This paper focuses on the causation of diseases, particularly on the idea of a “genetic cause” taking Alzheimer’s Disease (AD) as an example. We (1) provide some historical information and a synopsis of the current knowledge on the etiology and pathogenesis of AD, (2) analyse some conceptual problems related to the notion of “genetic disease” (3) elaborate on the alleged (genetic) cause of AD, and (4) place the discussion on the cause of AD in a broader philosophical context, paying attention (...) to a constructivist perspective, the notions of causal connection and causal selection, and to some practical and normative consequences of our analysis. We conclude (a) that AD is not a specific disease entity with one specific cause, (b) that the idea of a single (sufficient) cause can still function as a heuristic tool in AD research and practice, and (c) that a “belief” in causation can go together with the notions of multicausality and probability. (shrink)

In this paper we analyse some ethical and philosophical questions related to the development of memory enhancing drugs (MEDs) and anti-dementia drugs. The world of memory enhancement is coloured by utopian thinking and by the desire for quicker, sharper, and more reliable memories. Dementia is characterized by decline, fragility, vulnerability, a loss of the most important cognitive functions and even a loss of self. While MEDs are being developed for self-improvement, in Alzheimer’s Disease (AD) the self is being lost. Despite (...) this it is precisely those patients with AD and other forms of dementia that provide the subjects for scientific research on memory improvement. Biomedical research in the field of MEDs and anti-dementia drugs appears to provide a strong impetus for rethinking what we mean by ‘memory’, ‘enhancement’, ‘therapy’, and ‘self’. We conclude (1) that the enhancement of memory is still in its infancy, (2) that current MEDs and anti-dementia drugs are at best partially and minimally effective under specific conditions, (3) that ‘memory᾿and ‘enhancement᾿are ambiguous terms, (4) that there is no clear-cut distinction between enhancement and therapy, and (5) that the research into MEDs and anti-dementia drugs encourages a reductionistic view of the human mind and of the self. (shrink)

> Wealthy nations must do much more, much faster. The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis. They will meet again at the biodiversity summit in Kunming, China, and the climate conference 26) in Glasgow, UK. Ahead of these pivotal meetings, we—the editors of health journals worldwide—call for urgent action to keep average global temperature increases below 1.5°C, halt the destruction of nature (...) and protect health. Health is already being harmed by global temperature increases and the destruction of the natural world, a state of affairs health professionals have been bringing attention to for decades.1 The science is unequivocal; a global increase of 1.5°C above the preindustrial average and the continued loss of biodiversity risk catastrophic harm to health that will be impossible to reverse.2 3 Despite the world’s necessary preoccupation with COVID-19, we cannot wait for the pandemic to pass to rapidly reduce emissions. Reflecting the severity of the moment, this editorial appears in health journals across the world. We are united in recognising that only fundamental and equitable changes to societies will reverse our current trajectory. The risks to health of increases above 1.5°C are now well established.2 Indeed, no temperature rise is ‘safe’. In the past 20 years, heat-related mortality among people aged over 65 has increased by more than 50%.4 Higher temperatures have brought increased dehydration and renal function loss, dermatological malignancies, tropical infections, adverse mental health outcomes, pregnancy complications, allergies, and cardiovascular and pulmonary morbidity and mortality.5 6 Harms disproportionately affect the most vulnerable, including children, older populations, ethnic minorities, poorer communities and those with underlying health problems.2 4 Global heating is also contributing to the decline in …. (shrink)

In January 2023, the Science and Security Board of the Bulletin of the Atomic Scientists moved the hands of the Doomsday Clock forward to 90 s before midnight.

We observe a number of connections between recent developments in the study of constraint satisfaction problems, irredundant axiomatisation and the study of topological quasivarieties. Several restricted forms of a conjecture of Clark, Davey, Jackson and Pitkethly are solved: for example we show that if, for a finite relational structure M, the class of M-colourable structures has no finite axiomatisation in first order logic, then there is no set (even infinite) of first order sentences characterising the continuously M-colourable structures amongst compact (...) totally disconnected relational structures. We also refute a rather old conjecture of Gorbunov by presenting a finite structure with an infinite irredundant quasi-identity basis. (shrink)

In our days, the creedal phrase 'I believe in God the Father almighty' is interpreted primarily along Trinitarian lines: It is applied to God as the Father of Jesus Christ. Here I argue that it has a dual background: in Jesus' prayer practice, in which He consistently addressed God as 'Father', and in the Hellenistic habit of referring to the Creator as 'Father'. I discuss Jesus' use of the term 'Father' against its Old Testament background, and argue that it primarily (...) points to the intimacy of Jesus' relationship with His father. Against the Hellenistic background, however, the metaphor 'Father' means 'he who brings forth effortlessly'. Finally, I discuss some gender issues connected with the use of the term 'Father' for God. (shrink)

This article provides an introduction to what the Old Testament has to say regarding displacement and displaced people – refugees, migrants and the marginalized members of society. It surveys the instructions regarding the correct attitude and protective actions owed to ‘the stranger’ found in the Old Testament Law and it points to the divine preference to side with the suffering and the vulnerable evident in the Old Testament Prophets. Although not an exhaustive treatment of Old Testament passages tackling this topic, (...) the discussion helps make clear the fact that God is particularly concerned with justice and care for the disadvantaged members of the society, including aliens, refugees and migrants. The conclusion of the article calls the readers to consider some of the missiological-ethical implications of such concern in our contexts today. (shrink)

Research on Old Irish law was from the very beginning related to specific epistemological and political contexts in which Celtic and Indo-European Studies emerged as scientific disciplines at the end of the 19th century. The premise of historical linguistics that the Indo-European languages derived from a common ‘origin’ had far reaching implications for studies on medieval Celtic law tracts. Since linguists had discovered significant parallels between Old Irish and Sanskrit, the legal traditions of Ireland and India were believed to preserve (...) archaic Indo-European continuities as well. Against this background, and in a particular political context, Irish scholars of the 20th century argued for the autonomy and isolation of Old Irish law which was supposed to be unaffected by the Latin and Christian literature of continental Europe. However, later researches departed radically from this national perspective and emphasized the impact of Canon law, hagiography and the Bible on Irish written culture. This article takes up a different perspective by focusing on the persistence of a legal imagery that was by no means essentially Indo-European but still provided conceptual tools for the interpretation and ‘translation’ of texts, as they occur in vernacular adaptations of Latin literature. (shrink)

One important aspect of the transition to modernity is the survival of elements of the Old Regime beyond the French Revolution. It has been claimed that this can explain why in the late nineteenth and early twentieth centuries some Western countries adopted national corporatist structures while others transformed into liberal market economies. One of those elements is the persistence or absence of guild traditions. This is usually analyzed in a national context. This article aims to contribute to the debate by (...) investigating the development of separate trades in Germany, the United Kingdom, and The Netherlands throughout the nineteenth century. We distinguish six scenarios of what might have happened to crafts and investigate how the prevalence of each of these scenarios in the three countries had an impact on the emerging national political economies. By focusing on trades, rather than on the national political economy, our analysis demonstrates that in each country the formation of national political economies and citizenship rights was not the result of a national pattern of guild survival. Rather, the pattern that emerged by the end of the nineteenth century was determined by the balance between old and new industries, and that between national and regional or local government. (shrink)

In recent years, experts in geriatric care have increasingly promoted the use of reminiscence museums, collections of period objects that are used to help senior citizens draw on old memories in order to recall and talk about their past. Hands Off Not an Option is a practical guide to making and using such collections, showing how to establish and fill out a museum and illustrating the ways it can be used within senior care facilities and within individual homes. The book (...) will thus be of value both to those practicing in geriatric medical and social care and to individual families working with aged relatives. The book includes 1 DVD. (shrink)

Philosophers have committed sins while studying science, it is said – philosophy of science focused on physics to the detriment of biology, reconstructed idealizations of scientific episodes rather than attending to historical details, and focused on theories and concepts to the detriment of experiments. Recent generations of philosophers of science have tried to atone for these sins, and by the 1980s the exculpation was in full swing. Marcel Weber’s Philosophy of Experimental Biology is a zenith mea culpa for philosophy (...) of science: it carefully describes several historical examples from twentieth century biology to address both ‘old’ philosophical topics, like reductionism, inference, and realism, and ‘new’ topics, like discovery, models, and norms. Biology, experiments, history – at last, philosophy of science, free of sin. (shrink)

The key to understanding ourselves and the disenchantment of our world, is in fact the age-old logic of religion. This thesis is at the heart of the thought of Marcel Gauchet. For Gauchet, the growing departing from religion that characterises contemporary Western culture is made possible by the logic of religion itself, through its different historical re-articulations, in close interplay with the logic of the political it has given rise to. In a sense, this logic continues to shape our (...) social universe, but now in a way exactly opposite to its original form. The disenchantment of the world is thus not a movement againstreligion, but on the contrary a movement made possible by religion itself. Christianity especially has played a central rôle in all this: it is, in the famous formulation of Gauchet, “the religion for the departing from religion”. In this article, this whole complex movement is reconstructed in its essential steps: the rise of the state and its revolutionary implications for religion, the growth of the ‘higher religions’ and the dynamics of transcendence, the specificity of Christianity , opening up the possibility of a radically new and now disenchanted articulation of autonomy and heteronomy. Further, the background is examined from which Gauchet’s theory has taken shape , as well as the relation between Gauchet and other ‘theories of secularisation’, such as those of Weber, Blumenberg or Löwith. A critical assessment is made of Gauchet’s ‘political’ reading of religion, of its methodological presuppositions, and of his definition of ‘religion’ itself. Finally, the question is raised as to the future of religion according to this theory, and especially the future of Christianity. (shrink)

The key to understanding ourselves and the disenchantment of our world, is in fact the age-old logic of religion. This thesis is at the heart of the thought of Marcel Gauchet. For Gauchet, the growing departing from religion that characterises contemporary Western culture is made possible by the logic of religion itself, through its different historical re-articulations, in close interplay with the logic of the political it has given rise to. In a sense, this logic continues to shape our (...) social universe, but now in a way exactly opposite to its original form. The disenchantment of the world is thus not a movement againstreligion, but on the contrary a movement made possible by religion itself. Christianity especially has played a central rôle in all this: it is, in the famous formulation of Gauchet, “the religion for the departing from religion”. In this article, this whole complex movement is reconstructed in its essential steps: the rise of the state and its revolutionary implications for religion, the growth of the ‘higher religions’ and the dynamics of transcendence, the specificity of Christianity , opening up the possibility of a radically new and now disenchanted articulation of autonomy and heteronomy. Further, the background is examined from which Gauchet’s theory has taken shape , as well as the relation between Gauchet and other ‘theories of secularisation’, such as those of Weber, Blumenberg or Löwith. A critical assessment is made of Gauchet’s ‘political’ reading of religion, of its methodological presuppositions, and of his definition of ‘religion’ itself. Finally, the question is raised as to the future of religion according to this theory, and especially the future of Christianity. (shrink)

v. 1. Reflection & mystery -- v. 2. Faith & reality.

This edition of Marcel's inspiring Homo Viator has been updated to includle fifty-seven pages of new material available for the first time in English, making this the first English-language edition to conform to the standard French edition. Here, Christianity's foremost existentialist of the twentieth century gives us a prodigious personal insight on `man on the way' that will reinforce and commend our own pilgrimages in hope. "Homo Viator - "Homo Viator - or as Marcel calls him, `itinerate man' (...) - is an outstanding example of the philosophy concerned, not with technical problems, but with the urgent problems of man. Marcel talks to our condition, emphasizing our urgent need of hope, thus discovering beyond the lack of stability the values on which we may depend. "A subtle mind, a dramatist as well as a philosopher, close to the texture of human experience, he goes far beyond current platitudes to show that our Western tradition contains living truths that are as essential to our contemporary life as they were to our ancestors when they discovered them." - Eliseo Vivas "The theme of Marcel's Homo Viator is close to the center of all preoccupations: man in his pilgrim condition. With great virtuosity in the use of his own philosophical method, he probes into interpersonal relations and the threat to ethical values. Marcel excels here in his concrete analyses of the attitude of hope, the family community in its temporal and supratemporal aspects, and the forgotten virtue of personal fidelity." - James Collins. (shrink)

The central theme of this important book is that we are paying the price of an arrogance that refuses to recognize mystery. The author invites the reader to enter into the argument that he holds with himself on a great number of problems. Written in the early 1950s, Marcel's discussion of these topics are remarkably contemporary, e.g.: * Our crisis is a metaphysical, not merely social, one. * What a man is depends partly on what he thinks he is, (...) and a materialistic philosophy turns men into things. * Can a man be free except in a free country? * Stoicism is no longer a workable philosophy because today pressure can be put on the mind as well as on the body. * Technical progress is not evil in itself, but a technique is a means that, regarded as an end, can become either an idol or an excuse for self-idolatry. State control of scientific research, leading to a concentration on new means of destruction, is a calamity. * Fanaticism is an opinion that refuses to argue, and so the fanatic is an enemy of truth. * The kind of unification that science is bringing about today is really an ironing out of differences, but the only valuable kind of unity is one that implies a respect for differences. * We must beware of thinking in terms of great numbers and so blinding ourselves to the reality of individual suffering. Our philosophical approach to being is made possible only by our practical approach to our neighbor. * We must encourage the spirit of fraternity and distrust the kind of egalitarianism that is based on envy and resentment. * No man however humble should feel that he cannot spread the light among his friends. No easy solution is offered, but the author conveys his own faith that ultimately love and intelligence will triumph. (shrink)

This important collection of lectures and essays was regarded by Gabriel Marcel as the best introduction to his thought.

OBJECTIVES: Cognitive and sensory difficulties frequently jeopardize informed consent of frail elderly patients This study is the first to test whether preliminary research experience could enhance geriatric patients' capacity to consent. DESIGN/SETTING: A step-wise consent procedure was introduced in a study on fluid balance in geriatric patients. Eligible patients providing verbal consent participated in a try-out of a week, during which bioelectrical impedance and weight measurements were performed daily. Afterwards, written informed consent was requested. Comprehension, risk and inconvenience scores (ranges: (...) 0-10) were obtained before and after the try-out by asking ten questions about the study's essentials and by asking for a risk and inconvenience assessment on a ten-points rating scale. SUBJECTS AND RESULTS: Seventy of the 78 eligible subjects started the try-out and 53 (68%) provided written consent. The comprehension score increased from 5.0 (+/- 2.3) to 7.0 (+/- 1.9) following the try-out (P < 0.001). The number of subjects capable of weighing risks and inconveniences increased from 32 to 48 (P < 0.001). CONCLUSIONS: Research experience improved the capacity to consent, still enabling an acceptable participation rate. Therefore, experienced consent seems a promising tool to optimize informed consent in frail elderly subjects. (shrink)

This edition of Marcel's inspiring Homo Viator has been updated to includle fifty-seven pages of new material available for the first time in English, making this the first English-language edition to conform to the standard French edition. Here, Christianity's foremost existentialist of the twentieth century gives us a prodigious personal insight on 'man on the way' that will reinforce and commend our own pilgrimages in hope. Book jacket.

Comment expliquer que tant d'humains, en ce début de XXIe siècle, accordent encore foi aux discours des religions, que ce soit une religion chrétienne, musulmane ou juive? Possèdent-elles des vérités plus assurées que celles des sciences humaines ou maintiennent-elles leurs fidèles dans l'ignorance, de peur que ceux-ci ne quittent le bateau amiral des églises, des mosquées ou des synagogues? Que proposent-elles de si séduisant pour que l'on sente le besoin de suivre aveuglément leurs enseignements et que des croyants soient prêts (...) à mourir ou à occire pour elles? « Au moment où le créationnisme devient de plus en plus présent dans le cursus académique et où le programme Ethique et culture religieuse, enseigné à nos jeunes dans nos écoles, fait l'apologie du religieux et banalise la superstition, ce livre de Marcel Sylvestre a de quoi nous faire réfléchir sur l'importance à accorder à la raison. » Extrait de la préface de Louise Mailloux. (shrink)

The recent literature on causality has seen the introduction of several distinctions within causality, which are thought to be important for understanding the widespread scientific practice of focusing causal explanations on a subset of the factors that are causally relevant for a phenomenon. Concepts used to draw such distinctions include, among others, stability, specificity, proportionality, or actual-difference making. In this contribution, I propose a new distinction that picks out an explanatorily salient class of causes in biological systems. Some select causes (...) in complex biological systems, I argue, have the property of enabling coherent causal control of these systems. Examples of such control variables include hormones and other signaling molecules, e.g., TOR (target of rapamycin), morphogens or the products of homeotic selector genes in embryonic pattern formation. I propose an analysis of this notion based on concepts borrowed from causal graph theory. (shrink)

Several authors have used the notion of causal specificity in order to defend non-parity about genetic causes (Waters 2007, Woodward 2010, Weber 2017, forthcoming). Non-parity in this context is the idea that DNA and some other biomolecules that are often described as information-bearers by biologists play a unique role in life processes, an idea that has been challenged by Developmental Systems Theory (e.g., Oyama 2000). Indeed, it has proven to be quite difficult to state clearly what the alleged special role (...) of genetic causes consists in. In this paper, I show that the set of biomolecules that are normally considered to be information-bearers (DNA, mRNA) can be shown to be the most specific causes of protein primary structure, provided that causal specificity is measured over a relevant space of biological possibilities, disregarding physical as well as logically possible states of the causal variables. (shrink)

Due to its emphasis on experiential interests, animal ethics tends to focus on individuals as the sole unit of moral concern. Many issues in animal ethics can be fruitfully analysed in terms of obligations towards individual animals, but some problems require reflection about collective dimensions of animal life in ways that individualist approaches can’t offer. Criticism of the individualist focus in animal ethics is not new; it has been put forward in particular by environmental ethics approaches. However, the latter tend (...) to be so far removed from the concerns of animal ethicists that both groups talk at cross purposes. We think the gap between environmental and animal ethics could be bridged by on the one hand focusing more on the collective dimensions of our concerns with animals - after all, individuals are constituted by the collective of which they are a part - and on the other hand, by showing that moral status can also be attributed to groups in an indirect way, related to the moral status of their individual members. In our paper we explore various ways of conceptualising the moral relevance of collectiveness in animal life. We draw on insights from public health ethics, as this field of inquiry has also developed - at least partly—in response to individualist approaches in human bioethics, creating more room for recognizing the value of population health, interpersonal relations, solidarity, and ways in which a collective is constituted. (shrink)

Initiation à l'esthétique et à l'histoire du cinéma, à travers l'analyse systématique des procédés d'expression du langage filmique.

I examine different arguments that could be used to establish indeterminism of neurological processes. Even though scenarios where single events at the molecular level make the difference in the outcome of such processes are realistic, this falls short of establishing indeterminism, because it is not clear that these molecular events are subject to quantum mechanical uncertainty. Furthermore, attempts to argue for indeterminism autonomously (i.e., independently of quantum mechanics) fail, because both deterministic and indeterministic models can account for the empirically observed (...) behavior of ion channels. (shrink)

Virtue ethics is frequently billed as a remedy to the problems of deontological and consequentialist ethics that Bernard Williams identified in his critique of “the morality system.” But how far can virtue ethics be relied upon to avoid these problems? What does Williams’s critique of the morality system mean for virtue ethics? To answer this question, we offer a more principled characterisation of the defining features of the morality system in terms of its organising ambition—to shelter life against luck. This (...) reveals the system to be multiply realisable: the same function can be served by substantively different but functionally equivalent ideas. After identifying four requirements that ethical thought must meet to function as a morality system, we show that they can also be met by certain constellations of virtue-ethical ideas. We thereby demonstrate the possibility of virtue-ethical morality systems raising problems analogous to those besetting their deontological and consequentialist counterparts. This not only widens the scope of Williams’s critique and brings out the cautionary aspect of his legacy for virtue ethics. It also offers contemporary virtue ethicists a more principled understanding of the functional features that mark out morality systems and lie at the root of their problems, thereby helping them to avoid or overcome these problems. (shrink)

Grand specialiste de Ficin, Raymond Marcel expose ainsi les principes de son ambitieux programme: 1) resoudre un probleme dans l'evolution de la pensee europeenne, a savoir les relations entre les theologiens medievaux et les philosophes du XVIIe siecle. Ficin l'interesse en sa qualite de " point de repere " entre la philosophie medievale et moderne. Cette biographie est ainsi le travail d'un historien de la philosophie, historien au point de vue religieux, plus precisement thomiste. 2) livrer une introduction essentielle (...) a une serie de textes. Nous pouvons distinguer 2 grandes parties: 1) une introduction d'une centaine de pages " Renaissance et Platonisme " qui rappelle le probleme complexe et meconnu du platonisme dans la pensee occidentale de la Renaissance carolingienne a la moitie du XVe siecle. 2) La seconde partie, qui constitue le cur de l'ouvrage et s'appuie essentiellement sur la correspondance de Ficin, etudie plus specifiquement l'evolution intellectuelle de Ficin et la reception de ses ouvrages dans le contexte du platonisme du XVe siecle: les consequences du concile de Florence sur la pensee florentine, les rapports de Ficin avec Come de Medicis. (shrink)