Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol‐4‐phosphate (PI4P) has emerged as a key molecule in the regulation of a diverse array of cellular functions. In this review we will discuss selected examples of the findings that in the last few years have significantly increased our awareness of the regulation and roles of PI4P in the Golgi complex and beyond. We will also highlight the role of PI4P in infection and cancer. We believe (...) that, with the increasing number of regulators and effectors of PI4P identified, the time is ripe for a more integrated approach of study. A first step in this direction is the delineation of PI4P‐centered molecular networks that we provide using data from low and high throughput studies in yeast and mammals. (shrink)

Bernard Berenson used to refer to Giovanni Morelli as «the founder of the Method». With these words, he meant that Morelli was the scholar who, first, transformed connoisseurship in a science, giving to the discipline a stringent method. Does Morelli’s theory of painting really deserve this praise? To answer this question, this paper examines in the first part the philosophical and scientific background of Morelli’s doctrine, showing how its original debt payed to romantic philosophy went replaced by a neat (...) positivist orientation. In the second part, the Method itself is discussed, asking in which measure it was anticipated by the intuitions of art experts such as Giulio Mancini or Luigi Crespi and discussing the nature and epistemological relevance of the so-called “morellian details”, that is the forms of the nails, of the ears, of the hair’s curls in paintings. Are these details really sufficient for the attribution of a painting to an artist? Which role play the documents in connoisseurship? And, more generally, how important is aesthetic value in the morellian “Method”? (shrink)

This paper investigates the nature of emotional experience in relation to the senses, and it defends the thesis that emotional experience is partly non-sensory. In §1 I introduce my reader to the debate. I reconstruct a position I call ‘restrictivism’ and motivate it as part of a reductive approach to mind’s place in nature. Drawing on intuitive but insightful remarks on the nature of sensation from Plato, I map out the conditions under which the restrictivist thesis is both substantive and (...) plausible. I then present two arguments against it. The first argument, which I lay out in §2, draws on recent empirical results in emotion research to show that restrictivism cannot be reconciled with the possibility of knowledge of one’s own emotional state by acquaintance. The second argument, which I present in §3, individuates a claim on which most contemporary theories of emotional valence converge and uses it to demonstrate that restrictivism has a false implication: it must deny that valence is experientially felt. (shrink)

"Some patients find it difficult to be in the present because they are stuck in the past; others, by contrast, struggle to remain connected with the past and are suspended in a so-called present that is effectively atemporal, that is out of time”.1 For psychoanalysts, the most profound and ultimately ethical way that we can help individuals, is by helping them know themselves. This involves discovering how they were shaped by their past and how their ongoing self-experience cannot be understood (...) in isolation from its constitutive contexts. Psychoanalysts help patients explore foundational questions such as: ‘Who am I?’ ‘How did I get here?’ ‘How am I implicated in my own suffering?’ ‘How can I grow and flourish and truly engage with my life?’. The answers to these questions emerge from a detailed exploration of the persons lived relational history, their current social and relational context and the political systems within which they are embedded. It is via this expansion of self-awareness that individuals can access agency and true freedom of choice. The clinical approach presented by Notini et al 2 is grounded in a completely different, radically decontextualised understanding of human experience. Their conceptualisation of Phoenix’s gender identity is ahistorical and atemporal: it is indeed ‘out of time’. For these authors, gender identity is assumed to be an immutable core essence, much like Ehrensaft’s3 ‘true gender self….there from birth’. It simply ‘is’. This is a …. (shrink)

This paper aims to conceptualize the phenomenology of attentional experience as ‘embodied attention.’ Current psychological research, in describing attentional experiences, tends to apply the so-called spotlight metaphor, according to which attention is characterized as the illumination of certain surrounding objects or events. In this framework, attention is not seen as involving our bodily attitudes or modifying the way we experience those objects and events. It is primarily conceived as a purely mental and volitional activity of the cognizing subject. Against this (...) view, the phenomenology of Maurice Merleau-Ponty shows that attention is a creative activity deeply linked with bodily movements. This paper clarifies and systematizes this view and brings it into dialogue with current empirical findings as well as with current theoretical research on embodied cognition. By doing this, I spell out three main claims about embodied attention: the transcendentalism of embodiment for attention, the bodily subjectivity of attention, and the creativity of embodied attention. (shrink)

One might presume that elite educational environments, including colleges and universities, have been the exclusive venues for rhetorical theory. Rhetorical theory typically takes the form of published treatises, monographs, and essays. Thus, the status of theorist would have been denied to, among others, African Americans during the nineteenth century because they were not afforded opportunities to become literate or, even if literate, not admitted into realms of elite literacy. But there are the seeds of a competing story, particularly regarding the (...) narratives written by Frederick Douglass. Henry Louis Gates Jr., for example, has stated that Douglass used... (shrink)

The aim of this paper is to argue that logic can play an important role in the “toolbox” of molecular biology. We show how biochemical pathways, i.e., transitions from a molecular aggregate to another molecular aggregate, can be viewed as deductive processes. In particular, our logical approach to molecular biology — developed in the form of a natural deduction system — is centered on the notion of Curry-Howard isomorphism, a cornerstone in nineteenth-century proof-theory.

Traditionally the doping debate has been dominated by those who want to see doping forbidden (the prohibitionist view) and those who want to see it permitted (the ban abolitionist view). In this article, the authors analyse a third position starting from the assertion that doping use is a symptom of the paradigm of highly competitive elite sports, in the same way as addictions reflect current social paradigms in wider society. Based upon a conceptual distinction between occasional use, habitual use and (...) addiction, and focusing on the physical and/or mental dependency caused by the addictive use of a certain drug, we argue that marihuana, stimulants and anabolic steroid abuse—the most frequently detected substances in doping tests—satisfies at least one, often both, of these conditions. A conclusion to be drawn from the authors' arguments is that the prohibitionist view is inappropriate for dealing with doping, as the severe sanctions attached to it will cut the doper off her/his social and professional environment, thereby risking reinforcing her/his addictive conduct. But the ban abolitionist view seems inappropriate as well. At first sight, it seems neither rational nor humane not to intervene when confronted with conduct which is highly harmful for the individual and upon which she has reduced or no control whatsoever. Instead the authors' proposal will be to contextualise dopers' conduct within sport healthcare and see it strictly in relation to each athlete's personal background. Developing preventive programmes—implemented through person-tailored counselling and eventually treatment, rather than severe sanctions or the mere lifting of the ban—seems to be a more reasonable, and probably more efficient, way of conducting ‘the war against doping’. (shrink)

Attention is often dichotomized into controlled vs. automatic processing, where controlled processing is slow, flexible, and intentional, and automatic processing is fast, inflexible, and unintentional. In contrast to this strict dichotomy, there is mounting evidence for context-specific processes that are engaged rapidly yet are also flexible. In the present study we extend this idea to the domain of implicit learning to examine whether flexibility in automatic processes can be implemented through the reliance on contextual features. Across three experiments we show (...) that participants can learn implicitly two complementary sequences that are associated with distinct contexts, and that transfer of learning when the two contexts are randomly intermixed depends on the distinctiveness of the two contexts. Our results point to the role of context-specific processes in the acquisition and expression of implicit sequence knowledge, and also suggest that episodic details can be represented in sequence knowledge. (shrink)

Some real life processes, including molecular ones, are context-sensitive, in the sense that their outcome depends on side conditions that are most of the times difficult, or impossible, to express fully in advance. In this paper, we survey and discuss a logical account of context-sensitiveness in molecular processes, based on a kind of non-classical logic. This account also allows us to revisit the relationship between logic and philosophy of science (and philosophy of biology, in particular).

Opinion is divided about the certainty of the evidence base for gender-affirming medical interventions in youth. Proponents claim that these treatments are well supported, while critics claim the poor-quality evidence base warrants extreme caution. Psychotherapy is one of the only available alternatives to the gender-affirming approach. Discussion of the treatment of gender dysphoria in young people is generally framed in terms of two binary approaches: affirmation or conversion. Psychotherapy/exploratory therapy offers a treatment option that lies outside this binary, although it (...) is mistakenly conflated with conversion therapies. Psychotherapy does not impose restrictive gender stereotypes, as is sometimes claimed, but critically examines them. It empowers young people to develop creative solutions to their difficulties and promotes agency and autonomy. Importantly, an exploratory psychotherapeutic process can help to clarify whether gender dysphoria is a carrier for other psychological or social problems that may not be immediately apparent. Psychotherapy can therefore make a significant contribution to the optimal, ethical care of gender-dysphoric young people by ensuring that patients make appropriate, informed decisions about medical interventions which carry risks of harm and have a contested evidence base. (shrink)

One of Heidegger’s most important descriptions of bodily existence can be found in his Nietzsche lectures. This paper aims to elucidate this “metaphysics of the body” both in relation to Heidegger’s Leibniz-interpretation in the later Marburg lectures as well as in the context of his later thought. Leibniz and Nietzsche are Heidegger’s points of departure in the attempt to think the difference between θεωρία and πραξις beyond Being and Time: It is only by understanding their relationship, through a radical re-thinking (...) of the problem of corporeality, no longer as a noun (der Leib) but as a verb (leiben), that one can possibly move beyond every traditional dualism, between theory and praxis but also and most notably between being and becoming. (shrink)

The theme of the relationship between art and society is certainly not a central topic in the aesthetic reflection of Italian neo-idealism. Neither in Croce nor in Gentile it is ever discussed at length, and the few writings in which it is addressed are brief and polemically oriented. This essay, however, proposes to discuss the few hints present in Croce and Gentile on this subject. First, the debate on the materialistic interpretation of history will be examined, to which both Croce (...) and Gentile made important contributions at the end of the 19th century. Secondly, Croce’s own way of doing the history of literature will be discussed, showing the differences that distance him from the Desanctisian model and also from the model derived from the Hegelian Aesthetics. Croce’s way of making history of literature, indeed, aroused harsh criticism after World War II and provoked a request for a “return to De Sanctis”.Finally, but the theme will be only hinted at in the essay, a brief reference will be proposed to the opinions of Antonio Gramsci and his reading of Croce. (shrink)

Fino a vent’anni fa il nome di Solger, uno dei pensatori più significativi del Romanticismo tedesco, certo il più sistematico e filosoficamente attrezzato tra i protagonisti di quella grande stagione, era noto in Italia, anche fra gli studiosi di estetica, quasi soltanto per la menzione che delle sue teorie viene fatta nelle Lezioni di Estetica di Hegel. Nel giro di pochi anni, però, la situazione è radicalmente cambiata. Sono state tradotte le sue Lezioni di estetica, apparse postume nel 182...

El artículo pretende abordar el modo en el que la obra de Reiner Schürmann, a través de un original interpretación del pensamiento de Martin Heidegger, consigue desarrollar un tipo de filosofía política anárquica. Se intentará analizar, en la dispersa obra del filósofo holandés, la idea de anarquía como condición existencial, prestando especial atención al nexo entre el concepto de muerte de la metafísica y la posibilidad de una praxis política anárquica. El artículo se compone de tres partes: en la primera (...) se examinará la noción de Ser y de “a priori práctico” en el trabajo de Schürmann. En la segunda se verá la diferencia entre el nihilismo del autor y el de Vattimo, y en la tercera, se profundizará en las consecuencias más propiamente políticas del pensamiento de Schürmann. (shrink)

América Latina es uno de los territorios del mundo más inseguros para ser mujer, siendo el femicidio/feminicidio la expresión más dramática de la violencia que soportan las mujeres. Pese a ello, los Estados latinoamericanos y caribeños no generan información actualizada, interseccional, ni de libre y fácil acceso sobre estos crímenes, impidiendo la comprensión de la complejidad de escenarios y dificultando la elaboración de políticas públicas efectivas, eficientes y sostenibles en el tiempo para dar respuesta a este flagelo.

En este artículo se quiere trazar una teoría política de la insurrección en el pensamiento de Max Stirner, en tanto alternativa ética y política a la revolución. Se mostrará cómo, según el pensador alemán, la revolución es en última instancia una estrategia fallida de emancipación en tanto en cuanto no libera al individuo de las formas de subjetividad que lo mantienen dependiente del poder. Más en general, se enseñará como el orden liberal post-revolucionario, detrás del lenguaje secular de los derechos, (...) las libertades y la igualdad, engendra técnicas más sutiles de gobernabilidad del individuo. La insurrección, en cambio, puede ser vista como un rechazo de las identidades y de los roles que disciplinan al individuo. Al respecto, se prestará una atención especial al concepto stirneriano de Eigenheit, como estrategia ética de auto-determinación y liberación de las formas rígidas de la subjetividad. En última instancia, se querrá mostrar cómo todo el proyecto político de la insurrección stirneriana se basa en un anarquismo ontológico que rechaza la lógica teleocrática del racionalismo moderno y pone en entredicho la misma noción de realización. The aim of this article to outline a political theory of insurrection in Max Stirner’s thought as an ethical and political alternative to revolution. I will show that revolution is ultimately a failed strategy of emancipation as it does not free the individual from the forms of subjectivity that keep her dependent on power. Insurrection, on the other hand, can be seen as a rejection of the identities and roles that discipline the individual. In this regard, special attention will be paid to the Stirnerian concept of Eigenheit as an ethical strategy of self-determination and liberation from rigid forms of subjectivity. Ultimately, I will show how the whole political project of the Stirnerian insurrection is based on an ontological anarchism that rejects the teleocratic logic of modern rationalism and calls into question the very notion of realization. (shrink)

Kevin Liggieri, »Anthropotechnik«. Zur Geschichte eines umstrittenen Begriffs, Konstanz: Konstanz University Press 2020.

This article puts forward some observations about the literary form of Documentalità. The genre to which Documentalità belongs is undoubtedly the philosophical treatise. This is a novelty, because the philosophical treatise is not a popular literary form with contemporary philosophers. But it is a genre that proves to be functional in the project of philosophical reconstruction pursued by Ferraris, and that do not necessarily conflict with the Derridean roots from which Documentality moves.