Transdisciplinarity includes the assumption that within new institutional settings, scientific research becomes more closely responsive to practical problems and user needs and is therefore often subject to considerable application pressure. This raises the question whether transdisciplinarity affects the epistemic standards and the fruitfulness of research. Case studies show how user-orientation and epistemic innovativeness can be combined. While the modeling involved in all cases under consideration was local and focused primarily on features of immediate practical relevance, it was informed by theoretical (...) insights from basic research. Conversely, industrial research turns out sometimes to produce theoretical understanding. These findings highlight an interactive relationship between science and technology (moderate emergentism), which is distinct from the traditional view of a one-sided dependence of technology on science (cascade model) and from the newly received independence account (emergentism). (shrink)

Rational drug design is a method for developing new pharmaceuticals that typically involves the elucidation of fundamental physiological mechanisms. It thus combines the quest for a scientific understanding of natural phenomena with the design of useful technology and hence integrates epistemic and practical aims of research and development. Case studies of the rational design of the cardiovascular drugs propranolol, captopril and losartan provide insights into characteristics and conditions of this integration. Rational drug design became possible in the 1950s when theoretical (...) knowledge of drug-target interaction and experimental drug testing could interlock in cycles of mutual advancement. The integration does not, however, diminish the importance of basic research for pharmaceutical development. Rather, it can be shown that still in the 1990s, linear processes of innovation and the close combination of practical and epistemic work were interdependent. (shrink)

Rational drug design is a method for developing new pharmaceuticals that typically involves the elucidation of fundamental physiological mechanisms. It thus combines the quest for a scientific understanding of natural phenomena with the design of useful technology and hence integrates epistemic and practical aims of research and development. Case studies of the rational design of the cardiovascular drugs propranolol, captopril and losartan provide insights into characteristics and conditions of this integration. Rational drug design became possible in the 1950s when theoretical (...) knowledge of drug-target interaction and experimental drug testing could interlock in cycles of mutual advancement. The integration does not, however, diminish the importance of basic research for pharmaceutical development. Rather, it can be shown that still in the 1990s, linear processes of innovation and the close combination of practical and epistemic work were interdependent. (shrink)

It is a widely shared view among philosophers of science that the theory-dependence (or theory-ladenness) of observations is worrying, because it can bias empirical tests in favour of the tested theories. These doubts are taken to be dispelled if an observation is influenced by a theory independent of the tested theory and thus circularity is avoided, while (partially) circular tests are taken to require special attention. Contrary to this consensus, it is argued that the epistemic value of theory-dependent tests has (...) nothing to do with the circularity or non-circularity of the test, but is instead based on the minimal empiricality and reliability of observations. Since theory-dependence does not in general prevent observations fulfilling these requirements, it should not be regarded as a phenomenon that is basically detrimental, but as neutral with respect to successful scientific knowledge gathering. (shrink)

In: M. Carrier, D. Howard & J. Kourany (eds), Science and the Social: Knowledge, Epistemic Demands, and Social Values, Pittsburgh: University of Pittsburgh Press (im Erscheinen).

Naturwissenschaftliche Beobachtungen hängen auf vielfältige Weise von wissenschaftlichen Theorien ab. Diese These der Theoriebeladenheit galt lange als der Sargnagel wissenschaftlicher Objektivität. Der Autor untersucht wahrnehmungstheoretische, sprachphilosophische und methodologische Aspekte der Theoriebeladenheit. Er kommt zum Ergebnis, dass die Theoriebeladenheit nur in beschränktem Umfang besteht und als solche den wissenschaftlichen Erkenntnisprozess fördert. Dies führt zu einem verbesserten Verständnis der Rolle von Beobachtungen in den Naturwissenschaften.

Scientific claims can be assessed epistemically in either of two ways: according to scientific standards, or by means of philosophical arguments such as the no-miracle argument in favor of scientific realism. This paper investigates the basis of this duality of epistemic assessments. It is claimed that the duality rests on two different notions of epistemic justification that are well-known from the debate on internalism and externalism in general epistemology: a deontological and an alethic notion. By discussing the conditions for the (...) scientific acceptability of empirical results, it is argued that intrascientific justification employs the deontological notion. Philosophical disputes such as those on scientific realism can by contrast be shown to rest on the alethic notion. The implications of these findings both for the nature of the respective epistemic projects and for their interrelation are explored. (shrink)

Indikatoren sind im Wissenschaftsmanagement und auch in der Wissenschaftspolitik breit und vielfältig im Einsatz. Einige exemplarische Verwendungsweisen aus meiner beruflichen Praxis im Strategiedezernat der Technischen Universität Darmstadt stellt dieser Beitrag vor. Ich zeige Beispiele aus der indikatorabhängigen Mittelverteilung, dem Qualitätsmanagement und aus Hochschulrankings.

Drug development regularly has to deal with complex circumstances on two levels: the local level of pharmacological intervention on specific target proteins, and the systems level of the effects of pharmacological intervention on the organism. Different development strategies in the recent history of early drug development can be understood as competing attempts at coming to grips with these multi-level complexities. Both rational drug design and high-throughput screening concentrate on the local level, while traditional empirical search strategies as well as recent (...) systems biology approaches focus on the systems level. The analysis of these strategies reveals serious obstacles to integrating the study of interventive and systems complexity in a systematic, methodical way. Due to some fairly general properties of biological networks and the available options for pharmaceutical intervention, drug development is captured in an obstinate methodological dilemma. It is argued that at least in typical cases, drug development therefore remains dependent on coincidence, serendipity or plain luck to bridge the gap between development methodology and actual therapeutic success. (shrink)

Industrial drug design methodology has undergone remarkable changes in the recent history. Up to the 1970s, the screening of large numbers of randomly selected substances in biological test system was often a crucial step in the development of novel drugs. From the early 1980s, such ‘blind’ screening was increasingly rejected by many pharmaceutical researchers and gave way to ‘rational drug design’, a method that grounds the design of new drugs on a detailed mechanistic understanding of the drug action. Surprisingly, however, (...) the chance-based method of random screening returned to center stage of industrial drug development in the 1990s in the form of ‘high-throughput screening’ (HTS). I will argue in this paper that this to-and-fro in the prominence of random screening comes with fundamental changes in the epistemic significance of chance experiments in pharmaceutical development. While up to the 1970s, random screening used to be chosen as an empirical search strategy primarily because suffi- cient knowledge of the mechanistic basis of drug action was lacking, it has turned with high-throughput screening into an experimental method that employs chance variation and testing to illuminate this mechanistic basis. As a consequence, research into the underlying mechanisms of drug action and the development of new drugs have become closely integrated. The rise of HTS therefore not only shows how chance experiments have assumed a new epistemic role in drug development. It also allows for a detailed study of the much debated emergence of a new relationship between scientific understanding and the development of technological artifacts. (shrink)