas in terms of in-sample goodness of fit. In particular, we find that the t Copula-MIDAS model with EPU dominates the traditional time-varying t Copula in terms of in-sample fitting. Moreover, we observe that both the GEPU and AEPU have a significantly positive impact on the conditional dependence between China and U.S. stock markets, whereas CEPU has no significant impact. The tail dependence between China and U.S. stock markets exhibits an increasing trend, particularly in the recent years. (shrink)

We empirically analyze the impact of economic uncertainty due to the COVID-19 pandemic on the trading volume of each sector in the S&P 500 index. Wavelet coherence analysis is carried out using economic policy uncertainty data and the trading volume of each sector in the S&P 500 index from July 2004 to September 2020. Furthermore, we apply multifractal detrended fluctuation analysis to the trading volume series of all sectors. The wavelet coherence analysis shows that the COVID-19 pandemic has (...) substantially influenced trading volume in all sectors. However, the impact of the pandemic is different from that during the global financial crisis in some sectors, such as information technology, consumer discretionary, and communication services. Because of the lockdown taken to suppress COVID-19, increased remote working and remote learning are the main reasons for these results. Additionally, according to the MF-DFA analysis, the trading volume of all the sectors has clear multifractal characteristics, and they are all nonpersistent. Specifically, trading volumes of the real estate and materials sector are highly correlated, whereas the trading volumes of industry and information technology sectors are comparatively less correlated. (shrink)

External auditors owe a professional duty to the company''s stockholders and to society in general. However their remuneration is determined by management. The resulting conflicts of interest are particularly acute in distressed companies where the auditors are required to disclose uncertainties regarding future survival. We focus on the consequentialist self-fulfilling prophecy argument whereby auditors may fail to disclose such uncertainties due to the belief that the disclosure itself would precipitate the company''s bankruptcy. We find no empirical support for such beliefs (...) for a sample of distressed U.K. companies with audit reports published between 1986 and 1993. Companies whose auditors disclose going concern uncertainties are no more likely to fail than those without such disclosures; indeed three out of four reports containing going concern uncertaintiesare not followed by failure before publication of a subsequent set of accounts. Instead we find that it is the degree of financial distress that drives both bankruptcy and the auditor''s going concern disclosure rather than that the disclosure itself causes failure. Belief in the self-fulfilling prophecy effect nevertheless persists, and this despite the profession''s clear ethical guidelines that audit opinions should provide an objectively true and fair view, paying no regard to possible consequences. It may be that the continued attractiveness of the self-fulfilling prophecy belief is due to its providing a means of resolving intense auditor/management conflict in what is a particularly complex decision situation. We argue that, if the profession''s clear ethical guidelines are to play a greater role in this area, issues such as enforcement will need to be addressed. (shrink)

This qualitative social scientific interview study delves into the ways in which professional vision is constructed in clinical ethics consultation (CEC). The data consist of 11 semi-structured interviews that were conducted with clinical ethics consultants currently working in hospitals in one major urban area in the U.S. The interviews were analyzed with the qualitative research method of critical discourse analysis, with a focus on identifying the cultural structures of knowledge that shape CEC as a professional practice. The discourses were first (...) identified as belonging to two higher discourse categories, order and agency. Order was divided into three lower categories, emotional, managerial, and rational order, and discourses of agency into the lower categories of exploration, technique, deliberation, and distancing. An additional discourse of neutral interaction was identified as a bridging discourse, activated to level tensions emerging out of conflicting goals and agencies embedded in CEC practice. This analysis brings out as its main observation that clinical ethics consultants draw on and shift between potentially ideologically conflicting social positions that can create built-in tensions within the professional domain. The study calls attention to these tensions and suggests for the professional group to discuss the possibility of defining priorities between different kinds of order, identified in this study, that shape the CEC domain. (shrink)

Presenting U.S. history as contested interpretations of compelling problems, this text offers a clear set of principles and strategies, together with case studies and "Mystery Packets" of documentary materials from key periods in American history, that teachers can use with their students to promote and sustain problem-finding and problem-solving in history and social studies classrooms. Structured to encourage new attitudes toward history as hands-on inquiry, conflicting interpretation, and myriad uncertainties, the whole point is to create a user-friendly way of teaching (...) history "as it really is" - with all its problems, issues, unknowns, and value clashes. Students and teachers are invited to think anew as active participants in learning history rather than as passive sponges soaking up pre-arranged and often misrepresented people and events. New in the Second Edition: New chapters on Moundbuilders, and the Origins of Slavery; expanded Gulf of Tonkin chapter now covering the Vietnam and Iraq wars; teaching tips in this edition draw on years of teacher experience in using mysteries in their classrooms since the publication of the first edition. (shrink)

Bohr and Heisenberg suggested that the thermodynamical quantities of temperature and energy are complementary in the same way as position and momentum in quantum mechanics. Roughly speaking their idea was that a definite temperature can be attributed to a system only if it is submerged in a heat bath, in which case energy fluctuations are unavoidable. On the other hand, a definite energy can be assigned only to systems in thermal isolation, thus excluding the simultaneous determination of its temperature. Rosenfeld (...) extended this analogy with quantum mechanics and obtained a quantitative uncertainty relation in the form ΔU Δ(1/T) ≥ k, where k is Boltzmann's constant. The two “extreme” cases of this relation would then characterize this complementarity between isolation (U definite) and contact with a heat bath (T definite). Other formulations of the thermodynamical uncertainty relations were proposed by Mandelbrot (1956, 1989), Lindhard (1986), and Lavenda (1987, 1991). This work, however, has not led to a consensus in the literature. It is shown here that the uncertainty relation for temperature and energy in the version of Mandelbrot is indeed exactly analogous to modern formulations of the quantum mechanical uncertainty relations. However, his relation holds only for the canonical distribution, describing a system in contact with a heat bath. There is, therefore, no complementarily between this situation and a thermally isolated system. (shrink)

Galligan (Professor Emeritus, English, Western Michigan U.-Kalamazoo) argues that contemporary American critics should embrace literary truths with all of their uncertainties rather than cling to make- believe certainties of ideologies. He celebrates values commonly associated with modern, not postmodern, criticism, applying them to contemporary works in a series of fresh and unusual inquiries. He finds implications for criticism in work from the physical sciences and in the works of largely ignored novelists. Annotation copyrighted by Book News, Inc., Portland, OR.

Originally published by Ballinger, this book is a result of an Atlantic Council study of U.S. international relationships on energy. It examines the uncertainties of a political, strategic, economic, and technological nature that are involved in energy supply, as well as the unavoidable certainty of finite resources.

Algunos autores han intentado considerar los delirios como certezas –entendidas en el sentido de Wittgenstein– debido a las similitudes que parecen existir entre sus respectivos estatus epistemológicos. Sin embargo, dicho intento ha sido criticado con agudeza, entre otras razones, porque el contenido de los delirios choca frontalmente con el contenido de las certezas, por lo que los delirios no pueden ser comprendidos debido a los cambios en las relaciones de significado. Pero es evidente que, aunque los delirios no se puedan (...) contemplar como certezas, muchos delirios afectan de un modo u otro al sistema de certezas del paciente. Partiendo de esta base, no es descabellado pensar que dicha influencia pudiera ser también recíproca: en otras palabras, parece sumamente recomendable analizar si algunos delirios se podrían contemplar como el resultado de variaciones en certezas. En este artículo llevo a cabo dicho análisis al intentar mostrar que el origen de algunos delirios pedestres y severos puede ser hallado en lo que llamaré “ceguera a posibilidades” e “incertidumbre”, términos que he desarrollado teniendo en cuenta la obra del filósofo Ludwig Wittgenstein. (shrink)

Given that the benefits of Corporate Political Activity (CPA) are usually granted in the form of favorable industry regulation that benefits all industry participants rather than a single firm, small politically inactive firms are often able to take advantage of the benefits from CPA without investing in them. We argue that the free‐riding problem is context specific. Situations of extreme uncertainty create institutional voids that enable individual firms to more fully appropriate the returns from their CPA. In this paper, (...) we examine the influence that CPA had on the U.S. government’s disbursements of TARP funding in 2008. We find that politically active firms were able to avoid the free‐rider problem by obtaining more instances of TARP funding when compared to firms that were not politically active. In addition to being more likely to receive TARP funds, politically active firms received larger amounts of TARP funding than those firms who were not politically active. (shrink)

Psihoanaliza kao teorija, praksa i interpretacija nije se pojavila kao samo još jedan »izam« na početku 20. stoljeća, već i kao jedan bitan pomak od doista tradicionalističkog poimanja onog unutarnjeg u čovjeku spram vanjskog. Sam Lacan, u suvremenosti jedan od najpoznatijih teoretičara i interpreta psihoanalize, kaže da pristup koji bi odogonetnuo mjesto polazišta njenog istraživanja i definiranja »nije baš unutra, a ne zna se da li je izvana«. Ovim se željelo nagovijestiti da ona uporišta koje govore ne samo o psihoanalizi, (...) već i o mogućem nalaženju istih, iznose, pa i računaju s nekim nesigurnostima spram tradicije.U vrijeme nastanka i prvih aktualnosti psihoanalize i Freudovog učenja, u filozofiji se gotovo istovremeno sve češće pojavljuju napori da se ljudska psiha i uopće psihologijsko oslobodi kauzalnosti i mehanicističkih određenja, s jedne strane, i da se istovremeno oslobodi predstave i kauzalnosti nečeg iracionalnog i beskonačnog, s druge strane. Nastojeći izbjeći nejasna određenja i suprotstavljanja duše i/ili psihe, filozofija sustavnije od E. Husserla nastoji sve izrazitije naglasiti čovjekovu unutarnjost kroz reinterpretaciju transcendentalnih iskustva subjektivnosti i intersubjektivnosti. Individualna teorijska tvorba, međusobno teorijsko prožimanje, dodirne i razdvajajuće povijesno- teorijske i filozofijske točke ovih dvaju različitih, ali povremeno i komplementarnih ishodišta predmet su zanimanja i razmišljanja u ovom radu.Psychoanalysis as a theory, practice and interpretation did not occur like another -ism on the begining of the twentieth century, but also as one important step ahead from truly traditional understanding of inside of the man which is confronted with his outside existence. Jacques Lacan himself, today one of the most known theoritician and interpreter of psychoanalysis, says that approach which could figure out where is the starting point of its exploring and defining isn’t really inside, and it’s not sure if it’s outside. Saying this, one wants to foreshow that those foundations which speak not only of psychoanalysis, but also about possible findings of them.That is why there are some uncertainties about tradition in these considerations.At the time when psychoanalysis and Freud’s learnings became actual and new, in philosophy almost simultaneously more and more often are present efforts which human psyche and psychology in general were slowly making free of causalities and mechanistic charachteristics on one side. On the other side, in the same time, there have been efforts which would make the psyche free of such images that would define it as irational and infinte entity. Trying to avoid unclear definitions and confrontations in understanding of psyche and/or soul, philosophy is more sistematical with this problem since philosophy of Edmund Husserl. He’s trying to emphasize more utterly the world inside the man through the reinterpretation of transcedental experience of subjectivity and intersubjectivity. Individual philosophical creation, mutual theoretical coming between, connecting and separating historically-theoretical and philosophical standpoints of these two different, but occasionaly also complementary outcomes are the object of interest and reflections in this work. (shrink)

다산 역학의 성립과 정수, 그리고 그 경학적.사상사적의의를 논구한 저술.

The ethical tensions inherent in all Baby Doe treatment decisions are compounded by medical uncertainty. Physicians both here and abroad have adopted various strategies. Swedish doctors tend to withhold treatment from the beginning from infants for whom statistical data suggest a grim prognosis. The British are more likely to initiate treatment but withdraw it if the infant appears likely to die or suffer severe brain damage. The trend in the U.S. is to start treating any baby who is potentially (...) viable and continue until it is virtually certain that the infant will die. The “least worst” strategy is an individualized one: starting treatment gathering data, and then reassessing the decision. (shrink)

This paper discusses the operations meant to act on situations of ontological uncertainties for chemicals. Using examples related to substances developed as part of nanotechnology programs, it analyses technical and social instruments meant to define the existence of these substances, as « new » or « existing » chemicals. Carbon nanotubes developed by a French company offer an illustration of containment, while the legal disputes about nano silver in the U.S. display oppositions about whether or not these compounds are equivalent (...) to colloïdal silver. The operations meant to deal with the ontological uncertainty of these substances define categories and craft political organizations. As such, they suggest developing an analytical approach able to jointly examine the ontologies of material objects and the forms of political ordering. (shrink)

This study presents the fundamental concepts and technical details of a U-model-based control system design framework, including U-model realisation from classic model sets, control system design procedures, and simulated showcase examples. Consequently, the framework provides readers with clear understandings and practical skills for further research expansion and applications. In contrast to the classic model-based design and model-free design methodologies, this model-independent design takes two parallel formations: it designs an invariant virtual controller with a specified closed-loop transfer function in a feedback (...) control loop and it determines the real controller output by resolving the inverse of the plant U-model. It should be noted that this U-control provides a universal control system design platform for many existing linear/nonlinear and polynomial/state-space models and it complements many existing design approaches. Simulation studies are used as examples to demonstrate the analytically developed formulations and guideline for potential applications. (shrink)

ObjectivesTo examine the association between illness uncertainty, resourcefulness, and poststroke depression and identifies whether stroke patients’ resourcefulness plays a mediating role in the relationship between illness uncertainty and PSD.MethodsA cross-sectional study was conducted from September 2020 to April 2021. A convenience sample of 355 stroke patients was recruited. A general characteristic questionnaire, the Mishel Uncertainty in Illness Scale, the Resourcefulness Scale, and the Patient Health Questionnaire-9 were used to obtain data. Descriptive analysis, Student’s t-test, Mann–Whitney U-test, chi-squared (...) test, hierarchical regression analyses, Pearson correlation analysis, and mediation analysis with the PROCESS macro were used to analyze the data.ResultsIllness uncertainty, resourcefulness, and PSD were significantly related to each other. Resourcefulness partially mediated the relationship between illness uncertainty and PSD.ConclusionIllness uncertainty and resourcefulness were significantly associated with PSD, and resourcefulness played a mediating role between illness uncertainty and PSD. Interventions designed to reduce illness uncertainty and enhance resourcefulness may contribute to the prevention and improvement of PSD. (shrink)

Environmental releases of gene edited (GEdOs) and gene drive organisms (GDOs) will likely occur under conditions of high uncertainty and in complex socioecological systems. Therefore, public deliberation is especially important to account for diverse interpretations of safety, risks, and benefits; to draw on experiential and public wisdom in areas of proposed release; to ameliorate dangers of technological optimism; and to increase the public legitimacy of decisions. Yet there is a “democratic deficit” in the United States' oversight system for GEdOs (...) and GDOs, as unconflicted experts, publics, and skeptical stakeholders are most often excluded from decision‐making and unavailable to critically examine potential risks and benefits or raise broader concerns about socioeconomic or cultural impacts. This article argues for the need to open up decision‐making for GEdOs and GDOs, discusses the challenges for doing so within the current oversight framework, and finally, proposes institutional, policy, and attitudinal changes that are likely important for overcoming barriers to public deliberation. (shrink)

현대철학의 핵심문제로 제시되어온 주체의 개념을 유 럽철학사의 맥락으로 논한 저서.

As Post observes, accounting firms are unique among multinationals. They are more likely than firms in almost any other category to go abroad. They also have less choice in location as their expansion is determined largely by the desired locations of their clients. Given the widespread global presence of such firms, it can be argued that the global audit firm is uniquely at risk from variations in ethical perceptions across nations. This study extends the U.S. accounting literature on determinants of (...) cheating among accounting students to the U.K. Based on the work of Cohen et al. it develops a model that suggests that students in lower "uncertainty avoidance" countries will be both less likely to cheat, and when they do cheat, will be driven by internal rather than external mode. Our results supported the model as proposed as our results indicated that U.S. students were more likely to cheat and were more responsive to external stimuli than were the U.K. students. (shrink)

Reflections on Medicine is a rich sampling of 70 essays from a collection of more than 300 essays Robert Massey wrote for Connecticut Medicine: The Journal of the Connecticut State Medical Society, between 1973 and 2005. It is an elegant buffet of the thoughts and observations of a remarkable man. In his foreword to the book, Sherwin Nuland writes: "he applied his massive erudition to so many [other] themes, universal and specific—he accepted the uncertainty of human wisdom and even (...) knowledge, recognizing that it is for each generation to look anew at dilemmas both modern and ancient" (p. ix). In fact, there are countless references to the writings of Albert Schweitzer, T. S. Eliot, Mark Twain, and Lewis Thomas .. (shrink)

Quasi-Nelson logic (QNL) was recently introduced as a common generalisation of intuitionistic logic and Nelson's constructive logic with strong negation. Viewed as a substructural logic, QNL is the axiomatic extension of the Full Lambek Calculus with Exchange and Weakening by the Nelson axiom, and its algebraic counterpart is a variety of residuated lattices called quasi-Nelson algebras. Nelson's logic, in turn, may be obtained as the axiomatic extension of QNL by the double negation (or involutivity) axiom, and intuitionistic logic as the (...) extension of QNL by the contraction axiom. A recent series of papers by the author and collaborators initiated the study of fragments of QNL, which correspond to subreducts of quasi-Nelson algebras. In the present paper we focus on fragments that contain the connectives forming a residuated pair (the monoid conjunction and the so-called strong Nelson implication), these being the most interesting ones from a substructural logic perspective. We provide quasi-equational (whenever possible, equational) axiomatisations for the corresponding classes of algebras, obtain twist representations for them, study their congruence properties and take a look at a few notable subvarieties. Our results specialise to the involutive case, yielding characterisations of the corresponding fragments of Nelson's logic and their algebraic counterparts. (shrink)

Industry groups engage in venue shifting when they seek to overturn or alter restrictive regulations imposed by one political venue through another. A critical step in this process is resolving uncertainties surrounding the preference of the targeted venue and the nature of the relevant policy proposal. While existing studies emphasize a long-term trial-and-error process of policy learning, we focus on nascent industries and argue that ventures seek other information sources to resolve these uncertainties quickly. In particular, nascent industry groups are (...) likely to perceive that the targeted venue will support their policy proposal if the targeted venue is ideologically distant from the venue that has enacted the restrictive regulations, if the targeted venue has recently supported other nascent industry groups’ similar policy proposals, or if the industry groups themselves are more exposed to industry peers’ success in promoting the same policy proposal in other jurisdictions. Under these conditions, the industry groups invest more to influence the targeted venue in response to restrictive regulations enacted by other venues. We find support for our theory by examining how from 2013 to 2019 the small unmanned aircraft systems industry trade associations in the United States lobbied state governments to nullify local regulations. (shrink)