Although estrogens are widely considered circulating “sex steroid hormones” typically associated with female reproduction, recent evidence suggests that estrogens can act as local modulators of brain circuits in both males and females. The functional implications of this newly characterized estrogen signaling system have begun to emerge. This essay summarizes evidence in support of the hypothesis that the rapid production of estrogens in brain circuits can drive acute changes in both the production and perception of acoustic communication behaviors. These studies have (...) revealed two fundamental neurobiological concepts: (1) estrogens can be locally produced in brain circuits, independent of levels in nearby circuits and in the circulation and (2) estrogens can have very rapid effects within these brain circuits to modulate social vocalizations, acoustic processing, and sensorimotor integration. This vertebrate‐wide span of research, including vocalizing fishes, amphibians, and birds, emphasizes the importance of comparative model systems in understanding principles of neurobiology. (shrink)

Stem cell tourism is a small but growing part of the thriving global medical tourism marketplace. Much stem cell research remains at the experimental stage, with clinical trials still uncommon. However, there are over 700 clinics estimated to be operating in mostly developing countries – from Costa Rica and Argentina to China, India and Russia – that have lured many patients, mostly from industrialized countries, driven by desperation and hope, which in turn continue to fuel the growth of such tourism.While (...) much research has focused on such dimensions as the promotions that allow such businesses to make their services known, media coverage, some patient research, and regulatory conditions for developing country clinics, little attention has been paid to the non-affected members of the general population, the future potential users of such services. This empirical study based on five focus group discussions with a diverse group of healthy adults in a Canadian city, explored participant views of patients who use stem cell tourism services, the likelihood they would avail themselves of such services if they were to suffer similar illnesses, and the conditions under which they might do so, and the impact that admonitions and advice from international expert bodies might have on their decisions. Our findings suggest that these healthy adults are sympathetic to the drivers of hope and desperation, and, despite cautions about research limitations, may seek such treatments themselves under similar conditions. These findings are discussed in the context of the policy and ethical issues raised by this form of medical tourism. (shrink)

The paper tries to show that an evolutionary perspective helps us to address what is called the adaptation problem, that is, the remarkable coherence, and seemingly successful design, existing between our cognitive tools and the phenomena of the material world. It argues that a fine-grained description of the structure and function of experimental techniques—as a special type amongst evolving scientific practices—is a condition for a better understanding and, ultimately, an explanation of how adaptation among the heterogeneous elements of experimental knowledge (...) is attained. Some apparently contradictory features of techniques, such as their high context-dependency and their capabilities to reproduce and diversify outside their original contexts, are addressed with the help of the concepts of technical variation and the historical entrenchment of phenomena in techniques. In order to do so, a case-study on the construction of satellite-DNA and the evolution of nucleic acid hybridization, a research project carried out by Roy J. Britten and his colleagues in the 1960s, is presented in detail. This case illustrates the close relationship existing between the evolution of techniques and the stabilization of phenomena in experimental biology. (shrink)

The historical reconstruction of the origins of the Neutral Theory of Molecular Evolution (NTME) has been seen purely as an extension of a long-held theoretical debate between the classical and balance schools of Population Genetics. In this perspective, the NTME is but a different interpretation of the then recently published data on high intrapopulation genetic variability. In this paper we try to show that this thesis is deficient and partially incorrect. We show that the sources for the construction and development (...) of the NTME are more varied than this traditional account. We support the Dietrich Historical Thesis, which is the view that different versions of the NTME (Kimura, and King and Jukes) show different kinds of experimental and theoretical support and coincide in recognizing the importance of the then new molecular experimental approach and of its comparative results in evolutionary biology. We stress this case to show the limits of the traditional approach in history and philosophy of science that emphasizes the theoretical activities of scientists and the theoretical characterization of disciplines. (shrink)

Xenotransplantation, or the use of animal cells, tissues and organs for humans, has been promoted as an important solution to the worldwide shortage of organs. While scientific studies continue to be done to address problems of rejection and the possibility of animal-to-human virus transfer, socio-ethical and legal questions have also been raised around informed consent, life-long monitoring, animal welfare and animal rights, and appropriate regulatory practices. Many calls have also been made to consult publics before policy decisions are made. This (...) paper describes the Canadian public consultation process on xenotransplantation carried out by the Canadian Public Health Association in an arm’s length process from Health Canada, the ministry overseeing government health policy and regulation. Focusing on six citizen fora conducted around the country patterned after the citizen jury deliberative approach, the paper describes the citizen panelists’ recommendations to hold off on proceeding with clinical trials and the rationales behind this recommendation. The consultation process is discussed in the context of constructive technology assessment, a framework which argues for broader input into earlier stages of technology innovation, particularly at the technology design stage. (shrink)

Stem cell tourism is a small but growing part of the thriving global medical tourism marketplace. Much stem cell research remains at the experimental stage, with clinical trials still uncommon. However, there are over 700 clinics estimated to be operating in mostly developing countries – from Costa Rica and Argentina to China, India and Russia – that have lured many patients, mostly from industrialized countries, driven by desperation and hope, which in turn continue to fuel the growth of such tourism.While (...) much research has focused on such dimensions as the promotions that allow such businesses to make their services known, media coverage, some patient research, and regulatory conditions for developing country clinics, little attention has been paid to the non‐affected members of the general population, the future potential users of such services. This empirical study based on five focus group discussions with a diverse group of healthy adults in a Canadian city, explored participant views of patients who use stem cell tourism services, the likelihood they would avail themselves of such services if they were to suffer similar illnesses, and the conditions under which they might do so, and the impact that admonitions and advice from international expert bodies might have on their decisions. Our findings suggest that these healthy adults are sympathetic to the drivers of hope and desperation, and, despite cautions about research limitations, may seek such treatments themselves under similar conditions. These findings are discussed in the context of the policy and ethical issues raised by this form of medical tourism. (shrink)

We present empirical evidence from dialogue that challenges some of the key assumptions in the Pickering & Garrod (P&G) model of speaker-hearer coordination in dialogue. The P&G model also invokes an unnecessarily complex set of mechanisms. We show that a computational implementation, currently in development and based on a simpler model, can account for more of this type of dialogue data.

Resumo: Neste artigo, argumentamos a favor de uma versão sofisticada do realismo científico, tendo como eixo norteador a análise do desempenho do que consideramos ser o seu elemento de defesa estratégico: o “argumento do milagre”. O realismo científico é a perspectiva comprometida com as nossas melhores teorias científicas, isto é, com a existência de entidades, processos, relações etc., observáveis ou inobserváveis, indispensáveis para explicar o seu sucesso empírico, em particular, com aqueles componentes das teorias que são cruciais para se alcançar (...) novas previsões bem-sucedidas. O argumento do milagre é um tipo de abdução ou inferência da melhor explicação e se expressa na célebre formulação de Putnam : “O realismo científico é a única filosofia que não faz do sucesso da ciência um milagre.” Analisamos e rebatemos duas importantes modalidades de argumentação antirrealista: a indução pessimista e a circularidade viciosa da inferência da melhor explicação. Acreditamos estar justificados quanto à defesa da intuição básica do realismo científico, com o apoio de uma versão fortalecida e articulada do argumento do milagre, mediante as qualificações de novidade preditiva e fecundidade teórica: a ciência é bem-sucedida em explicar e prever fenômenos, inclusive novos, porque suas melhores teorias são verdadeiras e as entidades inobserváveis postuladas por essas teorias realmente existem. Concluímos que o argumento do milagre continua sendo basilar e estratégico na defesa do realismo científico.: In this article, we argue in favor of a sophisticated version of scientific realism, based on an analysis of what we consider to be the strategic element of its defense: the “miracle argument”. Scientific realism is the perspective applicable to our best scientific theories; that is, it applies to entities, processes, and relationships, etc., whether observable or unobservable, which are indispensable for explaining the empirical success of theories, and it applies particularly to those components of the theories that are crucial to achieving new and successful forecasts. The miracle argument is a type of abduction or inference to the best explanation, and is expressed in the famous formulation of Putnam : “[Scientific] realism is the only philosophy that doesn’t make the success of the science a miracle.” We analyze and refute two important modes of antirealist argument: pessimistic induction and vicious circularity of inference to the best explanation. We believe that we are justified in defending the basic intuition of scientific realism, supported by a strengthened version of the miracle argument, together with the attributes of predictive novelty and theoretical fecundity. From this perspective, science succeeds in explaining and predicting phenomena, including new phenomena, because its best theories are true, and the unobservable entities postulated by these theories actually exist. We conclude that the miracle argument continues to be basic and strategic in the defense of scientific realism. (shrink)

Biotechnology and nanotechnology are both strategic technologies, and the former provides several lessons that could contribute to more successful embedding and integration processes for the latter. This article identifies some of the key questions emerging from the biotechnology experience and summarizes several lessons learned in the context of constructive technology assessment. This approach broadens the range of social considerations relevant to the sustainable development of nanotechnology and emphasizes the need for developing social tools for nanotechnology innovation while the technology is (...) in its early stages of design. (shrink)

A new generation of climate fiction called Cli-fi has emerged in the last decade, marking the strong consensus that has emerged over climate change. Science fiction’s concept of cognitive estrangement that combines a rational imperative to understand while focusing on something different from our everyday world provides one linkage between climate fiction and science fiction. Five novels representing this genre that has substantial connections with science fiction are analyzed, focusing on themes common across these books: their framing of the climate (...) change problem, their representations of science and scientists, their portrayals of economic and environmental challenges, and their scenarios for addressing the climate challenge. The analysis is framed through Taylor’s ideas of the social imaginary and the sociology of expectations, which proposes that expectations are promissory, deterministic, and performative. The novels illustrate in varying ways the problems attending the science-society relationship, the economic imperatives that have driven the characters’ choices, and the contradictory impulses that define our connections with nature. Such representations provide a picture of the challenges that need to be understood, but scenarios that offer possibilities for change are not as fully developed. This suggests that these books may represent a given moment in the longer trajectory of climate fiction while offering the initial building blocks to reconsider our ways of living so that new expectations and imaginaries can be debated and reconceived. (shrink)

O presente artigo analisa o projeto filosófico de John Dewey (1859-1952) que consta de uma crítica radical à epistemologia tradicional a partir da concepção pragmatista de experiência. O status científico da filosofia, conforme Dewey, não exigirá uma teoria científica passível de prova, mas um programa metafísico construído a partir de lógicas situacionais. O presente artigo apresenta as dimensões históricas e científicas da metafísica empírica de Dewey, argumentando a favor da articulação entre as duas abordagens que configuram o projeto de reconstrução (...) da filosofia. Dewey compreende que a busca dos fundamentos últimos tornou a filosofia prisioneira de uma imagem da mente como construtora de representações - algumas exatas, outras não, mas todas com a pretensão de serem estudadas por meio de métodos puros, não empíricos. Diferentemente dessa tradição que supõe uma ideia de superioridade intelectual do saber, revelado por meio de métodos não empíricos, Dewey argumenta a favor do empírico em filosofia e se coloca contra uma comum concepção da realidade como segura, regular e acabada. Palavras Chave: Experiência. Natureza. Metafísica empírica. Reconstrução filosófica. (shrink)

Dewey desenvolveu um programa doutrinário que visa mostrar como o conhecimento se funda na experiência. Essa é a dimensão científico-naturalista da sua obra. Nesse sentido, o seu projeto consiste numa rigorosa argumentação contra as explicações em que a experiência e a natureza são apresentadas com base em distinções arbitrárias. Na obra, Reconstruction in Philosophy [Reconstrução em Filosofia], Dewey desenvolveu seu projeto metafísico de dimensão historicista, propondo uma reconstrução para a filosofia. Em Experience and Nature [Experiência e Natureza], ele apresentou uma (...) visada científica para a metafísica. Nessa obra, Dewey tenta pensar um sistema desenvolvido a partir da aplicação do método científico à filosofia tendo como base uma concepção filosófica da experiência. As concepções de Dewey acerca do conhecimento, do uso inteligente da razão e da natureza social da filosofia concorrem para a constituição de sua concepção de ciência. Nas duas obras fica evidente a sua crítica à noção tradicional de conhecimento como representação da realidade. Contra isso, Dewey passa a designar o conhecimento como um conjunto de “crenças” e “proposições” tomadas como garantias de usos ou assertividade garantida. Dewey se opõe à forma pela qual o problema epistemológico é formulado pela tradição, ou seja, a partir de uma posição realista ingênua no qual o conhecimento é visto como representação, desconsiderando o processo de conexão entre as coisas e entre o conhecedor e as coisas. (shrink)

O presente artigo analisa a epistemologia realista e naturalista de John Dewey, discutindo sua contribuição para a epistemologia contemporânea. O ponto de partida da investigação consiste em articular os conceitos experiência e natureza da epistemologia de John Dewey às teorias de base naturalistas. Ao final pretendemos revelar que o realismo de Dewey por se caracterizar como naturalista traz contribuições importantes para a epistemologia atual quando se coloca numa vertente contrária ao objetivismo, mas sem prescindir da ciência. Ao se opor a (...) epistemologia clássica Dewey não pretende apartar-se totalmente dessa área da filosofia, mas postular um novo modelo teórico em que o conhecimento possa ser compreendido como mediado por relações naturais, causais, cognitivas e culturais. Revelaremos que esta perspectiva antecipa-se às vertentes contemporâneas do conhecimento cuja explicação passa pela noção de complexidade e holismo. (shrink)

RESUMO O presente trabalho resulta de uma pesquisa sobre a produção intelectual do educador brasileiro Anísio Spínola Teixeira, denominada “ A Influência do Pragmatismo Estadunidense na Filosofia da Educação de Anísio Teixeira: a dimensão político pedagógica na defesa da escola pública”. A pesquisa visa investigar a influência do pragmatismo estadunidense, de modo especial, a presença das ideias do filosófico de John Dewey na obra de Anísio Teixeira e nos movimentos renovadores da educação nacional no Brasil. O trabalho inicia conceituando o (...) pragmatismo e a concepção de filosofia da educação de Anísio Teixeira e, por fim, analisa o documento “Manifesto dos Pioneiros da Educação Nova” fazendo um cotejamento de análise com os ideais de filosofia pragmatista de Teixeira. Na primeira parte do trabalho encontra-se a discussão sobre a origem e natureza do pragmatismo, suas características e desenvolvimentos. E, desta abordagem, mostraremos como se configura a filosofia da educação de Anísio Teixeira e qual o impacto destas ideias no pensamento renovador da Educação Brasileira. O nosso objetivo consiste em identificar nesta concepção de filosofia da educação, a influência do pragmatismo americano, analisar se esta abordagem tem impactos no conteúdo do “Manifesto dos Pioneiros da Educação Nova” e, por fim, nosso propósito é revelar como o Manifesto dos Pioneiros da Educação Nova, enquanto e movimento histórico está ligado à ideia de sociedade democrática da defesa da educação pública como um direito social. Palavras Chave: Pragmatismo. Filosofia da Educação. Manifesto dos Educadores. (shrink)