Love is a universal experience that most people desire. A serious, long-term, and stigmatized illness makes entering and maintaining close relationships difficult, however. Ten persons, who have been diagnosed with schizophrenia, and lived with their illness for between years and decades of their lifetimes, shared their stories. They reported how the illness has influenced their emotional experiences regarding love and their intimate relationship experiences. We present here a qualitative Interpretative Phenomenological analysis (IPA) of their narratives. This analysis has been done (...) with an explicit intention to give voice to the patient’s perspective. The results highlight how illness adjustment and hospitalizations have an alienating effect on relationships through stigmatization and self-stigmatization; how illness creates psychological obstacles to love, such as diminished trust toward oneself and others; and how long-term patients experience practical difficulties in creating and sustaining relationships, such as poverty. Moreover, we show how patients experience changes in sexuality and the risks involved in it, and discuss possible coping strategies from their perspectives. (shrink)

Hand function improvement in stroke survivors in the chronic stage usually plateaus by 6 months. Brain-computer interface (BCI)-guided robot-assisted training has been shown to be effective for facilitating upper-limb motor function recovery in chronic stroke. However, the underlying neuroplasticity change is not well understood. This study aimed to investigate the whole-brain neuroplasticity changes after 20-session BCI-guided robot hand training, and whether the changes could be maintained at the 6-month follow-up. Therefore, the clinical improvement and the neurological changes before, immediately after, (...) and 6 months after training were explored in 14 chronic stroke subjects. The upper-limb motor function was assessed by Action Research Arm Test (ARAT) and Fugl-Meyer Assessment for Upper-Limb (FMA), and the neurological changes were assessed using resting-state functional magnetic resonance imaging. Repeated-measure ANOVAs indicated that long-term motor improvement was found by both FMA (F[2,26]= 6.367,p= 0.006) and ARAT (F[2,26]= 7.230,p= 0.003). Seed-based functional connectivity analysis exhibited that significantly modulated FC was observed between ipsilesional motor regions (primary motor cortex and supplementary motor area) and contralesional areas (supplementary motor area, premotor cortex, and superior parietal lobule), and the effects were sustained after 6 months. The fALFF analysis showed that local neuronal activities significantly increased in central, frontal and parietal regions, and the effects were also sustained after 6 months. Consistent results in FC and fALFF analyses demonstrated the increase of neural activities in sensorimotor and fronto-parietal regions, which were highly involved in the BCI-guided training.Clinical Trial Registration:This study has been registered atClinicalTrials.govwith clinical trial registration number NCT02323061. (shrink)