Background. Drawing on social identity theory and positive psychology, this study investigated women’s responses to the social environment of physics classrooms. It also investigated STEM identity and gender disparities on academic achievement and flourishing in an undergraduate introductory physics course for STEM majors. 160 undergraduate students enrolled in an introductory physics course were administered a baseline survey with self-report measures on course belonging, physics identification, flourishing, and demographics at the beginning of the course and a post-survey (...) at the end of the academic term. Students also completed force concept inventories and physics course grades were obtained from the registrar. Results. Women reported less course belonging and less physics identification than men. Physics identification and grades evidenced a longitudinal bidirectional relationship for all students (regardless of gender) such that when controlling for baseline physics knowledge: (a) students with higher physics identification were more likely to earn higher grades; and (b) students with higher grades evidenced more physics identification at the end of the term. Men scored higher on the force concept inventory than women, although no gender disparities emerged for course grades. For women, higher physics (versus lower) identification was associated with more positive changes in flourishing over the course of the term. High-identifying men showed the opposite pattern: negative change in flourishing was more strongly associated with high identifiers than low identifiers. Conclusions. Overall, this study underlines gender disparities in physics both in terms of belonging and physics knowledge. It suggests that strong STEM identity may be associated with academic performance and flourishing in undergraduate physics courses at the end of the term, particularly for women. A number of avenues for future research are discussed. (shrink)

A basic component of moral objections to embryonic stem cell research is the claim that human embryos have the same moral status as typical adult human beings. There is no reason to accept this claim, however, unless adult humans once existed as embryos—that is, unless the developmental history of adult humans contains embryos to which the adults are numerically identical. The purpose of this paper is to argue that there are no such identities, and hence that no adult human (...) being ever existed as an embryo. (shrink)

This article centres on two distinct but intersecting questions: does it matter if we cannot definitively answer the question ‘what is philosophy?’ and do philosophers exhibit bias? The article will answer ‘yes’ to both questions for the following reasons. First because the uncertainty has allowed some answers to dominate. Second, because the answers necessarily demonstrate biases, and these have led to a lack of diversity in the discipline. Following this, the article will consider why philosophers have been slow or reluctant (...) to accept that bias plays a role in what we do. This lack of recognition has, I suggest, limited opportunity for diverse approaches, methods, and standpoints to flourish. The discipline has suffered as a result, and so too have diverse philosophers. Many fields in science, technology, engineering and mathematics meanwhile have sought to tackle the lack of diversity head on, and philosophers would do well to heed their examples. (shrink)

In this article, we develop critiques of the pipeline model which dominates Western science education policy, using discourse analysis of interviews with two Swedish young women focused on ‘identity work’. We argue that it is important to unpack the ways that the pipeline model fails to engage with intersections of gender, ethnicity, social class and nationality, and their impact on science and with debates about science as elitist and implicated in neoliberalism.

Endosteal stem cells are a subclass of bone marrow skeletal stem cell populations that are particularly important for rapid bone formation occurring in growth and regeneration. These stem cells are strategically located near the bone surface in a specialized microenvironment of the endosteal niche. These stem cells are abundant in young stages but eventually depleted and replaced by other stem cell types residing in a non‐endosteal perisinusoidal niche. Single‐cell molecular profiling and in vivo cell lineage (...) analyses play key roles in discovering endosteal stem cells. Importantly, endosteal stem cells can transform into bone tumor‐making cells when deleterious mutations occur in tumor suppressor genes. The emerging hypothesis is that osteoblast‐chondrocyte transitional identities confer a special subset of endosteal stromal cells with stem cell‐like properties, which may make them susceptible for tumorigenic transformation. Endosteal stem cells are likely to represent an important therapeutic target of bone diseases caused by aberrant bone formation. (shrink)

Identities formed with proper names may be contingent. this claim is made first through an example. the paper then develops a theory of the semantics of concrete things, with contingent identity as a consequence. this general theory lets concrete things be made up canonically from fundamental physical entities. it includes theories of proper names, variables, cross-world identity with respect to a sortal, and modal and dispositional properties. the theory, it is argued, is coherent and superior to its rivals, (...) in that it stems naturally from a systematic picture of the physical world. (shrink)

From where does the frequently explored connection between identity, difference and power stem? One thinker influencing contemporary discussions on this theme is Judith Butler. To her, the primary difference constituting identity is the difference between the subject and the historical power constructing it. Although they belong together, power can still be said to subjugate the subject. However, within this system, the origin of power cannot be accounted for. I will therefore attempt to examine this origin on the (...) basis of Martin Heidegger's The History of Being, written 1938-1940). According to him, power is something intrinsically dependent on subject metaphysics. The latter stems from what he calls the oblivion of being, which can also be expressed as the forgetting of the difference between beings and being. The abiding in this difference opens the way into that which Heidegger calls enowning, in which the human being can reach identity in a qualified respect, as a nearness to his own being. Only on this way can the regime of power, permeating identity construction, be overcome. (shrink)

Personal Identity and Ethics provides a lively overview of the relationship between the metaphysics of personal identity and ethics. How does personal identity affect our ethical judgments? It is a commonplace to hold that moral responsibility for past actions requires that the responsible agent is in some relevant respect identical to the agent who performed the action. Is this true? On the other hand, can ethics constrain our account of personal identity? Do the practical requirements of (...) moral theory commit us to holding that persons do remain identical over time? Or is it the case that personal identity is not, in fact, relevant to ethics? -/- Shoemaker provides the first comprehensive examination of these issues for the undergraduate audience. Topics include personal identity and prudential rationality; personal identity's significance for moral responsibility and ethical theory; and the practical consequences of accounts of personal identity for issues such as abortion, stem cell research, cloning, advance directives, populations ethics, multiple personality disorder, and the definition of death. (shrink)

Is there anything special about the ethical problems of intracerebral stem-cell transplantation and other forms of cell or tissue transplantation in the brain that provides neuroethics with a distinctive normative profile, setting it apart from other branches of medical ethics? This is examined with reference to some of the ethical problems associated with interventions in the brain such as potential changes in personal identity and potential changes in personality. It is argued that these problems are not sufficiently specific (...) to justify the autonomy of neuroethics as a separate discipline and can be handled by the established principles of medical ethics. The paper concludes with a constructive proposal how to deal with interventions in the brain for which the patient is unable to give valid ex-ante consent. (shrink)

The mind-brain identity theory, the thesis that sensations are identical with properties or processes of the brain, was introduced into contemporary discussion by U.T. Place, Herbert Feigl, and J.J.C Smart in the 1950s. Despite its widespread rejection in the following decades, the identity theory has received several carefully articulated defenses in recent years. Aside from developing novel responses to well-known arguments against the identity theory, contemporary identity theorists have argued that the epistemological resources available to support (...) the adoption of identities are more plentiful than has often been supposed; further, they have argued that mind-brain identities allow for the resolution of otherwise intractable explanatory puzzles about the phenomenal properties of experience. From an epistemological perspective, identity theorists have thus argued that a central reason for believing theoretical identities—both mind-brain identities as well as more mundane identities such as water = H2O—stems from the explanatory power that they confer. Yet from an explanatory perspective, identity theorists have maintained that identities cannot themselves be explained; indeed, they have maintained that it is hardly intelligible to request an explanation for an identity. This paper considers these ideas draws out an important tension between them. The central claim is that insofar as identity theorists insist on the explanatorily efficacy of identities, they should concede that there is a good sense in which theoretical identities can be explained. However, it is moreover argued that this concession is not especially problematic and, indeed, ought to be welcomed by identity theorists. (shrink)

Identity politics is commonly criticized as endangering democracy by undermining community, rational communication, and solidarity. Drawing on both radical democratic theory and standpoint theory, this article posits the opposite thesis: identity politics is pivotal for the democratization of democracy. Democratization through identity politics is achieved by disrupting hegemonic discourse and is, therefore, a matter of power, while such forms of power politics are reasonable when following minority standpoints generated through identity politics. The article develops this approach (...) by connecting radical democratic theories with standpoint theories and highlighting their commonalities and potential for mutual enhancement. Standpoint theory allows us to substantiate and reconcile two initially contradictory claims: particular minority standpoints are necessary to criticize the prevailing discursive and institutional orders, and these standpoints stem from intersubjective reason and embody ‘strong objectivity.’ This discussion presents a new perspective on the tension between particularity and universality, as well as the relationship between power and reason in democracy. Democratization is an oscillation between these polarities, and political theory should not aim to resolve this tension but to recognize and articulate it. Such recognition might involve elevating knowledge emerging from oppressed groups and exercising epistemic modesty when assessing specific forms of identity politics. (shrink)

Many philosophers have taken there to be an important relation between personal identity and several of our practical concerns (among them moral responsibility, compensation, and self-concern). I articulate four natural methodological assumptions made by those wanting to construct a theory of the relation between identity and practical concerns, and I point out powerful objections to each assumption, objections constituting serious methodological obstacles to the overall project. I then attempt to offer replies to each general objection in a way (...) that leaves the project intact, albeit significantly changed. Perhaps the most important change stems from the recognition that the practical concerns motivating investigation into personal identity turn out to be not univocal, as is typically thought, such that each of the different practical concerns may actually be related to personal identity in very different ways. (shrink)

Obesity is a public health problem influenced by behavioral patterns that span an ecological spectrum of individual-level factors, social network factors and environmental factors. Both individual and environmental approaches necessarily include significant influences from social networks, but how and under what conditions social networks influence behavior change is often not clearly mapped out either in the obesity literature or in many intervention designs. In this paper, we provide an analysis of recent empirical work in obesity research that explicates social network (...) influences on eating behaviors. We argue that a relational rather than individualistic view of personhood should help us better understand the content and context of social network relations that inform health behavior choices. We introduce the concept of ‘identity-constitutive affiliations’ as the glue that binds these social relationships together. Finally, we outline the implications for public health ethics in the development of effective interventions to address overweight and obesity, leveraging the content and context of social network ties to reinforce healthy (or alter unhealthy) eating. More complex treatment of positive and negative behaviors stemming from social network connections should lead to more comprehensive theoretical models of health behavior change and more effective public health interventions. (shrink)

Parthenogenesis is a form of asexual reproduction in which a gamete (ovum or sperm) develops without being fertilized. Tomer Jordi Chaffer uses parthenogenesis to challenge Don Marquis' future-like-ours (FLO) argument against abortion. According to Marquis, (1) what makes it morally wrong to kill us is that it would deprive us of a possible future that we might come to value—a future “like ours” (FLO) and (2) human fetuses are numerically identical to any adult human organism they may develop into, and (...) thus have a FLO. Chaffer contends that if human ova are capable of parthenogenesis, then they would have a FLO, which contraception may deprive them of, but contends this is absurd. Bruce P. Blackshaw challenges Chaffer, contending sexually fertilized embryos are not identical to unfertilized ovum, but this would yield a more absurd implication, that fertilization deprives an ovum of a FLO! Here I show Marquis' account of identity rules out both Chaffer's and Blackshaw's accounts. (shrink)

Reprogramming technologies show that cellular identity can be reprogrammed, challenging the classical conception of cell differentiation as an irreversible process. If non-stem cells can be reprogrammed into stem cells, then what is it to be a stem cell, and what kind of property is stemness? This article addresses this question both philosophically and biologically, states the different possibilities, and illustrates their potential consequences for science with the example of anti-cancer therapies.

In this article, I argue that the medical conceptualization of gender identity in the United States has entered a “new regime of truth.” Drawing from a mixed-methods analysis of medical journals, I illuminate a shift in the locus of gender identity from external genitalia and pathologization of families to genes and brain structure and individualized self-conception. The sexed body itself has also undergone a transformation: Sex no longer resides solely in genitalia but has traveled to more visible parts (...) of the body, implicating racialized aesthetic ideals in its new formulation. The re-imagining of gender identity as genetically and neurologically inscribed and the expanding locus of sex correspond to an inversion of the relationship between gender identity and the sexed body as well as shifts in medical jurisdiction. Whereas psychiatrists in the 1960s, ’70s, and ’80s understood gender as stemming from genital sex, the less popular idea that gender identity precedes the sexed body has gained traction in recent decades. If gender identity once derived from the sexed body, the sexed body must now be brought into alignment with gender identity. The increasing legitimacy of self-defined gender identity, the expanding definition of racialized sex, and the inversion of the sex–gender identity relationship elevates the role of surgeons in producing racialized and sexed bodies. (shrink)

Stem cells isolated from adult mammalian tissues may provide new approaches for the autologous treatment of disease and tissue repair. Although the potential of adult stem cells has received much attention, it has also recently been brought into question. This article reviews the recent work describing the ability of non‐hematopoietic stem cells derived from adult bone marrow to form neural derivatives and their potential for brain repair. Earlier transplantation experiments imply that grafted adult stem cells can (...) differentiate into neural derivatives. Recent reports suggest, however, that such findings may be misleading and grafted cells acquiring different identities may merely be explained by their fusion with host cells and not the result of radical changes to their program of cellular differentiation. Nonetheless, in vitro studies have shown that neural development by bone‐marrow‐derived stem cells also appears possible. Understanding the molecular mechanisms that specify the neural lineage will lead to the development of tools for the targeted production of neural cell types in vitro that may ultimately provide a source of material to treat specific neurological deficits. BioEssays 24:708–713, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Ubiquitination plays a central role in the regulation of stem cell self‐renewal, propagation, and differentiation. In this review, the functions of ubiquitin dynamics in a myriad of cellular processes, acting along side the pluripotency network, to regulate embryonic stem cell identity are highlighted. The implication of deubiquitinases (DUBs) and E3 Ubiquitin (Ub) ligases in cellular functions beyond protein degradation is reported, including key functions in the regulation of mRNA stability, protein translation, and intra‐cellular trafficking; and how it (...) affects cell metabolism, the micro‐environment, and chromatin organization is discussed. Finally, unsolved issues in the field are emphasized and will need to be tackled in order to fully understand the contribution of ubiquitin dynamics to stem cell self‐renewal and differentiation. (shrink)

African perspectives on personhood and personal identity and their relation to those of the West have become far more central in mainstream Western discussion than they once were. Not only are African traditional views with their emphasis on the importance of community and social relations more widely discussed, but that emphasis has also received much wider acceptance and gained more influence among Western philosophers. Despite this convergence, there is at least one striking way in which the discussions remain apart (...) and that is on a point of method. The Western discussion makes widespread use of thought experiments. In the African discussion, they are almost entirely absent. In this article, we put forward a possible explanation for the method of thought experiment being avoided that is based on considerations stemming from John Mbiti’s account of the traditional African view of time. These considerations find an echo in criticism offered of the method in the Western debate. We consider whether a response to both trains of thought can be found that can further bring the Western and African philosophical traditions into fruitful dialogue. (shrink)

As elsewhere, the ethical debate on embryonic stem cell research in Central Europe, especially Germany and Switzerland, involves controversy over the status of the human embryo. There is a distinctive Kantian flavor to the standard arguments however, and we show how they often embody a set of misunderstandings and argumentative shortcuts we term "embryological Kantianism." We also undertake a broader analysis of three arguments typically presented in this debate, especially in official position papers, namely the identity, continuity, and (...) potentiality arguments. It turns out that these arguments do not support the strong, quasi-personal status accorded to the embryos in these official opinions. (shrink)

The special and unique attitudes that we take towards events in our futures/pasts—e.g., attitudes like the dread of an impeding pain—create a challenge for “Reductionist” accounts that reduce persons to aggregates of interconnected person stages: if the person stage currently dreading tomorrow’s pain is numerically distinct from the person stage that will actually suffer the pain, what reason could the current person stage have for thinking of that future pain as being his? One reason everyday subjects believe they have a (...) substantially extended temporal existence stems from introspection—they introspectively experience their selves as being temporally extended. In this paper, I examine whether a Reductionist about personal identity can co-opt this explanation. Using Galen Strawson’s recent work on self-experience as a resource, I reach both a negative and a positive conclusion about the prospects of such a position. First, the relevant kind of self-experience—i.e., the introspective experience of one’s self as being a substantially temporally extended entity—will not automatically arise within a person stage simply in virtue of that stage being psychologically connected to/continuous with other person stages. Second, the relevant kind of self-experience will arise, however, in virtue of person stages weaving together their respective experiences, actions, etc. via a narrative. This positive conclusion points towards a new Reductionist position that focuses upon a narrative, and not mere psychological continuity, in attempting to justify the special attitudes we take towards events in our futures/pasts. (shrink)

Driven by privacy-related fears, users of Online Social Networks may start to reduce their network activities. This trend can have a negative impact on network sustainability and its business value. Nevertheless, very little is understood about the privacy-related concerns of users and the impact of those concerns on identity performance. To close this gap, we take a systematic view of user privacy concerns on such platforms. Based on insights from focus groups and an empirical study with 210 subjects, we (...) find that (i) Organizational Threats and (ii) Social Threats stemming from the user environment constitute two underlying dimensions of the construct Privacy Concerns in Online Social Networks . Using a Structural Equation Model, we examine the impact of the identified dimensions of concern on the Amount, Honesty, and Conscious Control of individual self-disclosure on these sites. We find that users tend to reduce the Amount of information disclosed as a response to their concerns regarding Organizational Threats. Additionally, users become more conscious about the information they reveal as a result of Social Threats. Network providers may want to develop specific mechanisms to alleviate identified user concerns and thereby ensure network sustainability. (shrink)

This paper poses a problem for traditional phylogenetics: The identity of organisms that reproduce through fission can be understood in several different ways. This prompts questions about how to differentiate parent organisms from their offspring, making vertical gene transfer unclear. Differentiating between parents and offspring stems from what I call the identity problem. How the problem is resolved has implications for phylogenetic groupings. If the identity of a particular asexual organism persists through fission, the vertical lineage on (...) a phylogenetic tree will split differently than if the identity of an organism does not survive the fission process. (shrink)

The following considerations are to be seen in the framework of nontraditional theory of predication (NTP), which stems in its basic features from Sinowjew (cf. Sinowjew 1970, Sinowjew/Wessel 1975), and which is described in detail in Wessel 1989.

The prelims comprise: Why Embryonic Stem Cells? Stem Cells for Organ and Tissue Transplant Immortality A Guarded Welcome for Stem Cell Research The Precautionary Principle The Ethics of ES Cell Research Stem Cells from Early Embryos The Moral Status of the Embryo Lessons from Sexual Reproduction Establishing a Pregnancy by Sexual Reproduction The Incoherence of Current US Federal Law The Symbolic Value of Life ART and Spare Embryos Tissue from Fetuses Doing Something Good is Better than (...) Doing Nothing! Interim Conclusions Genetic Identity Moral Complicity Acknowledgments. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:David Hume on Personal Identity and the Indirect Passions Robert S. Henderson Scholarly reflection on Hume's "doctrine" ofselfand personal identity continues to focus on the sections "Of Personal Identity" and the "Appendix" toA Treatise ofHuman Nature. To answer the question of why we have so great a propension to ascribe an identity to these successiveperceptions which make up experience, Hume says that we must distinguish (...) betwixtpersonal identity, as it regards our thought or imagination, and as it regards our passions or the concern we take in ourselves. He considers only the former in these sections. Towards the end of the personal identity section he writes that our identity with regard to the passions serves to corroborate that with regard to the imagination, by the making our distant perceptions influence each other, and by giving us a present concern for ourpast or future pains or pleasures (T 261). In the advertisement to the Treatise Hume says that the subjects of the understanding and passions make a compleat chain of reasoning by themselves (T xii). In light of the importance Hume attaches to the distinction, and since there are many indications that the Treatise should be read as an integral whole, it is surprising that so little attention is given to what he says of personal identity in the other books. As the title suggests, this paper concentrates on the second part of the distinction and especially on the discussion ofthe indirectpassions in Book II of the Treatise. This is not to suggest that self does not play an important role elsewhere in Hume's science ofman; for example, it is selfwhich experiences the impression ofwill and the direct passions. However, the indirect passions have a particularly important part to play in ascriptions of personal identity and this justifies the present investigation. II We can safely predict that personal identity as it regards our passions will not be the idea??some philosophers whose views of self as having the philosophical (strict) relation ofidentity Hume has rejected in "Of Personal Identity." The relationship between thought and passion to which he draws attention suggests that the idea of selfin this context has a relation to the positive suggestions in that earlier section of why Volume XVI Number 1 33 ROBERT S. HENDERSON we do speak meaningfully of the identity of the self. We are able so to speak because ofarelationship which is felt to exist between a person's distinct and changing perceptions. The relationship has to do with the discovery by memory of the connection of a person's perceptions through the association ofideas by resemblance and causation (T 261). Examination of the idea of self to which Hume makes frequent reference in Book II requires some review ofthe method ofthe Treatise. Perceptions make up human experience. Perceptions are either impressions or ideas which derive from impressions. Hume describes the indirect passions as secondary or reflective impressions and these stem from original impressions or from their ideas. He distinguishes between direct andindirect passions. Directpassionsarise immediately fromgood or evil, frompain orpleasure (T 276). Examples are joy, hope and fear. Indirect passionsproceed from the same principles, but by the conjunction ofother qualities (T 276). That is, the indirect passions not onlyhave a cause (an impression which excites them), but also an object (to which the passion directs our view when excited). We shall see that a significant quality of the indirect passions is the relation of these impressions to their objects, which are either one's own or another's self. In Book II of the Treatise Hume examines the indirect passions: love, hate, pride and humility. These passions are evaluations of persons; of selfin the case of pride and humility, and of another in the case of love and hatred. Evaluation of persons is a central feature of Hume's moral philosophy: To have the sense ofvirtue, is nothing but to feel a satisfaction of a particular kind from the contemplation of a character. The very feeling constitutes our praise or admiration (T 471). We shall see that the indirect passions in particular make an important contribution to the answer ofHume's original question ofthe source?? owe propension to ascribe an identity. Ill... (shrink)

This article examines the different discursive resources on which small business owner–managers draw when understanding their sense of self in relation to corporate social responsibility. In the small business context, identity provides a justifiable framework to study corporate social responsibility, as decisions regarding socially responsible activities are mainly taken by managers and stem from their sense of who they are in the world. On the basis of 25 thematic interviews with owner–managers, two broad discursive resources were found that (...) describe how they actively seek to create and legitimise their sense of self within the discussion on corporate social responsibility. These discursive resources are called being altruistic and being instrumental. The findings emphasise that the essential and also the most challenging feature in small business owner–managers' identity work is the process of reconciling economic values with the social and ethical aspects of business life. (shrink)

This article examines the different discursive resources on which small business owner–managers draw when understanding their sense of self in relation to corporate social responsibility. In the small business context, identity provides a justifiable framework to study corporate social responsibility, as decisions regarding socially responsible activities are mainly taken by managers and stem from their sense of who they are in the world. On the basis of 25 thematic interviews with owner–managers, two broad discursive resources were found that (...) describe how they actively seek to create and legitimise their sense of self within the discussion on corporate social responsibility. These discursive resources are called being altruistic and being instrumental. The findings emphasise that the essential and also the most challenging feature in small business owner–managers' identity work is the process of reconciling economic values with the social and ethical aspects of business life. (shrink)

The author traces the ways in which various patients and collective associations of patients come to regard themselves as the users of future stem cell technologies. The author uses Althusser’s notion of interpellation, whereby an identity is the result of the situated encounter of a subject and an authority, to analyze the ways in which patient associations’ current involvement with basic research is related to the enactment of science as a series of technology development projects. The author argues (...) that this ‘‘project-ness’’ forms a certain privileged logic that interpellates patients and their associations in specific ways. Through the listings of illnesses circulated in the mass media, which are hoped to be treatable or curable with stem cell therapies, patients come to recognize themselves as the projected users of stem cell technologies. The author fleshes out the process of this userfication and the various responses made by patients and their associations when hailed by the entrepreneurial projects of stem cell research. (shrink)

We examined unconscious priming in a stem-completion task with both identity and form-related primes. Participants were given exclusion instructions to avoid completing a stem with a briefly flashed masked word . In Experiment 1, priming of around 7% occurred for both identity and form-based primes at a 33 ms exposure duration. When examining only trials in which the participants failed to identify the prime, this effect increased to 12% for identity primes, but remained the same (...) for form-based primes. In Experiment 2, priming without prime identification was 9% for identity primes, 4% for homophone primes, and 3% for orthographic control primes. Although identity priming was greater than form priming in both experiments, regression analyses revealed that orthographic and phonological overlap alone between the flashed primes and targets could completely account for unconscious identity priming. Hence, we conclude that masked words may only activate their sublexical orthographic and phonological representations and not their lexical representations. (shrink)

Understanding the mechanisms of early embryonic patterning and the timely allocation of specific cells to embryonic regions and fates as well as their development into tissues and organs, is a fundamental problem in Developmental Biology. The classical explanation for this process had been built around the notion of positional information. Accordingly the programmed appearance of sources of Morphogens at localized positions within a field of cells directs their differentiation. Recently, the development of organs and tissues from unpatterned and initially identical (...) stem cells (adult and embryonic) has challenged the need for positional information and even the integrity of the embryo, for pattern formation. Here we review the emerging area of organoid biology from the perspective of Developmental Biology. We argue that the events underlying the development of these systems are not purely linked to “self‐organization,” as often suggested, but rather to a process of genetically encoded self‐assembly where genetic programs encode and control the emergence of biological structures. (shrink)

Can an act harm someone—a future someone, someone who does not exist yet but will—if that person would never exist but for that very action? This is one question raised by the non-identity problem. Many would argue that the answer is No: an action harms someone only insofar as it is worse for her, and an action cannot be worse for someone if she would not exist without it. The first part of this paper contends that the plausibility of (...) the ‘no harm’ argument stems from an equivocation. The second half argues for an account of harm that is both causal and contrastive. Finally, the paper contends that the contrastive account disarms the no harm argument and furthermore neutralizes a related argument that has been problematic for some previously proposed solutions to the non-identity problem. (shrink)

Scientists’ identities and social locations influence their work, but the content of scientific work can also influence scientists. Theory from feminist science studies, autoethnographic accounts, interviews, and experiments indicate that the substance of scientific research can have profound effects on how scientists are treated by colleagues and their sense of belonging in science. I bring together these disparate literatures under the framework of professional cultures. Drawing on the Survey of Earned Doctorates and the Web of Science, I use computational social (...) science tools to argue that the way scientists write about sex in their research influences the future gender ratio of PhDs awarded across 53 subfields of the life sciences over a span of 47 years. Specifically, I show that a critical paradigm of “feminist biology” that seeks to de-essentialize sex and gender corresponds to increases in women’s graduation rates, whereas “sex difference” research—sometimes called “neurosexism” because of its emphasis on essential, categorical differences—corresponds to decreases in women’s graduation rates in most fields. (shrink)

The author reviews one of the more intriguing articles in the stem cell research issue of the journal Metaphilosophy (April 2007), “Killing Embryos for Stem Cell Research,” by Jeff McMahan. He begins by recapitulating McMahan’s argument against the proposition that we are essentially individual human organisms. He then turns to two main critiques of the argument. First, he shows that the term “essentially” is insufficiently defined by McMahan and, more important, if we take the typical explication of the (...) concept by modal metaphysicians, then the claim “we are essentially human beings” is true—contrary to McMahan’s argument. Second, the author offers a counterexample to McMahan’s implicit acceptance of the principle that only beings who have developed the capacity for self-consciousness are the proper subjects of moral worth. The author presents a regenerative therapy example to show that McMahan’s commitment on this point is counterintuitive. National Catholic Bioethics Quarterly 8.2 (Summer 2008): 255–264. (shrink)

This article focuses on unjust credibility deficits in cases of testimony about emotional reactions towards acts of oppression. It argues that the injustice in these cases is not rooted in the hearer’s identity prejudices against the speaker, but the hearer's problematic way of dealing with his simulation of being in the speaker's situation. The simulation is in itself not morally problematic. However, I focus on a case where the hearer either recklessly or negligently fails to consider knowledge about the (...) differences in people’s emotional reactions and comes to believe that his simulated reaction is the only possible reaction, thus believing that the speaker does not report her emotions truthfully.In this case, the ‘epistemic poison’ results from the recklessness or negligence not necessarily from identity prejudice against the speaker. This credibility deficit is unjust, yet its persistent and systematic nature stems from the fact that a hearer who is not from the same marginalized or oppressed group as the speaker will simulate different emotional reactions to those reported by the speaker. Hence, the unjust credibility deficit can be connected to other forms of social injustices suffered by the speaker. (shrink)

A growing interest has been observed among K-12 school educators to incorporate maker pedagogy into science, technology, engineering, and mathematics education to engage students in the design and making process. Both cognitive engagement and emotional engagement of students can be promoted through satisfying the psychological need of relatedness that concerns a sense of connection and belonging. How to support relatedness would influence the effective development of students’ cognitive competencies, namely creativity and critical thinking, and non-cognitive characteristics, namely interest and (...) class='Hi'>identity. Therefore, the present study investigated how two relatedness support strategies—real-world problems and mentoring influence the development of student’s STEM-related cognitive competencies and non-cognitive characteristics in STEM marker activities. We implemented a 7-week intervention study with three classes of Grade 9 students in Hong Kong. Three intervention conditions were designed in the experiment, comprising textbook problem, RWP, and RWP with mentoring. Our analysis showed that the differences in creativity among the three groups were non-significant, the RWP and RWPM groups showed stronger critical thinking than the TBP group, and the RWPM group exhibited stronger STEM interest and identity than the other two groups. This study revealed the effectiveness of adopting RWP strategy in developing secondary students’ perceived cognitive competencies and the feasibility of employing a mentoring mechanism for cultivating learners’ perceived non-cognitive characteristics. Hence, we also offered practical suggestions for teachers. (shrink)

This general discussion asks just what social identity is and to what extent race, gender, and ethnicity contribute to it—the answer being, basically, very little. Social identity is how we are seen and classified by others, involving, in part, classifications that are empirically checkable; but there are also attitudes at work that are not wholly subject to testing. A major concern here is respect for and maintenance of human dignity, which in turn is analyzed into a fundamental “core” (...) notion, and a more “special” notion. It is argued that the core notion stems from general humanity and that respecting it is basic to all good social relations. The “special” notions, on the other hand, are more variable and we need to be careful not to subordinate the core conception to special ones; doing this might have the ill effect, say, of taking it that someone’s right not to be murdered is due to race or gender. (shrink)

This general discussion asks just what social identity is and to what extent race, gender, and ethnicity contribute to it—the answer being, basically, very little. Social identity is how we are seen and classified by others, involving, in part, classifications that are empirically checkable; but there are also attitudes at work that are not wholly subject to testing. A major concern here is respect for and maintenance of human dignity, which in turn is analyzed into a fundamental “core” (...) notion, and a more “special” notion. It is argued that the core notion stems from general humanity and that respecting it is basic to all good social relations. The “special” notions, on the other hand, are more variable and we need to be careful not to subordinate the core conception to special ones; doing this might have the ill effect, say, of taking it that someone’s right not to be murdered is due to race or gender. (shrink)

Are there persuasive approaches to embryonic stem cell (ESC) research that appeal, not just to those fellow-citizens in one’s own ideological camp, nor just to those undecided citizens in the middle, but to those citizens on the other side of the issue? I believe that there are such arguments and in this short paper I try to develop one of them. In particular, I argue that certain beliefs shared by some proponents and some opponents of ESC research—beliefs about the (...) personal identity and moral status of those who are victims of terrible brain diseases—are beliefs that should lead us to adopt a qualified endorsement of ESC research. (shrink)

The phenomenal proliferation of scientific studies into the nature of induced pluripotent stem (iPS) cells following publication of the findings of Takahashi and Yamanaka little more than 2 years ago, have significantly expanded our understanding of cellular mechanisms relating to cell lineage, differentiation, and proliferation. While the full potential of iPS cell lineages for both scientific tool and therapeutic applications is as yet unclear, findings from several lines of investigation suggests that multipotential and terminally differentiated cells from an array (...) of cell types are competent to undergo epigenetic reprogramming to a pluripotential state. The nature of this pluripotential state appears to be similar to, but not identical with that previously described for embryonic stem (ES) cells. Understanding the nature of this induced reprogrammed state will be critical to determining the full potential of iPS cells. Recently, this issue has been examined through an integrated analysis of the genome in fully and partially reprogrammed iPS cell lineages. These results provide a window onto the temporal components of reprogramming and suggest mechanisms by which the efficacy of reprogramming can be enhanced. (shrink)

Women continue to remain underrepresented in STEM, and this gender disparity is particularly pronounced in leadership positions. Through in-depth, qualitative interviews of 39 women leaders in STEM, we identify common gender microaggressions they experience, and explore how these microaggressions affect their leadership experience and outcomes in the workplace. Our findings highlight five types of gender microaggressions women most often encounter, and how and when these microaggressions occur. We explore the negative impact that microaggressions can have on women’s work (...) identities and how they can trigger a cycle of rumination and self-doubt that may ultimately result in women choosing to leave STEM. Importantly, we surface the interventional and empowering role that allies play in triggering a redemptive sensemaking process that can support women leaders to build resilience and counter the negative effects of microaggressions. (shrink)

Physicians frequently encounter situations in which their professional practice is intermingled with moral affordances stemming from other domains of the physician’s lifeworld, such as family and friends, or from general morality pertaining to all humans. This article offers a typology of moral conflicts ‘at the margins of professionalism’ as well as a new theoretical framework for dealing with them. We start out by arguing that established theories of professional ethics do not offer sufficient guidance in situations where professional ethics overlaps (...) with moral duties of other origins. Therefore, we introduce the moral theory developed by Christine M. Korsgaard, that centres around the concept of practical identity. We show how Korsgaard’s account offers a framework for interpreting different types of moral conflicts ‘at the margins of professionalism’ to provide either orientation for solving the conflict or an explanation for the emotional and moral burden involved in moral dilemmas. (shrink)

In this paper I propose a solution to the qualitative version of David Miller's verisimilitude reversal argument. Miller (1974) shows that verisimilitude rankings are relative to language choice and hence, are not objective. My solution stems from a reply to an earlier solution proposed by Eric Barnes (1991). Barnes argues that the verisimilitude reversal problem can be solved by revealing an epistemic dimension. I show that Miller's problem cannot be solved by side-stepping foundational metaphysical claims as his epistemic solution suggests. (...) Rather, a substantive metaphysical basis grounds identity relations among properties. The problem of verisimilitude cannot be solved without embracing the fundamental metaphysical distinctions between basic and composite properties that ground the relationship of partial identity among properties. (shrink)

Abstract:The attractiveness of life writings stems from its promise of exceptional intimacy with a writer. Yet that intimacy can come at a cost, especially in relation to writers from marginalized backgrounds. As many of them have noted, they can feel expected to produce vulnerable versions of themselves on the page for the vicarious satisfaction of white audiences. Such satisfactions can become especially problematic in the classroom when life writing by one author is allowed to stand for the experience of an (...) entire social group. This article details strategies for de-essentializing the use of life writing in the classroom by underscoring the complexities both of race and of the classroom reading experience. (shrink)

I argue that there is a hitherto unrecognized connection between Henry of Ghent’s general theory of real relations and his Trinitarian theology, namely the notion of numerical sameness without identity. A real relation (relatio) is numerically the same thing (res) as its absolute (non-relative) foundation, without being identical to its foundation. This not only holds for creaturely real relations but also for the divine persons’ distinguishing real relations. A divine person who is constituted by a real relation (relatio) and (...) the divine essence is numerically the same thing (res) as the divine essence without being identical to it. Further, I compare Mark Henninger’s and Jos Decorte’s interpretations of Henry’s general theory of real relations and show that Henninger’s is to be preferred and how it is consistent with my interpretation. I argue that the difficulty with Decorte’s interpretation stems, in part, from his misrepresentation of Henry’s Trinitarian theology. Subsequently, I fill in some missing pieces to Decorte’s presentation of Henry’s Trinitarian theology, and this in turn shows why Henninger’s interpretation in conjunction with mine is to be preferred. (shrink)

Much significant work on the topic of privacy and identity on social network sites stems from the realms of media, information and cultural studies, and sociology eschewing language-based disciplines almost entirely. To redress the balance, this article draws on discourse-centred online ethnography, an approach which blends online ethnography with discourse analysis, to explore how self-presentation on Facebook is regulated by means of privacy. To this end, I analyse a dataset of statuses, comments, links, photographs and interviews from five Greek (...) users. The findings highlight users’ creativity and criticality in combining software affordances with linguistic signals and textual practices to manage their privacy and hence their identity. (shrink)

Jean Dominique Bauby, former editor of Elle, suffereda stroke to his brain stem that left him with locked-in syndrome. Subsequently, through blinking his left eye, he writes his memoirof this experience, The Diving Bell and the Butterfly. Thispaper explores the meaning of embodiment, especially as one'sbody bears upon one's personal identity. It explores the variouschallenges and threats to selfhood that result from Bauby'sexperience and recounts how Bauby rises to the challenge throughhis memory and imagination.

In this paper, I examine whether Hume's view on personal identity is skeptical or not. the controversy stems from the question of whether, according to Hume, we can find a condition for a kind of real identity which a changing object satisfies. I argue that Hume holds a skeptical view on personal identity and his skepticism rests on his two principles: 1) all our perceptions are distinct; 2) we never perceive any real connection among objects.