In this paper we show how a student can learn the basics of the system databases using (W3school CSS) which was built as intelligent tutoring educational system by using the authoring tool called (ITSB). The learning material contains CSS and HTML. We divided the material in a group of lessons for novice learner which combines relational system and lessons in the process of learning. The student can learn using example of CSS, and types of CSS color. Furthermore, the intelligent tutoring (...) system supports not only lessons; but exercises of different difficult levels for each lesson. When a student finish successfully the first difficulty level in a lesson, the student is allowed to move to the next difficulty level of the exercises of the lesson. (shrink)

Background Little is known about communication between patients, families, and healthcare providers regarding ethical concerns that patients and families experience in the course of illness and medical care. To address this gap in the literature, we surveyed patients and family members to learn about their ethical concerns and the extent to which they discussed them with their healthcare providers. Methods We surveyed adult, English-speaking patients and family members receiving inpatient care in five hospitals in the Washington DC-Baltimore metropolitan area from (...) July 2017 to March 2020. Descriptive statistics were used to determine the frequency, comfortableness, and helpfulness of discussions regarding ethical concerns experienced when sick or receiving medical care. Univariable and multivariable stepwise logistic regression models were used to identify associations between healthcare provider and respondent characteristics and attitudes and (1) the likelihood of speaking to a healthcare provider about their ethical concern and (2) their level of comfort during these discussions. Results Of 468 respondents who experienced ethical issues, 299 (64%) reported discussing the situation with a member of their healthcare team; 74% (197/265) of respondents who had such a discussion found the discussion comfortable, and 77% (176/230) of respondents found the discussion helpful. To make discussions more comfortable and helpful, respondents proposed suggestions in open-ended responses involving (1) content and quality of communication; (2) positive healthcare provider qualities such as empathy, open-mindedness, knowledge, honesty, and trustworthiness; and (3) other contextual factors including having adequate time and available resources. Conclusions Patients and families often have ethical concerns that they discuss with clinicians, and they want clinicians to be routinely receptive and attentive to such discussions. (shrink)

The traditional philosophical questions around human freedom are to do with how to square freedom for human organisms with increasingly scientific understandings of the universe itself. At the beginning of Western philosophical consciousness, Plato, unlike later philosophers eligible of the label rationalist, maintained that there are obstacles to free and rational agency, owing in no small measure to pressures exerted by the human psyche from what later were referred to as biological drives and drives for social status. In subsequent eras, (...) these obstacles came under the heading of “weakness of will”—a conception shared widely in popular and traditional culture. Today the realities of addiction, social stresses, forces of habit, culture, social position, and group identity, together with psychological findings about cognitive biases, have come to dominate the landscape of empirically-based obstacles to agency. Can the image of the human being under the microscope of contemporary science, including cognitive and social science, be reconciled with the “manifest image” of human beings as sources of their individual behaviors (and held responsible accordingly), particularly if the scientific image is best construed in terms of governance by laws of nature? (The phrases manifest image and scientific image were coined by the twentieth-century American philosopher Wilfrid Sellars, see Sellars 1962.) How is it possible to square the idea of laws of nature with the manifest image in which humans exercise free agency as they play their various parts in the drama that is life? Does the manifest image thus square better with a theistic image of the world, as both seventeenth-century French philosopher René Descartes and eighteenth-century German philosopher Immanuel Kant seem to have thought, and by contrast the scientific image square better with atheism? A deterministic universe, such as was proposed during the Enlightenment, was early on thought to pose a threat to the idea of human freedom. (It does not pose the same threat to the idea of a sovereign creator, however, because the notion of a creator of the universe already puts the entity who qualifies for the office outside the regime of those laws, ahead of them both in time and in ontological status.) One traditional answer to the threat has been the notion of compatibilism— which simply asserts that freedom and determinism are not incompatible. The devil, of course, has been in the details of explaining how this can be so, and many schools of thought on the matter exist. It is worthwhile noting that there are enormously compelling reasons, from the quantum regime so well described by quantum theory, to reject determinism: the laws governing the universe are simply not fully deterministic. This, of course, vitiates the need to confront the threat as originally posed. However, the trouble, if one follows along this line of thought, is to make sense of the nature of freedom in a world governed partly by deterministic laws and partly by nondeterministic ones that admit of an element of chance. Is such a world itself any more compatible with the idea of human freedom? In this section we grapple with the question of human freedom, what it could mean, and whether it is best accepted in the context of a form of theism. We find that theism has no more resources for addressing these difficulties than atheism does. (shrink)

This book explores philosophical ethics in Arabo-Islamic thought.

This book demonstrates how and why vitalism—the idea that life cannot be explained by the principles of mechanism—matters now. Vitalism resists closure and reductionism in the life sciences while simultaneously addressing the object of life itself. The aim of this collection is to consider the questions that vitalism makes it possible to ask: questions about the role and status of life across the sciences, social sciences, and humanities and questions about contingency, indeterminacy, relationality and change. All have special importance now, (...) as the concepts of complexity, artificial life and artificial intelligence, information theory, and cybernetics become increasingly significant in more and more fields of activity. (shrink)

Memorisation of the Qur’ān occupies a central position in Muslim conception of religious education. The awareness of preserving the Qur’ān through memorisation is becoming prevalent and is still continued in these modern days in many educational institutions in many parts of the Muslim countries. This article examines different methods of Qur’ānic memorization being practiced in Malaysia. Similarities and uniqueness of those methods will be presented. The evaluation of those Qur’ānic memorisation techniques brings to the foreground the educative value of memorisation (...) as a learning tool and the implications memorisation methods have in enhancing an individual’s learning performance. (shrink)

The German philosopher, writer, and statesman Wilhelm von Humboldt (1767–1835) has played a key role in the transformation and development of education in Prussia and beyond its borders. If time is change and can be measured as progress towards social transformation, then time serves some concrete utility transposed in the field of education. For the purpose of social transformation and development of education, Humboldt has used various strategies, among which ethics or morals had a certain impact on education. Despite the (...) importance of this aspect, the ethical understanding of the philosopher has not been researched deeply yet. The following paper analyses this question according to Humboldt’s writings and shows its relevance for education. The aim of this research is to reveal insights that have the potential to serve the development of education even now. (shrink)

Social sciences face a well-known problem, which is an instance of a general problem faced as well by psychological and biological sciences: the problem of establishing their legitimate existence alongside physics. This, as will become clear, is a problem in metaphysics. I will show how a new account of structural explanations, put forward by Frank Jackson and Philip Pettit, which is designed to solve this metaphysical problem with social sciences in mind, fails to treat the problem in any importantly new (...) way. Then I will propose a more modest approach, and show how it does not deserve the criticism directed at a prototype by Jackson and Pettit. (shrink)

It is often said in physics that if two models of a theory are related by a symmetry, then the two models provide (or could provide) two different representations of the very same situation, alike the case of two maps of different color for the very same city. It is also said that the situations represented by two models of a theory are indiscernible in some ways when the models in question are related by a symmetry of the theory, just (...) like the situation in the interior of the cabin of a train when the train is at rest in the station is empirically indiscernible from the situation in the interior when the train is moving uniformly (in classical mechanics, these two situations are represented by two models related by a boost). In recent years, philosophers of physics have focused a lot of attention in developing various principles that aim to elucidate these and similar remarks on symmetries, models, physical equivalence, and representation that are widespread in physics practice. The goal of the current article is to provide a critical review of these principles, and suggest a new framework for thinking about these kinds of questions. One important upshot of the paper is that questions of indiscernibility, and questions of the representational capacity of models, must be distinguished from one another. (shrink)

Imagine that we are on a train playing with some mechanical systems. Why can’t we detect any differences in their behavior when the train is parked versus when it is moving uniformly? The standard answer is that boosts are symmetries of Newtonian systems. In this paper, I use the case of a spring to argue that this answer is problematic because symmetries are neither sufficient nor necessary for preserving its behavior. I also develop a new answer according to which boosts (...) preserve the relational properties on which the behavior of a system depends, even when they are not symmetries. (shrink)

Cet article esquisse les angles morts d’une histoire, celle de la qualification du savoir au xix e siècle, à partir de l’apparition conjointe du néologisme épistémologie et du syntagme philosophie des sciences. Au-delà des déterminations linguistiques et institutionnelles, il s’efforce de cerner la logique de leur assise commune, en un siècle qui consolida à la fois le rôle central de l’histoire et celui de la recherche d’un statut propre à la pensée. Ainsi, il espère suppléer aux confusions dues à l’impact (...) de la circulation des idées (traductions, traditions et réceptions) et souhaite exposer le lieu d’une profusion conceptuelle, en s’attachant à rendre compte de l’unité d’habitudes générées par l’héritage d’une époque. (shrink)

The radical probabilist counsels the prudent never to put away uncertainty, and hence always to balance judgment with probabilities of various sizes. Against this counsel I shall advise in favor of the practice of full belief — at least for some occasions. This advice rests on the fact that it is sometimes in a person's interests to accept certain propositions as a means of bringing it about that others recognize oneself as having accepted those propositions. With the pragmatists, therefore, I (...) shall reject the view that belief formation must in every instance be a truth-directed affair. Unlike the pragmatists, however, I shall conclude that the enterprise of belief formation is not directed exclusively, or even primarily, at attaining knowledge. In other words, pursuit of that which it profits to believe, on the one hand, and pursuit of knowledge on the other, are distinct enterprises, which overlap (when they do) only accidentally. (shrink)

İşbu makale Ebü’l-Berekât el-Bağdâdî’nin (ö. 560/ 1164-65’ten önce) ilâhî önbilgi ve insanın özgür iradesi sorununa dair konumunu tetkik etme amacındadır. Metin, Ebü’l-Berekât’ın ilâhî önbilgi ve insanın özgür iradesinin bağdaşması argümanın geçerli olmadığını düşündüğünü iddia ediyor. Bir kişi ya ilâhî önbilgiyi ya da insanın özgür iradesini savunabilir, başka bir çözüm yoktur. Kitâbu’l-Mu‘teber fi’l-hikme adlı kitabının mantık ve metafizik bölümleri içerisindeki bu meseleye dair açıklamalarını inceleyerek, Ebü’l- Berekât’ın ikinci alternatifi seçtiği belirgin kılınacaktır.

Consensus in the contemporary philosophical literature has it that conserved quantity theories of causation such as that of Dowe [2000]—according to which causation is to be analysed in terms of the exchange of conserved quantities (e.g., energy)—face damning problems when confronted with contemporary physics, where the notion of conservation becomes delicate. In particular, in general relativity it is often claimed that there simply are no conservation laws for (say) total-stress energy. If this claim is correct, it is difficult to see (...) how conserved quantity theories of causation could survive. In this article, we resist the above consensus and defend conserved quantity theories from this conclusion, at least when focusing on the apparent problems posed by general relativity. We argue that this approach to causation can continue to be defended in general relativity, once one appreciates (a) the availability of approximate symmetries in generic general relativistic spacetimes, and (b) the role of modelling and idealisation in that theory. Given these points, conserved quantity theories of causation must stand or fall on other grounds. (shrink)

In this text, I consider two examples in the history of emancipation and manumission of enslaved, Black populations in the Caribbean and South America in order to theorize a colonial mode of conceiving of freedom at play in the first half of the nineteenth century. This mode is marked by the figure of the promise, enacting a notion of freedom as a constantly deferred, external compensation. Indeed, instead of an immediate decision deeming the practice of enslavement and trade of human (...) beings unacceptable, and an effective liberation of the enslaved Black populations in these different emancipation proclamations, the various histories of manumission in Latin America and the Caribbean show a long series of political and legal attempts to reduce and limit the extent of the slave trade that deferred the process of liberation for decades. Moreover, in many of these territories the practice did not end with the official proclamation of emancipation but was continued by illegal practices and mutations into legal forms of exploitation and oppression that are still operative today. After outlining this first trajectory, reconstructing the promise of manumission in the historical examples of Martinique (as read by Édouard Glissant) and La Gran Colombia and the Republic of Nueva Granada (contemporary Panamá, Colombia, Venezuela, and Ecuador), I analyze a second mode of investigation in examples of individual and collective strategies of liberation coming from the enslaved themselves, as reconstructed by contemporary feminist scholars in South America. These strategies appropriate liberation not as a promise, but as a negotiation and calculation that begins with the enslaved’s resistance to their oppressive conditions and that ultimately depends on the external concession by juridical authorities. In the third section of the chapter, I read these practices not as marronage, as they are sometimes approached, but as a different mode of turning back to these glimpses of freedom that more effectively challenge the narrative of emancipation and, with it, the promise of manumission in our present. -/- . (shrink)

The recently reported cases of coerced sterilisation of women at a privately operated immigration detention facility in the USA are egregious in their disregard for human dignity and professional ethics, but sadly not surprising. These abuses represent a continuation of efforts to control the reproductive capacity of women, fueled by racist and xenophobic motives. Physicians helped create and legitimise the pseudoscientific framework for the eugenics movement, which would implement forceful sterilisation as its tool of choice to eliminate undesirable traits that (...) were thought to be biologically inherited and predominant among racial and ethnic minorities. Although state-endorsed forcible sterilisation programs have ended, incarcerated women have remained particularly vulnerable to sterilisation abuse. The intersectional vulnerabilities of racism, xenophobia and carcerality must be addressed to prevent such abuses from recurring. There are no data in this work. (shrink)

The present paper aims to explore the medieval philosopher Abū al-Barakāt al-Baghdādī’s (d. pre- 560 AH/1164-5) position concerning the problem of divine foreknowledge and human free will and argues Abū al-Barakāt to have considered the argument for compatibility between divine foreknowledge and human free will to be invalid. One can defend either divine foreknowledge or human free will; no other solution is available. By examining his accounts on this issue through the logic and metaphysics of his book al-Muʿtabar fi-l-ḥikma, Abū (...) al-Barakāt defense of human free will shall become evident. (shrink)

Using C. Wright Mills' book The Sociological Imagination as a touchstone for its discussion, this article addresses the relations between the sociological problem, relevance and experience as they are and could potentially be understood within sociology. Beginning with the historical relation between sociology, science and literature — a relation which has been productively but differently complicated by poststructuralist and postconstructivist theories — this article asks: to what extent does the empirical offer a referent for the sociological problem? To what is (...) sociology obliged to be relevant? Arguing for the continued relevance of relevance, particularly in the light of recent reforms in higher education in the UK and the USA, the article explores how the sociological problem might be transformed — and perhaps, more importantly, might be transformative — if the basic commitments of a research project were not to historical social structures but to virtual structures. (shrink)

Recent scholarship has emphasized the contributions of the great Maliki jurist Shihāb al-Dīn al-Qarāfī to Islamic legal thought. However, al-Qarāfī’s compilation of legal maxims and distinctions, al-Furūq, has not yet been studied, nor has the collection of his teacher, the prominent Shafiʿi jurist Ibn ʿAbd al-Salām, known as al-Qawāʿid al-kubrā. Furthermore, the original thought of Ibn ʿAbd al-Salām and his formative influence on al-Qarāfī have been understated. This article compares their two works to demonstrate that al-Qarāfī based his collection in (...) large part on Ibn ʿAbd al-Salām’s al-Qawāʿid and it examines the techniques that al-Qarāfī used, which included reordering, refining, and supplementing borrowed maxims, and anonymizing references to his teacher. Most salient, however, is al-Qarāfī’s “Malikization” of maxims, which entailed replacing Shafiʿi doctrines and authorities with their Maliki counterparts and deploying maxims to defend Maliki doctrines. The article concludes by explaining al-Qarāfī’s authorial choices in light of his Maliki affiliation and the politics between the legal schools in Mamluk Cairo. (shrink)

I shall introduce the units of decision problem in the theory of decision, which as I shall explain is a sibling to the units of selection problem in evolutionary theory. And I shall present an argument to the effect that, contrary to Bayesian wisdom on the subject, undertaking decision in group settings violates no precepts of rationality.

This article addresses the relations between ‘nature’ and ‘culture’ (and those characteristics associated with ‘the natural’ and ‘the cultural’) in the context of the debates about Prozac. Following Marilyn Strathern, I focus specifically on the contested issue of enablement - that is, on what Prozac does or does not enable, and on the relation between enablement and enhancement, normality and pathology. I argue that the implications of the model of the brain that accompanies explanations of Prozac are such that commentators (...) are obliged to address not only the nature of normality but also the nature of nature itself. Through a close analysis of these debates, I suggest that critiques of Prozac should be understood not as objections to reductionism - to a biology that closes things down - but rather to one that opens things up: that opens up the relations between nature, culture, biology and the individual, relations that are now cross-cut and thrown about by artificiality. Objections to Prozac, then, might be characterized as an attempt to put these concepts back into their ‘proper’ positions, to re-establish the relationality between them. In conclusion, I argue that the biology put forward by proponents of psychopharmacology, regardless of the desirability of the latter, challenges not only the frequent assumptions that are made about the claims of materialist science, but also some of the terms and concepts that are commonly deployed in the social sciences. (shrink)

In the context of the question of the extent to which science studies is able to mount an adequate critique of contemporary developments in science and technology, and in view of the proliferating interest in ethics across the social sciences, this article has two aims. Firstly to address some of the implications for ethics of Bruno Latour's, and to a lesser extent Alfred North Whitehead’s, conceptions of reality, both of which have a bearing on the long-standing dichotomy between facts and (...) values. Drawing on Whitehead's work, it also, secondly, seeks to make a positive argument for ethics and to ask again, in the light of this discussion, where the ethical dimensions of Latour's work might be located. Towards the end of the article, I suggest that Latour's concept of exteriority obliges him to pursue a politics of reality which is the special providence of ‘moralists’, rather than a politics of virtual reality in which all entities, human and non-human, are engaged. (shrink)

The recent debate about whether gauge symmetries can be empirically significant has focused on the possibility of 'Galileo's ship' types of scenarios, where the symmetries effect relational differences between a subsystem and the environment. However, it has gone largely unremarked that apart from such Galileo's ship scenarios, Greaves and Wallace (2014) proposed that gauge transformations can also be empirically significant in a 'non-relational' manner that is analogous to a Faraday-cage scenario, where the subsystem symmetry is related to a change in (...) a charged boundary state. In this paper, we investigate the question of whether such non-relational scenarios are possible for gauge theories. Remarkably, the answer to this question turns out to be closely related to a foundational puzzle that has driven a host of recent developments at the frontiers of theoretical physics. By drawing on these recent developments, we show that a very natural way of elaborating on Greaves and Wallace's claim of non-relational empirical significance for gauge symmetry is incoherent. However, we also argue that much of what they suggest is correct in spirit: one can indeed construct non-relational models of the kind they sketch, albeit ones where the empirical significance is not witnessed by a gauge symmetry but instead by a superficially similar boundary symmetry. Furthermore, the latter casts doubt on whether one really abandons Galileo's ship in such scenarios. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Knock at the Door: Utopian Dreams for Post-Covid TimesPedro Mora-Ramírez, María Amo-Hernández, and Paula García-RodríguezAnswering the Knock at the Door, Welcoming Utopian Futures, The Knock at the Door: Utopian Dreams for Post-Covid Times, May 21–24, 2023, University of Huelva, Spain, and University of Calgary, CanadaThe COVID-19 pandemic has fostered new adversities and vulnerabilities, prompting reflection on the economic, social, and political paradigms that endanger human and nonhuman (...) lives. For many, it was anxiety and uncertainty that “knock[ed] at the door”; for others, however, those same feelings of unease prompted one of hopefulness: reflecting on the possibilities for resilience and regeneration in the process of changing our vision of the world.1 The Knock at the Door conference brought contemporary utopianism to the forefront of thinking about how to respond to global crises while remaining attentive to other adversities of daily life. Scholars and artists answered the knock in an attempt to examine paths toward utopia, and to take advantage of the regenerative and resilient potential of the present.The conference was the culmination of author/activist Larissa Lai’s fellowship period at the University of Huelva. The 2022–23 María Zambrano Fellowship for the academic year2 allowed Lai to complete the project “Utopian Dreams for Post-Covid Times,” carried out in collaboration with the Huelva research group led by Professor Pilar Cuder-Domínguez, who hosted a number of online and in-person seminars on speculative fiction with Lai. The Knock at the Door conference, marking the end of Lai’s fellowship, created yet another space for scholars, artists, and critics to discuss the potential of utopian narratives. Lai asks: “What does our cultural moment require, and how can we get where we need to go from where we are? How can literature, especially speculative fiction literature, help us get from here to there?”3 [End Page 641] The intention of the conference was to encourage others to continue Lai’s work on how to imagine futures where human and posthuman beings need to remain vigilant to adversities. Utopian scholars, among others, might find the complications of “getting there from here” closely related to Lai’s conception of “insurgent utopias,” or “emergent insurgency.” They could find Lai’s concept of “insurgent utopianism” interesting as it lays the foundations of futurity in terms of crisis responses.The aim of the conference was to explore the imagination of better futures through utopian thinking and practice. In addition, it focused on “the knock at the door,” which is “a moment of contingent arrival... open to cooptation, destruction, bastardization, incorporation, death, or defusal.” Yet, it presents “the powerful possibility of critique—narratively or discursively, in its very materiality.”4 One way of doing this might be to look back at the past century of utopianism and ask who or what has been missing. The conference took up Lai’s idea of insurgent utopianism as a method of paving a path toward a multitude of dreams and actions, all shaped by the unique circumstances of one’s positionality.After the COVID-19 pandemic, the need for utopian thinking has become more pressing than ever. New horizons of hope must be created in the face of emerging anxieties. In a world where anthropocentrism is showing signs of its deadly potential, conference participants reflected on the relevance of the utopian imagination to political resistance and resilience building.Utopian Visions: Contesting Better Worlds in Neoliberal and Feminist UtopiasThe first two panels of the conference addressed the critique of two dominant theoretical (and interrelated) frameworks: capitalism and neoliberalism. Speakers reflected on both in light of theoretical interventions by theorists Rosi Braidotti and Francesca Ferrando. Panelists Benjamin Ghan and Marc Lynch reflected on how creative writers envision ideal worlds and temporalities. In Ghan’s view, utopian narratives create a symphony of voices historically excluded from the category of “the human”: women; LGBTQ+ people; Indigenous peoples. In a similar vein, Lynch described his own novel, A Wasp’s Waist, as highlighting the impossibility of imagining utopias within the capitalist paradigm—and thus the necessity of imagining futures beyond capitalism, and beyond... (shrink)

Resumen: La influencia de Schopenhauer en la filosofía de la ciencia del siglo XX ha sido poco estudiada. En este artículo defiendo que la teoría del conocimiento de Schopenhauer impulsó históricamente la idea de que al menos un objetivo de la investigación científica estriba en la exploración tenaz y creativa del potencial heurístico de un sistema teórico, de una matriz disciplinar o de un programa de investigación científica. Sostengo que en ella también se origina una ambigüedad en el significado de (...) los conceptos de descubrimiento objetivo e innovación epistémica.: Little research has been done on Schopenhauer’s influence on twentieth-century philosophy of science. This article defends the thesis that Schopenhauer’s epistemology historically promoted the idea that at least one of the objectives of epistemic research is the tenacious and creative exploration of heuristic potential of a theoretical system, a disciplinary matrix and a scientific research program. I further state that his theory of science leads to ambiguity about the meaning of concepts such as objective discovery and epistemic innovation. (shrink)

La tesis principal que aquí se defiende es que, para Popper, la validez del conocimiento estuvo vinculada siempre a la dimensión pragmática del contexto de descubrimiento (e incluso dependía de ella). Constituye, pues, un error afirmar que, para él, 1) dicha validez estaba ligada a un "empirismo encubierto" (opuesto a la tesis sobre la carga teórica de toda observación), según lo ha planteado Ana Rosa Pérez Ransanz, y que 2) en sus ideas, los factores pragmáticos carecían de importancia epistemológica, como (...) lo ha afirmado Ambrosio Velasco. Para justificar esta tesis, se examinan tres argumentos expuestos en The Logic of Scientific Discovery, enfatizando el que se refiere al carácter disposicional de los términos con los que, para Popper, se formulan los enunciados descriptivos. The main thesis I assert here is that for Popper validity of knowledge was always linked to (and even supported by) the pragmatic dimension of the context of discovery. I hold it's wrong to claim that for this author 1) validity of knowledge was linked to a "hidden empiricism" (opposed to the theory-laden character of observation), such as Ana Rosa Pérez Ransanz had propounded, and 2) pragmatic issues were epistemologically irrelevant in his philosophy, such as Ambrosio Velasco has argued. To justify my thesis I examine three arguments exposed in The Logic of Scientific Discovery, emphasizing especially Popper's argument about the dispositional character of the concepts in which descriptive statements are formulated. (shrink)

Ghosn, Mariam Predictive genetic testing Part 2 will examine the issues and ethical aspects that must be considered when adolescents below the age of majority make a request to undergo predictive genetic testing for Huntington's disease.

Ghosn, Mariam Huntington's disease (HD) is an inherited disorder. Sufferers usually develop symptoms in midlife between the ages of 30 and 50 years. HD causes neurodegeneration resulting in the progressive development of physical, cognitive and emotional symptoms. The impact on sufferers worsens over time with the final stage of the disease resulting in the need for professional assistance in a long-term care facility. More rarely HD develops in children and young adults, with less than 5% of HD sufferers being affected (...) by Juvenile HD. This article considers the ethical aspects of such testing. (shrink)

Ghosn, Mariam The causes of obesity are complex. Both our attitudes and lifestyles will need to change in order to successfully address this issue.

Ghosn, Mariam; Ford, Norman The adult stem cells are capable of self-renewal and are responsible for replenishing cells throughout an individual's lifetime, residing not only at embryonic stage but also in children and adults. The latest advancements and updates in adult stem cell technology demonstrate that it might be possible to generate stem cells for therapeutic uses without the creation or destruction of human embryos.

Ghosn, Mariam A seven-year $1 million dollar study conducted by Dr. M. Soffritti found that significant trend of increasing lymphoma and leukaemia incidence in female rats fed aspartame with a significant increase in the number of female rats affected at dosages of 20 mg/kg per day and upward, thus questioning aspartame's safety. However, the European Food Safety Authority's (EFSA's) Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) argued that there was not enough evidence (...) to conclude that aspartame causes an increased incidence of lymphomas and leukaemias, also arguing that the increase in the number of rats affected with lymphomas and leukaemias could be due to chronic respiratory infections of the rats used in the study. (shrink)

This article considers the grounds on which distinctions are drawn between the identities of gender, sexuality, `race' and class and explores the implications of these distinctions in relation to different kinds of identity politics and, in particular, to the politics implied by Judith Butler's theory of performativity. I argue that what is often taken to be the key site of much queer theory and activism - that is, the reappropriation of signifiers of difference - is problematic in the light of (...) a close analysis of subjectivities which are informed by `race', gender and class. More specifically, it may be that struggles which are frequently linked to issues of visibility are problematic in the context of subjectivities - class subjectivities - that are both enabled and constrained by a particular, and a particularly uneasy, relation to recognition and representation. (shrink)

Este trabajo esboza una forma de justificar el principio estructurador central de una teoría veritista de la evaluación epistémica, en respuesta a críticas planteadas por Eleonora Cresto a mi defensa del veritismo frente a una serie de objeciones en el sentido de que no es capaz de explicar la naturaleza y el valor del entendimiento. La primera sección presenta el esbozo de justificación del núcleo de una teoría veritista; la segunda responde a críticas más específicas de Cresto. This paper sketches (...) a way to justify the central tenet of a veritistic theory of epistemic evaluation, in response to problems raised by Eleonora Cresto concerning my defense of veritism, against a series of objetions to the effect that veritistic epistemology is uncapable of explaining the nature and value of understanding. The first section presents the sketch of justification of the nucleus of a veritistic theory, the second responds to some of Cresto's more specific criticisms. (shrink)

La ciencia se sustenta en la veracidad de los datos de investigación, y por ende, en la confianza sobre la integridad moral y profesional de los investigadores. Sin embargo, diversos factores ocasionan que la conducta inapropiada en la investigación sea un problema vigente. Revisamos los problemas éticos en el ensayo _Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization_ (EXCEL), que comparó el intervencionismo coronario percutáneo frente a la cirugía de revascularización en la enfermedad del (...) tronco coronario izquierdo con un SYNTAX score ≤32. Preocupaciones sobre la metodología, actividades asociadas a la veracidad de los datos, y conducta inapropiada durante la investigación son advertidas en este estudio de caso. Se concluye sobre la necesidad de revisar y reconsiderar la vigencia e importancia de los aspectos bioéticos en la investigación clínica, aspectos que no pueden soslayarse. (shrink)

In this paper, I accomplish a conceptual task and a historical task. The conceptual task is to argue that (1) Einstein’s Principle of Separability (henceforth “separability”) is not a supervenience principle and that (2) separability and entanglement are compatible. I support (1) by showing that the conclusion of Einstein’s incompleteness argument would still follow even if one assumes that the state of a composite system does not supervene on the states of the subsystems, and by showing that what Einstein says (...) in “Quantum Mechanics and Reality” (1948) strongly suggests that separability is not a principle about how subsystem states relate to the state of composite systems. I support (2) by showing that if separability was incompatible with entanglement, then Einstein’s argument would be incoherent in a trivial way. Thus, by arguing for (1) and (2) I directly challenge what has been, and still is, a very common reading of separability. The historical task is to offer the first detailed review of the different ways in which separability has been defined by physicists and philosophers in the last 60 years. Among other things, such a review distinguishes three different definitions of the principle, and shows that since the 1990s and up until the present date, it became standard to take separability (as presented by Einstein) to be a supervenience principle. (shrink)

This article aims to show that fundamentality is construed differently in the two most prominent strategies of analysis we find in physical science and engineering today: (1) atomistic, reductive analysis and (2) Systems analysis. Correspondingly, atomism is the conception according to which the simplest (smallest) indivisible entity of a certain kind is most fundamental; while systemism, as will be articulated here, is the conception according to which the bonds that structure wholes are most fundamental, and scale and/or constituting entities are (...) of no significance whatsoever for fundamentality. Accordingly, atomists maintain that the basic entities—the atoms—are fundamental, and together with the “external” interactions among them, are sufficient for illuminating all the features and behaviors of the wholes they constitute; whereas systemists proclaim that it is instead structural qualities of systems, that flow from internal relations among their constituents and translate directly into behaviors, that are fundamental, and by themselves largely (if not entirely) sufficient for illuminating the features and behaviors of the wholes thereby structured. Systemism, as will be argued, is consistent with the nonexistence of a fundamental “level” of nondecomposable entities, just as it is consistent with the existence of such a level. Still, systemism is a conception of the fundamental in quite different, but still ontological terms. Systemism can serve the special sciences—the social sciences especially—better than the conception of fundamentality in terms of atoms. Systemism is, in fact, a conception of fundamentality that has rather different uses—and importantly, different resonances. This conception of fundamentality makes contact with questions pertaining to natural kinds and their situation in the metaphysics of the special sciences—their situation within an order of autonomous sciences. The controversy over fundamentality is evident in the social sciences too, albeit somewhat imperfectly, in the terms of debate between methodological individualists and functionalists/holists. This article will thus clarify the difference between systemism and holism. (shrink)

This article addresses the serotonin hypothesis of depression, as it was formulated in clinical and laboratory experiments during the 1950s. In the first instance I argue that the `challenge' posed by patients' subjectivities in clinical investigations into the potentially anti-depressant drug iproniazid was not solely due to the tensions generated by the subject/object dichotomy, but to an excess that exceeds the properties of the objects of the experiment, as well as its requirements and conditions. I then suggest that the serotonin (...) hypothesis too is possessed of an excess, and that this can be understood in terms of a real (actual and virtual) existence in duration. By exploiting the notions of the event and of duration, I offer an under-standing of the hypothesis that pertains not to reduction, reproducibility and sameness, but to differentiation, innovation and creation. (shrink)

Este artículo trata el problema de los objetos creados que pueden ser repetidos, como las obras musicales y las literarias. En la sección 2 presentamos una serie de desiderata intuitivos que toda teoría debe satisfacer. En las secciones 3 y 4 presentamos un silogismo disyuntivo extendido. Los objetos en cuestión pueden ser o bien universales concretos, particulares concretos, universales abstractos o particulares abstractos. Mostramos cómo es que las teorías que consideran que son cualquiera de las tres últimas opciones fracasan. Por (...) lo tanto, debemos entender a dichos objetos como universales concretos. En la sección 5 ofrecemos una teoría breve pero detallada de la naturaleza metafísica de los universales concretos para después mostrar cómo esta propuesta permite dar cuenta de los desiderata intuitivos a la vez que se evitan las objeciones presentadas en contra de teorías alternativas. (shrink)