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Comparing Drug Effectiveness at Health Plans: The Ethics of Cluster Randomized Trials
Hastings Center Report 38 (5):39-48 (2008)
Abstract
"Cluster randomized trials," in which groups of patients are randomly assigned to different therapeutic interventions, provide a powerful way of evaluating drugs. CRTs have not been widely used, in good part because of concerns about whether patients must give informed consent to participate in them. A better understanding of how CRTs fit into clinical practice resolves the concerns.Links
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Citations of this work
Ethics of Clinical Science in a Public Health Emergency: Drug Discovery at the Bedside.Sarah Jl Edwards - 2013 - American Journal of Bioethics 13 (9):3-14.
Alternative consent models for comparative effectiveness studies: Views of patients from two institutions.Nancy Kass, Ruth Faden, Rachel E. Fabi, Stephanie Morain, Kristina Hallez, Danielle Whicher, Sean Tunis, Rachael Moloney, Donna Messner & James Pitcavage - 2016 - AJOB Empirical Bioethics 7 (2):92-105.
Inequalities and Fairness in Cluster Trials.Erin Conrad & Sarah Jl Edwards - 2011 - Research Ethics 7 (2):58-65.
Social science and ethics review: A question of practice not principle.Stuart G. Nicholls, Jamie Brehaut & Raphae Saginur - 2012 - Research Ethics 8 (2):71-78.
Informed consent in cluster randomised trials: new and common ethical challenges.Sapfo Lignou - 2018 - Journal of Medical Ethics 44 (2):114-120.
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