Los recientes acontecimientos económicos y su trascendental repercusión a nivel mundial, tienen entre alguna de sus más notables consecuencias la caída generalizada en los niveles de consumo. Paralelamente otro de los fenómenos cuasi-globales, el consumo masivo de objetos, se caracteriza cada vez más por la frugalidad de dichos objetos de consumo y la necesidad de sustituirlos por otros que aporten alguna novedad; lo que implica que el consumidor no pueda descansar en sus ansias consumistas. A partir de la unión de (...) estos dos aspectos, crisis económica y consumo posmoderno, se plantea un análisis social de algunos de los aspectos que caracterizan a la sociedad de consumo española en el momento presente y su repercusión en la distribución del gasto. (shrink)

The origin of eukaryotes is one of the major challenges of evolutionary cell biology. Other than the endosymbiotic origin of mitochondria and chloroplasts, the steps leading to eukaryotic endomembranes and endoskeleton are poorly understood. Ras‐family small GTPases are key regulators of cytoskeleton dynamics, vesicular trafficking and nuclear function. They are specific for eukaryotes and their expansion probably traces the evolution of core eukaryote features. The phylogeny of small GTPases suggests that the first endomembranes to evolve during eukaryote evolution had secretory, (...) and not phagocytic, function. Based on the reconstruction of putative roles for ancestral small GTPases, a hypothetical scenario on the origins of the first endomembranes, the nucleus, and phagocytosis is presented. BioEssays 25:1129–1138, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

The cilium/flagellum is a sensory-motile organelle ancestrally present in eukaryotic cells. For assembly cilia universally rely on intraflagellar transport (IFT), a specialised bidirectional transport process mediated by the ancestral and conserved IFT complex. Based on the homology of IFT complex proteins to components of coat protein I (COPI) and clathrin-coated vesicles, we propose that the non- vesicular, membrane-bound IFT evolved as a specialised form of coated vesicle transport from a protocoatomer complex. IFT thus shares common ancestry with all protocoatomer derivatives, (...) including all vesicle coats and the nuclear pore complex (NPC). This has major implications for the evolutionary origin of the cilium. First, it reinforces the tenet that duplication and divergence of pre-existing structures, rather than symbiosis, were the major themes during cilium evolution. Second, it suggests that the initial step in the autogenous origin of the cilium was the establishment of a membrane patch with transmembrane proteins transported by the ancestral vesicle-coating IFT complex. We propose a scenario for how the initial membrane patch gradually protruded to enhance exposure to the environment, then started to move, and finally compartmentalised to render receptor signalling and ciliary beating more efficient. BioEssays 28: 191–198, 2006. © 2006 Wiley periodicals, Inc. (shrink)

Con un'impostazione che coniuga la fedeltà testuale e l'approfondimento critico, il percorso di questo libro mira a ricondurre l'edificazione kierkegaardina - spesso considerata mera esortazione spirituale - allo spessore autenticamente filosofico d'una via soggettiva alla verità. Un modello antioggettivistico di filosofare senza perdere di vista né l'esercizio del dubbio né la dimensione della fede. Attraverso l' interpretazione kierkegaardiane di C. Fabro si è giunti all'esposizione e ai lineamenti descrittivi fondamentali della nozione del singolo. Il singolo viene presentato dallo stesso Kierkegaard (...) come la mia categoria. Sta di fatto che si può intendere l'intera produzione kierkegaardiana come un pensare soggettivamente il singolo. Pensiero etico carico di conseguenze pratiche, giacchè il danese non pretendeva fondare una scuola filosofica ma soltanto rendere attenti, svegliare le coscienze. (shrink)

The versatile clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system has emerged as a promising technology for therapy and molecular diagnosis. It is especially suited for overcoming viral infections outbreaks, since their effective control relies on an efficient treatment, but also on a fast diagnosis to prevent disease dissemination. The CRISPR toolbox offers DNA‐ and RNA‐targeting nucleases that constitute dual weapons against viruses. They allow both the manipulation of viral and host genomes for therapeutic purposes and the detection of viral (...) nucleic acids in “Point of Care” sensor devices. Here, we thoroughly review recent advances in the use of the CRISPR/Cas system for the treatment and diagnosis of viral deleterious infections such as HIV or SARS‐CoV‐2, examining their strengths and limitations. We describe the main points to consider when designing CRISPR antiviral strategies and the scientific efforts to develop more sensitive CRISPR‐based viral detectors. Finally, we discuss future prospects to improve both applications. Also see the video abstract here: https://www.youtube.com/watch?v=C0z1dLpJWl4. (shrink)

El presente artículo, refiere una investigación de carácter cualitativo, desarrollada con el propósito de interpretar los significados construidos por los docentes sobre la evaluación en sus prácticas, se contextualiza en la escuela primaria del Núcleo Escolar Rural N°323 en el estado Falcón, Venezuela, llevada a cabo en el año escolar 2016-2017. Asumido este quehacer como multireferencial, cíclico, emergente, co-construido y cambiante, fue abordado con una metódica orientada por la fenomenología social. Para la sistematización de la información se realizaron intercambios y (...) entrevistas en profundidad, mientras que los registros fueron realizados haciendo uso del diario del investigador y equipos tecnológicos como recursos. Los datos fueron analizados siguiendo los procesos de categorización y triangulación de fuentes, con la finalidad de ampliar el fenómeno estudiado para su comprensión. En el contraste, integración e interpretación de los significados se consideraron tres categorías medulares alusivas a la evaluación como proceso complejo, los nudos críticos en las prácticas evaluativas y la evaluación como componente curricular. Los hallazgos develados dan cuenta de los significados construidos por los docentes sobre la evaluación, quienes la plantean como un proceso auténtico, con el propósito de facilitar la mejora del proceso de aprendizaje. (shrink)

ABSTRACT:U.S. Organizational Sentencing Guidelines provide firms with incentives to develop formal ethics programs to promote ethical organizational cultures and thereby decrease corporate offenses. Yet critics argue such programs are cosmetic. Here we studied bank employees before and after the introduction of formal ethics training—an important component of formal ethics programs—to examine the effects of training on ethical organizational culture. Two years after a single training session, we find sustained, positive effects on indicators of an ethical organizational culture (observed unethical behavior, (...) intentions to behave ethically, perceptions of organizational efficacy in managing ethics, and the firm’s normative structure). While espoused organizational values also rose in importance post-training, the boost dissipated after the second year which suggests perceptions of values are not driving sustained behavioral improvements. This finding conflicts with past theory which asserts that enduring behavioral improvements arise from the inculcation of organizational values. Implications for future research are discussed. (shrink)

Self-confidence is associated with many positive outcomes, and training programs routinely seek to build participants’ self-efficacy. In this article, however, we consider whether self-confidence increases unethical behavior. In a series of studies, we explore the relationship between negotiator self-efficacy—an individual’s confidence in his or her negotiation ability—and the use of deception. We find that individuals high in negotiator self-efficacy are more likely to use deception than individuals low in negotiator self-efficacy. We also find that perceptions of the risk of deception (...) mediate this relationship. By identifying negotiator self-efficacy as an antecedent to unethical behavior, our findings offer important theoretical and empirical insights into the use of deception, the role of individual differences in ethical decision making, and the broader consequences of self-confidence in business and society. (shrink)

La encarnación del Verbo de Dios, que culmina en el misterio pascual de la muerte y resurección de Jesucristo, es el hecho fundamental y la novedad radial del Cristianismo. En la encarnación del Verbo, el Dios infinito y creador se autocomunica amorosamente a lo otro creado, para redención y divinización del hombre, para recapitulación del cosmos.

ABSTRACT:U.S. Organizational Sentencing Guidelines provide firms with incentives to develop formal ethics programs to promote ethical organizational cultures and thereby decrease corporate offenses. Yet critics argue such programs are cosmetic. Here we studied bank employees before and after the introduction of formal ethics training—an important component of formal ethics programs—to examine the effects of training on ethical organizational culture. Two years after a single training session, we find sustained, positive effects on indicators of an ethical organizational culture (observed unethical behavior, (...) intentions to behave ethically, perceptions of organizational efficacy in managing ethics, and the firm’s normative structure). While espoused organizational values also rose in importance post-training, the boost dissipated after the second year which suggests perceptions of values are not driving sustained behavioral improvements. This finding conflicts with past theory which asserts that enduring behavioral improvements arise from the inculcation of organizational values. Implications for future research are discussed. (shrink)

We examined how the cultural dimension of universalism–particularism influences managers’ attitudes toward relational favoritism. Paradoxically, we found in a survey study that Brazilian and Chinese managers perceived more negative consequences of relational favoritism than did American managers—even though the Brazilians and the Chinese perceived stronger particularistic cultural norms in their countries than Americans did in the United States. We attribute this pattern of results to “cultural reflexivity”—the ability of people from transforming economies to be culturally self-critical during a period of (...) dramatic societal change. This pattern of results also emerged in a scenario study in which we asked these same Brazilian, Chinese, and American participants to assess managerial succession decisions made by a General Manager. We varied the scenarios so that the promoted manager was either a colleague with no pre-existing relation with the GM or a colleague who was a relative, a close friend, from the same town, or from the same school. Consistent with the results of the survey study, we found that perceived cultural norms of particularism were negatively related to perceptions of fairness. In other words, Brazilians and Chinese, even while living in more particularistic cultures, were more harsh in judging relational favoritism. We conclude with a discussion on the implications of these paradoxical relationships. (shrink)

O objetivo do artigo é apresentar a discussão entre Fichte e Schelling em torno do conflito entre o idealismo transcendental da doutrina-da-ciência e a filosofia-da-natureza do Identitätssystem. Buscamos compreender, de um ponto de vista fichteano, se e em que medida é possível afirmar que a doutrina-da-ciência é uma filosofia da reflexão, tal como entendida por Schelling. Para tanto, em um primeiro momento, serão expostas as críticas de Schelling a Fichte, como ele progressivamente se afasta em relação à filosofia transcendental e (...) busca consolidar a filosofia-da-natureza. Em um segundo momento, daremos a palavra a Fichte e a seus apontamentos críticos em relação ao projeto filosófico de uma filosofia-da-natureza. Nossa análise limitar-se-á à correspondência entre os dois filósofos e aos textos escritos em torno do período de ruptura entre eles. No caso de Fichte, indo até 1804. The aim of this paper is to present the discussion between Fichte and Schelling around the conflict between the transcendental idealism of the doctrine of science and the philosophy of nature of the Identitätssystem. We seek to understand, under a Fichtean point of view, if and how far it is possible to state that the doctrine of science consists in a philosophy of reflection, such as Schelling states. For this, at first, will be exposed the Schelling’s critiques to Fichte, as the former progressively detaches himself from transcendental philosophy and consolidates a philosophy of nature. In a second moment, we will give the floor to Fichte’s critical notes related to the philosophical project of a philosophy of nature. Our analysis will be restraint to the correspondence between those two philosophers and to the texts written around this period of rupture between them. In the case of Fichte, this goes until 1804. (shrink)

We adapt Streicher and Kohlenbach's proof of the factorization S = KD of the Shoenfield translation S in terms of Krivine's negative translation K and the Gödel functional interpretation D, obtaining a proof of the factorization U = KB of Ferreira's Shoenfield-like bounded functional interpretation U in terms of K and Ferreira and Oliva's bounded functional interpretation B.

The paper offers a detailed investigation of select passages from the Vita II Sancti Remacli, a hagiographic text produced in the diocese of Liège in the last decades of the tenth century. The purpose of this investigation is threefold. First, to illustrate the point that the tenth-century Latin hagiographic texts produced in the diocese of Liège did not display quotations from classical and patristic authors only as petrified forms of frozen ancient wisdom with a merely decorative function, but rather as (...) raw gems which were polished and adjusted to fit seamlessly into a new framework. Thus, they could enhance both the form and contents of texts closely connected to their age’s political and intellectual realities. Second, to show that nineteenth- and twentieth-century editions of such texts can act as distorting mirrors to modern readers and researchers, since, due to an editorial strategy that privileged classical material over its medieval context, the editors sometimes completely neglected how quotations from ancient authors were re-worked by the tenth-century hagiographer following the stylistic requirements of rhymed prose. Third, to suggest as a necessary corrective to this distorting approach a new way of reading and consequently editing these types of texts, which places classical and patristic quotations in their proper context, by paying due attention to manuscript evidence, to the stylistic requirements of their new context, and to the complex functions they play in their new textual environment. (shrink)

La encarnación del Verbo de Dios, que culmina en el misterio pascual de la muerte y resurección de Jesucristo, es el hecho fundamental y la novedad radial del Cristianismo. En la encarnación del Verbo, el Dios infinito y creador se autocomunica amorosamente a lo otro creado, para redención y divinización del hombre, para recapitulación del cosmos.

In 2007. Terence Tao wrote on his blog an essay about soft analysis, hard analysis and the finitization of soft analysis statements into hard analysis statements. One of his main examples was a quasi-finitization of the infinite pigeonhole principle IPP, arriving at the "finitary" infinite pigeonhole principle FIPP₁. That turned out to not be the proper formulation and so we proposed an alternative version FIPP₂. Tao himself formulated yet another version FIPP₃ in a revised version of his essay. We give (...) a counterexample to FIPP₁ and discuss for both of the versions FIPP₂ and FIPP₃ the faithfulness of their respective finitization of IPP by studying the equivalences IPP ↔ FIPP₂ and IPP ↔ FIPP₃ in the context of reverse mathematics ([9]). In the process of doing this we also introduce a continuous uniform boundedness principle CUB as a formalization of Tao's notion of a correspondence principle and study the strength of this principle and various restrictions thereof in terms of reverse mathematics, i.e., in terms of the "big five" subsystems of second order arithmetic. (shrink)