Magnetic resonance imaging (MRI) can provide a number of measurements relevant to sport-related concussion (SRC) symptoms; however, most studies to date have used a single MRI modality and whole-brain exploratory analyses in attempts to localize concussion injury. This has resulted in highly variable findings across studies due to wide ranging symptomology, severity and nature of injury within studies. A multimodal MRI, symptom-guided region-of-interest (ROI) approach is likely to yield more consistent results. The functions of the cerebellum and basal ganglia transcend (...) many common concussion symptoms, and thus these regions, plus the white matter tracts that connect or project from them, constitute plausible ROIs for MRI analysis. We performed diffusion tensor imaging (DTI), resting-state functional MRI, quantitative susceptibility mapping (QSM), and cerebral blood flow (CBF) imaging using arterial spin labeling (ASL), in youth aged 12-18 years following SRC, with a focus on the cerebellum, basal ganglia and white matter tracts. Compared to controls similar in age, sex and sport (N = 20), recent SRC youth (N = 29; MRI at 8 ± 3 days post injury) exhibited increased susceptibility in the cerebellum (p = 0.032), decreased functional connectivity between the caudate and each of the pallidum (p = 0.035) and thalamus (p = 0.021), and decreased diffusivity in the mid-posterior corpus callosum (p < 0.038); no changes were observed in recovered asymptomatic youth (N = 16; 41 ± 16 days post injury). For recent symptomatic-only SRC youth (N = 24), symptom severity was associated with increased susceptibility in the superior cerebellar peduncles (p = 0.011) and reduced activity in the cerebellum (p = 0.013). Fewer days between injury and MRI were associated with reduced cerebellar-parietal functional connectivity (p < 0.014), reduced activity of the pallidum (p = 0.002), increased CBF in the caudate (p = 0.005), and reduced diffusivity in the central corpus callosum (p < 0.05). Youth SRC is associated with acute cerebellar inflammation accompanied by reduced cerebellar activity and cerebellar-parietal connectivity, as well as structural changes of the middle regions of the corpus callosum accompanied by functional changes of the caudate, all of which resolve with recovery. Early MRI post-injury is important to establish objective MRI-based indicators for concussion diagnosis, recovery assessment and prediction of outcome. (shrink)

En décembre 2007, Jacqueline Hamesse a fêté son 65ème anniversaire, puis a accédé à l’éméritat en 2008. Nombreux sont les collègues et amis qui ont souhaité marquer ces dates en rendant hommage à son dévouement aux études médiévales, que ce soit dans l’enseignement et la recherche ou pour la création et le développement d’institutions internationales dans ce domaine, sans oublier les efforts déployés pour l’édition de nombreux ouvrages collectifs et l’organisation de diverses rencontres scientifiques. Nous avons donc décidé de lui (...) dédier ce volume d’études intitulé «Florilegium mediaevale». L’ouvrage comprend des études concernant l’un des quatre thèmes suivants: les textes philosophiques dans leur contexte et leur support matériel, les instruments travail ainsi que le vocabulaire des textes philosophiques. En effet, ce sont des domaines qui ont surtout retenu son attention depuis de nombreuses années et dans lesquels elle a apporté des contributions significatives à la recherche. Contributions de: L-J. Bataillon (†) et O. Weijers (Paris / Den Haag), F. Bertelloni (Buenos Aires), Ch. Burnett (London), J. Casteigt (Toulouse), J. Celeyrette et J-L. Solère (Lille / Boston), W. Courtenay (Wisconsin-Madison), G. Dahan (Paris), G. Dinkova-Bruun (Toronto), K. Emery Jr. (Notre Dame), Ch. Erismann (Cambridge), B. Faes de Mottoni (Milano), G. Federici Vescovini (Firenze), B. Fernández de la Cuesta (Madrid), R. Friedman et Ch. Schabel (Leuven / Nicosia), D. Gottschall (Lecce), S. Harvey (Jerusalem), I. Heullant-Donat (Reims), R. Hissette (Köln), M. Hoenen (Freiburg i.B.), J. Meirinhos (Porto), O. Merisalo (Jyväskylä), M. Mulchahey (Toronto), M. J. Muñoz Jiménez (Madrid), M. C. Pacheco (Porto), G. Piaia (Padova), R. H. Pich (Porto Alegre), J. Puig Montada (Madrid), R. Ramón Guerrero (Madrid), C. Sirat et M. Geoffroy (Paris), G. Spinosa (Roma), I. Ventura (Louvain-la-Neuve). (shrink)

Response to commentaries on keynote article.

John Buridan was a fourteenth-century philosopher who enjoyed an enormous reputation for about two hundred years, was then totally neglected, and is now being 'rediscovered' through his relevance to contemporary work in philosophical logic. The final chapter of Buridan's Sophismata deals with problems about self-reference, and in particular with the semantic paradoxes. He offers his own distinctive solution to the well-known 'Liar Paradox' and introduces a number of other paradoxes that will be unfamiliar to most logicians. Buridan also moves on (...) from these problems to more general questions about the nature of propositions, the criteria of their truth and falsity and the concepts of validity and knowledge. This edition of that chapter is intended to make Buridan's ideas and arguments accessible to a wider range of readers. The volume should interest many philosophers, linguists and logicians, who are increasingly finding in medieval work striking anticipations of their own concerns. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 525 "an awareness of its perfection in perfect sell-identity" stems from his own theological bias: if God is to be connected with the world, His thinking cannot be merely a thinking about itself; His mind must also contain the Ideas of the sensible world. The inconsistency is quite apparent in the concluding paragraph of the introductory chapter three on "SellKnowledge ": If we study chapters seven and (...) nine of Book Lambda against the background of these texts on the meaning of friendship, it becomes apparent that a fortiori God's thinking must concern his own being and that "the thinking of thinking" is the supreme form of self-knowledge. Far from being an objectless returning to oneself, this knowledge concerns the very being of the First Principle. It would also seem to fot|ow that iust as knowing a friend is a certain degree of self-knowledge because of the ontological kinship between the self and a friend, God, in knowing himself, also knows, to a certain degree, the essential principles of things in so far as he is the first being encompassing within himself the perfections which other beings possess. This would, however, not imply that the first being would know the world as distinct from himself or as dependent on himself (pp. 33-34). How can God (the Unmoved Mover) think only of Himself, and at the same time, to a certain degree (whatever this means) know also the essential principles of things, the perfections which other beings possess? And what textual justification is there for attributing this position to Aristotle? There are a number of errors in the text. Some of them are as follows: (1) On p. 21 Elders quotes from Laws 987b, in spite of the fact that the Laws ends on 969c. The passage referred to would have to be in Epinomis, but at 987b there is nothing of the text he quotes, to wit, vo~g ~v n0ooXQf3o0oa~E~0~tv 6006g 0~tv. (2) On p. 24, note 41, he correctly gives the text at 432a4 as ~ ~oggdSEo~xotg do0n~o~g x6 vo~x6 ~oxt but makes it mean: '~ere are phantasmata in which the intelligible things are contained." Evidently he confuses this with the passage at 431b1--4. (3) On p. 279, p~.~oxr should read p~i~.t~r (4) On p. 5, ~oo~v should read 6.~ao6v. K. W. Hsaa~oroN Emery University In Our Image and Likeness: Humanity and Divinity in Italian Humanist Thought. Two Volumes. By Charles Trinkaus. (Chicago: The University of Chicago Press, 1970. Pp. 985. $22.50) I. Since the appearance of Burckhardt's classic essay more than a century ago, three schools of thought have grown up around the problem of the nature and extent of humanism 's relationship to Christianity. The classic position, represented by Burckhardt, Symends, Dilthey, Gentile, Cassirer, Saitta, and others, has interpreted humanism as an essentiaUy anti-Christian, anti-scholastic, rationatistic, and individualistic phenomenon caught up in an overwhelming concern for attaining to historical greatness in this world. If religion has been considered at all (and it is usually left to take care of itself), it has been so reinterpreted as to become consistent with the interests of emerging secularism, liberalism, and modern science. Opposing the Burckhardtian position, however, is one originally associated with the work of Giuseppe Toffanin and, more recently, Hiram Haydn. Here, Renaissance humanism is seen to be fundamentaUy Catholic, orthodox, and traditional---the two movements joined in perfect harmony by a common concern for antiquity and universaiism, for Latinity, faith, and corporate elitism, and by a common opposition to democratic particularism, heresy, individualism, modernity, and the vernaculars. What makes these two positions extreme, however, is the existence of the largest, most 526 HISTORY OF PHILOSOPHY moderate, and most diversified camp. Originating with Thode, Pastor, Olgiati, and Joachimsen, among a host of others, it has encompassed the general view that humanism and Christianity are separate yet interrelated. For some, medieval Catholicism is not the antithesis but the fountainhead of Renaissance humanism--the religious cause of a secular effect. For others, humanism is a novel intellectual movement, but one yet operating within a still... (shrink)

According to the prevailing sentiment, changing the past is logically impossible. The prevailing sentiment is wrong. In this paper, I argue that the claim that changing the past entails a contradiction ultimately rests upon an empirical assumption, and so the conclusion that changing the past is logically impossible is to be resisted. I then present and discuss a model of time which drops the empirical assumption and coherently models changing the past. Finally, I defend the model, and changing the past, (...) against objections. (shrink)

This original and lively book uses texts from ancient medicine, epic, lyric, tragedy, historiography, philosophy, and religion to explore the influence of Greek ideas on health and disease on Greek thought. Fundamental issues are deeply implicated: causation and responsibility, purification and pollution, the mind-body relationship and gender differences, authority and the expert, reality and appearances, good government, and good and evil themselves.

Dealing with the nature of historical knowledge, this book is concerned with both philosophical and historical questions. It involves considerations as various as statistical hypothesis testing, componential analysis and the problem of the Synoptic Gospels. --.

The purpose of this note is to acknowledge a gap in a previous paper, "The complexity of revision," and to provide a corrected version of the argument.