The complex bursting oscillation and bifurcation mechanisms in coupling systems of different scales have been a hot spot domestically and overseas. In this paper, we analyze the bursting oscillation of a generalized Duffing–Van der Pol system with periodic excitation. Regarding this periodic excitation as a slow-varying parameter, the system can possess two time scales and the equilibrium curves and bifurcation analysis of the fast subsystem with slow-varying parameters are given. Through numerical simulations, we obtain four kinds of typical bursting oscillations, (...) namely, symmetric fold/fold bursting, symmetric fold/supHopf bursting, symmetric subHopf/fold cycle bursting, and symmetric subHopf/subHopf bursting. It is found that these four kinds of bursting oscillations are symmetric. Combining the transformed phase portrait with bifurcation analysis, we can observe bursting oscillations obviously and further reveal bifurcation mechanisms of these four kinds of bursting oscillations. (shrink)