That there is a heritable or familial component of susceptibility to chronic non‐communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non‐genomically and that the processes whereby environmental influences act during early development to shape disease risk in later life can have effects beyond a single generation. Such heritability may operate through epigenetic mechanisms involving regulation of either imprinted or non‐imprinted genes but (...) also through broader mechanisms related to parental physiology or behaviour. We review evidence and potential mechanisms for non‐genomic transgenerational inheritance of ‘lifestyle’ disease and propose that the ‘developmental origins of disease’ phenomenon is a maladaptive consequence of an ancestral mechanism of developmental plasticity that may have had adaptive value in the evolution of generalist species such as Homo sapiens. BioEssays 29: 145–154, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Purpose This paper aims to formalize long-term trajectories of human civilization as a scientific and ethical field of study. The long-term trajectory of human civilization can be defined as the path that human civilization takes during the entire future time period in which human civilization could continue to exist. -/- Design/methodology/approach This paper focuses on four types of trajectories: status quo trajectories, in which human civilization persists in a state broadly similar to its current state into the distant future; catastrophe (...) trajectories, in which one or more events cause significant harm to human civilization; technological transformation trajectories, in which radical technological breakthroughs put human civilization on a fundamentally different course; and astronomical trajectories, in which human civilization expands beyond its home planet and into the accessible portions of the cosmos. -/- Findings Status quo trajectories appear unlikely to persist into the distant future, especially in light of long-term astronomical processes. Several catastrophe, technological transformation and astronomical trajectories appear possible. -/- Originality/value Some current actions may be able to affect the long-term trajectory. Whether these actions should be pursued depends on a mix of empirical and ethical factors. For some ethical frameworks, these actions may be especially important to pursue. (shrink)

Given a finite state space and common priors, common knowledge of the identity of an agent with the minimal (or maximal) expectation of a random variable implies ‘consensus’, i.e., common knowledge of common expectations. This ‘extremist’ statistic induces consensus when repeatedly announced, and yet, with n agents, requires at most log2 n bits to broadcast.

Engineers’ love of technology often gets in the way of their being useful. Consider Post-it Notes or, better yet, plain paper notepads. These probably seemed like trivial ideas, but they turned out to be terribly useful. Why? Because the marvel that is the human brain has a horrible short-term memory, which means that dumb-as-dirt memory aids can make people substantially smarter.

This article grows out of and hopes to remain a part of a conversation in which Jews and Christians ponder over the manner in which they can contribute to the public good from the richness of their Scriptures and traditions. It suggests a thoughtful hermeneutic that is simultaneously faithful to ancestral traditions and open to the contributions of all thoughtful individuals and groups within a diverse society.

Prophetic eschatology is transformed into apocalyptic at the point where the task of translating the cosmic vision into the categories of mundane reality is abdicated.

If one were to choose a single word to describe the reality for which God created the world, and in which he seeks to sustain the community of those who respond to his initiating grace as an invitation to participate in it, that word would be “shalom.”.

Conducting or overseeing research in correctional settings requires knowledge of specific federal rules and regulations designed to protect the rights of individuals in incarceration. To investigate the extent to which relevant groups possess this knowledge, using a 10-item questionnaire, we surveyed 885 IRB prisoner representatives, IRB members and chairs with and without experience reviewing HIV/AIDS correctional protocols, and researchers with and without correctional HIV/AIDS research experience. Across all groups, respondents answered 4.5 of the items correctly. Individuals who have overseen or (...) conducted correctional research had the highest scores; however, even these groups responded correctly only to slightly more than half of the items. These findings emphasize the need for ongoing training in federal guidelines governing correctional research, particularly for those individuals who are embarking on this type of research. (shrink)

Comment les interruptions des logiques capitalistes peuvent-elles devenir immédiatement des sites de reproduction, de sorte que nos tentatives pour réagir à la destruction capitaliste soient simultanément des pratiques de care capables de durer? Quelles tactiques et quels espaces, quelles relations sociales et écologiques doivent être sauvées du passé et reconnues comme capables d’agir au présent, alors que le capitalisme se reproduit en détruisant les conditions de la reproduction du vivant, de la vie psychique, culturelle, et écologique? Si la nostalgie tend (...) à caractériser la dialectique entre production et parti, hégémonie et pouvoir d’État, alors quelles empathies, quels deuils et quelles fureurs, doivent être trouvées et promues sur le terrain où s’expriment la violence directe et l’expropriation définissant notre présent? Un communisme intempéré se cherche dans cet article, pour donner forme à la conjuration politique des intempéries qui menacent notre existence terrestre. (shrink)

This paper describes a Bayesian method for constructing a super-resolved surface model by combining information from a set of images of the given surface. We develop the theory and algorithms in detail for the 2-D reconstruction problem, appropriate for the case where all images are taken from roughly the same direction and under similar lighting conditions. We show the results of this 2-D reconstruction on Viking Martian data. These results show dramatic improvements in both spatial and gray-scale resolution. The Bayesian (...) approach uses a neighbor correlation model as well as pixel data from the image set. Some extensions of this method are discussed, including 3-D surface reconstruction and the resolution of diffraction blurred images. (shrink)

Biographical sketch -- Philosophical context -- Observation -- Logic of discovery -- Philosophy and history of science -- Quantum theory -- Conceptual structure, analogy, and the logic of discovery revisited.

On a rainy day in May 1988, a lowland gorilla named Willie B. stepped outdoors for the first time in twenty-seven years, into a new landscape immersion exhibit. Born in Africa, Willie B. had been captured by an animal collector and sold to a zoo. During the decades he spent in a cage, zoos stopped collecting animals from the wild and Americans changed the ways they wished to view animals in the zoo. Zoos developed new displays to simulate landscapes like (...) the Amazon River basin and African forests. Exhibits similar to animals' natural habitats began to replace old-fashioned animal houses. But such displays are only the most recent effort of zoos to present their audiences with an authentic experience of nature. Since the first zoological park opened in the United States in Philadelphia in 1874, zoos have promised their visitors a journey into the natural world. And for more than a century they have been popular places for education and recreation: every year more than 130 million Americans go to zoos to look at the animals and enjoy a day outdoors. The first book-length history of American zoos, Animal Attractions examines the meaning of nature in the city by looking at the ways zoos have assembled and displayed their animal collections. Situated literally and culturally in the American middle landscape, zoos are concrete expressions of longstanding tensions between wildness and civilization, science and popular culture, education and entertainment. In their efforts to promote nature appreciation, they reveal much about how our culture envisions the natural world and the human place in it and how these ideas have changed. (shrink)

There is a widespread feeling that health is special; the rules that are usually used in other policy areas are not applied in health policy. Health economists, for example, tend to be reluctant to offer economists' usual prescription of competition and consumer choice, even though they have largely failed to justify this reluctance by showing that health economics involves special features such as public goods, externalities, adverse selection, poor consumer information, or unusually severe consequences.

We have been discussing some of the fundamental features of the classical calculus of probability. The equiprobability of rival events was seen to be a major assumption of the calculus. Moreover, it is an assumption which the pure mathematician need not bother to justify. He need only present his formal system as follows.

Among scientific realists and anti-realists, there is a well-known, perennial dispute about the reality and knowability of unobservable objects. This dispute is also present among structural realists, who all agree that science gives us genuine knowledge of structure at the unobservable level (however that structure may be understood). Ontic structural realists reduce or eliminate the ontological role of objects, while epistemic structural realists argue that objects do or might exist but are unknowable. In part because ontic structural realism has some (...) evidence from quantum mechanics and the consequent underdetermination of the metaphysics of objects in its favor, the majority of contemporary structural realists adopt that view. In contrast, I argue that epistemic structural realism is a highly compelling view, particularly in the form that remains agnostic about unobservable objects. This view can remain consistent with the empirical data from quantum mechanics, can give a satisfactory account of the metaphysics of structure, and can distinguish itself from other extant versions of realism. I provide two arguments in favor of agnosticism about objects, the first of which argues that suspending belief is consistent with the impetus of naturalized metaphysics, and the second of which argues that agnosticism about objects is a rational response to reflection on the limits and aims of science. Thus, I show that agnostic epistemic structural realism is a defensible and compelling view in the philosophy of science that demands more attention in the literature. (shrink)