In the “Critique of Pure Reason” and subsequent “Prolegomena to Any Future Metaphysics...”, “Metaphysical Principles of Natural Science”, “Opus Postumum” Kant develops one of the modes of his transcendentalism, the metaphysics of possible experience, whose task is to study the transcendental conditions for the possibility of our (cognition), which, according to Kant, has a priori character. P. Strawson calls this mode of metaphysics ‘ descriptive metaphysics ’ and connects it with the analyzing the ‘conceptual structure’ of our thinking about the (...) world. The contemporary realistic trend (primarily within the framework of the analytical philosophical tradition) in the interpretation of Kant’s transcendental philosophy is associated with the modern theory of “two aspects” (80s of the 20th century), which replaced the classical theory of “two objects/worlds” (compare also with the opposition “ theory of appearance vs. theory of appearances ”). Within the framework of this theory, the Kantian ‘appearance’ receives an objectified status, it is not our mental representation, but corresponds (as its signs) to really existing things, or Kantian ‘objects of experience’. The article traces the formation of the historical and conceptual background of the ‘ metaphysics of experience ’ (H. Paton's original expression). Historically, the metaphysics of experience inherits the neo-Kantian approach to interpreting Kant's transcendentalism as a ‘theory of experience’ (H. Cohen, E. Cassirer), then it develops in logical positivism/empiricism (H. Reichenbach, R. Carnap; further in post-posivivism: the theory of I. Lakatos and T. Kuhn), analytical philosophy of science (W. Sellars, G. Buchdal, H. Putnam), and at present the metaphysics of experience is developing in a number of contemporary works of an analytical orientation (P. Strawson, K. Ameriks, L. Allais and etc.). (shrink)

The 13th International Kant Congress was held on August 6-9, 2019 in Oslo, Norway. The main tasks of this review are to analyse the central theme of the Congress, “The Court of Reason”, the related spheres of philosophical inquiry such as metaphilosophy and philosophical methodology, as well as to reveal the main approaches and development trends of transcendental philosophy in “theoretical” and “practical” fields and modern Kant studies, notably transcendental philosophy of language and consciousness. The solution of these tasks will (...) make it possible to raise the question of the prospects of Kantian transcendentalism in relation to the pressing problems of our time and to chart the paths of such development. (shrink)

Chromosomal rearrangements frequently occur at specific places (“hot spots”) in the genome. These recombination hot spots are usually separated by 50–100 kb regions of DNA that are rarely involved in rearrangements. It is quite likely that there is a correlation between the above‐mentioned distances and the average size of DNA loops fixed at the nuclear matrix. Recent studies have demonstrated that DNA loop anchorage regions can be fairly long and can harbor DNA recombination hot spots. We previously proposed that chromosomal (...) DNA loops may constitute the basic units of genome organization in higher eukaryotes. In this review, we consider recombination between DNA loop anchorage regions as a possible source of genome evolution. (shrink)

Les notions d'ordre, de raison, de conscience sont des concepts de la philosophie de Rousseau et, en même temps, les valeurs de sa vie. L'idéal de la société constitue un cadre de réflexions sur ces valeurs, exprimant son identité d'écrivain dans la vie sociale et intellectuelle de son temps. Ainsi, il s'écarte de l'utopie au sens propre du mot.

En partant du constat que les significations du terme « utopie » varient en fonction des différents niveaux de langue (politique, professionnel, commun, etc.) l’auteur s’interroge sur les modalités des « expérimentations utopiques » dans la société. Dans la lignée des analyses de Paul Ricœur et de Robert Nozick, ainsi qu’en s’appuyant sur les conclusions de ses propres recherches consacrées aux représentations utopiques au XVIIIe siècle, l’auteur montre que l’utopie permet à l’individu d’exprimer son idéal de la société basé sur (...) des choix axiologiques personnels, ainsi qu’à fonder l’identité d’un groupe dont les membres disputent à l’idéologie sa prétention à la domination. Enfin, l’utopie sous la forme de fiction constitue un élément important d’un discours théorique portant sur les modèles institutionnels alternatifs et questionnant l’idéologie. L’étude des modes de l’existence sociale de l’utopie permet d’interpréter la façon dont elle se manifeste et perdure dans la société. (shrink)

Alternative theories to quantum mechanics motivate important fundamental tests of our understanding and descriptions of the smallest physical systems. Here, using spontaneous parametric downconversion as a heralded single-photon source, we place experimental limits on a class of alternative theories, consisting of classical field theories which result in power-dependent normalized correlation functions. In addition, we compare our results with standard quantum mechanical interpretations of our spontaneous parametric downconversion source over an order of magnitude in intensity. Our data match the quantum mechanical (...) expectations, and do not show a statistically significant dependence on power, limiting quantum mechanics alternatives which require power-dependent autocorrelation functions. (shrink)

The topic of this article is the problem of World and Infinity. The concepts “Weltanschauung,” (I. Kant) and “Umgreifende” (K. Jaspers) are introduced. A transcendental analysis of the concepts "World" and "Infinite" as ideas of reason is carried out. The theory of the world by L. Tengely is analyzed. Metaphysical and mathematical interpretations of the infinite are compared (actual and potential infinity, openness, horizon).

En partant du constat que les significations du terme « utopie » varient en fonction des différents niveaux de langue (politique, professionnel, commun, etc.) l’auteur s’interroge sur les modalités des « expérimentations utopiques » dans la société. Dans la lignée des analyses de Paul Ricœur et de Robert Nozick, ainsi qu’en s’appuyant sur les conclusions de ses propres recherches consacrées aux représentations utopiques au XVIIIe siècle, l’auteur montre que l’utopie permet à l’individu d’exprimer son idéal de la société basé sur (...) des choix axiologiques personnels, ainsi qu’à fonder l’identité d’un groupe dont les membres disputent à l’idéologie sa prétention à la domination. Enfin, l’utopie sous la forme de fiction constitue un élément important d’un discours théorique portant sur les modèles institutionnels alternatifs et questionnant l’idéologie. L’étude des modes de l’existence sociale de l’utopie permet d’interpréter la façon dont elle se manifeste et perdure dans la société. (shrink)

The question of the Russian man – his past, present and future – is the central one in the philosophy of history. Unfortunately, at present this area of philosophy is not suffciently developed in Russia. Partly the reason for this situation is the lack of understanding by researchers of the role played by Russian classical literature and its philosophizing writers in historiosophy. The Hunting Sketches, a collection of short stories by I.S. Turgenev, is a work still undervalued, not fully considered (...) not only in details but also in general meanings. And this is understandable because it is the frst systematic encyclopedia of Russian worldview, which is not envisaged by the literary genre. To a certain extent, Turgenev’s line is continued by I. Goncharov, L. Tolstoy, F. Dostoevsky, A. Chekhov. This article examines the philosophical nature of The Hunting Sketches, its structure and content. According to author’s opinion, stories can be divided into ten groups according to their dominant meanings. Thus, in The Hunting Sketches the main Russian types are depicted: “natural man,” rational, submissive, cunning, honest, sensitive, passionate, poetic, homeless, suffering, calmly accepting death, imbued with the immensity of the world. In the image and the comments of the wandering protagonist, Ivan Turgenev reveals his own philosophical credo, which he defnes as a moderate liberalism – freedom of thought and action, without prejudice to others. (shrink)

The presented article compares the points of view on time developed in analytical philosophy and in phenomenology actively developed by B. Russell and L. Tengelyi. The objective of the study coincides with the identifying a common horizon for understanding time in analytical philosophy and phenomenology. This help to clarify the possibilities of productive interaction between analytical philosophy and phenomenology. The author of the article believes that a positive answer to this question can be ensured by a special thought experiment. The (...) experiment involves assessing the perception of time in extreme circumstances in terms of phenomenology and analytical philosophy. (shrink)

Many enveloped viruses are released from infected cells by maturing and budding at the plasma membrane. During this process, viral core components are incorporated into membrane vesicles that contain viral transmembrane proteins, termed ‘spike’ proteins. For many years these spike proteins, which are required for infectivity, were believed to be incorporated into virions via a direct interaction between their cytoplasmic domains and viral core components. More recent evidence shows that, while such direct interactions drive budding of alphaviruses, this may not (...) be the case for negative strand RNA viruses and retroviruses. These viruses can bud particles in the absence of spike proteins, using only viral core components to drive the process. In some cases the spike proteins, without the viral core, can be released as virus‐like particles. Optimal budding and release may, therefore, depend on a ‘push‐and‐pull’ concerted action of core and spike, where oligomerization of both components plays a crucial role. (shrink)

IN THIS ESSAY I ASSERT THAT AFFLUENT CONSUMER CULTURES INCULCATE in their residents certain forms of desiring. One of those forms tends to silence the complicity that the affluent enjoy through appropriating the material benefits that come to them through the labor and poor living conditions of people in domestic and global poverty. A prime example is the cheap food that political policy and economic structures promote. The affluent are themselves spiritually stunted through the dynamics of complicity. The essay suggests (...) that contrition is a gift of grace in the face of complicity. Consumerism blocks contrition; that is the operative dynamic here. The failure to be contrite blocks the work of grace in people's lives. However, contrition can slingshot those who experience the Christian vision of desire into a budding transformation which reeducates their desires. Some of those consequences involve a redirection of our sensory experience and an increase in community and compassion. (shrink)

Sporulation in the mold Neurospora crussa can proceed along three very different pathways, leading to the production of three types of spores. Two asexual sporulation pathways that lead to the formation of macroconidia and microconidia involve budding from hyphae by two different mechanisms. A much more complex sexual reproductive pathway involves the formation of a fruiting body called a perithecium, in which meiosis takes place and ascospores are formed in sac‐like cells called asci. Numerous mutations exist that affect these developmental (...) pathways, and genes have been isolated that are expressed preferentially during sporulation. The Neurospora sporulation pathways offer a simple system with which to study mechanisms and regulation of development that are usually obscured by complex cell‐cell interactions involved in animal and plant development. (shrink)

Research over the last two decades has identified a group of meiosis‐specific proteins, consisting of budding yeast Spo13, fission yeast Moa1, mouse MEIKIN, and Drosophila Mtrm, with essential functions in meiotic chromosome segregation. These proteins, which we call meiosis I kinase regulators (MOKIRs), mediate two major adaptations to the meiotic cell cycle to allow the generation of haploid gametes from diploid mother cells. Firstly, they promote the segregation of homologous chromosomes in meiosis I (reductional division) by ensuring that sister kinetochores (...) face towards the same pole (mono‐orientation). Secondly, they safeguard the timely separation of sister chromatids in meiosis II (equational division) by counteracting the premature removal of pericentromeric cohesin, and thus prevent the formation of aneuploid gametes. Although MOKIRs bear no obvious sequence similarity, they appear to play functionally conserved roles in regulating meiotic kinases. Here, the known functions of MOKIRs are reviewed and their possible mechanisms of action are discussed. Also see the video abstract here https://youtu.be/tLE9KL89bwk. (shrink)

Recent findings regarding the cellular biology and immunology of BST‐2 (also known as tetherin) indicate that its function could be exploited as a universal replication inhibitor of enveloped respiratory viruses (e.g., influenza, respiratory syncytial virus, etc.). BST‐2 inhibits viral replication by preventing virus budding from the plasma membrane and by inducing an antiviral state in cells adjacent to infection via unique inflammatory signaling mechanisms. This review presents the first comprehensive summary of what is currently known about BST‐2 anti‐viral function against (...) respiratory viruses, how these viruses construct countermeasures to antagonize BST‐2, and how BST‐2 function might be targeted to develop therapies to treat respiratory virus infections. The authors address the current gaps in knowledge, including the need for mechanistic understanding of BST‐2 antagonism by respiratory viruses, that should be bridged to achieve that goal. (shrink)

In their environment, plants are continuously submitted to natural stimuli such as wind, rain, temperature changes, wounding, etc. These signals induce a cascade of events which lead to metabolic and morphogenetic responses. In this paper the different steps are described and discussed starting from the reception of the signal by a plant organ to the final morphogenetic response. In our laboratory two plants are studied: Bryonia dioica for which rubbing the internode results in reduced elongation and enhanced radial expansion and (...) Bidens pilosa for which the response occurs at distance, hence pricking the cotyledon of a plantlet induces the growth inhibition of both the hypocotyl and the axillary bud of the pricked cotyledon. Reception of the signal and transmission of the message. In Bryonia the signal is received by epidermal cells while in Bidens they are the cells adjacent to the midrib of the cotyledon which receive the mechanical signal. In both plants the message is transmitted via a wave of electric depolarization. This latter is composed of an action potential associated with a slow wave whose transmission rates are respectively 1cm s−1 and 1 mm s−1. Recent results have shown the involvement of Ca2+ in the triggering of the slow wave and the role of the H+ pump during the slow wave. Transient and fast biochemical responses. An entry of extraceilular Ca2+ into the cells and a transient increase in IP3 occur within seconds following the mechanical stimulus. At the same time, the membrane becomes more fluid, correlated with qualitative changes in phospholipids. The rapid increase in the concentration of peroxidated lipids may be correlated with ethylene biosynthesis which is stimulated after rubbing. Other parameters such as cytoplasmic pH, relative water content, hydric potential, membrane potential and modifications of K+, Mg2+-ATPase and Ca2+-ATPase activities, play a key role in the early responses induced by the traumatisms. Irreversible-biochemical responses. The mechanical stimulus performed on a Bryonia internode induces an acceleration of: i) enzymatic activities related to the lignification, ii) esterification of phenolic acids in the cell wall. Consequently the lignification process is accelerated. Storage of the information. After being received by the target cells the information can be stored during several days before being expressed. At the level of cotyledonary bud, the first message, previously stored, can be expressed or not by a second treatment. Bidens thus behaves as if it was able to “store” and to “retrieve” morphogenetic messages, using a sort of rudimentary memory. The nuclei of the bud cells of the pricked cotyledon show that these cells, initially in G2 phase, divide and then remain in the G1 phase. In Bryonia, calli derived from young stimulated internodes, keep thigmomorphogenetic characteristics during several weeks. In the last part of this paper the particularity of our plant model which permits a study of the transmission and storage of the message, is underlined. The links between the different steps induced by the stimulus are discussed. Special attention is devoted to second messengers and to the amplification of the message. (shrink)

In their environment, plants are continuously submitted to natural stimuli such as wind, rain, temperature changes, wounding, etc. These signals induce a cascade of events which lead to metabolic and morphogenetic responses.In this paper the different steps are described and discussed starting from the reception of the signal by a plant organ to the final morphogenetic response. In our laboratory two plants are studied: Bryonia dioica for which rubbing the internode results in reduced elongation and enhanced radial expansion and Bidens (...) pilosa for which the response occurs at distance, hence pricking the cotyledon of a plantlet induces the growth inhibition of both the hypocotyl and the axillary bud of the pricked cotyledon. (shrink)

ABSTRACT The term “applied science,” as it came to be popularly used in the 1870s, was a hybrid of three earlier concepts. The phrase “applied science” itself had been coined by Samuel Taylor Coleridge in 1817, translating the German Kantian term “angewandte Wissenschaft.” It was popularized through the Encyclopaedia Metropolitana, which was structured on principles inherited from Coleridge and edited by men with sympathetic views. Their concept of empirical as opposed to a priori science was hybridized with an earlier English (...) concept of “practical science” and with “science applied to the arts,” adopted from the French. Charles Dupin had favored the latter concept and promoted it in the reconstruction of the Conservatoire Nationale des Arts et Métiers. The process of hybridization took place from the 1850s, in the wake of the Great Exhibition, as a new technocratic government favored scientific education. “Applied science” subsequently was used as the epistemic basis for technical education and the formation of new colleges in the 1870s. (shrink)

ABSTRACT Such categories as applied science and pure science can be thought of as “ideological.” They have been contested in the public sphere, exposing long-term intellectual commitments, assumptions, balances of power, and material interests. This group of essays explores the contest over applied science in Britain and the United States during the nineteenth century. The essays look at the concept in the context of a variety of neighbors, including pure science, technology, and art. They are closely related and connected to (...) contemporary historiographic debate. Jennifer Alexander links the issues raised to a recent paper by Paul Forman. Paul Lucier and Graeme Gooday deal with the debates in the last quarter of the century in the United States and Britain, respectively. Robert Bud deals with the earlier part of the nineteenth century, with an eye specifically on the variety of concepts hybridized under the heading of “applied science.” Eric Schatzberg looks at the erosion of the earlier concept of art. As a whole, the essays illuminate both long-term changes and nuanced debate and are themselves intended to provoke further reflection on science in the public sphere. (shrink)

We prove that a propositional Linear Temporal Logic with Until and Next has unitary unification. Moreover, for every unifiable in LTL formula A there is a most general projective unifier, corresponding to some projective formula B, such that A is derivable from B in LTL. On the other hand, it can be shown that not every open and unifiable in LTL formula is projective. We also present an algorithm for constructing a most general unifier.

We develop a general theory of FDE-based modal logics. Our framework takes into account the four-valued nature of FDE by considering four partially defined modal operators corresponding to conditions for verifying and falsifying modal necessity and possibility operators. The theory comes with a uniform characterization for all obtained systems in terms of FDE-style formula-formula sequents. We also develop some correspondence theory and show how Hilbert-style axiom systems can be obtained in appropriate cases. Finally, we outline how different systems from the (...) literature can be expressed in our framework. (shrink)

This paper is dedicated to developing a formalism that takes rejection seriously. Bilateral notation of signed formulas with force indicators is adopted to define signed consequences which can be viewed as the bilateral counterpart of Tarskian consequence relations. Its relation to some other bilateral approaches is discussed. It is shown how David Nelson’s logic N4 can be characterized bilaterally and the corresponding completeness result is proved. Further, bilateral variants of three familiar notions are considered and investigated: that of a fragment, (...) of definitional equivalence, and of a conservative extension. (shrink)