Business Ethics, the Environment & Responsibility, EarlyView.

As emphasised in Islamic sources, justice is one of the most important issues covered in the religion of Islam. In fact, justice is a central theme in Islam and has a special value in this regard. Conversation about justice and its nature, as well as its realisation in human communities, has been thus far a necessity in human life. Actually, the establishment and implementation of justice in all areas are crucial for the utopia. Given the importance of this subject, the (...) present study aims to determine and explain the components of the justice-oriented Islamic community based on the teachings of Nahj al-Balaghah. Therefore, the components that introduce justice orientation in the Islamic community are extracted from the sermons, letters and wise sayings (viz. narrations) of Nahj al-Balaghah. Afterward, the extracted components are classified based on the similarity of the themes and concepts. In the end, five classifications are introduced, including distributive justice, procedural justice, interactional justice, social justice and fairness.Contribution: Based on the determined indices, the model of justice-oriented Islamic community is developed. It is thus recommended to pay more attention to the realisation of a justice-oriented Islamic community by researchers and leaders. This is mainly because of the fact that the opposite of a justice-oriented community is one with injustice, where oppression and disrespect for the rights of others occur, divine blessings change, divine wrath and anger are provoked and destruction approaches. (shrink)

Academic integrity is a vital pedagogical responsibility that educational institutions should explicitly address. One of the best ways to uphold academic integrity is to create a culture of academic integrity throughout the school. This is especially imperative at high schools where students develop their moral identity because students who act dishonestly at high school will likely behave accordingly in post-secondary education and ultimately be dishonest in familial and professional settings. Creating a culture of academic integrity is a challenging, long and (...) multifaceted journey. In this respect, this exploratory case study set out to create a culture of academic integrity at a high school in Türkiye and explore what facilitates and impedes the process. We followed Stephens’ (2016) Multilevel Intervention Model and implemented a School-Wide Education program to guide us through the process. We conducted various activities throughout one academic year, from seminars to competitions. At the end of the term, we conducted individual and focus group interviews with the members of the school community and analyzed the interview data to identify facilitators and barriers of the process. The analysis yielded five facilitators (1) creating buy-in, (2) administrative embracement and support, (3) activities that promote student involvement, (4) external expert and school collaboration as praxis, and (5) policy as the blueprint and five barriers (1) deficiencies in responding academic misconduct, (2) prioritization of academic success over academic integrity, (3) teacher resistance against change, (4) exam-based assessment design, and (5) timing of the activities. Each theme was discussed in detail, and recommendations were made for high schools which set out on a journey of creating academic integrity culture. (shrink)

We show in this paper that the AGM postulates are too weak to ensure the rational preservation of conditional beliefs during belief revision, thus permitting improper responses to sequences of observations. We remedy this weakness by proposing four additional postulates, which are sound relative to a qualitative version of probabilistic conditioning. Contrary to the AGM framework, the proposed postulates characterize belief revision as a process which may depend on elements of an epistemic state that are not necessarily captured by a (...) belief set. We also show that a simple modification to the AGM framework can allow belief revision to be a function of epistemic states. We establish a model-based representation theorem which characterizes the proposed postulates and constrains, in turn, the way in which entrenchment orderings may be transformed under iterated belief revision. (shrink)

Refusing consent to organ donation remains unacceptably high, and improving consent rates from family or next-of-kin is an important step to procuring more organs for solid organ transplantation in countries where this approval is sought. We have thus far failed to translate fully our limited understanding of why families refuse permission into successful strategies targeting consent in the setting of deceased organ donation, primarily because our interventions fail to target underlying cognitive obstacles. Novel interventions to overcome these hurdles, incorporating an (...) understanding of cognitive psychology and behavioral change therapy, may be beneficial. One potential intervention is to use the concept of nudge theory, where decision-making is influenced by encouraging positive reinforcement and indirect suggestion. Purposefully nudging families to given consent for organ donation by understanding, and then overcoming, their inherent cognitive biases is novel but also controversial. This article explores the roles of relatives in decisions about organ donation, how nudge theory translates to organ donation and discusses the arguments for and against its application. (shrink)

Recent work has shown that the input-output behavior of some common machine learning classifiers can be captured in symbolic form, allowing one to reason about the behavior of these classifiers using symbolic techniques. This includes explaining decisions, measuring robustness, and proving formal properties of machine learning classifiers by reasoning about the corresponding symbolic classifiers. In this work, we present a theory for unveiling the _reasons_ behind the decisions made by Boolean classifiers and study some of its theoretical and practical implications. (...) At the core of our theory is the notion of a _complete reason,_ which can be viewed as a necessary and sufficient condition for why a decision was made. We show how the complete reason can be used for computing notions such as sufficient reasons (also known as PI-explanations and abductive explanations), how it can be used for determining decision and classifier bias and how it can be used for evaluating counterfactual statements such as “a decision will stick even if...because....” We present a linear-time algorithm for computing the complete reasoning behind a decision, assuming the classifier is represented by a Boolean circuit of appropriate form. We then show how the computed complete reason can be used to answer many queries about a decision in linear or polynomial time. We finally conclude with a case study that illustrates the various notions and techniques we introduced. (shrink)

The philosophy of religion and theology are related to the culture in which they have developed. These disciplines provide a source of values and vision to the cultures of which they are part, while at the same time they are delimited and defined by their cultures. This book compares the ideas of two contemporary philosophers, John Hick and Seyyed Hossein Nasr, on the issues of religion, religions, the concept of the ultimate reality, and the notion of sacred knowledge. On a (...) broader level, it compares two world-views: the one formed by Western Christian culture, which is religious in intention but secular in essence; the other Islamic, formed through the assimilation of traditional wisdom, which is turned against the norms of secular culture and is thus religious both in intention and essence. (shrink)

Salim Kemal clarifies the nature of aesthetic judgements and their epistemological status, and examines the scope of Kant's justification of their validity.

Are the employees working in different countries and enjoying healthy compensation truly loyal to their organization? Our study attempts to answer this question by examining the role of perception of politics on the affective commitment of expatriates in the Sultanate of Oman. Following the axiom of equity theory, the relationships between the perception of politics (POP) to affective commitment (AC) and Islamic work ethics (IWE) to affective commitment (AC) was tested. The moderating role of Islamic work ethics was also examined (...) in the POP-AC relationship. Responses from 146 employees were collected following a simple random sampling technique. Employees working in different organizations at various managerial levels were approached for data collection. Descriptive statistics, correlation, and regression tests were applied to test hypotheses using SPSS-22.0 and SmartPLS-4. Results confirmed the positive relationship between Islamic work ethics to affective commitment and the negative relationship between perception of politics to affective commitment. Moreover, the negative relationship between the perception of politics with affective commitment was weaker when Islamic work ethics were high. Practical implications of the study are presented based on the results. (shrink)

A common feature of all standard theories of the laws of nature is that they are "absolutist": They take laws to be either all metaphysically necessary or all contingent. Science, however, gives us reason to think that there are laws of both kinds, suggesting that standard theories should make way for "non-absolutist" alternatives: theories which accommodate laws of both modal statuses. In this paper, we set out three explanatory challenges for any candidate non-absolutist theory and discuss the prospects of the (...) two extant candidates in light of these challenges. We then develop our own non-absolutist theory, the essentialist DTA account, which combines the nomic-necessitation or DTA account with an essentialist approach to metaphysical modality in order to meet the three explanatory challenges. Finally, we argue that the distinction between kinematical and dynamical laws found in physical theories supports both non-absolutism in general and our proposed essentialist DTA view in particular. (shrink)

Grounding necessitarianism (GN) is the view that full grounds necessitate what they ground. Although GN has been rather popular among philosophers, it faces important counterexamples: For instance, A=[Socrates died] fully grounds C=[Xanthippe became a widow]. However, A fails to necessitate C: A could have obtained together with B=[Socrates and Xanthippe were never married], without C obtaining. In many cases, the debate essentially reduces to whether A indeed fully grounds C – as the contingentist claims – or if instead C is (...) fully grounded in A+, namely A plus some supplementary fact S (e.g. [Xanthippe was married to Socrates]) – as the necessitarian claims. Both sides typically agree that A+ necessitates C, while A does not; they disagree on whether A or A+ fully grounds C. This paper offers a novel defence of the claim that, in these typical cases, unlike A+, A fails to fully ground C – thereby bringing further support to GN. First and foremost, unlike A+, A fails to fully ground C because it fails to contain just what is relevant to do so, in two distinct senses – explanatory and generative relevance. Second, going for A, rather than A+, as a full ground undermines not just grounding necessitarianism, but modally weaker views which even contingentists may want to preserve. (shrink)

In a recent paper, Tuomas Tahko has argued for a hybrid view of the laws of nature, according to which some physical laws are metaphysically necessary, while others are metaphysically contingent. In this paper, we show that his criterion for distinguishing between these two kinds of laws — which crucially relies on the essences of natural kinds — is on its own unsatisfactory. We then propose an alternative way of drawing the metaphysically necessary/contingent distinction for laws of physics based on (...) the central kinematical/dynamical distinction used in physical theorising, and argue that the criterion can be used to amend Tahko’s own account, but also that it can be combined with different metaphysical views about the source of necessity. (shrink)

This book brings together a distinguished group of scholars from music, drama, poetry, performance art, religion, classics and philosophy to investigate the complex and developing interaction between performance and authenticity in the arts. The volume begins with a perspective on traditional understandings of that relation, examining the crucial role of performance in the Poetics, the marriage of art with religion, the experiences of religious and aesthetic authenticity, and modernist conceptions of authenticity. Several essays then consider music as a performative art. (...) The final essays discuss the link of authenticity to sincerity and truth in poetry, explain how performance, as an authentic feature of poetry, embodies a collective effort, and culminate in a discussion of the dark side of performance - its constant susceptibility to inauthenticity. Together the essays suggest how issues of performance and authenticity enter into consideration of a wide range of the arts. (shrink)

Varlığa ilk adım attığı andan itibaren hayatı seven insanoğlu, yaşı ilerle-dikçe tanıştığı ve bağlandığı diğer insanların sayısının artmasıyla hayata daha da bağlanmaktadır. Ancak ne var ki anne-baba, evlat-torun, eş-dost yakınlıklarıyla şenlenen hayatın sonunu ve ayrılıkların yakınlaşmakta olduğunu haber veren ihtiyarlık gün içinde ikindiye, yıl içerisinde de sonbahara benzemektedir. Karanlık gece ve soğuk kışların habercisi olan ihtiyarlık dönemi beka arzusuyla coşkun insan tabiatı açısından hüzünlü bir dönemi ifade etmektedir. “Yaşlılık” olgusu, duygusal yoğunluklardan hayatını alan edebiyatın dikkatini çeken temalarından biridir. Hemen her (...) dil edebiyatında kendinden şikâyetle bahsedilen ihtiyarlık, özellikle Arap edebiyatında sıklıkla işlenen konulardandır. Klasik Arap edebiyatının büyük şairlerinden neredeyse tamamı ihtiyarlıktan bahsetmiştir. İhtiyarlık onların gözünde çoğu zaman tatlı hayatın acı yönüdür. Bu makalede klasik Arap şiirinde şairlerin yaşlılık konusunu nasıl ele aldıklarını onların şiirlerinden hareketle inceleyecektir. Girişte yaşlılık hakkında ayet ve hadislerde yer verilen bilgilerle bir sunum yapılacaktır. Sonrasında ise Arap edebiyatında yaşlılık olgusunu farklı şekilde ele alan yaklaşımlar başlıklar halinde tasnif edilecektir. (shrink)

Multiple sequence alignment is one of the major problems that can be encountered in the bioinformatics field. MSA consists in aligning a set of biological sequences to extract the similarities between them. Unfortunately, this problem has been shown to be NP-hard. In this article, a new algorithm was proposed to deal with this problem; it is based on a quantum-inspired cuckoo search algorithm. The other feature of the proposed approach is the use of a randomized progressive alignment method based on (...) a hybrid global/local pairwise algorithm to construct the initial population. The results obtained by this hybridization are very encouraging and show the feasibility and effectiveness of the proposed solution. (shrink)

Creation, collection and retention of knowledge in digital communities is an activity that currently requires being explicitly targeted as a secure method of keeping intellectual capital growing in the digital era. In particular, we consider it relevant to analyze and evaluate the empathetic cognitive personalities and behaviors that individuals now have with the change from face-to-face communication to computer-mediated communication online. This document proposes a cyber-humanistic approach to enhance the traditional SECI knowledge management model. A cognitive perception is added to (...) its cyclical process following design thinking interaction, exemplary for improvement of the method in which knowledge is continuously created, converted and shared. In building a cognitive-centered model, we specifically focus on the effective identification and response to cognitive stimulation of individuals, as they are the intellectual generators and multiplicators of knowledge in the online environment. Our target is to identify how geographically distributed—digital—organizations should align the individual’s cognitive abilities to promote iteration and improve interaction as a reliable stimulant of collective intelligence. The new model focuses on analyzing the four different stages of knowledge processing, where individuals with sympathetic cognitive personalities can significantly boost knowledge creation in a virtual social system. For organizations, this means that multidisciplinary individuals can maximize their extensive potential, by externalizing their knowledge in the correct stage of the knowledge creation process, and by collaborating with their appropriate sympathetically cognitive remote peers. (shrink)

On what I call absolutist essentialism about modality (AE), the metaphysical necessities are the propositions that are true in virtue of the essence (i.e. Aristotelian, absolute essence) of some entities. Other kinds of necessity can then be defined by restriction – e.g. the conceptual necessities are the propositions that are true in virtue of the essence of conceptual entities specifically. As an account of metaphysical modality and some other kinds (e.g. logical, conceptual), AE may have important virtues. However, when it (...) comes to accounting for further important kinds, like natural or normative necessity, it faces a challenge. Three main options have been defended: treat those kinds as further restricted forms of metaphysical necessity; define them as conditional forms of metaphysical necessity; treat them as primitive kinds. -/- In this paper, I propose a new option, which combines the main idea of AE (reducing necessities to essences) with an idea which has been developed largely independently: that of relative essence. On the proposed view, those kinds (e.g. natural necessity) that cannot be grounded in the essences (i.e. absolute essences) of the relevant entities (e.g. natural entities) may be grounded in their relative essences instead. Thus, I propose a generalized, or extended, version of AE, which I call relativized essentialism about modality (RE). In particular, RE offers prospects for a general framework for kinds of modality which is flexible enough to cover a large range of kinds (both absolute and relative ones) while remaining parsimonious and unified. (shrink)

The transition from empire to nation-state poses challenges in managing religious and ethnic pluralism. Empires, characterized by hierarchical structures and diversity, contrast with nation-states, which aim for uniformity and unity. As empires modernize administratively, they grapple with different approaches to pluralism. While Habsburgs were more in favor of a federal plurality, the Romanovs pushed for centralization and assimilation. Throughout the nineteenth century, the Ottomans vacillated between these two alternative paths. This vacillation is most evident in their approach to millet system (...) which simultaneously followed the contradictory policies of undermining millet boundaries in order to promote a sense of unity across the multi-faith society and policies of promoting and safeguarding the privileges and group-specific rights of non-Muslim communities. Ottoman nationalism eventually shifted towards a homogenizing model, akin to the Romanov approach, leading to the exclusion of religious minorities. This process of homogenization continued in the nationalist policies of modern Turkey and resulted in the secular Turkish Republic being less tolerant towards non-Muslims than the Islamic Ottoman Empire. (shrink)

In his book The Intellectual Virtues and the Life of the Mind: On the Place of the Virtues in Contemporary Epistemology, Jonathan Kvanvig argues that there is an interchangeability of personal and doxastic justification, which ‘blocks the quick route to virtue epistemology’. To prove that personal justification is reducible to doxastic justification, he utilizes λ-calculus expressions that aim to show the logical equivalence of the two notions of justification. In this paper, I argue that he has made an illegitimate move (...) in his translation of the ordinary talk of personal justification into λ-expressions because his translation involves both an elimination from and an addition to the ordinary language. Pace Kvanvig, there is no logical equivalence of personal to doxastic justification. So, his argument for the reducibility of personal to doxastic justification founders. More importantly, since he has failed to disprove that personal justification is irreducibly primitive, he hasn’t shown that the prospects for virtue epistemology are ‘hopeless’. (shrink)

It is widely accepted that necessity comes in different varieties, often called ‘kinds': metaphysical necessity, logical necessity, natural necessity, conceptual necessity, moral necessity, to name but a few – and the same goes for the varieties of possibility. What is usually not fully appreciated, however, is that modal variety is not simply ‘unidimensional': it does not only involve one main variable – kind, whose values are the particular kinds of necessity. Rather, I argue, it is ‘bidimensional', involving two distinct variables (...) – domain and strength. In the first part of the paper, I introduce and develop the proposed bidimensional picture of modal variety, defending it against the common, unidimensional one. In the second part, I consider how the main available accounts of necessities and their relations rely, at least to a significant extent, on the latter picture, pointing out important limitations that they face as a result. I also show how, accordingly, alternative accounts based on a clear and systematic distinction between domain and strength would overcome those limitations. I conclude that, beyond the particular bidimensionalist view defended, our understanding of the modal realm may benefit from more direct debate on whether and how it is multidimensional. (shrink)

History in this age needs to record and analyze the events in the light of modern concept of contemporary world. When the historians narrate the brutal condition of Indo-Pak history, they never forget the work and services of Shaykh Ahmad Sirhindi to transform the society according to the current values. For his services, he is hailed as Mujaddid Alf-I-Thani. The Muslim society had degenerated when Mujaddid Alf-I-Thani appeared on the horizon. A number of Hindu customs and practices had become the (...) part of their creed. The commandments of Shariat and Sunnah were being floated. Moreover, the Mughal emperor Akbar had adopted controversial policies detrimental to the very existence of Muslim society. Mujaddid Alf -Thani made strenuous and constant efforts to turn the tide. When Mujadded-Alf-Thani started his social reform movement, he found that the Muslim society was embracing un-Islamic practices such as widespread belief in Karamat had developed under the influence of Hindu thinking. Moreover, the Islamic teachings had been vitiated by adopting customs and practices of other religions such as inter marriages between Hindus and Muslims and ban on cow slaughter etc. Shaykh Ahmad Sirhindi never entered into any political conflict directly. He endeavored to restore pure doctrine to Islamic thought and to compel the Muslims to follow Shariat and Sunnah in letter and spirit. He was a social reformer, great Alim, Sufi and Mujaddid. He initiated a process of social change, inspired by Islamic Ideal, in an age, which was becoming secular. This research paper is an attempt to mention the role of Shaykh Ahmad Sirhindi for saving the society from un-Islamic values and customs in the sub-continent and its impact on society. By utilizing the historical method, this paper aims at analyzing the effect of social reforms of Shaykh Ahmed Sirhindi on Muslim society. (shrink)

We address in this paper the problem of counting the models of a propositional theory under incremental changes to its literals. Specifcally, we show that if a propositional theory Δ is in a special form that we call smooth, deterministic, decomposable negation normal form, then for any consistent set of literals S, we can simultaneously count the models of Δ ∪ S and the models of every theory Δ ∪ T where T results from adding, removing or flipping a literal (...) in S. We present two results relating to the time and space complexity of compiling propositional theories into sd-DNNF. First, we show that if a conjunctive normal form has a bounded treewidth, then it can be compiled into an sd-DNNF in time and space which are linear in its size. Second, we show that sd-DNNF is a strictly more space efficient representation than Free Binary Decision Diagrams. Finally, we discuss some applications of the counting results to truth maintenance systems, belief revision, and model-based diagnosis. (shrink)

Two approaches to elevating certain laws of nature over others have come to prominence recently. On the one hand, according to the meta-laws approach, there are meta-laws, laws which relate to laws as those laws relate to particular facts. On the other hand, according to the modal, or non-absolutist, approach, some laws are necessary in a stricter sense than others. Both approaches play an important role in current research, questioning the ‘orthodoxy’ represented by the leading philosophical theories of natural laws—Humeanism, (...) the DTA view, dispositional essentialism and primitivism. This paper clarifies the relations between these two emerging approaches, as well as their applicability to physical laws and the status of the challenges they pose for standard theories of laws of nature. We first argue that, despite some significant similarities between the two approaches (especially in the context of Lange’s counterfactual account of laws), they are in general distinct and largely independent of each other. Then, we argue that the support for meta-laws from physical theory and practice is more questionable than usually presented. (shrink)

Given that health systems research involves different aims, approaches, and methodologies as compared to more traditional clinical trials, the ethical issues present in HSR may be unique or particularly nuanced. This article outlines eight pertinent ethical issues that are particularly salient in HSR and argues that the ethical review process should be better tailored to ensure more efficient and appropriate oversight of HSR with adequate human protections, especially in low- and middle-income countries. The eight ethical areas we discuss include the (...) nature of intervention, types of research subjects, units of intervention and observation, informed consent, controls and comparisons, risk assessment, inclusion of vulnerable groups, and benefits of research. HSR involving human participants is necessary to ensure health systems strengthening and quality of care and to guide public policy intelligently. Health systems researchers must carefully define their intent and goals and openly clarify the values that may influence the premises and design of protocols. As new types of population-level research activities become more commonplace, it is critical that institutional review board and research ethics committee review processes evolve to evaluate these research protocols in ways that address the nuanced features of these studies. (shrink)

We address in this paper the problem of counting the models of a propositional theory under incremental changes to its literals. Specifcally, we show that if a propositional theory Δ is in a special form that we call smooth, deterministic, decomposable negation normal form (sd-DNNF), then for any consistent set of literals S, we can simultaneously count (in time linear in the size of Δ) the models of Δ ∪ S and the models of every theory Δ ∪ T where (...) T results from adding, removing or flipping a literal in S. We present two results relating to the time and space complexity of compiling propositional theories into sd-DNNF. First, we show that if a conjunctive normal form (CNF) has a bounded treewidth, then it can be compiled into an sd-DNNF in time and space which are linear in its size. Second, we show that sd-DNNF is a strictly more space efficient representation than Free Binary Decision Diagrams (FBDDs). Finally, we discuss some applications of the counting results to truth maintenance systems, belief revision, and model-based diagnosis. (shrink)

Do causes necessitate their effects? Causal necessitarianism is the view that they do. One major objection—the “monotonicity objection”—runs roughly as follows. For many particular causal relations, we can easily find a possible “blocker”—an additional causal factor that, had it also been there, would have prevented the cause from producing its effect. However—the objection goes on—, if the cause really necessitated its effect in the first place, it would have produced it anyway—despite the blocker. Thus, CN must be false. Though different (...) from Hume’s famous attacks against CN, the monotonicity objection is no less important. In one form or another, it has actually been invoked by various opponents to CN, past and present. And indeed, its intuitive appeal is quite powerful. Yet, this paper argues that, once carefully analysed, the objection can be resisted—and should be. First, I show how its success depends on three implicit assumptions concerning, respectively, the notion of cause, the composition of causal factors, and the relation of necessitation. Second, I present general motivations for rejecting at least one of those assumptions: appropriate variants of them threaten views that even opponents to CN would want to preserve—in particular, the popular thesis of grounding necessitarianism. Finally, I argue that the assumption we should reject is the one concerning how causes should be understood: causes, I suggest, include an element of completeness that excludes blockers. In particular, I propose a way of understanding causal completeness that avoids common difficulties. (shrink)

Introduction : law, religion and the challenge of accommodation -- Muslim communities in a multicultural context -- Contextualishing Shari ̀ah : Shari ̀ah in the Common Law world -- Muslims, family relationships and the Common Law -- Muslims, crime and the Common Law -- Muslims, business transactions and the Common Law -- Conclusion.

Ways of Being Free: Introduction -- War Is Everything's Father: History and Death as Causes of Existential Angst -- Introduction: Causes of Existential Angst -- Change and Changelessness in Midnight's Children -- The Road of Existential Struggle in The Famished Road -- History and the "Nervous Condition" in The English Patient -- Death as a Drive to Meaningful Existence in Midnight's Children -- Becoming Dead-to-the-World in The English Patient -- Ideological Re-appropriation through Death in The Famished Road -- Authenticity -- (...) Authenticity: Introduction -- From Self-Sufficiency to Inoperative Community in The English Patient -- Revolution Revisited in The Famished Road -- From Communalism to the Comic Absurd in Midnight's Children. (shrink)

203 surveys were considered complete and were included in the analysis. Written consent was not used by nearly 40% of the researchers.

a relatively more sympathetic attitude among younger judges, many of them women, and among trainees, may reflect a historical evoluti.

This article draws attention to the limited amount of scholarship on what constitutes fairness and equity in resource allocation to health research by individual funders. It identifies three key decisions of ethical significance about resource allocation that research funders make regularly and calls for prioritizing scholarship on those topics – namely, how health resources should be fairly apportioned amongst public health and health care delivery versus health research, how health research resources should be fairly allocated between health problems experienced domestically (...) versus other health problems typically experienced by disadvantaged populations outside the funder's country, and how domestic and non-domestic health research funding should be further apportioned to different areas, e.g. types of research and recipients. These three topics should be priorities for bioethics research because their outcomes have a substantial bearing on the achievement of health justice. The proposed agenda aims to move discussion on the ethics of health research funding beyond its current focus on the mismatch between worldwide basic and clinical research investment and the global burden of disease. Individual funders’ decision-making on whether and to what extent to allocate resources to non-domestic health research, health systems research, research on the social determinants of health, capacity development, and recipients in certain countries should also be the focus of ethical scrutiny. (shrink)

ABSTRACT Introduction: Informed consent has been recognized as an important component of research protocols and procedures of disclosure and consent in collaborative research have been criticized, as they may not be in keeping with cultural norms of developing countries. This study, which is part of a larger project funded by the United States National Bioethics Advisory Commission, explores the opinions of developing country researchers regarding informed consent in collaborative research. Methods: A survey of developing country researchers, involved in human subject (...) research, was conducted by distributing a questionnaire with 169 questions, which included questions relating to informed consent. In addition, six focus group discussions, eight in‐depth interviews and 78 responses to open‐ended questions in the questionnaire provided qualitative data. Results: 203 surveys were considered complete and were included in the analysis. Written consent was not used by nearly 40% of the researchers in their most recent studies. A large proportion of respondents recommended that human subject regulations should allow more flexibility in ways of documenting informed consent. 84% of researchers agreed that a mechanism to measure understanding should be incorporated in research studies as part of the process of informed consent. Discussion: This paper is an empirical step in highlighting the ethical issues concerning disclosure. Health researchers in developing countries are well aware of the importance of consent in health research, and equally value the significance of educating human subjects regarding study protocols and associated risks and benefits. However, respondents emphasize the need for modifying ethical regulations in collaborative research. (shrink)

Several protective cellular mechanisms protect against the accumulation of reactive oxygen species (ROS) and the concomitant oxidative stress. Therefore, any reduction in glucose or fatty acid flux into cells leading to a decrease in the production of reducing equivalents would also lead to a decreased ROS production and protect cells against oxidative stress. In the presence of insulin, FOXO proteins are localized from the nucleus to the cytoplasm and degraded. An increase in cellular glucose uptake will lead to increased production (...) of ROS. This in turn activates the stress‐responsive Jun‐N‐terminal kinase (JNK), which promotes nuclear translocation of FOXO proteins, upregulating some important target genes including stress resistance. Consequently, insulin resistance should result in decreased cellular ROS production. For this reason, insulin resistance could be a physiological mechanism activated at the cellular level in response to conditions stimulating ROS production and leading to the prevention of oxidative stress, and extension of life. Concerning the whole organism, however, IR is a maladaptive process in the long term causing a diabetic state. BioEssays 29:811–818, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Despite the fact that in order to become a liveable space for humankind the world owes many things to the scientific point of view, to fill that space with meaning so that it can be our home, is only possible due to the aesthetic relation which man establishes with life. The meaning which is required so that man could make sense of this space can only be brought into this world through the fictional strength of language. Existence which in itself (...) alone is meaningless, indifferent and neutral can only become a stage where humanity dares to appear, thanks to the attributes that it gains through the act of making sense. By overlooking that point the theoretical approach which is symbolized by the Enlightenment destroys according to Nietzsche the basics of the relation between man and life. Today the scientific and technological Perspective which have become the forces of our culture and civilization have already withdrawn themselves from the question of the meaning of life to the point of ignoring its importance. On the other side, due to its natural mechanism, the advantage which the artistic approach possesses comes from the capacity to transform the reality through fiction. Hence, art is maybe one of the most important accomplishments which contributes to the creation of meaning so that man won't perish against this essential indifference of existence. (shrink)

Özgür istemeyi bir illüzyona dönüştüren deterministik öğelere sahip olan bir ideoloji içerisinde insan varoluşunun anlamsız ve saçma bir nitelik arz edeceğini düşünen Dostoyevski, Yeraltından Notlar’da kurguladığı yeraltı adamı karakteri aracılığıyla, doğa yasalarını temel alan ve Çernişevski gibi materyalist düşünürler tarafından savunulan toplumsal mühendislik fikrinin hiçbir şekilde uygulamaya konulmayacağını göstermek ister. Bunu gerçekleştirmek için dolaylı bir yol izleyen ve yeraltı adamı aracılığıyla determinist bir ideolojinin penceresinden dünyaya bakan bir karakter yaratan Dostoyevski, bu karakterin bakışından hareketle tüm insani edimlerin zorunlu bir nedensellik (...) tarafından belirlendiğini idrak eden bilincin verdiği irrasyonel, çelişkili ve bir anlamda saçma tepkileri gün yüzüne çıkarır. Karşıt olduğu öğretinin perspektifinden bir anlatı ortaya koyan Dostoyevski böylece materyalist bir determinizm ileri süren ideolojiyi adeta içeriden çürütmeye çalışır. Bu makalenin amacı Dostoyevski’nin Yeraltından Notlar’ını takip ederek, istemelerini, arzularını ve seçimlerini özgürce hayata geçiremeyeceğinin bilincine varan yeraltı adamının düştüğü çelişkili varoluşu irdelemek ve böylece determinist öğretilerin kabul edilmesi güç olan pratik sonuçlarını anlaşılır kılmaktır. (shrink)