Researchers, educators and clinicians have long recognized the profound influence of the mid‐twentieth century focus on interpersonal relations and relationships on nursing. Today, in nursing, as well as in medicine and other social sciences, neuroanatomy, neurobiology and neurophysiology have replaced interpersonal dynamics as keys to understanding human behavior. Yet concerns are being raised that the teaching, research and practice of the critical importance of healing relationships have been overridden by a biological focus on the experiences of health and illness. As (...) a way to move forward, we return to Hildegard Peplau's seminal ideas about the transformative power of relationships in nursing. We propose that Peplau's formulations and, in particular, her seminal Interpersonal Relations in Nursing can provide direction. We do not propose that her formulations or her book be simply transposed from the 1950s to today's classroom and clinic. But we do believe that her ideas and writings are dynamic documents containing concepts and derived operations that can be brought to life in clinical practice. Finally, we explore Peplau's transformative idea that nursing is, at its core, an interpersonal process both to acknowledge an idea that has shaped our past and can guide us into our future. (shrink)

Volume 20, Issue 10, October 2020, Page 65-66.

Background Ethical decision making in intensive care is a demanding task. The need to proceed to ethical decision is considered to be a stress factor that may lead to burnout. The aim of this study is to explore the ethical problems that may increase burnout levels among physicians and nurses working in Portuguese intensive care units . A quantitative, multicentre, correlational study was conducted among 300 professionals.Results The most crucial ethical decisions made by professionals working in ICU were related to (...) communication, withholding or withdrawing treatments and terminal sedation. A positive relation was found between ethical decision making and burnout in nurses, namely, between burnout and the need to withdraw treatments , to withhold treatments and to proceed to terminal sedation . This did not apply to physicians. Emotional exhaustion was the burnout subdimension most affected by the ethical decision. The nurses' lack of involvement in ethical decision making was identified as a risk factor. Nevertheless, in comparison with nurses , it was the physicians who more keenly felt the need to proceed to ethical decisions in ICU.Conclusions Ethical problems were reported at different levels by physicians and nurses. The type of ethical decisions made by nurses working in Portuguese ICUs had an impact on burnout levels. This did not apply to physicians. This study highlights the need for education in the field of ethics in ICUs and the need to foster inter-disciplinary discussion so as to encourage ethical team deliberation in order to prevent burnout. (shrink)

NCG 4.0 is the latest update of the Network of Cancer Genes, a web-based repository of systems-level properties of cancer genes. In its current version, the database collects information on 537 known (i.e. experimentally supported) and 1463 candidate (i.e. inferred using statistical methods) cancer genes. Candidate cancer genes derive from the manual revision of 67 original publications describing the mutational screening of 3460 human exomes and genomes in 23 different cancer types. For all 2000 cancer genes, duplicability, evolutionary origin, expression, (...) functional annotation, interaction network with other human proteins and with microRNAs are reported. In addition to providing a substantial update of cancer-related information, NCG 4.0 also introduces two new features. The first is the annotation of possible false-positive cancer drivers, defined as candidate cancer genes inferred from large-scale screenings whose association with cancer is likely to be spurious. The second is the description of the systems-level properties of 64 human microRNAs that are causally involved in cancer progression (oncomiRs). Owing to the manual revision of all information, NCG 4.0 constitutes a complete and reliable resource on human coding and non-coding genes whose deregulation drives cancer onset and/or progression. NCG 4.0 can also be downloaded as a free application for Android smart phones. (shrink)

Mit dem Untertitel »Streitfragen« bringt dieser Band 44 der Fichte-Studien eine Gruppe von Beiträgen, die das Hauptthema »Fichte und seine Zeit« behandeln und es aus unterschiedlichen Gesichtspunkten entfalten.

O presente artigo pretende discutir e refletir sobre as contribuições da chamada Teoria Crítica da Sociedade para o campo da educação em tempos de crescente desenvolvimento tecnológico. Para tanto, voltamos o olhar para as obras de três autores expoentes da Teoria Crítica: Walter Benjamin, Theodor W. Adorno e Herbert Marcuse, destacando as reflexões e análises desses autores e utilizando-as como subsídio no campo educativo. A educação autorreflexiva e autocrítica é pensada em seu potencial para a superação das condições de dominação (...) que permanecem em nossa sociedade, cada vez mais tecnificada e pretensamente democrática. Desse modo, pensar a práxis educativa se afigura como algo urgente e necessário para que se rompa com certas condições que mantêm nosso potencial à barbárie. (shrink)

Prawitz has recently developed a theory of epistemic grounding that differs in many respects from his earlier semantics of arguments and proofs. An innovative approach to inferences yields a new conception of the intertwinement of the notions of valid inference and proof. We aim at singling out three reasons that may have led Prawitz to the ground-theoretic turn, i.e.: a better order in the explanation of the relation between valid inferences and proofs; a notion of valid inference based on which (...) valid inferences and proofs are recognisable as such; a reconstruction of the deductive activity that makes inferences capable of yielding justification per se. These topics are discussed by Prawitz with reference to a very general and ancient question: why and how correct deduction has the epistemic power to compel us to accept its conclusions, provided its premises are justified? We conclude by remarking that, in spite of some improvements, the ground-theoretic approach shares with the previous one a problem of vacuous validity which, as Prawitz himself points out, blocks in both cases a satisfactory explanation of epistemic compulsion. (shrink)

We define a class of formal systems inspired by Prawitz’s theory of grounds. The latter is a semantics that aims at accounting for epistemic grounding, namely, at explaining why and how deductively valid inferences have the power to epistemically compel to accept the conclusion. Validity is defined in terms of typed objects, called grounds, that reify evidence for given judgments. An inference is valid when a function exists from grounds for the premises to grounds for the conclusion. Grounds are described (...) by formal terms, either directly when the terms are in canonical form, or indirectly when they are in non-canonical form. Non-canonical terms must reduce to canonical form, and two terms may be said to be equal when they converge towards equivalent grounds. In our systems these properties can be proved through rules distinguished according to whether they concern types or logic. Type rules involve type introduction and elimination, equality for application of operational symbols, and re-writing equations for non-canonical terms. The logic amounts to a sort of intuitionistic system in a Gentzen format. To conclude, we show that each system of our class enjoys a normalization property. (shrink)

Dag Prawitz’s theory of grounds proposes a fresh approach to valid inferences. Its main aim is to clarify nature and reasons of their epistemic power. The notion of ground is taken to denote what one is in possession of when in a state of evidence, and valid inferences are described in terms of operations that make us pass from grounds we already have to new grounds. Thanks to a rigorously developed proof-as-chains conception, the ground-theoretic framework permits Prawitz to overcome some (...) conceptual difficulties of his earlier proof-theoretic explanation. Though from different points of view, anyway, the two accounts share an issue of recognizability of relevant operational properties. (shrink)

We outline a class of term-languages for epistemic grounding inspired by Prawitz’s theory of grounds. We show how denotation functions can be defined over these languages, relating terms to proof-objects built up of constructive functions. We discuss certain properties that the languages may enjoy both individually and with respect to their expansions. Finally, we provide a ground-theoretic version of Prawitz’s completeness conjecture, and adapt to our framework a refutation of this conjecture due to Piecha and Schroeder-Heister.

The extracellular‐signal regulated kinases 1/2 (ERK or ERKs) are involved in the regulation of important neuronal functions, including neuronal plasticity in normal and pathological conditions. We present findings that support the notion that the kinetics and localization of ERK are intrinsically linked, in that the duration of ERK activation dictates its subcellular compartmentalization and/or trafficking. The latter, in turn, dictates whether ERK‐expressing cells would enter a program of cell death, survival or differentiation. We summarize experimental data showing that chronic activation (...) of ERK plays a role in the mechanisms that trigger neurodegeneration. We also discuss how MKPs, members of the subclass of dual specificity phosphatases, might be the link between ERK kinetics and its subcellular localization. BioEssays 25:1085–1095, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Die Absicht des vorliegenden Buches ist es, das Geflecht der unterschiedlichen Fragestellungen, die mit dem Stichwort „Fichte und seine Zeit“ verbunden sind, in Betracht zu ziehen und ihre internen Zusammenhänge und ihre Geschlossenheit deutlich zu machen. The intention of this book is to take the network of different issues that are associated with the main theme " Fichte and his time" into consideration and make their internal relationships and their closeness significantly.

Alzheimer's disease (AD) is the most common cause of dementia, and there is currently no cure. The “β‐amyloid cascade hypothesis” of AD is the basis of current understanding of AD pathogenesis and drug discovery. However, no AD models have fully validated this hypothesis. We recently developed a human stem cell culture model of AD by cultivating genetically modified human neural stem cells in a three‐dimensional (3D) cell culture system. These cells were able to recapitulate key events of AD pathology including (...) β‐amyloid plaques and neurofibrillary tangles. In this review, we will discuss the progress and current limitations of AD mouse models and human stem cell models as well as explore the breakthroughs of 3D cell culture systems. We will also share our perspective on the potential of dish models of neurodegenerative diseases for studying pathogenic cascades and therapeutic drug discovery. (shrink)

The proceedings of a June 1995 conference in Luino, Italy. One poem and 16 papers explore various issues in the philosophy of science with an emphasis on the foundations of probability and statistics and quantum mechanics. The topics include subjective probability, Bayesian statistics, probability kinematics, causal decision making, and probability and realism in quantum mechanics. The problem of collecting new evidence and updating probability judgements are addressed in reference to different applications. No index. Reprinted from Erkenntnis vol. 45, nos. 2-3 (...) (1996). Annotation copyrighted by Book News, Inc., Portland, OR. (shrink)

In Prawitz’s semantics, the validity of an argument may be defined, either relatively to an atomic base which determines the meaning of the non-logical terminology, or relatively to the whole class of atomic bases, namely as logical validity. In the first case, which may be qualified as local, one has to choose whether validity of arguments is or not monotonic over expansions of bases, while in the second case, which may be qualified as global, one has to choose whether the (...) reduction functions which justify non-primitive inferences are or not base-depending. I claim that these oppositions enjoy some conceptual symmetries, and that these symmetries may be understood as putting restrictions on one’s choice both at the local and at the global level. This produces two different proof-theoretic semantics in line with Prawitz’s tenets. However, I also argue that the symmetries stem from a deeper interaction within Prawitz’s semantics, i.e. non-logical meanings vs interpretation of rules. This interaction is in turn based on some primitive ingredients which, when suitably combined, produce other two Prawitz-compatible readings. The four readings form a diagram where some order relations hold. I finally claim that this diagram is complete, namely that, if we combine the ingredients in ways other than those giving rise to the four readings above, we obtain nothing new, or nothing compatible with general semantic requirements. Thus, symmetries between the local and the global level, and interaction between non-logical meaning and interpretation of rules, produce a complete classification of potential Prawitzian semantics. (shrink)

I provide a general introduction to the notion at issue in this volume, i.e. deduction, and to some akin notions like inference and reasoning. I also argue that logic is, or should be concerned with three attitudes: an archaeological attitude, a nomological attitude, and an aetiological attitude. Then, I sum up the content of the contributions in this volume.

This broad and insightful book presents current scholarship in important subfields of philosophy of science and addresses an interdisciplinary and multidisciplinary readership. It groups carefully selected contributions into the four fields of I) philosophy of physics, II) philosophy of life sciences, III) philosophy of social sciences and values in science, and IV) philosophy of mathematics and formal modeling. Readers will discover research papers by Paul Hoyningen-Huene, Keizo Matsubara, Kian Salimkhani, Andrea Reichenberger, Anne Sophie Meincke, Javier Suárez, Roger Deulofeu, Ludger Jansen, (...) Peter Hucklenbroich, Martin Carrier, Elizaveta Kostrova, Lara Huber, Jens Harbecke, Antonio Piccolomini d'Aragona and Axel Gelfert. This collection fosters dialogue between philosophers of science working in different subfields, and brings readers the finest and latest work across the breadth of the field,illustrating that contemporary philosophy of science has successfully broadened its scope of reflection. It will interest and inspire a wide audience of philosophers as well as scholars of the natural sciences, social sciences and the humanities. The volume shares selected contributions from the prestigious second triennial conference of the German Society for Philosophy of Science/ Gesellschaft für Wissenschaftsphilosophie (GWP.2016, March 8, 2016 - March 11, 2016). (shrink)

The traditional teaching style in which the teacher is in control and there is a submissive attitude in students is predominant in Mexico. The development of identity in preadolescence is subjected to social groups, which could develop interpersonal difficulties through the controlling teaching style. Although the fear of negative evaluation in students and competitive sport has been studied in education, relatively little research has been done in the area of physical education in relation to the controlling style. The purpose of (...) this study was to investigate the correlation and predictive relationship between controlling teaching and the fear of negative evaluation mediated by the frustration of the basic psychological needs, controlled motivation, and individualism/competitiveness through the theoretical framework of self-determination theory. Participants were 1132 students in the fifth and sixth grades in public elementary schools in the state of Chihuahua, Mexico, with ages between 10 and 13. Results indicate the perceived controlling teaching style positively predicted the fear of negative evaluation in students of this study through BPN frustration, that is positively related to low-quality motivation, which is related to a higher level of individualism/competitiveness. This, in turn, is proven to be a predictor of the fear of negative evaluation. The results also discuss the promotion of the autonomy support style, avoiding the controlling teaching style, for the minimization of negative results related to the perception of fear and the development of student well-being both within and beyond the school context. (shrink)

Recent Canadian and international events have sparked dialogue and action to address racism within the nursing discipline. While the urgency to seek and implement antiracist solutions demands the attention of nurses, we contend that a contemporary analysis of the mechanisms that continue to perpetuate racism within nursing's theoretical foundation is required first. This study reconsiders the perceived functions of racism within the current state of nursing concepts and theories. In particular, we expose the role that covert racism plays by inadvertently (...) sustaining racism through nursing's theoretical foundation, and how this process strengthens white supremacy. We argue that, in the absence of exposing these covert mechanisms, the development of solutions will be futile in dismantling racism. By making visible the covert mechanisms of racism within nursing's theoretical foundation, we attempt to establish an opportunity for the nursing discipline to dismantle its racist foundation and engage in sustained antiracist action. Lastly, this study demonstrates the need to equip the discipline with a moral commitment to antiracism in an effort to emancipate nursing from its racist legacies. (shrink)