According to an argument by Colin Howson, the no-miracles argument is contingent on committing the base-rate fallacy and is therefore bound to fail. We demonstrate that Howson’s argument only applies to one of two versions of the NMA. The other version, which resembles the form in which the argument was initially presented by Putnam and Boyd, remains unaffected by his line of reasoning. We provide a formal reconstruction of that version of the NMA and show that it is valid. Finally, (...) we demonstrate that the use of subjective priors is consistent with the realist implication of the NMA and show that a core worry with respect to the suggested form of the NMA can be dispelled. (shrink)

Howson famously argues that the no-miracles argument, stating that the success of science indicates the approximate truth of scientific theories, is a base rate fallacy: it neglects the possibility of an overall low rate of true scientific theories. Recently a number of authors has suggested that the corresponding probabilistic reconstruction is unjust, as it concerns only the success of one isolated theory. Dawid and Hartmann, in particular, suggest to use the frequency of success in some field of research \ to (...) infer a probability of truth for a new theory from \. I here shed doubts on the justification of this and similar moves and suggest a way to directly bound the probability of truth. As I will demonstrate, my bound can become incompatible with the assumption specific testing and Dawid and Hartmann’s estimate for success. (shrink)

It is not uncommon in the history of science and philosophy to encounter crucial experiments or crucial objections the truth-value of which we are ignorant, that is, about which we suspend judgment. Should we ignore such objections? Contrary to widespread practice, I show that in and only in some circumstances they should not be ignored, for the epistemically rational doxastic attitude is to suspend judgment also about the hypothesis that the objection targets. In other words, suspension of judgment “propagates” from (...) the crucial objection to the hypothesis. In this paper I study under which conditions this phenomenon occurs, and discuss its significance for the topics of skepticism, scientific realism, and peer disagreement. (shrink)

First, I answer the controversial question ’What is scientific realism?’ with extensive reference to the varied accounts of the position in the literature. Second, I provide an overview of the key developments in the debate concerning scientific realism over the past decade. Third, I provide a summary of the other contributions to this special issue.

If well-designed, the results of a Randomised Clinical Trial can justify a causal claim between treatment and effect in the study population; however, additional information might be needed to carry over this result to another population. RCTs have been criticized exactly on grounds of failing to provide this sort of information Evidence, inference and enquiry. Oxford University Press, New York, 2011), as well as to black-box important details regarding the mechanisms underpinning the causal law instantiated by the RCT result. On (...) the other side, so-called In Silico Clinical Trials face the same criticisms addressed against standard modelling and simulation techniques, and cannot be equated to experiments Philosophy of molecular medicine: foundational issues in research and practice, Routledge, New York, 2017; Parker in Synthese 169:483–496, 2009; Parke in Philos Sci 81:516–536, 2014; Diez Roux in Am J Epidemiol 181:100–102, 2015 and related discussions in Frigg and Reiss in Synthese 169:593–613, 2009; Winsberg in Synthese 169:575–592, 2009; Beisbart and Norton in Int Stud Philos Sci 26:403–422, 2012). We undertake a formal analysis of both methods in order to identify their distinct contribution to causal inference in the clinical setting. Britton et al.’s study :E2098–E2105, 2013) on the impact of ion current variability on cardiac electrophysiology is used for illustrative purposes. We deduce that, by predicting variability through interpolation, ISCTs aid with problems regarding extrapolation of RCTs results, and therefore in assessing their external validity. Furthermore, ISCTs can be said to encode “thick” causal knowledge —as opposed to “thin” difference-making information inferred from RCTs. Hence, ISCTs and RCTs cannot replace one another but rather, they are complementary in that the former provide information about the determinants of variability of causal effects, while the latter can, under certain conditions, establish causality in the first place. (shrink)

The main purpose of this paper is to investigate various notions of empirical equivalence in relation to the two main arguments for realism in the philosophy of science, namely the no-miracles argument and the indispensability argument. According to realism, one should believe in the existence of the theoretical entities postulated by empirically adequate theories. According to the no-miracles argument, one should do so because truth is the the best explanation of empirical adequacy. According to the indispensability argument, one should do (...) so because the theoretical terms employed in the formulation of an empirically adequate theory are practically indispensable for the formulation of its empirical content. The no-miracles argument might be refuted if one can establish an underdetermination thesis to the effect that every theory has empirically equivalent rivals that are incompatible with each other. Insofar as truth cannot explain the empirical adequacy of two incompatible theories, there is an obvious conflict between the underdetermination thesis and the no-miracles argument. I show that, under certain assumptions, some but not all notions of empirical equivalence support the underdetermination thesis. The indispensability argument might be refuted if one can establish a dispensability thesis to the effect that, for any theory with a practical formulation, there is an empirically equivalent theory with a practical formulation in purely empirical terms. I show that some but not all notions of empirical equivalence support this thesis. (shrink)

Scientific realism, the position that successful theories are likely to be approximately true, is threatened by the pessimistic induction according to which the history of science is full of suc- cessful, but false theories. I aim to defend scientific realism against the pessimistic induction. My main thesis is that our current best theories each enjoy a very high degree of predictive success, far higher than was enjoyed by any of the refuted theories. I support this thesis by showing that both (...) the amount, and quality, of scientific evidence has increased enormously in the recent past, resulting in a big boost of success for the best theories. (shrink)