The discovery of conserved protein domains found in many Drosophila and mammalian developmental gene products suggests that fundamental developmental processes are conserved throughout evolution. Our understanding of development has been enhanced by the discovery of the widespread role of the homeodomain (HD). The action of HD‐containing proteins as transcriptional regulators is mediated through a helix‐turn‐helix motif which confers sequence specific DNA binding. Unexpectedly, the well conserved structural homology between the HD and the prokaryotic helix‐turn‐helix proteins contrasts with their divergent types (...) of physical interaction with DNA. A C‐terminal extension of the HD recognition helix has assumed the role that the N‐terminus of the prokaryotic helix plays for specification of DNA binding preference. However, the HD appears also capable of recognizing DNA in an alternative way and its specificity in vivo may be modified by regions outside the helix‐turn‐helix motif. We propose that this intrinsic complexity of the HD, as well as its frequent association with other DNA binding domains, explains the functional specificity achieved by genes encoding highly related HDs. (shrink)

A Scientific Integrity Consortium developed a set of recommended principles and best practices that can be used broadly across scientific disciplines as a mechanism for consensus on scientific integrity standards and to better equip scientists to operate in a rapidly changing research environment. The two principles that represent the umbrella under which scientific processes should operate are as follows: Foster a culture of integrity in the scientific process. Evidence-based policy interests may have legitimate roles to play in influencing aspects of (...) the research process, but those roles should not interfere with scientific integrity. The nine best practices for instilling scientific integrity in the implementation of these two overarching principles are Require universal training in robust scientific methods, in the use of appropriate experimental design and statistics, and in responsible research practices for scientists at all levels, with the training content regularly updated and presented by qualified scientists. Strengthen scientific integrity oversight and processes throughout the research continuum with a focus on training in ethics and conduct. Encourage reproducibility of research through transparency. Strive to establish open science as the standard operating procedure throughout the scientific enterprise. Develop and implement educational tools to teach communication skills that uphold scientific integrity. Strive to identify ways to further strengthen the peer review process. Encourage scientific journals to publish unanticipated findings that meet standards of quality and scientific integrity. Seek harmonization and implementation among journals of rapid, consistent, and transparent processes for correction and/or retraction of published papers. Design rigorous and comprehensive evaluation criteria that recognize and reward the highest standards of integrity in scientific research. (shrink)

This collection, the first of its kind, brings together specially commissioned academic essays to mark fifty years since the death of John Kennedy Toole.

The program committee of the North American Nietzsche Society recently elected to suspend their long-standing practice of holding group sessions in conjunction with divisional meetings of the American Philosophical Association, and to organize bi-annual conferences instead. This journal will continue to bring its readers select presentations from those events. In the meantime, the seven articles in this issue represent the last of the complete Proceedings and Addresses of the North American Nietzsche Society.The first two articles, on the affirmation and the (...) denial of life, by Guy Elgat and Daniel I. Harris, were selected by the program committee... (shrink)

Building on the success and importance of three previous volumes, _Relational Psychoanalysis_ continues to expand and develop the relational turn. Under the keen editorship of Lewis Aron and Adrienne Harris, and comprised of the contributions of many of the leading voices in the relational world, _Volume 4_ carries on the legacy of this rich and diversified psychoanalytic approach by taking a fresh look at recent developments in relational theory. Included here are chapters on sexuality and gender, race and class, (...) identity and self, thirdness, the transitional subject, the body, and more. Thoughtful, capacious, and integrative, this new volume places the leading edge of relational thought close at hand, and pushes the boundaries of the relational turn that much closer to the horizon. Contributors: Neil Altman, Jessica Benjamin, Emanuel Berman, Jeanne Wolff Bernstein, Susan Coates, Ken Corbett, Muriel Dimen, Martin Stephen Frommer, Jill Gentile, Samuel Gerson, Virginia Goldner, Sue Grand, Hazel Ipp, Kimberlyn Leary, Jonathan Slavin, Malcolm Owen Slavin, Charles Spezzano, Ruth Stein, Melanie Suchet. (shrink)

It has recently been suggested that a distinctive metaphysical relation— ‘Grounding’—is ultimately at issue in contexts in which some goings-on are said to hold ‘in virtue of’’, be ‘metaphysically dependent on’, or be ‘nothing over and above’ some others. Grounding is supposed to do good work in illuminating metaphysical dependence. I argue that Grounding is also unsuited to do this work. To start, Grounding alone cannot do this work, for bare claims of Grounding leave open such basic questions as whether (...) Grounded goings-on exist, whether they are reducible to or rather distinct from Grounding goings-on, whether they are efficacious, and so on; but in the absence of answers to such basic questions, we are not in position to assess the associated claim or theses concerning metaphysical dependence. There is no avoiding appeal to the specific metaphysical relations typically at issue in investigations into dependence—for example, type or token identity, functional realization, classical mereological parthood, the set membership relation, the proper subset relation, the determinable/determinate relation, and so on—which are capable of answering these questions. But, I argue, once the specific relations are on the scene, there is no need for Grounding. (shrink)

An argument that moral functioning is immeasurably complex, mediated by biology but not determined by it. Throughout history, humanity has been seen as being in need of improvement, most pressingly in need of moral improvement. Today, in what has been called the beginnings of “the golden age of neuroscience,” laboratory findings claim to offer insights into how the brain “does” morality, even suggesting that it is possible to make people more moral by manipulating their biology. Can “moral bioenhancement”—using technological or (...) pharmaceutical means to boost the morally desirable and remove the morally problematic—bring about a morally improved humanity? In The Myth of the Moral Brain, Harris Wiseman argues that moral functioning is immeasurably complex, mediated by biology but not determined by it. Morality cannot be engineered; there is no such thing as a “moral brain.” Wiseman takes a distinctively interdisciplinary approach, drawing on insights from philosophy, biology, theology, and clinical psychology. He considers philosophical rationales for moral enhancement, and the practical realities they come up against; recent empirical work, including studies of the cognitive and behavioral effects of oxytocin, serotonin, and dopamine; and traditional moral education, in particular the influence of religious thought, belief, and practice. Arguing that morality involves many interacting elements, Wiseman proposes an integrated bio-psycho-social approach to the consideration of moral enhancement. Such an approach would show that, by virtue of their sheer numbers, social and environmental factors are more important in shaping moral functioning than the neurobiological factors with which they are interwoven. (shrink)

ABSTRACT Many phenomena appear to be indeterminate, including material macro-object boundaries and certain open future claims. Here I provide an account of indeterminacy in metaphysical, rather than semantic or epistemic, terms. Previous accounts of metaphysical indeterminacy have typically taken this to involve its being indeterminate which of various determinate states of affairs obtain. On my alternative account, MI involves its being determinate that an indeterminate state of affairs obtains. I more specifically suggest that MI involves an object's having a determinable (...) property, but not having any unique determinate of that determinable. I motivate the needed extension of the traditional understanding of determinables, then argue that a determinable-based account of MI accommodates, in illuminating fashion, both ‘glutty’ and ‘gappy’ cases of MI, while satisfactorily treating concerns about MI stemming from Evans’ argument and the problem of the many. (shrink)

Motivated by the seeming structure of the sciences, metaphysical emergence combines broadly synchronic dependence coupled with some degree of ontological and causal autonomy. Reflecting the diverse, frequently incompatible interpretations of the notions of dependence and autonomy, however, accounts of emergence diverge into a bewildering variety. Here I argue that much of this apparent diversity is superficial. I first argue, by attention to the problem of higher-level causation, that two and only two strategies for addressing this problem accommodate the genuine emergence (...) of special science entities. These strategies in turn suggest two distinct schema for metaphysical emergence---'Weak' and 'Strong' emergence, respectively. Each schema imposes a condition on the powers of entities taken to be emergent: Strong emergence requires that higher-level features have more token powers than their dependence base features, whereas Weak emergence requires that higher-level features have a proper subset of the token powers of their dependence base features. Importantly, the notion of “power” at issue here is metaphysically neutral, primarily reflecting commitment just to the plausible thesis that what causes an entity may bring about are associated with how the entity is---that is, with its features. (shrink)

Both the special sciences and ordinary experience suggest that there are metaphysically emergent entities and features: macroscopic goings-on (including mountains, trees, humans, and sculptures, and their characteristic properties) which depend on, yet are distinct from and distinctively efficacious with respect to, lower-level physical configurations and features. These appearances give rise to two key questions. First, what is metaphysical emergence, more precisely? Second, is there any metaphysical emergence, in principle and moreover in fact? Metaphysical Emergence provides clear and systematic answers to (...) these questions. Wilson argues that there are two, and only two, forms of metaphysical emergence of the sort seemingly at issue in the target cases: 'Weak' emergence, whereby a dependent feature has a proper subset of the powers of the feature upon it depends, and 'Strong' emergence, whereby a dependent feature has a power not had by the feature upon which it depends. Weak emergence unifies and illuminates seemingly diverse accounts of non-reductive physicalism; Strong emergence does the same as regards seemingly diverse anti-physicalist views positing fundamental novelty at higher levels of compositional complexity. After defending the in-principle viability of each form of emergence, Wilson considers whether complex systems, ordinary objects, consciousness, and free will are actually metaphysically emergent. She argues that Weak emergence is quite common, and that there is Strong emergence in the important case of free will. (shrink)

I argue that an adequate account of non-reductive realization must guarantee satisfaction of a certain condition on the token causal powers associated with (instances of) realized and realizing entities---namely, what I call the 'Subset Condition on Causal Powers' (first introduced in Wilson 1999). In terms of states, the condition requires that the token powers had by a realized state on a given occasion be a proper subset of the token powers had by the state that realizes it on that occasion. (...) Accounts of non-reductive realization conforming to this condition are implementing what I call 'the powers-based subset strategy'. I focus on the crucial case involving mental and brain states; the results may be generalized, as appropriate. I first situate and motivate the strategy by attention to the problem of mental causation; I make the case, in schematic terms, that implementation of the strategy makes room (contra Kim 1989, 1993, 1998, and elsewhere) for mental states to be ontologically and causally autonomous from their realizing physical states, without inducing problematic causal overdetermination, and compatible with both Physicalism and Non-reduction; and I show that several contemporary accounts of non-reductive realization (in terms of functional realization, parthood, and the determinable/determinate relation) are plausibly seen as implementing the strategy. As I also show, implementation of the powers-based strategy does not require endorsement of any particular accounts of either properties or causation---indeed, a categoricalist contingentist Humean can implement the strategy. The schematic location of the strategy in the space of available responses to the problem of mental (more generally, higher-level) causation, as well as the fact that the schema may be metaphysically instantiated, strongly suggests that the strategy is, appropriately generalized and instantiated, sufficient and moreover necessary for non-reductive realization. I go on to defend the sufficiency and necessity claims against a variety of objections, considering, along the way, how the powers-based subset strategy fares against competing accounts of purportedly non-reductive realization in terms of supervenience, token identity, and constitution. (shrink)

Contemporary philosophers commonly suppose that any fundamental entities there may be are maximally determinate. More generally, they commonly suppose that, whether or not there are fundamental entities, any determinable entities there may be are grounded in, hence less fundamental than, more determinate entities. So, for example, Armstrong takes the physical objects constituting the presumed fundamental base to be “determinate in all respects” (1961, 59), and Lewis takes the properties characterizing things “completely and without redundancy” to be “highly specific” (1986, 60). (...) Here I look at the usually cited reasons for these suppositions as directed against the case of determinable properties, in particular, and argue that none is compelling (Sections 1 to 3). The discussion in Section 3 moreover identifies positive reason for taking some determinable properties to be part of a fundamental (or relatively fundamental) base. I close (Section 4) by noting certain questions arising from the possibility of fundamental determinables, as directions for future research. (shrink)

We introduce a St. Petersburg-like game, which we call the ‘Pasadena game’, in which we toss a coin until it lands heads for the first time. Your pay-offs grow without bound, and alternate in sign (rewards alternate with penalties). The expectation of the game is a conditionally convergent series. As such, its terms can be rearranged to yield any sum whatsoever, including positive infinity and negative infinity. Thus, we can apparently make the game seem as desirable or undesirable as we (...) want, simply by reordering the pay-off table, yet the game remains unchanged throughout. Formally speaking, the expectation does not exist; but we contend that this presents a serious problem for decision theory, since it goes silent when we want it to speak. We argue that the Pasadena game is more paradoxical than the St. Petersburg game in several respects. We give a brief review of the relevant mathematics of infinite series. We then consider and rebut a number of replies to our paradox: that there is a privileged ordering to the expectation series; that decision theory should be restricted to finite state spaces; and that it should be restricted to bounded utility functions. We conclude that the paradox remains live. (shrink)

I problematize Grounding-based formulations of physicalism. More specifically, I argue, first, that motivations for adopting a Grounding-based formulation of physicalism are unsound; second, that a Grounding-based formulation lacks illuminating content, and that attempts to imbue Grounding with content by taking it to be a strict partial order are unuseful and problematic ; third, that conceptions of Grounding as constitutively connected to metaphysical explanation conflate metaphysics and epistemology, are ultimately either circular or self-undermining, and controversially assume that physical dependence is incompatible (...) with explanatory gaps; fourth, that in order to appropriately distinguish physicalism from strong emergentism, a Grounding-based formulation must introduce one and likely two primitives in addition to Grounding; and fifth, that understanding physical dependence in terms of Grounding gives rise to ‘spandrel’ questions, including, e.g., “What Grounds Grounding?”, which arise only due to the overly abstract nature of Grounding. (shrink)

Some claim that Non- reductive Physicalism is an unstable position, on grounds that NRP either collapses into reductive physicalism, or expands into emergentism of a robust or ‘strong’ variety. I argue that this claim is unfounded, by attention to the notion of a degree of freedom—roughly, an independent parameter needed to characterize an entity as being in a state functionally relevant to its law-governed properties and behavior. I start by distinguishing three relations that may hold between the degrees of freedom (...) needed to characterize certain special science entities, and those needed to characterize their composing physical entities; these correspond to what I call ‘reductions’, ‘restrictions’, and ‘eliminations’ in degrees of freedom. I then argue that eliminations in degrees of freedom, in particular—when strictly fewer degrees of freedom are required to characterize certain special science entities than are required to characterize their composing physical entities—provide a basis for making sense of how certain special science entities can be both physically acceptable and ontologically irreducible to physical entities. (shrink)

Selective serotonin reuptake inhibitors (SSRIs) have gained a degree of prominence across recent moral enhancement literature as a possible intervention for dealing with antisocial and aggressive impulses. This is due to serotonin's purported capacity to modulate persons’ averseness to harm. The aim of this article is to argue that the use of SSRIs is not something worth getting particularly excited about as a practicable intervention for moral enhancement purposes, and that the generally uncritical enthusiasm over serotonin's potential as a moral (...) enhancer is a consequence of the paucity of viable options for envisaging practicable moral enhancement interventions. While there are many conceptual issues raised by the idea of moral enhancement generally, and by the idea of serotonin as a morally affective agent, the aim here is to look at practical concerns. It is argued that SSRIs do not, nor cannot in the reasonably foreseeable future, be made to work as a reliably safe or reliably effective means for moral enhancement, even within the very limited remit of treating “reactive” aggression. SSRIs might be effective as a limited and partial mental health intervention (even this is questionable), but not as a generally effective moral enhancement technology. (shrink)

A case study provides the basis for consideration of the purpose of business ethics teaching, the importance of reflection and the evaluation of ethics teaching. The way in which personal reflection and an increased capacity for ethical action can be encouraged and openly identified as aims of the course is discussed. The paper considers changes in the design and delivery of the international management ethics and values course taught at the University of South Australia as part of the undergraduate management (...) degree in Australia, Singapore and Hong Kong. As a result of student and teaching staff responses, and course evaluations, the course design, teaching and assessment has moved steadily toward an aim which explicitly refers to behaviour, without losing the significant conceptual base. Ways in which opportunities can be provided to enhance the development of a reflective capability are considered, including narrative, role models, ethical reflection, journal‐keeping and practice. The changes required a change in assessment practice. The difficulties of assessing intention and commitment to ethical action, whether in an individual course or across the curriculum, are discussed. (shrink)

Biomedical research is so important that there is a positive moral obligation to pursue it and to participate in itScience is under attack. In Europe, America, and Australasia in particular, scientists are objects of suspicion and are on the defensive.i“Frankenstein science”5–8 is a phrase never far from the lips of those who take exception to some aspect of science or indeed some supposed abuse by scientists. We should not, however, forget the powerful obligation there is to undertake, support, and participate (...) in scientific research, particularly biomedical research, and the powerful moral imperative that underpins these obligations. Now it is more imperative than ever to articulate and explain these obligations and to do so is the subject and the object of this paper.Let me present the question in its starkest form: is there a moral obligation to undertake, support and even to participate in serious scientific research? If there is, does that obligation require not only that beneficial research be undertaken but also that “we”, as individuals and “we” as societies be willing to support and even participate in research where necessary?Thus far the overwhelming answer given to this question has been “no”, and research has almost universally been treated with suspicion and even hostility by the vast majority of all those concerned with the ethics and regulation of research. The so called “precautionary approach”9 sums up this attitude, requiring dangers to be considered more likely and more serious than benefits, and assuming that no sane person would or should participate in research unless they had a pressing personal reason for so doing, or unless they were motivated by a totally impersonal altruism. International agreements and protocols—for example, the Declaration of Helsinki10 and the CIOMS Guidelines11—have been directed principally at …. (shrink)

Newtonian forces are pushes and pulls, possessing magnitude and direction, that are exerted (in the first instance) by objects, and which cause (in particular) motions. I defend Newtonian forces against the four best reasons for denying or doubting their existence. A running theme in my defense of forces will be the suggestion that Newtonian Mechanics is a special science, and as such has certain prima facie ontological rights and privileges, that may be maintained against various challenges.

Many contemporary philosophers accept Hume's Dictum, according to which there are no metaphysically necessary connections between distinct, intrinsically typed entities. Tacit in Lewis 's work is a potential motivation for HD, according to which one should accept HD as presupposed by the best account of the range of metaphysical possibilities---namely, a combinatorial account, applied to spatiotemporal fundamentalia. Here I elucidate and assess this Ludovician motivation for HD. After refining HD and surveying its key, recurrent role in Lewis ’s work, I (...) present Lewis ’s appeal to HD as providing a broadly axiomatic generating basis for the space of metaphysical modality, and canvas the prima facie advantages of the resulting combinatorial principle---HD ---as being principled, extensionally adequate and modally reductive. Most criticisms of Lewis 's combinatorialism have targeted seeming ways in which the theory overgenerates the desired space; I rather argue that HD seriously undergenerates the desired space in three different ways. For each way I argue that available means of overcoming the undergeneration either fail to close the gap, undermine the claim that HD is a principled generator of metaphysical modal space, undermine the reductive status of Lewis 's combinatorialism, or call into question the truth of HD. (shrink)

Here I compare two accounts of metaphysical indeterminacy (MI): first, the 'meta-level' approach described by Elizabeth Barnes and Ross Cameron in the companion to this paper, on which every state of affairs (SOA) is itself precise/determinate, and MI is a matter of its being indeterminate which determinate SOA obtains; second, my preferred 'object-level' determinable-based approach, on which MI is a matter of its being determinate---or just plain true---that an indeterminate SOA obtains, where an indeterminate SOA is one whose constitutive object (...) has a determinable property, but no unique determinate of that determinable. In S1, I first note an important difference between our accounts, concerning whether MI is taken to induce propositional indeterminacy; in S2, I highlight and defend certain advantages of my account; in S3, I address certain of Barnes and Cameron's objections to my account. (shrink)

Grounding, understood as a primitive posit operative in contexts where metaphysical dependence is at issue, is not able on its own to do any substantive work in characterizing or illuminating metaphysical dependence---or so I argue in 'No Work for a Theory of Grounding' (Inquiry, 2014). Such illumination rather requires appeal to specific metaphysical relations---type or token identity, functional realization, the determinable-determinate relation, the mereological part-whole relation, and so on---of the sort typically at issue in these contexts. In that case, why (...) posit 'big-G' Grounding in addition to the 'small-g' grounding relations already in the metaphysician's toolkit? The best reasons for doing so stem from the Unity argument, according to which the further posit of Grounding is motivated as an apt unifier of the specific relations, and the Priority argument, according to which Grounding is needed in order to fix the direction of priority of the specific relations. I previously considered versions of these arguments, and argued that they did not succeed; in two papers, however, Jonathan Schaffer aims to develop a better version of the Unity argument, and offers certain objections to my reasons for rejecting the Priority argument. Here I consider these new arguments for Grounding. (shrink)

In this paper, I propose a novel interpretation of the role of the understanding in generating the unity of space and time. On the account I propose, we must distinguish between the unity that belongs to determinate spaces and times – which is a result of category-guided synthesis and which is Kant’s primary focus in §26 of the B-Deduction, including the famous B160–1n – and the unity that belongs to space and time themselves as all-encompassing structures. Non-conceptualist readers of Kant (...) have argued that this latter unity cannot be the product of categorial synthesis. While they are correct that this unity is not the product of any particular act of category-guided synthesis, I argue that conceptualists are right to nevertheless attribute this unity to the understanding. I argue that it is a result of what we can think of as the ‘original’ synthesis of understanding and sensibility themselves – it is a synthesis, moreover, in which the whole is logically prior to the parts. (shrink)

The harmonious free play of the imagination and understanding is at the heart of Kant’s account of beauty in the Critique of the Power of Judgement, but interpreters have long struggled to determine what Kant means when he claims the faculties are in a state of free play. In this article, I develop an interpretation of the free play of the faculties in terms of the freedom of attention. By appealing to the different way that we attend to objects in (...) aesthetic experience, we can explain how the faculties are free, even when the subject already possesses a concept of the object and is bound to the determinate form of the object in perception. (shrink)

Horgan (1993) proposed that "superdupervenience" - supervenience preserving physicalistic acceptability - is a matter of robust explanation. I argued against him (1999) that (as nearly all physicalist and emergentist accounts reflect) superdupervenience is a matter of Condition on Causal Powers (CCP): every causal power bestowed by the supervenient property is identical with a causal power bestowed by its base property. Here I show that CCP is, as it stands, unsatisfactory,for on the usual understandings of causal power bestowal, it is trivially (...) satisfied or falsified. I offer a revision of CCP which incorporates the evident fact that causal powers are grounded in fundamental forces. (shrink)

The debate between exceptionalists and anti-exceptionalists about logic is often framed as concerning whether the justification of logical theories is a priori or a posteriori (for short: whether logic is a priori or a posteriori). As we substantiate (S1), this framing more deeply encodes the usual anti-exceptionalist thesis that logical theories, like scientific theories, are abductively justified, coupled with the common supposition that abduction is an a posteriori mode of inference, in the sense that the epistemic value of abduction is (...) (and, indeed, must be) a posteriori. In past work, however, we have argued that this common supposition is incorrect: abduction is an a priori mode of inference, in the sense that the epistemic value of abduction is (and indeed, must be) a priori (Biggs and Wilson 2017a, 2017b, 2019). After sketching our two main argumentative strategies for this conclusion (S2), we go on (S3) to consider its import on the proper understanding of anti-exceptionalism about logic. (shrink)

These comments are part of a book symposium on Karen Bennett's book, _Making Things Up_.

Every paper in this collection is worth reading, for one reason or another. Still, due to certain problematic metametaphysical presuppositions most of these discussions miss the deeper mark, on the pessimist as well as the optimist side. My reasons for thinking this come from considering how best to answer three metametaphysical questions. First, why be pessimistic about metaphysics – why be Carnapian in a post-positivist age? There is, I’ll suggest, a post-positivist strategy for reviving Carnapian pessimism, but it is almost (...) entirely neglected here; and the motivations that pessimists offer instead are not compelling. Second, why think that the best way to approach metametaphysical questions is by attention to features of language, and in particular to quantifier semantics, in ordinary or ontological language(s)? Here again we are offered little motivation for this supposition, which, notwithstanding its acceptance by nearly all contributors, faces clear difficulties. Third, granting that quantification is somehow bound up with first-order questions about what exists, what is the nature of this connection, and what are the associated implications for metametaphysics? Here I find the accounts of the connection on offer implausible, especially as compared to an alternative that makes better sense of metaphysical practice and disagreement. The moral following consideration of these questions is that real progress in metametaphysics is likely to occur less by attention to semantic issues pertaining to representation, translation and quantification and more to non-semantic issues pertaining to epistemology and metaphysical determinacy. (shrink)

In this paper, I examine the role of attention in Kant’s aesthetic theory in the Critique of the Power of Judgment. While broadly Kantian aestheticians have defended the claim that there is a distinct way that we attend to objects in aesthetic experience, Kant himself is not usually acknowledged as offering an account of aesthetic attention. On the basis of Kant’s more general account of attention in other texts and his remarks on attention in the Critique of the Power of (...) Judgment, I reconstruct Kant’s account of aesthetic attention. On this account, aesthetic attention is simultaneously directed at the form of an object and at the judging subject’s own mental states as she attends to the object. In the experience of beauty, we specifically attend to the harmonious relation between the faculties of imagination and understanding. (shrink)

There is a popular and widely accepted version of the precautionary principle which may be expressed thus: “If you are in a hole—stop digging!”. Tom Baldwin, as Deputy Chair of the Human Fertilisation and Embryology Authority , may be excused for rushing to the defence of the indefensible,1 the HFEA’s sex selection report,2 but not surely for recklessly abandoning so prudent a principle. Baldwin has many complaints about my misrepresenting the HFEA and about my supposed elitist contempt for public opinion; (...) readers of this exchange will decide for themselves.REDRAFTING THE REPORTBaldwin begins with a piece of wishful thinking:"Harris objects that in this recommendation “an absurdly high standard of caution is employed”, since a theoretical risk is associated with almost all medical procedures. This objection is misplaced: as paragraph 142 of the report indicates, the phrase “theoretical risk” is to be understood here in the light of the earlier discussion of the risks arising from the fact that flow cytometry exposes sperm to laser energy, a procedure which is known to be liable to damage DNA."Paragraph 142 does not make that clear. It does indeed refer back to a set of earlier paragraphs but these give, if anything, an upbeat assessment of the safety of flow cytometry. Paragraph 121 states: “However whilst potentially less intrusive, and with potentially lower risk to the health of patients, flow cytometry …” .2 But even if the overall burden of the report does indicate unresolved fears, the standard is still absurdly high. However, so far from endorsing the report’s judgement that flow cytometry has “potentially lower risk to the health of patients”, Baldwin now regards the risk of flow cytometry as “serious”1:"Since the application of flow cytometry to humans is a new procedure, the risk of … ". (shrink)

Many contemporary philosophers accept a strong generalization of Hume's denial of necessary causal connections, in the form of Hume's dictum (HD), according to which there are no metaphysically necessary connections between distinct, intrinsically typed entities. Hume's version of his dictum occurs during his investigation into the source of the idea of causal connection. The most powerful role that HD plays in Lewis's system concerns its providing a basis for, as Lewis puts it, a "principle of plentitude" that will guarantee "that (...) the worlds are abundant, and logical space is somehow complete". Lewis's combinatorialism promises to provide a principled, extensionally adequate, and reductive generator of metaphysical modal space. Beyond combinatorialism, there are many other accounts of metaphysical modality that need to be considered, not just with an eye to extensional adequacy but also to the clear desideratum to provide an account of the space of metaphysical modality that is principled. (shrink)

Over the last twenty years, literary theory has become peculiarly fascinated with what language cannot do, and with the impossibility of language meaning what the individual intends it to mean. In Interprive Acts, rather than ask whether communication is possible, Professor Harris explores the issues that arise from the question: how does communication occur?

Is there such a thing as a social conception of disability? Recently two writers in this journal have suggested not only that there is a coherent social conception of disability but that all non-social conceptions, or “medical models” of disability are fatally flawed. One serious and worrying dimension of their claims is that once the social dimensions of disability have been resolved no seriously “disabling” features remain. This paper examines and rejects conceptions of disability based on social factors but notes (...) that physical and mental conditions which disadvantage the individual have social dimensions. (shrink)

The nonlinearity of a composite system, whereby certain of its features (including powers and behaviors) cannot be seen as linear or other broadly additive combinations of features of the system's composing entities, has been frequently seen as a mark of metaphysical emergence, coupling the dependence of a composite system on an underlying system of composing entities with the composite system's ontological autonomy from its underlying system. But why think that nonlinearity is a mark of emergence, and moreover, of metaphysical rather (...) than merely epistemological emergence? Are there diverse ways in which nonlinearity might enter into an account of properly metaphysical emergence? And what are the prospects for there actually being phenomena that are metaphysically emergent in any available sense? Here I explore the mutual bearing of nonlinearity and metaphysical emergence, with an eye towards answering these and related questions. (shrink)

Mary Shepherd (1777–1847) was a fierce and brilliant critic of Berkeley and Hume, who moreover offered strikingly original positive views about the nature of reality and our access to it which deserve much more attention (and credit, since she anticipates many prominent views) than they have received thus far. By way of illustration, I focus on Shepherd's 1824 Essay Upon the Relation of Cause and Effect, Controverting the Doctrine of Mr. Hume, Concerning the Nature of that Relation (ERCE). After a (...) brief setup, I canvas certain of her trenchant objections to Hume’s argumentation; I then present the positive core of her response to Hume, which consists in providing novel accounts of how reason alone or reason coupled with experience can justify, first, that every effect must have a cause, and second, that it is necessary that like causes produce like effects. Among other contributions here, Shepherd provides a distinctively metaphysical argument for the claim that nothing can begin to exist 'of itself' (going beyond an appeal to the Principle of Sufficient Reason, in particular), and leverages difference-making considerations to make the case that a single 'experimentum crucis' can justify causal belief (anticipating Mill's 'method of difference'). I close by highlighting salient features of Shepherd's metaphysics of causation, whereby causation is singularist and local (anticipating Ducasse and Anscombe) and involves synchronic interactions (anticipating Mill's and certain contemporary accounts), and according to which objects are essentially characterized by their causes and effects (anticipating contemporary causal or dispositional essentialist positions). (shrink)

This paper explores the relationship of mourning and the gift in the work of Jacques Derrida. I argue that mourning is not a Derridean gift, but mourning does open us to the gift. Reading the works of Aristotle, Cicero, and Kierkegaard on friendship and love to the dead in the wake of Derrida’s Politics of Friendship makes this relation among mourning and the gift apparent for he presents mourning as the opening to a democracy to-come whose logic is the gift. (...) Through these accounts, I maintain that in preparing us for the gift, mourning the dead other can help us to relate better with the living other in ethical, political, and ontological terms. (shrink)

The article explores an aspect of spiritual intelligence characterized as a lifelong search for meaning. Slow knowing involves wrestling with perplexity. Periods of such tarrying gradually facilitate an unfolding of meaning. More than just the content of one's knowledge, it is the relationship, the how or manner of one's relationship with meaning that grounds the spiritual generativity of the seeking. Slow knowing is presented as an existential orientation, a lifelong process akin to ongoing conversion. Part 1 distinguishes such slow knowing (...) from other senses of slow in current discourse (Kahneman's fast/slow thinking framework, and meditative concepts of slow mind). Part 2 explores slow knowing through the lenses of lectio divina and the use of metaphor in religious language. Slow knowing is characterized as having both individual and social dimensions. The article concludes with the concern that the conditions needed for slow knowing—and thus for spiritual intelligence—are undermined by the hasty pace of contemporary life. (shrink)

The article explores the interaction of verbal and nonverbal semantic levels in the performance of Christian ritual. The article maps the distinction between theoretical and performative knowledge onto Barnard and Teasdale's Interacting Cognitive Systems model to give a (partial) account of how meaning emerges in ritual participation. With Christian ritual, both know-how and know-that are needed. Above all, it is their interaction that generate the richness of meaning in ritual performance. Three core claims are made. First, many contemporary concepts of (...) ritual have at least one flaw in that they do not grasp the relationality between verbal and nonverbal, wherein both dimensions have a semantic integrity of their own. Second, there is an ideological valuation of the semantic levels. The experiential level is not only meaningful in its own right, but the fundamental ground of spiritual knowing. Third, combining learning styles and kinds of attention can be valuable for eliciting the full semantic richness of ritual participation. (shrink)

This introductory article to the thematic section on “Spiritual Intelligence” sets out the ways in which spiritual intelligence is currently conceptualized. Most prominently, spiritual intelligence is understood as an adaptive intelligence which enables people to develop their values, vision, and capacity for meaning. Questions arise as to whether spiritual intelligence is a distinct form of intelligence, and how to frame it if it is. It is questionable whether psychometric approaches justify concluding there is a distinct spiritual intelligence, and the authors (...) reject any notion of a God spot in the brain specifically dedicated to spiritual intelligence, which is a much more broadly embodied phenomenon. The authors suggest that spiritual intelligence most likely makes use of existing cognitive architecture, though applied in a distinctive way. This article finishes with a brief introduction to the four main articles in this thematic section, which present spiritual intelligence as a kind of participation in transcendent being. The four articles approach the cognitive, embodied, meditative, and ritual aspects of spiritual intelligence as participation. (shrink)

Why believe Hume's Dictum, according to which there are, roughly speaking, no necessary connections between wholly distinct entities? Schaffer suggests that HD, at least as applied to causal or nomological connections, is motivated as required by the best account of of counterfactuals---namely, a similarity-based possible worlds account, where the operative notion of similarity requires 'miracles'---more specifically, worlds where entities of the same type that actually exist enter into different laws. The main cited motivations for such an account of similarity are (...) first, that some salient contexts presuppose CF asymmetry, and second, that accounts of CFs failing to presuppose CF asymmetry are epistemologically problematic, such that under conditions of determinism, the variations in initial micro-conditions needed to implement a given counterfactual antecedent would result in so many changes to macro-states that evaluation of CFs would be rendered practically impossible. Against the first reason, I argue that no non-artificial contexts presuppose CF asymmetry; against the second, I observe that such micro-variation is compatible, in principle, with significant similarity as regards macroscopic states of affairs---enough, in particular, to allow CFs to be appropriately evaluated. (shrink)

I argue that the present (if not insuperable) lack of fixed standards in philosophy is associated with three barriers to philosophical progress, pertaining to intra-disciplinary siloing, sociological rather than philosophical determinants of philosophical attention, and the encouraging of bias.

In what does philosophical progress consist? 'Vertical' progress corresponds to development within a specific paradigm/framework for theorizing (of the sort associated, revolutions aside, with science); 'horizontal' progress corresponds to the identification and cultivation of diverse paradigms (of the sort associated, conservativism aside, with art and pure mathematics). Philosophical progress seems to involve both horizontal and vertical dimensions, in a way that is somewhat puzzling: philosophers work in a number of competing frameworks (like artists or mathematicians), while typically maintaining that only (...) one of these is correct (like scientists). I diagnose this situation as reflecting that we are presently quite far from the end of inquiry into philosophical methodology. The good news is that we appear to be making advances on this score. The bad news is that failure to recognize or make explicit that our standards are in flux often leads to dogmatism, as I illustrate by attention to three assumptions presently operative in metaphysical and metametaphysical contexts. I close by identifying a tension between vertical and horizontal progress in philosophy, and suggesting an updated version of Carnap's principle of tolerance for new philosophical forms. (shrink)

Frances Kamm sets out to draw and make plausible distinctions that would show how and why it is, in some circumstances, permissible to kill some to save many more, but is not so in others. To do so she draws on a famous, and famously artificial, example of Judith Thomson, which illustrates the fact that people intutitively reject some instances of such killings but not others. The irrationality, implausibility and in many cases the self-defeating nature of such distinctions I had (...) attempted to expose in my 'The Survival Lottery' over 25 years ago. I still think these distinctions irrational and implausible and I will try, in this response, to show why this remains the case and why doctrines of additional effects, to however many powers they are taken, remain unhelpful in ethics. (shrink)