Abstract

A concern for evidence can be viewed as a fundamental aspect of human existence. The biological structure of our bodies evolved during over thousands of years in which survival was predicated on a capacity to interpret small signs, such as crushed grass, smells, and sounds as evidence of the whereabouts of prey. The emergence of modern science and medicine was built on the ability to learn about what counted as evidence for what, and to observe it reliably. Evidence is information that matters. Drinking a glass of water because one feels thirsty is not evidence, unless there is a suspicion of an underlying condition for which water intake is a symptom. Appraisal of evidence is a complex task. It relies on the...