We review the history of the road to a manifestly covariant perturbative calculus within quantum electrodynamics from the early semi-classical results of the mid-twenties to the complete formalism of Stueckelberg in 1934. We choose as our case study the calculation of the cross-section of the Compton effect. We analyse Stueckelberg's paper extensively. This is our first contribution to a study of his fundamental contributions to the theoretical physics of the twentieth century.

This paper reports a study of planning processes in the five-disc Tower of London (TOL) task in 20 younger and 20 older adult participants. A concurrent direct ''think-aloud'' method was used to obtain data on planning processes prior to moving discs in the TOL. A check was made of the effects of verbalising by comparing performance data from the experimental groups with data from control groups who did not verbalise during planning or moving. Verbalising slowed down planning and moving but (...) did not appear to distort the participants' approaches to the task. Older and younger participants did not differ in average moves taken to solve the tasks. However, older participants' planning was less complete and more error-prone than that of younger participants. The planning processes were characterised as showing a means-ends ''goal selection'' strategy. In this strategy participants (1) identify a single active goal disc at the start, (2) select moves and move sequences to enable the placing of the current goal disc in its target position, and (3) continue in this way until all discs are in their target positions. Age differences were found in the planning stage, during which there was no stimulus support and hence a substantial working memory load. During the move phase there was stimulus support and hence little loading of working memory. Age differences in moves required were not found in the move phase. As older participants tend to have depleted working memory capacity the present results suggest that working memory is heavily loaded in TOL planning but less so in the move phase of TOL. (shrink)

In 2018-2019, at the Keck School of Medicine of the University of Southern California, we developed and piloted a narrative-based health systems science intervention for patients living with HIV and medical students in which medical students co-wrote patients’ life narratives for inclusion in the electronic health record. The pilot study aimed to assess the acceptability of the “life narrative protocol” from multiple stakeholder positions and characterize participants’ experiences of the clinical and pedagogical implications of the LNP. Students were recruited from (...) KSOM. Patients and staff were recruited from the Maternal, Child, and Adolescent/Adult Center for Infectious Disease and Virology at Los Angeles County+USC Medical Center. Ten patients, seventeen students, and ten MCA staff participated in the pilot study. Qualitative methods were used to gather data from students’, patients’, and staff’s perspectives. Three themes emerged from the thematic analysis: patients’ life narratives conveyed their unique life experiences and voices; the protocol could result in wide-ranging effects on HIV care; the LNP enabled students to contribute value to patients’ healthcare. Across groups, participants considered the LNP an acceptable intervention. The LNP, its limitations, and implications for HIV care, narrative medicine, and health information technology are presented. (shrink)

Background: Discussions about medical errors facilitate professional learning for physicians and may provide emotional support after an error, but little is known about physicians’ attitudes and practices regarding error discussions with colleagues.Methods: Survey of faculty and resident physicians in generalist specialties in Midwest, Mid-Atlantic and Northeast regions of the US to investigate attitudes and practices regarding error discussions, likelihood of discussing hypothetical errors, experience role-modelling error discussions and demographic variables.Results: Responses were received from 338 participants . In all, 73% of (...) respondents indicated they usually discuss their mistakes with colleagues, 70% believed discussing mistakes strengthens professional relationships and 89% knew at least one colleague who would be a supportive listener. Motivations for error discussions included wanting to learn whether a colleague would have made the same decision , wanting colleagues to learn from the mistake and wanting to receive support . Given hypothetical scenarios, most respondents indicated they would likely discuss an error resulting in no harm , minor harm or major harm . Fifty-seven percent of physicians had tried to serve as a role model by discussing an error and role-modelling was more likely among those who had previously observed an error discussion .Conclusions: Most generalist physicians in teaching hospitals report that they usually discuss their errors with colleagues, and more than half have tried to role-model discussions. However, a significant number of these physicians report that they do not usually discuss their errors and some do not know colleagues who would be supportive listeners. (shrink)

Castelli has again managed to bring together in Rome some of the greatest specialists of mythology, biblical exegesis, of the different branches of linguistics, with a generous sprinkling of philosophers, theologians, and historians. From the very large number of contributions, especially important are E. Benveniste: Blasphemy and euphemy; K. Kerényi: The language of theology and the theology of language; D. McKinnon: The problem of "the system of projection" in reference to the Christian theological affirmations; R. Panikkar: Silence and word, The (...) smile of the Buddha; B. Bäumer: The secret name in Hinduism; E. Levinas: The name of God after some rabbinical texts; S. Cotta: The name of God in juridical language; P. Ric£ur: Paternity: from the phantasm to the symbol; A. de Waelhens: Paternity and the Oedipus-complex in psychoanalysis; S. Breton: Religious language, theological language; J. Brun: The pseudonyms of God; H. Bouillard: The name of God in the Credo; G. Vahanian: Writing and history; I. Manchini: A nonreligious interpretation of God; X. Tilliette: Attempt at a transition from the God of the philosophers to the God of the Christians; M. Olivetti: The beginnings of Jacobi's philosophy of language.--M. J. V. (shrink)

One of the movements sharply critical of the Enlightenment was illuminism. Weishaupt, Saint-Martin, Eckertshausen are little more than names today yet in their time they contributed to the birth of a new and rich intellectual world, that of Romanticism. Through the life of a well-to-do citizen of Berne, Kirchberger, we see the fortunes of the illuminists, their hopes, their doubts, their ultimately marginal destiny. The book begins with a careful historical account of the papers of Kirchberger followed by a description (...) of his life. Later on we are introduced into a more speculative world: that of the post-Boehmean speculation on the Divine Sophia. The speculative mysticism of these times was an offspring of heterodox theological speculation and condemned quietistic spirituality. Kirchberger, with his rich and diverse correspondence, is an interesting witness of this movement.--M. J. V. (shrink)

While outcomes for children with T-cell acute lymphoblastic leukemia have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid resistance is more common than resistance to other chemotherapies at relapse. In addition, failure to clear peripheral blasts during a prednisone prophase correlates with an elevated risk of relapse in newly diagnosed patients. Here we show that intrinsic GC resistance is present at diagnosis in early thymic precursor T-ALLs as well as in a subset (...) of non-ETP T-ALLs. GC-resistant non-ETP T-ALLs are characterized by strong induction of JAK/STAT signaling in response to interleukin-7 stimulation. Removing IL7 or inhibiting JAK/STAT signaling sensitizes these T-ALLs, and a subset of ETP T-ALLs, to GCs. The combination of the GC dexamethasone and the JAK1/2 inhibitor ruxolitinib altered the balance between pro- and anti-apoptotic factors in samples with IL7-dependent GC resistance, but not in samples with IL7-independent GC resistance. Together, these data suggest that the addition of ruxolitinib or other inhibitors of IL7 receptor/JAK/STAT signaling may enhance the efficacy of GCs in a biologically defined subset of T-ALL.Leukemia advance online publication, 30 May 2017; doi:10.1038/leu.2017.136. (shrink)

This big book is a welcome collection of some of the most important theological studies on St. Paul written by German scholars of this century. Some of the authors are among the greatest names of modern exegetical science and the present selection enables the reader to have access to a wide range of first-rate, often classical, accounts of Paulinian research, without being forced to go through the back-issues of German theological journals. Besides the classical studies, written for encyclopedical purposes, by (...) A. Schaatter and W. Wrede, we can compare A. Schweitzer's and R. Bultmann's accounts on the state of Paulinian researches. Another article of R. Bultmann is about the ethics of St. Paul while von Soden studies sacrament and ethics in the work of the apostle of the Gentiles. Other major articles are: K. Holl: Paul's concept of the Church in its relationship to the primitive Christian community; R. Reitzenstein: Paul as a pneumatician; [[sic]] M. Dibelius: Paul and the Mystic; M. Pohlenz: Paul and the Stoa; L. Baeck: The faith of Paul; G. Bornkamm: Faith and reason in Paul.--M. J. V. (shrink)

Karl Barth's younger brother died shortly before the publication of this monumental work, the crowning piece of his long philosophical career. Since Sein und Zeit and L'Etre et le Néant the present book has been the first real "treatise" in what now we might call "the existentialistic tradition." Such a short notice cannot even hope to enumerate the major themes of this huge volume. This is a truly significant work covering most of the themes that attract a passionate concern for (...) the history of Western philosophizing. The continuity with this history is preserved through the determination of existence as knowledge. The question and the quest about appearance is conducted in such a way that neither the existentialist nor the transcendental elements are neglected. Throughout the entire book it is argued that appearance and existence are positively grounded in transcendence.—M. J. V. (shrink)

This Festschrift is one of the best we have been offered during the last decade. German, French, Turkish, Italian, South African, and Austrian scholars have written 23 essays in honor of one of the foremost historians of philosophy in this century, H. Heimsoeth. Half of the book is devoted to Kantian-scholarship; especially impressive are: Guéroult's study on the structure of the second analogy of experience, Belaval's comparison between Kant and Leibniz, and the richly documented long investigation by G. Tonelli on (...) the presuppositions of Kant's table of judgments in the logic of the eighteenth century. The second part of the present volume is more heterogeneous than the first. One reads with genuine enthusiasm H. Fuhrmans' "The God-World relationship in Schelling's late philosophy." L. Landgrebe's article on the philosophical problem of the end of history is grounded in Kantian soil, but other essays are little connected to Heimsoeth's major interests. These essays include: E. Lichtenstein on the philosophical development of the concept of culture from Meister Eckhart to Hegel; F. Nicolin on the systematic situation of the history of pedagogy since Herbart and Schleiermacher; and H. Wagner's paper on Plato and the beginning of metaphysics as a science. The book concludes with a rich bibliography of Heimsoeth's publications since 1911.--M. J. V. (shrink)

The problems of the tolal energy and quasilocalenergy density or an isolated spherically symmetric static system in general relativity (GR) are considered with examples of some exact suintions. The field formulation of GR dereloped earlier hy L. P. Grishchuk. el al. (1984). in ihe framework of which all the dynamical fields, including the gravitation field, are considered in a fixed background spacetime is used intensively. The exact Schwarzschild and Reissner Nordstrom solutions are investigated in detail, and the results are compared (...) with those in the recent work by J. D. Brown and J. W. York. Jr. (1993) as well as discussed with respect to the principle of nonlocalization of the gravitational energy in GR. Those examples are illustrative and simple because the background is selected as Minkowski spacetime and, in fact, the field configurations are studied in the framework of special relativity. It is shown that some problems of the Schwarzschild solution which are difficult to resolve in the standard geometrical framework of GR are resolved in the framework of the field formulation. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)