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Stochastic gene expression stabilization as a new therapeutic strategy for cancer
Bioessays 34 (3):170-173 (2012)
Abstract
Graphical AbstractCurrent differentiation therapies for cancer may not be effective because it might not be enough to only use molecules targeting chromatin remodelers. It may also be necessary to stabilize the re-expressed genes to convert malignant cells into benign ones.My notes
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Citations of this work
Tissue‐disruption‐induced cellular stochasticity and epigenetic drift: Common origins of aging and cancer?Jean-Pascal Capp & Frédéric Thomas - 2021 - Bioessays 43 (1):2000140.
Analytic philosophy for biomedical research: the imperative of applying yesterday's timeless messages to today's impasses.Sepehr Ehsani - 2020 - In P. Glauner & P. Plugmann (eds.), Innovative Technologies for Market Leadership - Investing in the Future. Springer. pp. 167-200.
References found in this work
Characterization of stem cells and cancer cells on the basis of gene expression profile stability, plasticity, and robustness.Kunihiko Kaneko - 2011 - Bioessays 33 (6):403-413.
Stochastic gene expression, disruption of tissue averaging effects and cancer as a disease of development.Jean-Pascal Capp - 2005 - Bioessays 27 (12):1277-1285.
Epigenetic cancer therapy: Proof of concept and remaining challenges.Cora Mund & Frank Lyko - 2010 - Bioessays 32 (11):949-957.
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