A general framework by which dynamic interactions within a protein will promote the necessary series of structural changes, or “conformational cycle,” required for function is proposed. It is suggested that the free‐energy landscape of a protein is biased toward this conformational cycle. Fluctuations into higher energy, although thermally accessible, conformations drive the conformational cycle forward. The amino acid interaction network is defined as those intraprotein interactions that contribute most to the free‐energy landscape. Some network connections are consistent in every structural (...) state, while others periodically change their interaction strength according to the conformational cycle. It is reviewed here that structural transitions change these periodic network connections, which then predisposes the protein toward the next set of network changes, and hence the next structural change. These concepts are illustrated by recent work on tryptophan synthase. Disruption of these dynamic connections may lead to aberrant protein function and disease states. (shrink)

A critical account of the case for historicism from Popper to Foucault, this volume, originally published in 1989, shows the viability of an historicist account of knowledge by replying to traditional objections and the need for defenses of realism and reference at the heart of most alternatives to historicism. The book provides insights to those in philosophy as well as literary criticism, intellectual history, history of science, and cultural criticism.

My review of Cornelius Castoriadis' book Crossroads in the Labyrinth ended with the apt reference, I now see, to the emperor being naked. In Joel Whitebook's second review, largely irrelevant to my criticisms of Castoriadis, he fears, though he doesn't know me personally, that only the lack of psychological counseling can explain my uncontrolled anger against Castoriadis. Let me dignify his long distance psychoanalysis by passing over it in silence. Silence is also the best remedy for Whitebook's transcendental deduction that (...) I have a “pluralistic, localistic, discontinuous ontology.” Even if I knew what that was I find it amazing that he located it in a 10 page review. Perhaps Whitebook just “feels” the presence of this ontology along with evidence of my mental problems. (shrink)

, Lawrie Reznek argues that disease is not a natural kind term. I raise objections to Reznek's two central arguments for establishing that disease is not a natural kind. In criticizing his a priori, conceptual argument against naturalism, I argue that his conclusion rests on a weaker argument that appeals to the empirical diversity in the symptoms and manifestations of disease. I also raise questions about the account of natural kinds which Reznek utilizes and his point that conventions for classification (...) are excluded by there being natural kinds. Keywords: Disease, natural kind, value judgement CiteULike Connotea Del.icio.us What's this? (shrink)

Contemporary Continental Philosophy steps back from current debates comparing Continental and analytic philosophy and carefully, yet critically outlines the tradition’s main philosophical views on epistemology and ontology. Forgoing obscure paraphrases, D’Amico provides a detailed, clear account and assessment of the tradition from its founding by Husserl and Heidegger to its challenge by Derrida and Foucault. Though intended as a survey of this tradition throughout the twentieth century, this study’s focus is on the philosophical problems which gave it birth and even (...) now continue to shape it.The book reexamines Husserl as an early critic of epistemological naturalism whose grasp of the philosophical importance of the theory of meaning was largely ignored. Heidegger’s contrasting effort to revive ontology is examined in terms of his distinction between ontic and ontological questions. In contrast with many earlier studies, the author outlines confusions engendered by the misappropriation of the distinct philosophical agendas of Husserl and Heidegger by such famous figures as Sartre and Merleau-Ponty. The book is also original in its emphasis on how social externalism in epistemology, inspired by Karl Mannheim, influenced this tradition’s structuralist and Marxist phases. The philosophical defenses of a theory of interpretation by Gadamer and Habermas are closely examined and assessed and the study concludes with a a probing yet balanced account of Foucault and Derrida as critics of philosophical autonomy. The book concludes by reassessing this century-long divide between the analytic and Continental traditions and its implication for the future of philosophy. (shrink)

This writer who has warned us of the “ideological” function of both the oeuvre and the author as unquestioned forms of discursive organization has gone quite far in constituting for both these “fictitious unities” the name (with all the problems of such a designation) Michel Foucault. One text under review, La Volonté de Savoir, is the methodological introduction of a projected five-volume history of sexuality. It will apparently circle back over that material which seems to have a special fascination for (...) Foucault: the gradual emergence of medicine as an institution, the birth of political economy, demography and linguistics as “human sciences,” the invention of incarceration and confinement for the control of the “other” in society (the mad, the libertine, the criminal) and that special violence that lurks beneath the power to control discourse. (shrink)

What roles do women play in world politics? Who are these women, and what impact do they have on international relations? D'Amico and Beckman have assembled a diverse array of contributors who provide a variety of answers. Some contributors consider women as national leaders and profile Chamorro, Gandhi, Thatcher, and Aquino as examples. Autobiographical essays and interviews describe the experiences of Margaret Anstee, Benazir Bhutto, Jeane Kirkpatrick, and Golda Meir. Other contributors analyze international women's movements, the roles of women (...) in the Green Movement and in the revolutionary movements in Cuba and Nicaragua, and the work of Jane Addams in the peace movement. Some analyze the attitudes and beliefs of America's leading opinion makers on the subject of women and men in leadership roles. Written for beginning students in comparative politics and international relations, their work is both fundamental as an introductory text and pioneering in scope and conception. (shrink)

Este artículo analiza el contexto en el que surge la Universidad en el occidente latino medieval y en ese marco la teorización y profesionalización de la filosofía. Por otra parte, expone de qué manera esta profesionalización impone su propia negación como la filosofía en lengua vulgar y los saberes no universitarios. Finalmente, reflexiona sobre la Universidad hoy.

Title: The Common Mind: An Essay on Psychology, Society, and PoliticsPublisher: Oxford University PressISBN: 0195106458Author: Philip PettitTitle: Republicanism: A Theory of Freedom and GovernmentPublisher: Oxford University PressISBN: 0198296428Author: Philip Pettit.

The article analizes the several times of Proclus‘s reception by Nicholas of Cusa’s thought. The direct reading of Proclus can be established because Expositio in Parmenidem Platonis –Cod.Cus. 186– and Elementatio theological –Cod.Cus.195– (Moerbeke’s translation) and De theologia Platonis Libri VI –Cod.Cus.185– (Petrus Balbus’s translation) are in his Library in Bernkastel-Kues with his marginalia. The assimilation of doctrines can be considered assuming that the implicits and explicits references to Plato’s Diadochus, especially in the last works.

Title: Discipline and PunishPublisher: Pantheon booksISBN: 978-0394499420Author: Michel FoucaultTitle: Language, Counter-Memory, PracticePublisher: Wiley-BlackwellISBN: 978-0631182405Author: Michel FoucaultTitle: La Volonte de SavoirPublisher: GallimardAuthor: Michel FoucaultTitle: Oublier FoucaultPublisher: Editions GalileeISBN: 978-2718600604Author: Jean Baudrillard.

This article concerns the metaphysics of disease. Is disease a fixed feature of the world or a social value or preference? I argue that disease is not a value-laden concept and thus debates concerning it differ fundamentally from debates concerning health, harm, or suffering where evaluative judgements are central. I show how the so-called social constructionist view of disease has been motivated both by ethical concerns with medical practices and general theoretical doubts about scientific naturalism. If I can show that (...) ethical concerns about medical treatment can be answered without adopting social constructionism, that leaves only the broader theoretical question of naturalism. I cannot completely answer those theoretical doubts, but I show that the theoretical motivation is less convincing when it is separated from the moral challenge often accompanying it. I conclude that a convincing defense of the non-naturalistic conception of disease is rarely attempted and proves more difficult and counter-intuitive than its proponents assume. (shrink)

This volume contains an essay by Martha Nussbaum in defense of world citizenship or “cosmopolitanism,” as opposed to patriotism, which she defines as any view treating “national boundaries as morally salient,” together with a series of brief supportive (Anthony Appiah and Amartya Sen) and critical (Benjamin Barber, Gertrude Himmelfarb, Hilary Putnam, Immanuel Wallerstein, and Michael Walzer, et al.) comments. The essay originally appeared in The Boston Review in 1994 and led to bringing together the “usual suspects” for a bit of (...) popular edification and policy-making. Such posturing by what passes today for public intellectuals is rarely successful and not always…. (shrink)

Written as an introductory textbook for the study of world politics and the analysis of gender, this work is suitable for courses in International Relations, ...