Any living organism interacts with and responds specifically to environmental molecules by expressing specific olfactory receptors. In this paper, this specificity will be first examined in causal terms with particular emphasis on the mechanisms controlling olfactory gene expression, cell-to-cell interactions and odor-decoding processes. However, this type of explanation does not entirely justify the role olfactory receptors have played during evolution, since they are also expressed ectopically in different organs and/or tissues. Homologous olfactory genes have in fact been found in such (...) diverse cells and/or organs as spermatozoa, testis and kidney where they are assumed to act as chemotactic sensors or renin modulators. To justify their functional diversity, homologous olfactory receptors are assumed to share the same basic role: that of conferring a self-identity to cells or tissues under varying environmental conditions. By adopting this standpoint, the functional attribution as olfactory or chemotactic sensors to these receptors should not be seen either as a cause conditioning receptor gene expression, or as a final effect resulting from genetically predetermined programs, but as a direct consequence of the environmental conditions olfactory receptor genes have explored during evolution. The association of odorant patterns with specific environmental or contextual situations makes their relationship semiotically triadic, due to the emergence of an interpretant capable of perceiving odorants as meaningful signs out of a noisy background. This perspective highlights the importance of odorant-receptor relationships as respect to the properties of the interacting partners. It is our contention that only when taken together can these different explanatory strategies provide a realistic account of how olfactory receptor genes have been structurally and functionally modified during evolution. (shrink)

The majority of G protein-coupled receptors (GPCRs) self-assemble in the form dimeric/oligomeric complexes along the plasma membrane. Due to the molecular interactions they participate, GPCRs can potentially provide the framework for discriminating a wide variety of intercellular signals, as based on some kind of combinatorial receptor codes. GPCRs can in fact transduce signals from the external milieu by modifying the activity of such intracellular proteins as adenylyl cyclases, phospholipases and ion channels via interactions with specific G-proteins. However, in spite of (...) the number of cell functions they can actually control, both GPCRs and their associated signal transduction pathways are extremely well conserved, for only a few alleles with null or minor functional alterations have so far been found. This would seem to suggest that, beside a mechanism for DNA repairing, there must be another level of quality control that may help maintaining GPCRs rather stable throughout evolution. We propose here receptor oligomerization to be a basic molecular mechanism controlling GPCRs redundancy in many different cell types, and the plasma membrane as the first hierarchical cell structure at which selective categorical sensing may occur. Categorical sensing can be seen as the cellular capacity for identifying and ordering complex patterns of mixed signals out of a contextual matrix, i.e., the recognition of meaningful patterns out of ubiquitous signals. In this context, redundancy and degeneracy may appear as the required feature to integrate the cell system into functional units of progressively higher hierarchical levels. (shrink)

Receptor oligomerization plays a key role in maintaining genome stability and restricting protein mutagenesis. When properly folded, protein monomers assemble as oligomeric receptors and interact with environmental ligands. In a gene-centered view, the ligand specificity expressed by these receptors is assumed to be causally predetermined by the cell genome. However, this mechanism does not fully explain how differentiated cells have come to express specific receptor repertoires and which combinatorial codes have been explored to activate their associated signaling pathways. It is (...) our contention that the plasma membrane acts as the locus where several contextual cues may be integrated. As such it allows the semiotic selection of those receptor configurations that provide cells with the minimum essential requirements for agency. The occurrence of protein misfolding makes it impossible for receptor monomers to assemble along the membrane and to sustain meaningful relationships with environmental ligands. How could a cell lineage deal with these loss-of-function mutations during evolution and restrain gene redundancy accordingly? In this paper, we will be arguing that the easiest way for bacteria clones to accomplish this goal is by getting rid of cells expressing mutated receptor proteins. The mechanism sustaining this cell selection is also occurring in many somatic tissues and its function is currently believed to counteract in vivo protein mutagenesis. Our discussion will be mainly focused on the significance and semiotic nature of the interplay between membrane receptors and the epigenetic control of gene expression, as mediated by the control of mismatched repairing and protein folding mechanisms. (shrink)

Il testo consiste nella trascrizione rimaneggiata di un dialogo che il gruppo di ricerca indipendente “Inoperoso” ha intrattenuto con Roberto Esposito in data 11 maggio 2023. Il tema della discussione è consistito nella messa in questione di una possibile attualità critica della prospettiva ontologico-politica che lo stesso Esposito ha definito dapprima “pensiero impolitico” e poi, in testi più recenti, “pensiero destituente”. Nel rivendicare una tale attualità, i membri di “Inoperoso” si sono confrontati con il successivo sviluppo del pensiero (...) di Esposito, e in particolare con le critiche alle contraddizioni della prospettiva destituente da lui avanzate nella sua recente trilogia dedicata alla proposta del “paradigma istituente”. L’intento ultimo del dialogo era sviluppare una pratica filosofica incentrata non su questioni interne ad una considerazione ristretta di un singolo autore o di tema specifico, bensì rivolta ad esercizio collettivo di riflessione sulle grandi questioni e sulle tematiche che toccano ogni essere umano, guardando da un lato alle forme nelle quali l’attuale congiuntura istituzionale tende ad ostacolare un simile esercizio, e dall’altro alle opportunità di trasformazione che essa può concretamente offrire. (shrink)

This high-level study discusses Newtonian principles and 19th-century views on electrodynamics and the aether. Additional topics include Einstein's electrodynamics of moving bodies, Minkowski spacetime, gravitational geometry, time and causality, and other subjects. Highlights include a rich exposition of the elements of the special and general theories of relativity.

Recordando a Bachelard a medio siglo de su muerte (2011) -- Filosofia de la relatividad (2011) -- La proliferación de los conceptos de especie en la biología evolucionista (2010).

Volume 19, Issue 9, September 2019, Page 37-39.

A critical survey of the main philosophical theories about events and event talk, organized in three main sections: (i) Events and Other Categories (Events vs. Objects; Events vs. Facts; Events vs. Properties; Events vs. Times); (ii) Types of Events (Activities, Accomplishments, Achievements, and States; Static and Dynamic Events; Actions and Bodily Movements; Mental and Physical Events; Negative Events); (iii) Existence, Identity, and Indeterminacy.

This paper is concerned with certain ontological issues in the foundations of geographic representation. It sets out what these basic issues are, describes the tools needed to deal with them, and draws some implications for a general theory of spatial representation. Our approach has ramifications in the domains of mereology, topology, and the theory of location, and the question of the interaction of these three domains within a unified spatial representation theory is addressed. In the final part we also consider (...) the idea of non-standard geographies, which may be associated with geography under a classical conception in the same sense in which non-standard logics are associated with classical logic. (shrink)

Considering topology as an extension of mereology, this paper analyses topological variants of mereological essentialism (the thesis that an object could not have different parts than the ones it has). In particular, we examine de dicto and de re versions of two theses: (i) that an object cannot change its external connections (e.g., adjacent objects cannot be separated), and (ii) that an object cannot change its topological genus (e.g., a doughnut cannot turn into a sphere). Stronger forms of structural essentialism, (...) such as morphological essentialism (an object cannot change shape) and locative essentialism (an object cannot change position) are also examined. (shrink)

El autor analiza algunos aspectos de los debates sobre la democracia en la llamada transición de los años ̓80, para advertir sobre la preeminencia que adquirieron las disposiciones procedimentales y representativas —elevadas a condición metanormativa— y la conceptualización de la política como producción de consensos. Esas orientaciones impidieron una recuperación de las experiencias democráticas que la dictadura intentó cancelar, y fueron incapaces de poner en foco las figuras de subjetividad que el terror estatal y el neoliberalismo produjeron en tanto intervenciones (...) sobre las tramas sociales. Finalmente, el autor se detiene brevemente en algunas experiencias políticas democratizadoras, en tanto formas de aparición de los pueblos en estos últimos 40 años. (shrink)

Reasons-first theorists claim that facts about reasons for attitudes are normatively primitive, and that all other normative facts ultimately reduce to facts about reasons. According to their view, for example, the fact that something is good ultimately reduces to facts about reasons to favour it. I argue that these theories face a challenging dilemma due to the normativity of arational lifeforms, for instance the fact that water is good for plants. If all normative facts are, ultimately, facts about reasons for (...) attitudes, then reasons-first theorists must either (a) show that these facts do reduce to facts about reasons, or (b) concede that they do not and, instead, show that this is not a problem for their view. Both options, however, are riddled with difficulties—or so I will try to argue. (shrink)

This book describes the mathematical aspects of the semantics of programming languages. The main goals are to provide formal tools to assess the meaning of programming constructs in both a language-independent and a machine-independent way, and to prove properties about programs, such as whether they terminate, or whether their result is a solution of the problem they are supposed to solve. In order to achieve this the authors first present, in an elementary and unified way, the theory of certain topological (...) spaces that have proved of use in the modelling of various families of typed lambda calculi considered as core programming languages and as meta-languages for denotational semantics. This theory is now known as Domain Theory, and was founded as a subject by Scott and Plotkin. One of the main concerns is to establish links between mathematical structures and more syntactic approaches to semantics, often referred to as operational semantics, which is also described. This dual approach has the double advantage of motivating computer scientists to do some mathematics and of interesting mathematicians in unfamiliar application areas from computer science. (shrink)

Neste artigo, temos como objetivo perscrutar o funcionamento da verbo-visualidade de uma perspectiva dialógica do discurso, utilizando, como material de análise, uma videomontagem humorística acerca do ator político Dilma Rousseff, durante a campanha presidencial brasileira do ano de 2010. Primeiramente, procuramos refletir acerca de alguns pressupostos teórico-metodológicos de Bakhtin e de Brait, qual seja, o de verbo-visualidade, alicerçado na concepção bakhtiniana de linguagem. Em um segundo momento, detivemo-nos na análise do texto objeto do artigo, que se pautou na seguinte indagação: (...) como contribuem e funcionam os elementos verbais e visuais para produção e direcionamento de sentidos na videomontagem? Nossa hipótese é a de que os discursos carregados pela montagem criam uma trilha ideológica de sentido que leva os interlocutores a interpretar a então candidata como uma pessoa sem discurso, manipulável. Diante do exposto, tentaremos demonstrar a hipótese que sustentamos. (shrink)

ABSTRACT The philosophical tradition approaches to morals have their grounds predominantly on metaphysical and theological concepts and theories. Among the traditional ethics concepts, the most prominent is the Divine Command Theory (DCT). As per the DCT, God gives moral foundations to the humankind by its creation and through Revelation. Morality and Divinity are inseparable since the most remote civilization. These concepts submerge in a theological framework and are largely accepted by most followers of the three Abrahamic traditions: Judaism, Christianity, and (...) Islam: the greatest part of the human population. Holding faith and Revelation for its grounds, the Divine Command Theories are not strictly subject to the demonstration. The opponents to the Divine Command conception of morals, grounded in the impossibility of demonstration of its metaphysical and religious assumptions, have tried for many centuries (albeit unsuccessfully) to devalue its importance. They held the argument that it does not show material evidence and logical coherence and, for this reason, cannot be taken into account for scientific nor philosophical purposes. It is just a belief and, as so, should be understood. Besides these extreme oppositions, many other concepts contravene the Divine Command theories, in one or another way, in part or in full. Many philosophers and social scientists, from the classic Greek philosophy up to the present date, for instance, sustain that morality is only a construct, and thus culturally relative and culturally determined. However, this brings many other discussions and imposes the challenge to determine what is the meaning of culture, which elements of culture are morally determinant, and finally, what are the boundaries of such relativity. Moral determinists claim that everything related to human behavior, including morality, is determined, once free will does not exist. More recently, modern thinkers argued that there is a strict science of morality. However, the scientific method alone, despite explaining several facts and evidence, cannot enlighten the entire content and full meaning of ethics. Morals’ understanding requires a broader perception, and an agreement among philosophers, which they have never achieved. All of these questions have many different configurations depending on each philosophical strand, and start complex analysis and endless debates, as long as many of them are reciprocally conflictive. The universe and the atmosphere involving this thesis are the dominions of all these conceptual conflicts, observed from an objective and evolutionary standpoint. Irrespective of this circumstance and its intrinsic importance, however, these questions are far distant from the methodological approach of an analytical discussion on objective morals, what is, indeed, the aim and scope of this work. We should briefly revisit these prominent traditional theories because this thesis shelters a comparative study, and its assumptions at least differ profoundly from all traditional theories. Therefore, it becomes necessary offering direct and specific elements of comparison to the reader, for the right criticism, dispensing interruptive researches. However, even revisiting the traditional theories, for this comparative and critical exposure purpose, they will be kept by the side of our main concerns, as “aliena materia.” Irrespective of the validity of any or all of the elements of this discussion, and their meaning as the philosophical universe of this thesis, the purpose of this work is demonstrating and justifying the existence and meaning of prehistoric moral archetypes arisen directly from the very first social needs and efforts for survival. These archetypes are the definition of the essential foundation of ethics, its aggregation to the collective unconscious and corresponding logic organization and transmission to evolutionary stages of the human genome and different relations space-time, irrespective of any contemporary experience of the individuals. The system defined by these archetypes composes an evolutionary human social model. Is this a metaethical position? Yes, it is. Moreover, as in any metaethical reasoning, we should look carefully for the best and coherent routes, as the Analytical Philosophy offers them. Thus, this work should reasonably demonstrate that morals are not a cultural product of the civilized men or modern societies and that despite being subject to several cultural relative aggregations and subtractions, its essential foundations are archetypal and have never structurally changed. This reasoning induces that morality is an original attribute of the “homo sapiens”; it is not a property and nor an accident: it integrates the human essence and belongs to the realm of the ontological human identity. The human phenomena is a continuing process, playing its role between random determination and free will, and we need to question how morality began and how did it come to us in the present. (shrink)

In this paper, we extend the expressive power of the logics K3, LP and FDE with anormality operator, which is able to express whether a for-mula is assigned a classical truth value or not. We then establish classical recapture theorems for the resulting logics. Finally, we compare the approach via normality operator with the classical collapse approach devisedby Jc Beall.

"Perhaps not all the stories that follow are true. They could, however, be true, and the Reader is invited to ponder this." So begins _Insurmountable Simplicities_, Roberto Casati and Achille Varzi's colorful incarnation of the many philosophical conundrums that hide in the wrinkles of everyday life. Why do mirrors seem to invert left and right but not up and down? How do we know whether strawberries taste the same for everyone? Where is it written that we must observe the (...) law, and if it is not written, why should we observe it? What if we could swap brains-or the rest of our bodies? _Insurmountable Simplicities_ is filled with stories, dialogues, and epistolary exchanges that cover a range of themes-such as personal identity, causality and responsibility, fortune, the nature of things, the paradoxes of time and space, the interface between logic and language-in captivating and inventive ways. Clear, concise, and intellectually engaging, this internationally acclaimed book brilliantly demonstrates that the beauty of philosophy resides in its thorough engagement with the simplicities of the world, insurmountable as they might initially appear. (shrink)

"A pleasure to read. Gracefully written by a scholar well grounded in the relevant philosophical, historical, and technical background. . . . a helpfully clarifying review and analysis of some issues of importance to recent philosophy of science and a source of some illuminating insights."--Burke Townsend, Philosophy of Science.

v. 1. A alma é o corpo -- v. 2. A arma é o corpo.

CONTENIDO: La ciencia del derecho y el lenguaje jurídico - Algunas estructuras lógicas del pensamiento jurídico - Valores, normas morales y validez del derecho - Las técnicas de control social y el derecho - El concepto de obligación jurídica y las formas de responsabilidad - Derecho subjetivo y relación jurídico - El concepto de órgano de derecho y las categorías derivadas - La personificación del sujeto de derecho - Los sistemas normativos y la idea del derecho como un orden - (...) Las fuentes del derecho - Producción, compatibilización y anulación de normas jurídicas - La interpretación de las normas y el conocimiento científico del derecho. (shrink)

Roberto Esposito is one of the most prolific and important exponents of contemporary Italian political theory.