Systems biology is largely tributary to genomics and other “omic” disciplines that generate vast amounts of structural data. “Omics”, however, lack a theoretical framework that would allow using these data sets as such (rather than just tiny bits that are extracted by advanced data-mining techniques) to build explanatory models that help understand physiological processes. Systems biology provides such a framework by adding a dynamic dimension to merely structural “omics”. It makes use of bottom-up and top-down models. The former are based (...) on data about systems components, the latter on systems-level data. We trace back both modeling strategies (which are often used to delineate two branches of the field) to the modeling of metabolic and signaling pathways in the bottom-up case, and to biological cybernetics and systems theory in the top-down case. We then argue that three roots of systems biology must be discerned to account adequately for the structure of the field: pathway modeling, biological cybernetics, and “omics”. We regard systems biology as merging modeling strategies (supplemented by new mathematical procedures) from data-poor fields with data supply from a field that is quite deficient in explanatory modeling. After characterizing the structure of the field, we address some epistemological and ontological issues regarding concepts on which the top-down approach relies and that seem to us to require clarification. This includes the consequences of identifying modules in large networks without relying on functional considerations, the question of the “holism” of systems biology, and the epistemic value of the “systeome” project that aspires to become the cutting edge of the field. (shrink)

This Festschrift in honour of Werner G. Jeanrond, currently Master of St Benet's Hall, University of Oxford, UK, investigates the challenge of alterity for Christianity, exploring and elaborating on this core concern in Jeanrond's hermeneutical theology. Blurring disciplinary boundaries, more than thirty of Jeanrond's colleagues and companions from ten countries track the dynamics of difference driven by the encounter with the self as other, the other as other, and God as the radical other. Who is my other? What do (...) I encounter when I encounter my other? And what responses and responsibilities does the encounter with my other evoke? Grappling with questions like these, the contributions to this compilation analyse alterity in the Bible, alterity in philosophy, alterity in theology, alterity in interreligious dialogues, and the radical alterity of God. Tying in with Jeanrond's explorations of the many faces and facets of the other, this Festschrift ultimately aims to advocate openness to the other as a necessity for both religion and reflections on religion. (shrink)

Visual conscious perception could be grounded in a nonconscious sensorimotor domain. Although invisible, information can be processed up to the level of response activation. Moreover, these nonconscious processes are modified by actual intentions. This notion bridges a gap in the theoretical framework of O'Regan & Noë.

Karl Jaspers zählt zu den bedeutendsten Philosophen des 20. Jahrhunderts. Obwohl es bereits eine international etablierte Jaspersforschung gibt, haben die meisten seiner Werke jedoch noch keinen angemessenen Eingang in die historische und systematische Lehre der Philosophie gefunden. Diese Aufsatzsammlung gibt erstmals einen Einblick in die wichtigsten Begriffe seines philosophischen Denkens. Zu diesen Begriffen gehören Begriffe wie Grenzsituation, Freiheit, Menschenbild, Kommunikation, Philosophischer Glaube, Chiffre, Böses, Wahrheit, Vernunft, Gehäuse, Wissenschaft, Logik, Sprachphilosophie, Psychopathologie, Psychologie der Weltanschauung, Ethik, Einsamkeit, Erziehung, Politik, Universität, Achsenzeit, Philosophia (...) perennis und interkulturelle Philosophie. Einige dieser Begriffe wurden von Jaspers geprägt und gingen dauerhaft als neue Begriffe in die Philosophie, die Psychologie und die Psychopathologie ein. Die anderen Begriffe knüpfen zwar dem Wortlaut nach an die klassische Tradition der europäischen Philosophie an, wurden von Jaspers jedoch im Sinne einer Weltphilosophie umgestaltet und erweitert. Dieser Sammelband ist nicht nur ein einführendes Kompendium für Studierende der Philosophie, der verschiedenen Theologien der Weltreligionen sowie der Sozial- und Kulturwissenschaften. Er kann auch philosophisch Interessierten den Zugang zur Philosophie von Jaspers erleichtern. (shrink)

In einer kühnen Metapher haben einst Hieronymus, Erasmus und Luther die Heilige Schrift als ein Labyrinth bezeichnet, das die Leser bei fortgesetztem Lesen in eine sich sogar steigernde Verwirrung stürze. Beinah im selben Atemzug wird eben dieselbe Heilige Schrift von eben denselben Autoren als der einzige Faden gepriesen, der die Leser aus dem Labyrinth ihres Lebens herausführe. Eines und dasselbe als Labyrinth und als Faden: Diese Figur ist paradigmatisch. Im Labyrinth der Ethik geht es nicht anders zu. Nur wer sich (...) ihm überläßt, findet aus ihm heraus. 24 Beiträge von namhaften Theologen und Theologinnen zur Theologischen Ethik finden sich in den fünf Abschnitten des vorliegenden Buches, das nacheinander "Biblische Grundlagen", "Theologische Systematik", "Ethische Modelle", "Ethische Leitbegriffe" und "Ethik und die Religionen" behandelt: Hans-Dieter Bastian: Zwischen Glauben und Handeln: Bibel-Lesen - Werner H. Schmidt: Glaube und Handeln. Aspekte des Alten Testaments - Wolfgang Schrage: Der 1. Korintherbrief als Paradigma paulinischer Ethik - Michael Wolter: Der Kompromiß bei Paulus - Jörg Haustein: Beobachtungen zum Schriftverständnis ökumenischer Dokumente - Gerhard Sauter: "Schrifttreue" in ethischer Urteilsbildung Günter Bader: Handeln im Namen Gottes - Erich Gräßer: Die ersten und die letzten Dinge. Bemerkungen zur theologischen und ethischen Schöpfungswahrnehmung - Marcin Hintz: Glaube, Tradition, Vernunft: Auf den Spuren theologischer Urteilsbildung im polnischen Protestantismus - Rolf Schäfer: Christliche Glaubens- und Sittenlehre bei Schleiermacher - Karl-Wilhelm Dahm: Herausforderungen für Selbstverständnis und Rolle des protestantischen Pfarrers im Zuge des Modernisierungsprozesses Traugott Jähnichen: Sozialethik auf dem Weg der Ausbildung von Bereichsethiken - Historische Traditionen und perspektivische Herausforderungen - Ulrich Eibach: Christengemeinde und christliches Leben und Handeln in der pluralistischen Gesellschaft - Ludger Honnefelder: Gesundheit unser "höchstes Gut"? Wertentscheidungen im Rahmen der Ressourcenallokation im Gesundheitswesen - Jörg Hübner: Kollektives Handeln im Zeitalter der Globalisierung. Perspektiven für eine zukünftige politische Ethik - Gottfried Hütter: Menschenwürde und Menschenrechte für Tiere? - Tobias Schlingensiepen: Adam, wo bist du? Die Entkontextualisierung menschlichen Lebens als Problem u. Herausforderung evangelischer Ethik Edgar Thaidigsmann: "Ehrfurcht vor dem Leben". Das Problem der Begründung einer Ethik der Verantwortung für das Lebendige bei Albert Schweitzer und Hans Jonas - Konrad Stock: Laster - der "vielnamige Frevel". Eine theologische Erinnerung an ein vergessenes Problem - Ulrich H. J. Körtner: Bildung und Wertebewußtsein. Anmerkungen zum Wertbegriff in der aktuellen Bildungsdiskussion - Hans G. Ulrich: Güter oder Werte? Zur Aufgabe der Theoriebildung in der evangelischen Sozialethik - Hartmut Kreß: Toleranz als Verpflichtung protestantischer Ethik Hans Waldenfels: Unterwegs zu einer interreligiösen Theologie - Sung-Hee Lee-Linke: Interreligiöse Ethik. Ein Modell für die Zukunft? (shrink)

Gutes und Guter, Leben, Leib, Tugend - in diesem Band werden die Vortrage der ersten vier Symposien der Mainz Moral Meetings aus den Jahren 2009-2011 zu diesen Themen zusammengefasst. Ein interdisziplinarer Zugang durch Bibelwissenschaft, Judaistik, Altphilologie, Philosophie, Patristik, Systematische Theologie und weiteren Disziplinen eroffnet einen Blick auf die ethischen Normen des fruhen Christentums. Die Autoren der Beitrage fragen nach den Moglichkeiten von Norm und Normbegrundung einer fruhchristlichen Ethik in ausgewahlten Bereichen sowohl im Kontext antiker Philosophie als auch in gegenwartiger Verantwortung. (...) Mit Beitragen von: Jochen Althoff, Frederick D. Aquino, Wilhelm Blumer, Maximilian Forschner, Christian Hengstermann, Christoph Horn, Friedrich W. Horn, David Horrell, Manfred Lang, Sebastian Moll, Maren Niehoff, Jorg Roder, Eckart David Schmidt, Nikolaus Schneider, Lorenzo Scornaienchi, Notger Slenczka, Mira Stare, Gerd Theissen, Ulrich Volp, Jan G. van der Watt, Werner Zager, Ruben Zimmermann. (shrink)

Nicht nur mit Engelszungen: Beiträge zur semitischen Dialektologie—Festschrift für Werner Arnold zum 60. Geburtstag. Edited by Renaud Kuty; Ulrich Seeger; and Shabo Talay. Wiesbaden: Harrassowitz Verlag, 2013. Pp. xx + 412. €118.

Modal dispositionalists hold that dispositions provide the foundation of metaphysical necessity and possibility. According to the kind of modal dispositionalism that can be found in the present literature, a proposition p is possible just in case some things are disposed to be such that p. In the first part of this paper I show that combining this classic form of dispositionalism with the assumptions that the laws of nature are necessary and deterministic and that all dispositions are forward-looking in time (...) leads to the unattractive conclusion that every truth is necessary. I argue that the classic dispositionalist should be troubled by this result and in the second part of the paper I suggest a novel variant of dispositionalism that avoids it. This extended form of dispositionalism allows that some propositions are only indirectly underwritten by dispositions. (shrink)

Das Buch weist die Fruchtbarkeit einer strukturgenetisch fundierten Rekonstruktionsperspektive für die Analyse der historisch und kulturell differenten Weltbilder nach. Anhand der für die Geschichte der Denksysteme zentralen Vorstellungen über die Natur-Kultur-Differenz und die physikalische Kausalität werden Reichweite und Grenzen der These einer universalen Entwicklungslogik kritische geprüft. Die historischen Studien bieten dabei einen neuartigen Blick auf die Aristotelische Physik und ihre mittelalterlichen Fortentwicklungen. Schließlich werden die materialen Ergebnisse in Richtung einer differenztheoretisch orientierten Theorie der Entstehung des Neuen in der Entwicklung ausgedeutet.

Plato's dialogues frequently criticize traditional Greek myth, yet Plato also integrates myth with his writing. Daniel S. Werner confronts this paradox through an in-depth analysis of the Phaedrus, Plato's most mythical dialogue. Werner argues that the myths of the Phaedrus serve several complex functions: they bring nonphilosophers into the philosophical life; they offer a starting point for philosophical inquiry; they unify the dialogue as a literary and dramatic whole; they draw attention to the limits of language and the (...) limits of knowledge; and they allow Plato to co-opt cultural authority as a way of defining and legitimating the practice of philosophy. Platonic myth, as a species of traditional tale, is thus both distinct from philosophical dialectic and similar to it. Ultimately, the most powerful effect of Platonic myth is the way in which it leads readers to participate in Plato's dialogues and to engage in a process of self-examination. (shrink)

Presents German physicist Werner Heisenberg's 1958 text in which he discusses the philosophical implications and social consequences of quantum mechanics and other physical theories.

Affective congruency effects in the evaluation task can be explained by either spreading of activation or response competition. Eliminating effects of response compatibility by using other tasks (semantic categorisation, naming task) typically also eliminates affective congruency effects. However, there is no need for processing the affective information of the stimuli in these tasks either, which could be necessary for an affectively mediated spreading of activation (Spruyt et al., 2007, 2009, 2012). We introduced a new task to further test this hypothesis. (...) The valent/neutral-categorisation task does not confound affective congruency with response compatibility, but still requires a processing of the stimuli's valence. No affective congruency effect was obtained with this task in two experiments, disfavouring a conditional spreading activation account. On the other hand, a significant priming effect was found for associated word pairs in Experiment 1, providing evidence for the sensitivity of the task to detect spreading activation processes. (shrink)

This paper argues that institutions are higher-level autonomous systems enacted by patterns of participatory sense-making. Therefore, unlike in the standard equilibrium theory, institutions are not themselves thought of as behavioural patterns. Instead, they are problem domains that these patterns have brought forth. Moreover, these are not merely any patterns, but only those devoted to maintaining a specific strategy of problem solving, called the strategy of ‘letting be’. The latter refers to, following Hanne de Jaegher, a balance between underdetermination and overdetermination (...) of individual behaviour by a collective. Such an understanding of institutions becomes an option once a hybrid ‘equilibrium + rules’ theory of institutions, such as the one proposed by Frank Hindriks, is supplemented with insights from enactivism. In this light, drawing a connection between these two areas is the additional, meta-theoretical goal of this paper. This connection is beneficial, I argue, in particular since it allows for a satisfactory, in-depth account of the normative character of institutions as well as their local character. (shrink)

Die politische Ideengeschichte kennt nicht viele Autoren, die derart umstritten sind, wie der Abbé Sieyés: Für manche Interpreten ist er Wegbereiter des Jakobiner-Terrors, für andere dagegen der Vater des parlamentarischen Regierungssystems unserer Zeit. Der vorliegende Band unterzieht diese und ähnliche Klischees einer kritischen Prüfung.

Schon seit ihrer Gr ndung in den 1970er-Jahren ist die Reihe Germanistische Linguistik (RGL) exponiertes Forum des Faches, dessen Namen sie im Titel f hrt. Hinsichtlich der thematischen Breite (Sprachebenen, Variet ten, Kommunikationsformen, Epochen), der Forschungsperspektiven (Theorie und Empirie, Grundlagenforschung und Anwendung, Inter- und Transdisziplinarit t) und des methodologischen Spektrums ist die Reihe offen angelegt. Das Aufgreifen neuer Trends hat in ihr ebenso Platz wie das Fortf hren von Bew hrtem. Die Publikationsformen reichen von Monographien und Sammelb nden bis zu (...) W rterb chern. Wissenschaftlicher Beirat (ab November 2011): Prof. Dr. Karin Donhauser (Berlin) Prof. Dr. Stephan Elspa (Augsburg) Prof. Dr. Helmuth Feilke (Gie en) Prof. Dr. J rg Fleischer (Marburg) Prof. Dr. Stephan Habscheid (Siegen) Prof. Dr. R diger Harnisch (Passau). (shrink)

This paper discusses a puzzle raised by Sharon Berry, published in Analysis. The question in the background of this puzzle is how we should deal with seemingly plausible possibility judgements that commit us to counterfactual truths that find no basis in reality. Three answers to this question and their corresponding solutions to the puzzle will be discussed. The last answer provides a way to make sense of the claim that it is in some cases indeterminate whether a proposition is possible (...) and offers an account of indeterminate modal status. (shrink)

This paper defends three theses: that presentism is either trivial or untenable; that the debate between tensed and tenseless theories of time is not about the status of presentism; and that there is no temporal analogue of the modal thesis of actualism.

The explanation of animal communication by means of concepts like information, meaning and reference is one of the central foundational issues in animal behaviour studies. This book explores these issues, revolving around questions such as: • What is the nature of information? • What theoretical roles does information play in animal communication studies? • Is it justified to employ these concepts in order to explain animal communication? • What is the relation between animal signals and human language? The book approaches (...) the topic from a variety of disciplinary perspectives, including ethology, animal cognition, theoretical biology and evolutionary biology, as well as philosophy of biology and mind. A comprehensive introduction familiarises non-specialists with the field and leads on to chapters ranging from philosophical and theoretical analyses to case studies involving primates, birds and insects. The resulting survey of new and established concepts and methodologies will guide future empirical and theoretical research. (shrink)

The article examines philosophical conceptions of responsibility found in the contributions of Martin Buber, Hans Jonas and Emmanuel Levinas. It argues that, despite the significant differences of these contributions, they all share important goals, significant structural features, and corresponding challenges. All three thinkers try to overcome the solipsistic limitations of Edmund Husserl’s phenomenology as well as the egocentrism of Heidegger’s concept of "solicitude" or "self-care." All three try to overcome the Kantian subject-object dichotomy. All three understand responsibility as a bipolar (...) relation only. In consequence, all of them face similar challenges resulting from new forms of dichotomies and the exclusion of “thirdness” that are the result of their conceptual decisions. (shrink)

Much recent work on natural information has focused on probabilistic theories, which construe natural information as a matter of probabilistic relations between events or states. This paper assesses three variants of probabilistic theories (due to Millikan, Shea, and Scarantino and Piccinini). I distinguish between probabilistic theories as (1) attempts to reveal why probabilistic relations are important for human and non-human animals and as (2) explications of the information concept(s) employed in the sciences. I argue that the strength of probabilistic theories (...) lies in the first project. Probability-raising can enable organisms to draw specific inferences they otherwise could not entertain and I show how exactly they help to explain the behaviour of organisms. In addition, probability-raising warrants inferences by providing incremental inductive support. (shrink)