Abstract

Histopathological lung cancer segmentation using region of interest is one of the emerging research area in the field of health monitoring system. In this paper, the histopathological images were collected from the database Stanford Tissue Microarray Database (TMAD). After image collection, pre-processing was performed using a normalization technique, which enhances the quality of the histopathological image by eliminating unwanted noise. After pre-processing, segmentation was carried out using the modified kernel-based fuzzy c-means clustering (KFCM) approach along with the edge bridge and fill technique (EBFT). It was a flexible high-level machine learning technique to localize the object in a complex template. The experimental result shows that the proposed approach segments the normal and abnormal cancer regions by means of precision, recall, specificity, accuracy, and Jaccard coefficient. The proposed methodology improved the classification accuracy in lung cancer segmentation up to 2.5–5% compared to the existing methods deep convolutional neural network (DCNN) and diffusion-weighted approach.