The thymus is a unique primary lymphoid organ that supports the production of self‐tolerant T‐cells essential for adaptive immunity. Intrathymic microenvironments are microanatomically compartmentalised, forming defined cortical, and medullary regions each differentially supporting critical aspects of thymus‐dependent T‐cell maturation. Importantly, the specific functional properties of thymic cortical and medullary compartments are defined by highly specialised thymic epithelial cells (TEC). For example, in the medulla heterogenous medullary TEC (mTEC) contribute to the enforcement of central tolerance by supporting deletion of autoreactive T‐cell (...) clones, thereby counterbalancing the potential for random T‐cell receptor generation to contribute to autoimmune disease. Recent advances have further shed light on the pathways and mechanisms that control heterogeneous mTEC development and how differential mTEC functionality contributes to control self‐tolerant T‐cell development. Here we discuss recent findings in relation to mTEC development and highlight examples of how mTEC diversity contribute to thymus medulla function. (shrink)

Claudian compares Eutropius in his consular robes to a monkey, dressed in silk to amuse dinner guests, but with his buttocks bare . The situation has not failed to attract the notice of scholars. Christiansen and Fargues called attention to the striking and original use of the monkey-simile . Alan Cameron has suggested that the present example is drawn from life: ‘Who can doubt that this was a typical dinner divertissement in the elegant circles of Claudian's day-or at least one (...) Claudian himself had witnessed?’ He cites E. R. Curtius's assertion that metaphorical apes are uncommon in ancient literature ; that may be relatively true, but when Demosthenes is entitled to address his opponent as similar licence in subsequent invective is unlimited. (shrink)