The Laboratory for Research on the Structure of Matter, University of Pennsylvania, was built in 1965 as part of the Advanced Research Projects Agency's Interdisciplinary Laboratories program intended to foster interdisciplinary research and training in materials science. The process that led to the construction of the four-story structure served as the focus of intense debates over the meaning and process of interdisciplinary research in universities. The location of the building, its size, internal design, and functionalities were all subject to (...) heated negotiations among patrons, scientists, and university administrators, to find the proper place of interdisciplinary materials science on the University of Pennsylvania's campus. Building on the recent work on laboratory architecture, this paper argues that the negotiations and controversies over the LRSM building were concrete representations of the broader struggle over the appropriate place of interdisciplinary research and training within a university. (shrink)

ArgumentThis article adopts a historical perspective to examine the development of Laboratory Animal Science and Medicine, an auxiliary field which formed to facilitate the work of the biomedical sciences by systematically improving laboratory animal production, provision, and maintenance in the post Second World War period. We investigate how Laboratory Animal Science and Medicine co-developed at the local level (responding to national needs and concerns) yet was simultaneously transnational in orientation (responding to the scientific need that knowledge, practices, (...) objects and animals circulate freely). Adapting the work of Tsing (2004), we argue that national differences provided the creative “friction” that helped drive the formation of Laboratory Animal Science and Medicine as a transnational endeavor. Our analysis engages with the themes of this special issue by focusing on the development of Laboratory Animal Science and Medicine in Norway, which both informed wider transnational developments and was formed by them. We show that Laboratory Animal Science and Medicine can only be properly understood from a spatial perspective; whilst it developed and was structured through national “centers,” its orientation was transnational necessitating international networks through which knowledge, practice, technologies, and animals circulated. (shrink)

This paper examines two moments in the globalization of human genetics, focusing on the American University of Beirut as a site of interaction between American, European and Middle Eastern scientific actors and research subjects. In the interwar period, the establishment of clinical laboratories at AUB's medical school enabled the development of an informal large-scale programme to study human heredity through anthropometry and sero-anthropology. AUB's Middle Eastern students were trained in these techniques, and research results were disseminated locally in Arabic as (...) well as in international scientific journals. In the post-war period, new technologies transformed human genetics into an internationally coordinated science with specialized laboratories. However, an attempt to establish such a lab at AUB during the 1960s ended in failure: the Anthropological Blood Grouping Laboratory functioned for only four years before closing. The American and British personalities who promoted the ABGL in Lebanon aimed to collect blood samples from across the region without committing to long-term relationships with local scientists and research subjects. As an ‘outpost’ for Western scientists, the ABGL embodied the neo-colonial structure of post-war human population genetics, both in its unfulfilled aspirations to serve metropolitan research agendas and in its marginalization of Middle Eastern scientists. (shrink)

Ideas for explaining the mechanism of gravity involving the expansion of matter have been proposed several times since the 1890’s. Due to their radical nature and other reasons, these ideas have not gotten much attention. Another essential feature needed to augment the viability of the model proposed here---even more important than matter expansion---is that of space generation. I.e., the production of space by matter, involving motion into or outfrom a fourth spatial dimension. An experiment is proposed whose result would unequivocally (...) either falsify the model or support it. Analyses of star cluster velocity dispersions suggest that some support already exists. The simplest, most definitive way to test the model is to build and operate an apparatus that may be called a Small Low-Energy Non-Collider. Essentially the same experiment was proposed by Galileo in 1632. We are way overdue to at last bring to fruition this idea put forth by the Father of Modern Science so long ago. (shrink)

Chemistry laboratories, as buildings, have been surprisingly little studied by historians of science; interest has been focused on them more as sites of specific scientific activity, with particular emphasis on the personalities who worked within them. This has overshadowed aspects of laboratories such as their specification, design, construction, fitting-out, adaptation, replacement, status as civic and academic structures, and so on. Systematic study of them would be aided by an agreed taxonomy of laboratory types, according to their purpose, and (...) a scheme is proposed here. Practically no pre-1800 chemical laboratories survive, and there are very few dating from earlier than 1900, at least in their original state. Encouragingly, there have been several recent archaeological excavations which have turned up interesting evidence of early examples from various cultures. Little interest has been shown in the preservation of laboratories as significant architectural or historical structures, certainly when compared with other building types. The paper closes by considering those English laboratories which enjoy some level of legal protection but questioning the criteria adopted in deciding the programme of preservation. (shrink)

Novel nanomedical interventions require human testing to evaluate their safety and effectiveness. To establish a proper evidentiary basis for human trials, nanomedical innovations must first be subjected to animal and other laboratory testing. But it is uncertain whether the traditional laboratory approaches to safety evaluation will supply adequate information on nanotechnology risks to humans. This uncertainty, together with other features of nanomedical innovation, heightens the ethical challenges in conducting FIH nanotrials.

American university globalization has increasingly targeted and been courted by authoritarian states. While the reasons for these partnerships are manifold—including the ease of top-down large-scale monetary investment, “knowledge economy” development strategies, social engineering programs, and other corporate and imperial entanglements—an overwhelming discourse has emerged around higher education initiatives in places like the Arabian Peninsula, China, Singapore, and Central Asia that juxtaposes liberalism with the illiberal, authoritarian contexts it is supposedly encountering within the framework of neoliberal globalization. Through a discussion of (...) American branch campuses in Qatar and the UAE, this article traces a more complex web of actors whose interests may include neoliberal and imperial inclinations but are not reducible to them. By focusing on the discursive framings of these branch campus initiatives, we show how the notion of “liberal education” operates as a global discourse of power through American branch campuses in the Arabian Peninsula and, by extension, other nondemocratic states around the world. Specifically, we argue that the very concept of “authoritarianism” is discursively produced in and through these university projects, and simultaneously builds an idealized narrative about the national self in the United States that erases existing and emerging inequalities—indeed, authoritarianisms—within the home spaces of American academia. (shrink)

Novel computational representations, such as simulation models of complex systems and video games for scientific discovery, are dramatically changing the way discoveries emerge in science and engineering. The cognitive roles played by such computational representations in discovery are not well understood. We present a theoretical analysis of the cognitive roles such representations play, based on an ethnographic study of the building of computational models in a systems biology laboratory. Specifically, we focus on a case of model-building by an engineer (...) that led to a remarkable discovery in basic bioscience. Accounting for such discoveries requires a distributed cognition analysis, as DC focuses on the roles played by external representations in cognitive processes. However, DC analyses by and large have not examined scientific discovery, and they mostly focus on memory offloading, particularly how the use of existing external representations changes the nature of cognitive tasks. In contrast, we study discovery processes and argue that discoveries emerge from the processes of building the computational representation. The building process integrates manipulations in imagination and in the representation, creating a coupled cognitive system of model and modeler, where the model is incorporated into the modeler's imagination. This account extends DC significantly, and we present some of the theoretical and application implications of this extended account. (shrink)

Designing, building, and experimenting with physical simulation models are central problem‐solving practices in the engineering sciences. Model‐based simulation is an epistemic activity that includes exploration, generation and testing of hypotheses, explanation, and inference. This paper argues that to interpret and understand how these simulation models function in creating knowledge and technologies requires construing problem solving as accomplished by a researcher–artifact system. It draws on and further develops the framework of “distributed cognition” to interpret data collected in ethnographic and cognitive‐historical studies (...) of two biomedical engineering research laboratories, and articulates the notion of distributed model‐based cognition to answer the question posed in the title. (shrink)

I present a case study of scientific discovery, where building two functional and behavioral approximations of neurons, one physical and the other computational, led to conceptual and implementation breakthroughs in a neural engineering laboratory. Such building of external systems that mimic target phenomena, and the use of these external systems to generate novel concepts and control structures, is a standard strategy in the new engineering sciences. I develop a model of the cognitive mechanism that connects such built external systems (...) with internal models, and I examine how new discoveries, and consensus on discoveries, could arise from this external‐internal coupling and the building process. The model is based on the emerging framework of common coding, which proposes a shared representation in the brain between the execution, perception, and imagination of movement. (shrink)

Buildings are solid, monolithic, static structures of steel, stone and glass. Buildings are at their most dynamic during the phases of construction and ossify from the point of completion. They occupy a different timescale to the rest of us, unlike the mayfly that enacts its lifespan in the space of a day, or our three score and ten, buildings emerge from a long gestation to face the elements for periods that can span a thousand years. Or they (...) used to - increasingly the contemporary built environment ebbs and flows, generating a dynamically changing landscape as buildings are designed, constructed and demolished in the time it used to take to construct a model. This state of flux is enhanced by the addition of surveillance systems, telematic communication networks and environmental monitoring and control technologies. All these factors provide a new tangible dimensionality to contemporary architecture. Arch-OS is an ‘operating system’ that harnesses these new architectural, technological and social dimensions. Arch-OS, ‘software for buildings’, has been developed to manifest the social, technological and environmental life of a building and provide a living laboratory for cultivating transdisciplinary knowledge. Arch-OS buildings will be permanently in a state of flux. By feeding on the diverse forms of dynamic data that are generated by a building, its environment and its occupants, Arch-OS transforms the architect’s drawings, the brick, steel, glass and fibre-optic infrastructure into a living, breathing environment. Arch- OS provides users of buildings with a spatial and temporal consciousness, essentially re-programming human activity through a heightened social, architectural awareness. Arch-OS combines a rich mix of the physical and virtual into a new dynamic architecture, an ‘intelligent’ entity, that interacts, responds and anticipates: Arch-OS is a nervous system for multidimensional buildings. ‘Soft Buildings’ explores some of the ‘dimensions’ made manifest by Arch-OS. Specifically the generation of new kinds of space, a new kind of model, generated by a soft building. (shrink)

RESUMEN El presente trabajo está dirigido a exponer elementos inherentes al modelo de superación profesional del tecnólogo de la salud en laboratorio clínico desde la integración ciencias básicas biomédicas-laboratorio. Entre los métodos teóricos empleados, el analítico-sintético permitió la determinación de los fundamentos epistemológicos y praxiológicos del proceso de superación, el inductivo-deductivo posibilitó la determinación de las categorías que surgen en el proceso investigativo, el sistémico estructural funcional para fundamentar el carácter de sistema del modelo y la modelación con la finalidad (...) de construirlo. Se concluye que se establecen como subsistemas del modelo, la proyección profesional de las ciencias básicas biomédicas, la contextualización profesional de la integración ciencias básicas biomédicas-laboratorio y la valoración contextual de la integración en el proceso de superación, lo que explica el proceso de superación del tecnólogo de la salud en laboratorio clínico. ABSTRACT This paper aims at setting out elements inherent to the health technologist in clinical laboratory’s professional training model from the integration of basic biomedical-laboratory sciences. Among the theoretical methods used, analysis-synthesis allowed establishing the epistemological and praxeological basis of the training process; the inductive-deductive method made it possible to determine the categories that result from the research process and the systemic-structural-functional method was used to support the system-like nature of the model and modelling with the end of building it. In conclusion, subsystems of the model are established: basic biomedical sciences professionals’ aims, professional conceptualization of the integration of basic biomedical-laboratory sciences and the contextual assessment of integration in the training process, which expounds the training process of the health technologist in clinical laboratory. (shrink)

The auctions of the Federal Communication Commission, designed in 1994 to sell spectrum licences, are one of the few widely acclaimed and copied cases of economic engineering to date. This paper includes a detailed narrative of the process of designing, testing and implementing the FCC auctions, focusing in particular on the role played by game theoretical modelling and laboratory experimentation. Some general remarks about the scope, interpretation and use of rational choice models open and conclude the paper.

The main technical errors are in the literature survey. On pages 44, 93-94, 131 and 133 I claim that Fitting's and/or Rautenberg's systems are incomplete because they omit contraction. The claim is wrong because contraction is implicit in their set notation. Their systems are complete because they allow contraction on any formula whereas the systems in this technical report explicitly build contraction into certain rules, allowing contraction only on certain types of formulae. Please accept my apologies for any confusion this (...) causes you. (shrink)

Midstream modulation is a form of public engagement with science which benefits from strategic application of science and technology studies (STS) insights accumulated over nearly 20 years. These have been developed from STS researchers’ involvement in practical engagement processes and research with scientists, science funders, policy and other public stakeholders. The strategic aim of this specific method, to develop what is termed second-order reflexivity amongst scientist-technologists, builds upon and advances earlier more general STS work. However this method is focused and (...) structured so as to help generate such reflexivity—over the ‘upstream’ questions which have been identified in other STS research as important public issues for scientific research, development and innovation—amongst practising scientists-technologists in their specialist contexts (public or private, in principle). This is a different focus from virtually all such previous work, and offers novel opportunities for those key broader issues to be opened up. The further development of these promising results depends on some important conditions such as identifying and engaging research funders and other stakeholders like affected publics in similar exercises. Implementing these conditions could connect the productive impacts of midstream modulation with wider public engagement work, including with ‘uninvited’ public engagement with science. It would also generate broader institutional and political changes in the larger networks of institutional actors which constitute contemporary technoscientific innovation and governance processes. All of these various broader dimensions, far beyond the laboratory alone, need to be appropriately open, committed to democratic needs, and reflexive, for the aims of midstream modulation to be achieved, whilst allowing specialists to work as specialists. (shrink)

Hidden within the office of the Secretary of War during World War II was a little-known agency called the Advisory Specialist Group. Strategically located between the laboratory, the factory, the battlefield, and civilian bureaucracy, the ASG solved the complex problem of reconciling new technologies and new military operations. In doing so, it combined incongruous domains of activity, contributed to Allied victory, and opened a channel to the problem-solving state. It is easy to overlook or misunderstand the ASG, because it (...) was born in processes, addressed problems, and took a form unfamiliar to historical institutionalists. Drawing on Padgett and Powell’s networked theory of organizational genesis and pragmatist theories of experimentalist governance, this article explains the ASG’s emergence, networked form, and experimentalist procedures. A founding moment for the problem-solving state, this case provides empirical and theoretical guidance to study its historical and ongoing evolution. (shrink)

We describe the emergence of a new field, Mind Brain and Education, dedicated to the science of learning, as well as the roles researchers, policy makers, and educators need to play in developing this collaborative effort. The article highlights the challenges that MBE faces and the strategy researchers and educators in Texas are developing to meet these challenges. In particular, through the creation of a Research Schools Network, educators and researchers are creating an infrastructure to identify and test ideas critical (...) to educators. This network builds on Dewey's laboratory school by creating new responsibilities and partnerships. To this end we identify four critical objectives: develop a clear vision; build trusting relationships; set a standard for rigorous research and scholarship; and, promote meaningful assessment tools. (shrink)

This essay explores how mid-twentieth-century mathematicians at New York University envisioned their discipline, cultural identities and social roles, and how these self-constructed identities materialized in the planning of their new academic building, Warren Weaver Hall. These mathematicians considered their research to be a ‘living part of the stream of science’, requiring a mathematics research library which they equated to a scientific laboratory and a complex of computing rooms which served as an interdisciplinary research centre. Identifying as ‘scientists’, they understood (...) their societal value to be that of researchers, outputting mathematics research valuable to the natural sciences, the emerging field of computer science and the United States government and military, as well as educators. When the building opened in 1965, it was touted by the university administration as an ‘example of excellence’; it later, in 1970, became the site of heated negotiations when university student and faculty protestors staged a sit-in rebuking the Atomic Energy Commission's Computing Center housed on the second floor. A close study of the correspondence between the mathematicians and their peers in the university's administration, private foundations, government agencies and an architectural firm not only illuminates the day-to-day work practices of this eminent group of mathematicians, but also sheds light on their own self-constructed academic and social identities within their contemporaneous Cold War culture. (shrink)

Copresence, the idea that the presence of other actors shapes individual behavior, links macro- and micro-theorizing about social interaction. Traditionally, scholars have focused on the physical proximity of other people, assuming copresence to be a given, objective condition. However, recent empirical evidence on technologically mediated (e.g., e-mail), imaginary (e.g., prayer), and parasocial (e.g., watching a television show) interactions challenges classic copresence assumptions. In this article we reconceptualize copresence to provide theoretical building blocks (definitions, assumptions, and propositions) for a revitalized research (...) program that allows for the explicit assessment of copresence as an endogenous, subjective variable dynamically related to social context. We treat copresence as the degree to which an actor perceives mutual entrainment (i.e., synchronization of attention, emotion, and behavior) with another actor. We demonstrate the ramifications of this reconceptualization for classic theorizing on micro-macro linkages and contemporary research questions, including methodological artifacts in laboratory research and disparities in patient-provider rapport. (shrink)

Scholars and practitioners have long viewed learners as works-in-progress and as somewhat empty vessels to be filled with appropriate knowledge and skills to become future expert practitioners. However, based on an ethnography of two engineering laboratories, I found that laboratory members regularly swap the roles of learner and instructor, regardless of their status as an undergraduate student, a graduate student, or a faculty member. Furthermore, undergraduate students make crucial contributions to their research communities in the form of knowledge, creativity, (...) and opportunities for other members to learn and build relationships through teaching. What, then, do the identities of “novice” and “expert” mean in practice? I argue that it is more productive to define the identity of a community based on mutual learning and epistemic exchange rather than on expertise. (shrink)

The main purpose of this study is the scientific practice of Edgard Roquette-Pinto at the National Museum of Rio de Janeiro during the 1910’s and 1920’s in the XXth Century. The article examines the relationship between laboratory science and nation building. Driven by Physicians-Anthropologists like Edgard Roquette-Pinto among others, the investigations performed at the Anthropology Laboratory there reveal the dynamic of the borders between Laboratory and Field Sciences, and the new biological parameters adopted at that time. The (...) investigative agenda involved plants, animals and human bodies, and it was related to the current Anthropology concept aligned with the debate of Nation construction. The physiological studies amplified the scientific exchange with different institutions, emphasizing cultural exchange between Brazil and Paraguay, and the role played by Edgard Roquette-Pinto there as he inaugurated the Physiological course at Faculty of Medicine at University of Asunción. (shrink)

Building on a previously published contextualization of Marco Buzzoni’s Neo- Kantian account of scientific thought-experiments, this paper examines the explanatory power of this account. It is argued that Buzzoni’s account suffers from a number of shortcomings. Einstein’s clock-in-the-box thought experiment facilitates the demonstration of these deficits. In the light of both the identified inadequacies of Buzzoni’s account and the long-standing history of Kantian approaches to thought experiments, this paper finally sketches an alternative Neo-Kantian account. This alternative utilizes Michael Friedman’s reading (...) of Kant’s a priori within a Kuhnian account of thought experiments along the lines of conceptual constructivism as anticipated by Georg Lichtenberg and further developed recently by Tamar Gendler. (shrink)

In response to widespread policy prescriptions for responsible innovation, social scientists and engineering ethicists, among others, have sought to engage natural scientists and engineers at the ‘midstream’: building interdisciplinary collaborations to integrate social and ethical considerations with research and development processes. Two ‘laboratory engagement studies’ have explored how applying the framework of midstream modulation could enhance the reflections of natural scientists on the socio-ethical context of their work. The results of these interdisciplinary collaborations confirm the utility of midstream modulation (...) in encouraging both first- and second-order reflective learning. The potential for second-order reflective learning, in which underlying value systems become the object of reflection, is particularly significant with respect to addressing social responsibility in research practices. Midstream modulation served to render the socio-ethical context of research visible in the laboratory and helped enable research participants to more critically reflect on this broader context. While lab-based collaborations would benefit from being carried out in concert with activities at institutional and policy levels, midstream modulation could prove a valuable asset in the toolbox of interdisciplinary methods aimed at responsible innovation. (shrink)

This chapter describes the development of a workshop series focused on helping students develop research lab ethics guidelines. The workshop was developed through a National Science Foundation-funded project that situates ethics education within the research environment. Students in four departments at a private research university were recruited to join a Student Ethics Committee that collaboratively developed context-specific codes-of-ethics-based guidelines for their departments. These bottom-up developed guidelines were revised in an iterative process, including feedback from faculty, other graduate students, and the (...) original Student Ethics Committee. The goal of the workshops was to promote the cultivation of an ethical culture in experimental laboratories by integrating research stakeholders in a bottom-up approach to developing context-specific guidelines and to identify factors that students consider relevant to the ethical conduct of research. After describing the workshop series, this chapter presents a qualitative content analysis of the guidelines. The guidelines developed by the Student Ethics Committees reflect the current culture of experimental labs in these departments and the ethical issues that students think are important. The content of these guidelines and the ethical issues the students focused on contrast in some key ways with what ethical issues faculty who head research groups saw as paramount. The chapter describes the first two iterations of the ethics education workshop module, a qualitative analysis of the first draft of these guidelines, and finally reflects on future work in this area of in situ ethics education. (shrink)

Our study highlights specific ways in which race and gender create inequality in the workplace. Using in-depth interviews with 67 biology PhD students, we show how engagement with research and service varies by both gender and race. By considering the intersection between gender and race, we find not only that women biology graduate students do more service than men, but also that racial and ethnic minority men do more service than white men. White men benefit from a combination of racial (...) and gender privilege, which places them in the most advantaged position with respect to protected research time and opportunities to build collaborations and networks beyond their labs. Racial/ethnic minority women emerge as uniquely disadvantaged in terms of their experiences relative to other groups. These findings illuminate how gendered organizations are also racialized, producing distinct experiences for women and men from different racial groups, and thus contribute to theorizing the intersectional nature of inequality in the workplace. (shrink)

We describe the emergence of a new field, Mind Brain and Education, dedicated to the science of learning, as well as the roles researchers, policy makers, and educators need to play in developing this collaborative effort. The article highlights the challenges that MBE faces and the strategy researchers and educators in Texas are developing to meet these challenges. In particular, through the creation of a Research Schools Network, educators and researchers are creating an infrastructure to identify and test ideas critical (...) to educators. This network builds on Dewey's laboratory school by creating new responsibilities and partnerships. To this end we identify four critical objectives: develop a clear vision; build trusting relationships; set a standard for rigorous research and scholarship; and, promote meaningful assessment tools. (shrink)

This monograph revisits Uruguay’s remarkable transformation from a volatile product of ‘balkanisation’ in the River Plate area into Latin America’s first welfare-state democracy, associated with President José Batlle y Ordóñez (1903–7, 1911–15). Central to the country’s belated polity formation and nation-building was its school reform. The author investigates this, for the first time, from its start in 1868 under José Pedro Varela to the end of Batlle’s second term and argues that continuities in change prevailed over the alleged rupture of (...) 1903, including at the level of normative ideas. Moreover, by placing Uruguay into the broader context of what scholars have called the “Corridor of Ideas” from Santiago de Chile through Buenos Aires and Montevideo to Porto Alegre, this pioneering study also shows how Uruguay acted as a crossroads of intellectuals and a laboratory for the contestation, assimilation, and merger of global and autochthonous political and pedagogical philosophies. Jens R Hentschke is Professor of Latin American History and Politics at Newcastle University in the UK. (shrink)

This article examines Chen Ziying, an American-trained Chinese biologist and his prewar efforts to bring his Woods Hole experience from the United States to China between 1930 and 1936. I argue that the Marine Biological Laboratory appears as a prominent American scientific institution in the twentieth century among visiting Chinese students and scholars who were drawn to the American approach of building world-class seaside laboratories to facilitate marine biological study while cultivating a collaborative culture via songs of biology. Chen (...) was one of the leading US-trained Chinese scientists who aspired to the international trend of developing coastal biology in the early twentieth century and was determined to modernize China’s discipline-building of biology with the construction of marine research facilities similar to the MBL. I show that Chen’s efforts of bringing the MBL practice to China took place at a time when science in China was overshadowed by the impulse of nationalism. Despite the nationalistic rhetoric, Chen was able to establish a Chinese connection with Woods Hole by introducing the MBL cultural practices of songs with biological significance. Lyrics from popular biological songs such as “It’s a Long Way from Amphioxus” and “Songs of Amoy” reflect not just Darwinian themes but also a transnational connection between American and Chinese biologists in Republican-era China––a period in modern Chinese history that is often characterized by soaring sentiments of nationalism. This paper sets out to reconsider the interplay of scientific nationalism and scientific internationalism in shaping marine science in modern China, as well as to reflect on the meanings of value-laden terms such as “nationalism” and “foreignness” and their conceptual impacts on writing the historiography of biology in twentieth-century China. (shrink)

Traditional methods of instruction can fail to produce enduring ways of learning, especially in rapidly changing disciplines in the life sciences. Educators and funding agencies are thus calling for new, integrated teaching approaches to address the life sciences. Hierarchical frameworks are being proposed as ways to tackle curricula with large numbers of concepts. Comparing lecture‐based and interactive formats by measuring performance with pre‐ and post‐tests indicated significantly higher learning gains and better conceptual understanding in the more interactive course. Other work (...) has examined how the history of biology can be used to infuse relevance into the biology curriculum. In this paper, I describe a project at Stanford to create, implement, and evaluate an integrated curriculum in undergraduate stem cell education comprised of scientific, laboratory, and ELSI topics. (shrink)

Development-oriented funding schemes such as the UK Global Challenges Research Fund (GCRF) have opened up opportunities for collaborations between low-middle income countries (LMICs) and high-income country (HIC) researchers. In particular, funding for medical technology research has seen a rise in previously under-represented disciplines such as physics and engineering. These collaborations have considerable potential to advance healthcare in LMICs, yet can pose challenges experienced to researchers undertaking these collaborations. Key challenges include a lack of tradition of HIC/LMIC collaborations within participating departments, (...) lack of experience with development agendas, designing contextually-appropriate technologies and ensuring long-term viability of research outputs. This paper reflects on these key challenges, using the experiences of the authors on the Open Laboratory Instrumentation (OLI) project as a focalizing lens. This project was a GCRF-funded collaboration between physicists in the UK and engineers in Tanzania to develop an open-source, 3D-printed, fully-automated laboratory microscope. The paper highlights key ethics lessons learnt. (shrink)

Development-oriented funding schemes such as the UK Global Challenges Research Fund (GCRF) have opened up opportunities for collaborations between low-middle income countries (LMICs) and high-income country (HIC) researchers. In particular, funding for medical technology research has seen a rise in previously under-represented disciplines such as physics and engineering. These collaborations have considerable potential to advance healthcare in LMICs, yet can pose challenges experienced to researchers undertaking these collaborations. Key challenges include a lack of tradition of HIC/LMIC collaborations within participating departments, (...) lack of experience with development agendas, designing contextually-appropriate technologies and ensuring long-term viability of research outputs. This paper reflects on these key challenges, using the experiences of the authors on the Open Laboratory Instrumentation (OLI) project as a focalizing lens. This project was a GCRF-funded collaboration between physicists in the UK and engineers in Tanzania to develop an open-source, 3D-printed, fully-automated laboratory microscope. The paper highlights key ethics lessons learnt. (shrink)

Development-oriented funding schemes such as the UK Global Challenges Research Fund (GCRF) have opened up opportunities for collaborations between low-middle income countries (LMICs) and high-income country (HIC) researchers. In particular, funding for medical technology research has seen a rise in previously under-represented disciplines such as physics and engineering. These collaborations have considerable potential to advance healthcare in LMICs, yet can pose challenges experienced to researchers undertaking these collaborations. Key challenges include a lack of tradition of HIC/LMIC collaborations within participating departments, (...) lack of experience with development agendas, designing contextually-appropriate technologies and ensuring long-term viability of research outputs. This paper reflects on these key challenges, using the experiences of the authors on the Open Laboratory Instrumentation (OLI) project as a focalizing lens. This project was a GCRF-funded collaboration between physicists in the UK and engineers in Tanzania to develop an open-source, 3D-printed, fully-automated laboratory microscope. The paper highlights key ethics lessons learnt. (shrink)

Responsibility within life science research is a highly scrutinised field. Increasingly, scientists are presented with a range of duties and expectations regarding their conduct within the research setting. In many cases, these duties are presented deontologically, forgoing extensive discussion on how these are practically implemented into the minutiae of daily research practices. This de-contextualized duty has proven problematic when it comes to practical issues of compliance, however it is not often considered as a fundamental aspect of building ethics discourse. This (...) paper examines this issue in detail, particularly focusing on how differences in the contrasts between the ideal and real physical research environments cause conceptual problems for scientists and retard ethical engagement. Such issues are particularly pertinent in low- and middle-income countries. This paper combines theoretical and empirical analyses using the concept of “dual-use” as a focalizing topic. The data show that the research environment acts as an intimate component in the interpretation and implementation of ethical actions. (shrink)

One of the effects of the current COVID-19 pandemic is that low-income countries were pushed further into extreme poverty, exacerbating social inequalities and increasing susceptibility to drug use/abuse in people of all ages. The risks of drug abuse may not be fully understood by all members of society, partly because of the taboo nature of the subject, and partly because of the considerable gap between scientific production/understanding and communication of such knowledge to the public at large. Drug use is a (...) major challenge to social development and a leading cause of school dropout rates worldwide. Some public policies adopted in several countries in recent decades failed to prevent drug use, especially because they focused on imposing combative or coercive measures, investing little or nothing in education and prevention. Here we highlight the role of neuroscience education as a valid approach in drug use education and prevention. We propose building a bridge between schools and scientists by promoting information, student engagement and honest dialogue, and show evidence that public policy regulators should be persuaded to support such science-based education programs in their efforts to effect important positive changes in society. (shrink)

To better detect fish in an aquaculture environment, a high-accuracy real-time detection model is proposed. An experimental dataset was collected for fish detection in laboratory aquaculture environments using remotely operated vehicles. To overcome the inaccuracy of the You Only Look Once v3 algorithm in underwater farming environment, a suitable set of hyperparameters was obtained through multiple sets of experiments. Then, a real-time image recovery algorithm is applied before YOLOv3 to reduce the effects of both noise and light on images (...) whilst keeping the real-time capability, leading to a mean average precision of 0.85 and frame rate of 17.6 fps, respectively. Finally, compared with the base detection model using only the YOLOv3 algorithm, the enhanced detection model presented results in a reduction of miss detection rate from 23% to only 9% across different environments and with the detection accuracy of the target in different environments being improved from 8% to 37%. (shrink)

We analyze the Michelson type experiment performed by Brillet and Hall. The order of magnitude of the gravitational effect (a beating frequency between two lasers) is calculated. We prove that Newtonian tidal forces could be observed when they originate from the oblateness of the Earth, from its rotation, from local masses, from the Moon or the Sun but not from the Galaxy (contrary to what has been recently claimed). We conclude that it is important to build a new parametrized theoretical (...) framework for the analysis of high-precision experiments. (shrink)

This article addresses the heritage of Grotius's concept of common goods as developed in his seminal work Mare liberum. This contribution identifies the basic tenets of Grotius's thinking on the nature of common property and identifies the relevance of these ideas for the present day management of global commons, i.e., the areas and natural resources beyond the limits of national jurisdiction. Successively, the article examines the regimes for: the deep seabed, the high seas, and marine mammals; outer space, particularly the (...) moon; the two polar regions; and the atmosphere, in particular the ozone layer and the climate system. The article demonstrates how some of the original tenets of Grotius's concept of res communis – in particular the idea of inexhaustibility – can no longer be upheld and how the freedom of access to the global commons has become increasingly qualified and supplemented, if not replaced by a new law of international co-operation aimed at conservation and sustainable use of natural wealth and resources beyond the limits of national jurisdiction. The global commons function as laboratories for the testing of new principles of international law and new forms of international co-operation, which can be said to clearly build upon the Grotian heritage. (shrink)

In many experimental sciences, like particle physics or molecular biology, the proper place for establishing facts is the laboratory. In the sciences of population biology, however, the laboratory is often seen as a poor approximation of what occurs in nature. Results obtained in the field are usually more convincing. This raises special problems: it is much more difficult to obtain stable, repeatable results in the field, where environmental conditions vary out of the experimenter’s control, than in the (...) class='Hi'>laboratory. We examine here how this problem affected an influential experimental research tradition in community ecology, the study of the ecology of the rocky seashores. In the 1960s, a handful of North-American ecologists, most notably Joseph Connell, Robert Paine and Paul Dayton, made the rocky seashores a model study system for experimenting in the field. Their experiments were deceptively simple: they removed species living on the seashore and described the resulting effects on the local ecology. These experiments exerted a deep influence on community ecology. They provided evidence for speculative developments concerning the theory of interspecific competition, the factors responsible for species richness and the ecology of food webs. They also stimulated novel conceptual developments. In particular, Paine developed the predation hypothesis, which states that the presence of predators can favour species richness, before introducing the keystone species concept, according to which some species exert disproportionate effects on ecological systems. More broadly, these experiments gave support to a methodological trend in favour of field experimentation. Only controlled perturbations in the field, it seemed, provided a reliable method to get insights into the structure of ecological communities. However, as experiments were continued in time and repeated in different sites, divergent results appeared. We analyse here how intertidal researchers coped with the variability of environmental conditions and tried to stabilize their results. In the process, they reconsidered not only their early conclusions, but also the exclusive status given to field experiments. Expanding on this case study, we discuss some significant differences between laboratory and field experiments. (shrink)

This article addresses the heritage of Grotius's concept of common goods as developed in his seminal work Mare liberum. This contribution identifies the basic tenets of Grotius's thinking on the nature of common property and identifies the relevance of these ideas for the present day management of global commons, i.e., the areas and natural resources beyond the limits of national jurisdiction. Successively, the article examines the regimes for: the deep seabed, the high seas, and marine mammals; outer space, particularly the (...) moon; the two polar regions; and the atmosphere, in particular the ozone layer and the climate system. The article demonstrates how some of the original tenets of Grotius's concept of res communis – in particular the idea of inexhaustibility – can no longer be upheld and how the freedom of access to the global commons has become increasingly qualified and supplemented, if not replaced by a new law of international co-operation aimed at conservation and sustainable use of natural wealth and resources beyond the limits of national jurisdiction. The global commons function as laboratories for the testing of new principles of international law and new forms of international co-operation, which can be said to clearly build upon the Grotian heritage. (shrink)

Medical schools are among the most important spaces for the history of the body. It is here that students come to know the anatomical bodies of their future patients and, through a process of cognitive and embodied practice, that the knowing bodies of future clinicians are also shaped. Practical and theoretical understandings of medicine are formed in these affective and historied buildings and in collaboration with a broad material culture of education. Medical schools are, however, both under-theorised and under-historicised. (...) This article integrates ‘materialist’ considerations of the body with Henri Lefebvre’s philosophy of space and rhythm in order to compare two markedly different spaces – the 19th-century Anatomy Department at Semmelweis University in Hungary and the mid-20th-century ‘skills laboratory’ at Maastricht University in the Netherlands. This comparison suggests that biomedical bodies are variously shaped by the agential and affective material histories present in the everyday experience of contemporary medical education. (shrink)

Ranging from miniaturized biological robots to organoids, multi-cellular engineered living systems (M-CELS) pose complex ethical and societal challenges. Some of these challenges, such as how to best distribute risks and benefits, are likely to arise in the development of any new technology. Other challenges arise specifically because of the particular characteristics of M-CELS. For example, as an engineered living system becomes increasingly complex, it may provoke societal debate about its moral considerability, perhaps necessitating protection from harm or recognition of positive (...) moral and legal rights, particularly if derived from cells of human origin. The use of emergence-based principles in M-CELS development may also create unique challenges, making the technology difficult to fully control or predict in the laboratory as well as in applied medical or environmental settings. In response to these challenges, we argue that the M-CELS community has an obligation to systematically address the ethical and societal aspects of research and to seek input from and accountability to a broad range of stakeholders and publics. As a newly developing field, M-CELS has a significant opportunity to integrate ethically responsible norms and standards into its research and development practices from the start. With the aim of seizing this opportunity, we identify two general kinds of salient ethical issues arising from M-CELS research, and then present a set of commitments to and strategies for addressing these issues. If adopted, these commitments and strategies would help define M-CELS as not only an innovative field, but also as a model for responsible research and engineering. (shrink)

During the late 1940s and 1950s, radioisotopes became important resources for biological and medical research. This article explores the strategies used by French researchers to get access to this material, either from the local Atomic Energy Commission (CEA) or from suppliers in the United States or United Kingdom. It focuses on two aspects of this process: the transatlantic circulation of both isotopes and associated instrumentation; the regulation of use and access by the administrative bodies governing research in France. Analyzing the (...) investigations conducted within laboratories associated either with the atomic energy agency or with the local National Institute of Health (INH), the paper discusses the part played by the new tools in the postwar transformation of biomedical research. It contrasts the INH successful development of biological studies and metabolic tracing with the mixed results of CEA in advancing cancer radiotherapy, thus highlighting locally defined "normal paths" to radiobiology. (shrink)

Biological field stations proliferated in the Rocky Mountains region of the western United States during the early decades of the twentieth century. This essay examines these Rocky Mountain field stations as hybrid lab-field sites from the perspective of the field side of the dichotomy: as field sites with raised walls rather than as laboratories whose walls with the natural world have been lowered. Not only were these field stations transformed to be more like laboratories, but they were also embedded within (...) the particular regional environmental and institutional context of the Rocky Mountains. Using the University of Colorado’s Mountain Laboratory at Tolland and other contemporaneous sites as examples, this essay analyzes key features of these sites, including their location within transportation networks, buildings, equipment, personnel, scheduling, recreational and social activities, and other material and social practices on the ground. Considering both the distinctive and shared characteristics of the Rocky Mountain field stations in comparison to other types of field stations provides a more complete picture of the diversity and range of lab-field hybrid sites in the biological sciences in the early twentieth-century United States. (shrink)

This book seeks to build bridges between neuroscience and social science empirical researchers and theorists working around the world, integrating perspectives from both fields, separating real from spurious divides between them and delineating new challenges for future investigation. Since its inception in the early 2000s, multilevel social neuroscience has dramatically reshaped our understanding of the affective and cultural dimensions of neurocognition. Thanks to its explanatory pluralism, this field has moved beyond long standing dichotomies and reductionisms, offering a neurobiological perspective on (...) topics classically monopolized by non-scientific traditions, such as consciousness, subjectivity, and intersubjectivity. Moreover, it has forged new paths for dialogue with disciplines which directly address societal dynamics, such as economics, law, education, public policy making and sociology. At the same time, beyond internal changes in the field of neuroscience, new problems emerge in the dialogue with other disciplines. Neuroscience and Social Science - The Missing Link puts together contributions by experts interested in the convergences, divergences, and controversies across these fields. The volume presents empirical studies on the interplay between relevant levels of inquiry (neural, psychological, social), chapters rooted in specific scholarly traditions (neuroscience, sociology, philosophy of science, public policy making), as well as proposals of new theoretical foundations to enhance the rapprochement in question. By putting neuroscientists and social scientists face to face, the book promotes new reflections on this much needed marriage while opening opportunities for social neuroscience to plunge from the laboratory into the core of social life. This transdisciplinary approach makes Neuroscience and Social Science - The Missing Link an important resource for students, teachers, and researchers interested in the social dimension of human mind working in different fields, such as social neuroscience, social sciences, cognitive science, psychology, behavioral science, linguistics, and philosophy. (shrink)

In this paper, we build upon Bruno Latour’s political writings to address the current impasse regarding algorithms in public life. We assert that the increasing difficulties at governing algorithms—be they qualified as “machine learning,” “big data,” or “artificial intelligence”—can be related to their current ontological thinness: deriving from constricted views on theoretical practices, algorithms’ standard definition as problem-solving computerized methods provides poor grips for affective dissensions. We then emphasize on the role historical and ethnographic studies of algorithms can potentially play (...) in the politicization of algorithms. By both digging into the genealogy of algorithms’ constricted definition and by making their contemporary constitutive relationships more visible, both historical and ethnographic studies can contribute to vascularizing algorithms and making them objects of enlarged disputes. We conclude by giving a flavor of the political potential of the vascularization efforts we call for, using materials from an ethnographic study conducted in a computer science laboratory. (shrink)

At the Donald Berman Laboratory for Information Technology and Law, La TrobeUniversity Australia, we have been building legal decision support systems for a dozenyears. Whilst most of our energy has been devoted to conducting research in ArtificialIntelligence and Law, over the past few years we have increasingly focused uponbuilding legal decision support systems that have a commercial focus.In this paper we discuss the evolution of our systems. We begin with a discussion ofrule-based systems and discuss the transition to hybrid (...) rule-based/case-based systems.We next discuss how we have used machine learning in building legal decision supportsystems. Our focus on using machine learning led us to investigate the domains ofexplanation and argumentation. We conclude by discussing our current work onbuilding negotiation support systems and tools for constructing web-based legaldecision support systems. (shrink)