uBiome offers a gut bacteria sequencing service to consumers to entice data donation. It aims to establish a genomic repository for microbiomics. In 2013, some bloggers worried that uBiome operations had not received any Institutional Review Board ethics approval. uBiome co-founders Richman and Apte replied by effectively arguing that crony research agencies hamper innovation by requiring cumbersome for-fee IRBs to so-called “citizen science” projects. The debate soon ascended from ethics to appropriate institutional design for research and innovation. I reconstruct the (...) ethical issues underpinning the uBiome-IRB debate and situate them in the emerging context of entrepreneurial science relying on crowdsourcing. This paper contributes to the dialogue between social scientists and bioethicists promoted in this volume by offering an analysis of a case study that requires attention to the organizational and economic context and lends itself to collaboration across disciplines. (shrink)

Recent evidence of intergenerational epigenetic programming of disease risk broadens the scope of public health preventive interventions to future generations, i.e. non existing people. Due to the transmission of epigenetic predispositions, lifestyles such as smoking or unhealthy diet might affect the health of populations across several generations. While public policy for the health of future generations can be justified through impersonal considerations, such as maximizing aggregate well-being, in this article we explore whether there are rights-based obligations supervening on intergenerational epigenetic (...) programming despite the non-identity argument, which challenges this rationale in case of policies that affect the number and identity of future people. We propose that rights based obligations grounded in the interests of non-existing people might fall upon existing people when generations overlap. In particular, if environmental exposure in F0 will affect the health of F2 through epigenetic programming, then F1 might face increased costs to address F2's condition in the future: this might generate obligations upon F0 from various distributive principles, such as the principle of equal opportunity for well being. (shrink)

A proper understanding of the moral and political significance of migration requires a focus on global inequalities. More specifically, it requires a focus on those global inequalities that affect people’s ability to participate in the production of economic goods and non-economic goods. We call cooperative infrastructures the complex material and immaterial technologies that allow human beings to cooperate in order to generate human goods. By enabling migrants to access high-quality cooperative infrastructures, migration contributes to the diffusion of technical and socio-political (...) innovations. In this way, it positively affects the ability of individuals from poorer countries to participate in the production of human goods, to benefit from such production, and to contribute to human development. Migration can also damage the material and immateri al components of the cooperative infrastructures accessible in both the host and sending countries; these potential downsides of migration should not be ignored, although arguably they can often be neutralized, alleviated, or compensated. (shrink)

Crowdfunding is increasingly common in medical research. Some critics are concerned that by adopting crowdfunding, some researchers may sidestep the established systems of review of the social and scientific value of studies, especially mechanisms of expert-based review. I argue firstly that such concerns are based on a misleading picture of how research value is assessed and secondly that crowdfunding may turn out to be an useful complement of extant funding systems. I start with the idea that medical knowledge is a (...) structured and intermediate public good and explain from this perspective that funding systems as a whole, rather than any of their parts ought to be considered devices for the discovery of the social and scientific value of research. If so, we should not be concerned with whether crowdfunding bypasses expert reviews, but with whether it may constitute an improvement of extant funding systems. In the second part, I speculate that crowdfunding may ameliorate, albeit limitedly, some recalcitrant failures of funding systems, such as the sponsorship of research on neglected diseases, and smooth funding adaptations for scientific transitions. If, after trial, such hypotheses turn out to be true, crowdfunding ought to be promoted. (shrink)

Are humans a domesticated species? How is this issue related to debates on the roles of human agency in human evolution? This article discusses four views on human domestication: Darwin’s view; the view of those who link human domestication to anthropogenic niche construction and, more specifically, to sedentism; the view of those who link human domestication to selection against aggression and the domestication syndrome; and a novel view according to which human domestication can be conceived of in terms of a (...) process of political selection. The article examines and compares these views to illustrate how discussions of human domestication can contribute to debates about how, and to what extent, human agency has affected human evolution. (shrink)

Migration often causes what I refer to in this paper as ‘anti-immigration backlashes’ in receiving countries. Such reactions have substantial costs in terms of the undermining of national solidarity and the diffusion of political distrust. In short, anti-immigration backlashes can threaten the social and political stability of receiving countries. Do such risks constitute a reason against permissive immigration policies which are otherwise desirable? I argue that a positive answer may depend on a skeptical view based on the alleged constraints that (...) certain political facts - especially facts about human nature - pose on political intervention. This view does not stand conceptual and empirical scrutiny in the case of anti-immigration backlashes, where feasibility comes in degree. Yet focusing on the recalcitrance to change of these facts is practically important when devising action plans. This pragmatic core of the skeptical view yields a gradualist and naturalistic way of thinking about constraints in political theorising about migration, and elsewhere. (shrink)

Recent epidemiological reports of associations between socioeconomic status and epigenetic markers that predict vulnerability to diseases are bringing to light substantial biological effects of social inequalities. Here, we start the discussion of the moral consequences of these findings. We firstly highlight their explanatory importance in the context of the research program on the Developmental Origins of Health and Disease (DOHaD) and the social determinants of health. In the second section, we review some theories of the moral status of health inequalities. (...) Rather than a complete outline of the debate, we single out those theories that rest on the principle of equality of opportunity and analyze the consequences of DOHaD and epigenetics for these particular conceptions of justice. We argue that DOHaD and epigenetics reshape the conceptual distinction between natural and acquired traits on which these theories rely and might provide important policy tools to tackle unjust distributions of health. (shrink)

According to some evolutionary theorists human prosocial dispositions emerged in a context of inter-group competition and violence that made our psychology parochially prosocial, ie. cooperative towards in-groups and competitive towards strangers. This evolutionary hypothesis is sometimes employed in bioethical debates to argue that human nature and contemporary environments, and especially large-scale societies, are mismatched. In this article we caution against the use of mismatch theories in moral philosophy in general and discuss empirical evidence that puts into question mismatch theories based (...) on parochial prosociality. Evolutionary mismatch theories play at best a rhetorical role in these moral debates and may misrepresent the status of relevant evolutionary research. We finally recommend that moral philosophers interested in the evolutionary literature also engage with dispositions such as xenophilia and social tolerance to counterbalance the focus on psychological mismatches adopted so far. (shrink)

In this paper we argue that there is a duty to inform consumers about the environmental impact of foods, and discuss what this duty entails and to whom it falls. We analyze previous proposals that justify ethical traceability with arguments from sustainability and the respect for the autonomy of consumers, showing that they cannot ground a duty to inform. We argue instead that the duty rests on the right of consumers not to be harmed, insofar as consumers have an interest (...) in the morality of their own agency that is frustrated if they are not informed about the environmental impact of the production and transport of what they consume. Our argument detaches the regulation of labeling from substantive theories of environmental ethics or perfectionist conceptions of citizens’ responsibility, thus defending a case for labeling that is compelling also for those who take the role of the state to be limited to the prevention of harm. (shrink)

Este artículo estudia los números de la Revista de Psicoanálisis publicados entre 1946 y 1955 en Argentina. En particular, analiza los artículos escritos por los psicoanalistas argentinos que allí aparecen y las notas e informaciones que se incluyen en las últimas páginas de la revista. Se propone, por un lado, rastrear qué es el psicoanálisis en esos años, pensando este saber como un objeto discursivo, y, por el otro, indagar sobre el modo en que se construye la comunidad discursiva psicoanalítica (...) de la APA. Este recorrido ha evidenciado, por un lado, que el psicoanálisis es entendido, en ese entonces, como una teoría científica y una práctica contigua a la práctica médica, limitado al tratamiento individual. Por el otro, ha identificado que la revista, además de constituir un medio de comunicación privilegiado para la institución, contribuye a la consolidación de la comunidad discursiva psicoanalítica. (shrink)

Dopo aver svelato parte della storia e dell’attività di Giulio Sambon (1837-1921) con la sua «Impresa di Vendite in Italia» a Milano, Firenze, Roma e Napoli,1 si propone un approfondimento sul suo incontro con il mercante d’arte Francesco Molinari (1813-1866). Quest’ultimo, attivo in Italia e probabilmente anche in Europa, si colloca nel panorama del collezionismo milanese della seconda metà dell’Ottocento con una particolare attenzione alle opere d’arte lombarda, configurandosi un crocevia ancora non indagato del secolo dei conoscitori. L’occasione che ha (...) portato i due mercanti ad avvicinarsi è stata la chiusura del negozio che Molinari aveva a Milano, per la cui occasione questi chiama Sambon per allestire un’asta con quanto ancora in esposizione. L’episodio diventa l’inizio della dispersione di una raccolta che conta più di 350 opere, documentata attraverso cataloghi d’asta e certificati d’esportazione che mischiano informazioni di carattere storico-artistico e di gusto. (shrink)

The evolution of Interaction Design could be read as a radicalization of the dogma of modern functionalism, Less is More, and a "rediscovery" of certain theories of Minimal Art. This radicalization is reflected in the same evolution that has taken place since the early Nineties within the Human-Computer Interaction, with the gradual replacement of User Experience as a major category of interaction design. Designing the interactive experience becomes more important than Usability. But if the experience becomes the specific object of (...) design, the materiality of the object, its shell, loses its importance. The evolution of design, through the spread of computing, leads to a pervasive dematerialization of everyday objects. (shrink)

Computing has become ubiquitous and organic. The “new” human ecosystem is increasingly composed of "intelligent" objects. Since the Nineties there has been a constant application of the practice of disappearance of everyday objects. The daily experience changes, since the objects we use, in their disappearance and imperceptibility, do not divide us from the Life-World. At the same time, the designer is called to rewrite and amplify human experience, and design reflects a different conception of the aesthetic, which must be intended (...) not only as a theory of the artistic and/or cosmetic beauty, but mainly as a science of the experience as such. The designer is no longer limited to designing objects, but he can also design human beings. (shrink)

En este artículo se hace una crítica de los enfoques teóricos, aquí llamados por analogía o analógicos, que pretenden abstraer conceptos darwinistas del sustrato biológico para aplicarlos a dominios ontológicos (parcialmente) distintos, estrategia adoptada por versiones de la epistemología evolutiva y, sobre todo, por la teoría memética. Para ello se utiliza el argumento de la exclusión causal, tomado en préstamo de la filosofía de la mente; se hace evidente la existencia de un paralelismo entre causalidad mental y memética, y se (...) muestra cómo cualquier posible caracterización de la segunda a partir de la primera conduce a graves problemas metafísicos y epistemológicos. En las conclusiones se esbozan, sin intención de exhaustividad, algunas ideas sobre cómo evitar posiciones reduccionistas sin adoptar una postura teórica analógica. The main purpose of this paper is criticize theoretical approaches -here called by analogy, or analogical- which aim to extract Darwinian concepts from a biological substrate to apply them to (partially) different ontological domains. This strategy is adopted by some versions of evolutionary epistemology and, especially, by memetics theory. An argument borrowed from philosophy of mind, namely, the argument of causal exclusion, is used to carry out the critique. The existence of a parallelism between memetics and mental causation will be shown, and it will be argued that any possible characterization of the first in terms of the second implies serious metaphysical and epistemological problems. In the conclusions, with no intention of completeness, some ideas on how to avoid reductionist positions, without taking an analogical posture, will be outlined. (shrink)

RESUMEN La pesquisa tuvo como objetivo precisar las prácticas que caracterizan la elaboración de los fundamentos teóricos en las investigaciones en ciencias pedagógicas. A partir de una muestra de artículos publicados en revistas científico pedagógicas certificadas, se evaluó la actualidad de la bibliografía empleada, su correspondencia con el objeto de la investigación, las relaciones de contenido por la naturaleza de los referentes, el lugar de la cultura en el análisis de esos referentes, y la capacidad del autor para captar esencias. (...) El resultado alcanzado fue la precisión de las tendencias predominantes en la elaboración del marco teórico, frecuentemente caracterizada por la dispersión conceptual y teórica. ABSTRACT The study was aimed at identifying the educational researchers' current practice in constructing theoretical framework. By comparing a sample of articles published in well-established education scientific journals, the authors appraise the update character or references, its correspondence to the research objective, the redundant, developmental or contrasting character of references included the place of culture in the framework construction and the researchers' capacity to figure out salient points and conclusions. The main finding is the identification of current trends in framework construction mainly characterized by a scattering of concepts and theories. (shrink)

1 Introduzione Per Searle, la realtà sociale è un enorme ontologia invisibile che comprende obblighi, promesse, matrimoni, proprietà, governi e in generale tutti quegli enti che non sono solamente fisici, tangibili, ma neppure esclusivamente mentali, privati. Alla sua base c’è la capacità intrinseca all’uomo di attribuire funzioni agli oggetti che lo circondano. La costruzione della realtà sociale è precisamente un processo attraverso il quale l’intenzionalità umana dispone della possibilità,...

Within Nicholas de Cusa's philosophical approach, there is bound to be a level of unity lower than the one pertaining to God as such but higher than those of common creatures. The intermediate level belongs to the Intellect and is characterized by an affirmative coincidence of opposites hinging around universal equality. Such intellectual equality among all things, as they are in the Intellect, constitutes the root of number and multiplicity.

En este artículo propongo denominar insondable al concepto de pensar en Heidegger para referirme tanto al pensar como acontecimiento, como a aquello a lo que se refiere el pensar. Se trata, por una parte, del pensar pensante, reflexionante, meditativo que se da precisamente en el tránsito que va de una metafísica de la representación al pensamiento que ha de pensar la verdad del ser. Pero lo insondable hace referencia también al qué del pensar, al misterio del ser que es siempre (...) el misterio de una donación abierta que no se deja encapsular en el férreo dogmatismo de ningún sistema. Lo primero nos sitúa ante el final de la filosofía tal y como ha sido concebida hasta ahora. Lo segundo, ante el inicio de un pensar auténtico del ser que, en nuestra opinión, es a la vez contemplativo y crítico y a la vez que posibilita renovar la relación del hombre con el mundo, con lo ente, marcada por la serenidad consecuente con el cuidado. (shrink)

RESUMEN Frente a la hybris de la subjetividad que culmina en el proyecto moderno-humanista, surge la necesidad de pensar de otra manera la esencia del hombre ya sin el lastre de toda la tradición filosófica occidental. Este viraje que Heidegger imprime al pensar se explica aquí desde lo que denomino tesis para la reconstrucción de un posthumanismo en la perspectiva de la kénosis y que se resume en: la superación de las leyes de la gramática y el acento en el (...) decir poético; el reconocimiento del mientras tanto de la existencia humana finita siempre en camino; y, por último, el preciso abajamiento del pensar tal y como corresponde no ya a la incontestable potestad del señor del ente sino a la esencial pobreza del pastor. ABSTRACT Before the hybris of subjectivity that culminates in the modern-humanist project, there arises the need to think the essence of man, in another way, a way already without the burden of the entire western philosophical tradition. This turn that Heidegger gives to thinking is here explained from what I call: thesis for the reconstruction of post-humanism in the perspective of kenosis, which can be summarized as overcoming the laws of grammar and accent in the poetic saying, recognition of a meanwhile of the finite human existence always on its way and, finally, the precise reduction of thinking as it corresponds not to the power of the lord of the being but to the essential shepherd’s poverty. (shrink)

Intento del presente saggio è quello di tracciare le linee principali della filosofia di Wittgenstein definendone l’orizzonte operativo e la strategia d’azione. Seguiremo inizialmente i cambiamenti nella concezione del linguaggio e del significato del filosofo austriaco utilizzandoli come traccia per registrare le corrispondenti revisioni degli obiettivi, delle tecniche e delle forme del far filosofia da lui proposte. Cercheremo poi di analizzare la pratica filosofica prospettata dal Wittgenstein maturo evidenziandone alcuni aspetti che ci consentiranno di qualificarla come clinica.

Qu’est-ce qu’une norme? Y a-t-il des relations logiques entre les normes? Sur quoi repose la validité d’un système normatif? Qu’est-ce que la validité déontique? Les verbes performatifs peuvent-ils agir sur le monde? Quelles sont les différentes façons d’agir en fonction d’une règle? Que sont les règles constitutives? Et qu’est-ce que la vérité? Ce sont là quelques-unes des questions que posent les essais d’Amedeo Giovanni Conte rassemblés dans cette anthologie. Ces essais offrent quelques-unes des contributions les plus originales et les plus (...) significatives de la philosophie du langage normatif. Amedeo Giovanni Conte (Pavie, 1934-Cava Manara, 2019), professeur émérite de l’Université de Pavie, membre de l’Accademia Nazionale dei Lincei, fut l’un des philosophes les plus originaux du droit italien. Parmi ses œuvres : Saggio sulla completezza degli ordinamenti giuridici (1962), les trois volumes de Filosofia del linguaggio normativo (1989-2001), Filosofia dell’ordinamento normativo (1997), Sociologia filosofica del diritto (2011) et Adelaster : Il nome del vero (2016). (shrink)

La celebración del segundo centenario del nacimiento de Ch. Darwin, no puede por menos de renovar la problemática teológica, asociada a esta revolución científica. Aceptado el hecho de la evolución filogenética, incluso con respecto al cuerpo humano y al origen del hombre sobre la tierra , ello no resuelve todos los problemas, sino que los hace aparecer a partir de esa aceptación, que es, por lo demás, ineludible. Especialmente el del dogma sobre el pecado original. Algunos, para salir del atolladero, (...) se decantan por suprimir sin más tal dogma o dejarlo de lado, olvidarlo. Es como eliminar el problema, pero sin solucionarlo. El autor cree que ese dogma es una parte innegable de la dogmática cristiana, según los cánones del Concilio Trento. Pero lo que allí se define es su existencia, la existencia de “un pecado” de origen. No se define su naturaleza. Partiendo de esto, podemos obtener una nueva visión y comprensión del dogma, incluso más positiva, y que se ajuste mejor tanto a otros dogmas de fe, como a los conocimientos que actualmente tenemos acerca del origen del hombre. (shrink)