The emergent Coronavirus Disease 2019 caused by the Severe Acute Respiratory Syndrome Coronavirus 2 could produce a maternal immune activation via the inflammatory response during gestation that may impair fetal neurodevelopment and lead to postnatal and adulthood mental illness and behavioral dysfunctions. However, so far, limited evidence exists regarding long-term physiological, immunological, and neurodevelopmental modifications produced by the SARS-CoV-2 in the human maternal-fetal binomial and, particularly, in the offspring. Relevant findings derived from epidemiological and preclinical models show that a MIA (...) is indeed linked to an increased risk of neurodevelopmental disorders in the offspring. We hypothesize that a gestational infection triggered by SARS-CoV-2 increases the risks leading to neurodevelopmental disorders of the newborn, which can affect childhood and the long-term quality of life. In particular, disruption of either the maternal or the fetal cholinergic anti-inflammatory pathway could cause or exacerbate the severity of COVID-19 in the maternal-fetal binomial. From a translational perspective, in this paper, we discuss the possible manifestation of a MIA by SARS-CoV-2 and the subsequent neurodevelopmental disorders considering the role of the fetal-maternal cytokine cross-talk and the CAP. Specifically, we highlight the urgent need of preclinical studies as well as multicenter and international databanks of maternal-fetal psychophysiological data obtained pre-, during, and post-infection by SARS-CoV-2 from pregnant women and their offspring. (shrink)

In this paper, we try to expose the fundamental ideas at the basis of Jorge Millas’ axiology. First, we will expose synoptically the core of the legal philosophy that the Chilean thinker develops on his works on the subject, including his conception about philosophy in general , and about legal science in particular . Secondly, we will expose the epistemological suppositions of his legal philosophy , and his consequent conception of law’s essence , the legal rule and its foundation, and (...) the axiological theory that Millas develops on the basis of the distinction and relationship between “is” and “ought” . We conclude with a critical analysis that pretends to expose the strengths and weaknesses of the legal theory of this Chilean author. (shrink)

Typically, existentialist analyses of “America” have been limited to North America (more specifically, the United States). I argue that developing an adequate framework for existentially analyzing America requires a turn to Mexican existentialism. In Emilio Uranga’s and Jorge Portilla’s writings, we discover new conceptual tools for understanding Americanness as such. These thinkers help us imagine an account of American being that does not restrict itself to the United States by using the concepts of existentialism to describe the crises their neighbors (...) to the north as well as they themselves face. American existence has been historically characterized by a convergence (oftentimes clash) of disparate races, ethnicities, languages, cultures, religions, and identities. As history unfolded, this convergence led to various existential crises across the Americas. Whereas the US American way of life is marred by a blustering, naïve, and purposeless misuse of freedom that disregards the other, the existential crisis the Mexican lives is characterized by “accidentality” and “zozobra.” Despite these important differences, all existentialists, and the Mexican existentialists of the Hyperion Group especially, remind us that there is a common way to overcome the various existential crises plaguing the Americas, and that is to exercise freedom in a purposeful, communally conscious manner. (shrink)

In this article, I argue that, contrary to scholarly consensus, Antonio Caso draws inspiration from important principles and ideas from Kant’s philosophy in his critique of positivism. I first examine the prima facie textual reasons why someone might believe that Caso and Kant are philosophical enemies. To contradict this notion, I proceed by noting and developing three core ideas that the two share in common. First, Caso and Kant are both ardent critics of dogmatic philosophizing. Second, both Caso and Kant (...) carve out special room for intuition in their respective accounts of cognition, resisting the idea that the understanding has a more prominent role in the formation of knowledge. Third, Kant’s doctrine of aesthetic judgment paves the way for Caso’s de-intellectualized aesthetics. In the end, we see that Kant and Caso are closer to being philosophical friends than enemies. (shrink)

Je rappelle ici l’une des plus constantes préoccupations de la pensée de Jean-Luc Nancy : celle du destin d’un Occident qui, au moment même où il paraît accomplir son élargissement au monde entier, est amené à faire, de plus en plus, le constat de son propre effacement, de son déclin, ou de sa finitude. Je le fais tout en déplaçant quelque peu le point de vue d’où le problème se pose « normalement » car, comme c’est arrivé maintes fois dans (...) mes échanges avec Nancy lui-même, j’y fais jouer mon écart, ou mon arrabal hispanique. (shrink)

Using Koszmider's strongly unbounded functions, we show the following consistency result: Suppose that κ, λ are infinite cardinals such that κ++ + ≤ λ, κ<κ = κ and 2κ = κ+, and η is an ordinal with κ+ ≤ η < κ++ and cf = κ+. Then, in some cardinal-preserving generic extension there is a superatomic Boolean algebra equation image such that equation image, equation image for every α < η and equation image. Especially, equation image and equation image can (...) be cardinal sequences of superatomic Boolean algebras. (shrink)

Frecuentemente se ha interpretado la filosofía política de Julien Freund como una lectura decisionista y polemocéntrica de lo político de fuertes ecos schmittianos. Sin entrar en sus raíces intelectuales, pretendo justificar el sentido que asume en su obra la adhesión a la tradición realista, distanciándose sin embargo de una interpretación tanto cratológica como nihilista de la política que tendiera a reducir los asuntos públicos al solo dominio estratégico de los medios. Entiendo, al contrario, que el realismo de Freund coincide con (...) su perspectiva “mesocrática” o, si se prefiere, “liberal” en un sentido “árquico”, no minarquista o neutralizador. Esto exige un cambio de enfoque en el estudio de su obra que evite fundamentalmente dos extremos: la reducción de lo político a la sola dialéctica del mando y la obediencia, a costa de la integración de todos sus factores, y la sobrevaloración del problema de los medios respecto de los fines. (shrink)

O presente trabalho é uma tradução do espanhol para o português de três contos do livro "Cuentos de Amor de Locura y de Muerte" do escritor uruguaio Horacio Quiroga. Os contos selecionados são: "La Gallina Degollada", "El Almohadón de Plumas" e "A la Deriva". Os textos traduzidos ficaram com os seguintes nomes: "A Galinha Degolada" "O Travesseiro de Penas" e "À Deriva".

La experiencia filosófica de Pablo Posada Varela queda lejos de ser un currículo de filósofo académico. Cuando el verdadero filósofo escribe está movido siempre por motivaciones éticas, para fortalecer el sentido que se busca. Un sentido en contacto permanente con su φρενός, una «inteligencia frenética» al margen de los espasmos del cogito cartesiano y su posterior narcosis. Tampoco ese sentido tiene que ver con la búsqueda de la verdad de su perpetuum mobile. En Pablo Posada Varela hay una verdadera topología (...) del sentido, ideas del sentido fuera del sentido. (shrink)

El propósito de esta entrada es hacer notar la inquietud de Marc Richir en sus Méditations phénoménologiques (1992: 61), de que una estética fenomenológica era más necesaria que nunca aun moviéndonos en cualquier horizonte, imposible de hecho, como a veces pueda serlo el lenguaje en busca del sentido; pero esta entrada se enmarca en una parrhesía de lenguaje más bien débil centrada en lo antiguo donde el arte, (tomando como referencia o inicio (ὑπάρχω) las tragedias griegas en el plano de (...) la mímesis, en correspondencia con la Einfühlung, identificación fenomenológica, la identidad de la obra en las tragedias), tanto si imita sólo con lenguaje (arte de la sofística), como si se habla de la verdadera creación, la tragedia, sobrepasa las etiquetas de cualquier logos en permanente lucha: trágico, intencional, pasional o trascendental; no encontramos ninguna mitología semántica que lo identifique en una cerca intencional, por su pérdida espontánea, o lo recupere en un sentido estético incoativo, en una fase (φάσις), o forma que dejará ver o no según le dé la luz; Platón no lo llega a cazar en el Sofista (al arte de la sofística), porque transgrede cualquier conducta, desde dentro y desde fuera, es decir, tanto si es un disimulo pasional del poeta (catarsis antigua), como si lo consideramos desde el marco de Aristóteles en el cierre artístico clásico de la tragedia (symmetría) en la experiencia generada en el espectador como un fenómeno estético insuficiente (catarsis trágica). (shrink)

With the advent of the cloud computing model allowing a shared access to massive computing facilities, a surging demand emerges for the protection of the intellectual property tied to the programs executed on these uncontrolled systems. If novel paradigm as confidential computing aims at protecting the data manipulated during the execution, obfuscating techniques (in particular at the source code level) remain a popular solution to conceal the purpose of a program or its logic without altering its functionality, thus preventing reverse-engineering (...) on the program even with the help of computing resources. The many advantages of code obfuscation, together with its low cost, makes it a popular technique. This paper proposes a novel methodology for source code obfuscation that can be used together with other traditional obfuscation techniques, making the code more robust against reverse engineering attacks. Three program complexity metrics are used to define three different single-objective combinatorial optimization versions of the problem, which are solved and analysed. Additionally, three multi-objective problems are defined, those considering each of the selected metrics together with the program execution time, in order to avoid strong obfuscations penalizing the performance. The goal of the defined problems is to find sequences of LLVM optimizations that lead to highly obfuscated versions of the original code. These transformations are applied to the back-end pseudo-assembly code (i.e., LLVM Intermediate Representation), thus avoiding any further optimizations by the compiler. Classical genetic algorithms (GAs) are used to solve the studied problems, namely a basic cellular GA for the single-objective problems and the popular NSGA-II for the multi-objective ones. The promising results show the potential of the proposed technique. (shrink)

Los escritos de Jürgen Habermas han despertado en España un interés notable y sostenido en el tiempo. Han ejercido una fuerte influencia intelectual no solo en los círculos académicos, sino también en amplios sectores de la esfera pública, algo sorprendente teniendo en cuenta su complejidad y su carácter más bien técnico. En sus textos los lectores españoles han encontrado elementos que sintonizan constructivamente con los cambios acaecidos en su propia sociedad y en el mundo. Como argumento de autoridad o como (...) referencia a rebatir, Habermas se ha hecho habitual en la filosofía y en la teoría social pensada y escrita en español. En este artículo se tratará de presentar los diversos contextos que posibilitaron la acogida de sus ideas, así como los principales actores que con sus trabajos y reflexiones han protagonizado la propagación de su pensamiento. (shrink)

The purpose of this article is making a critical revision of the field of communication –understood as a field of research and reflection– and the way its existence has been tried to be legitimated since the postwar period. Our stance holds that, even though it is possible to find relatively linear and continuous narratives to understand communication, what is regarded here is reaching comprehension of the fragmentation and language games brought together in it. Besides, the core problem does not rely (...) on the consolidation of a linear and scientific epistemological narrative, but on the manner discourse is articulated, giving place to such narratives turning around their political charges and not the supposed scientific value attributed to them. (shrink)

By using the notion of a simplified (κ,1)-morass, we construct κ-thin-tall, κ-thin-thick and, in a forcing extension, κ-very thin-thick superatomic Boolean algebras for every infinite regular cardinal κ.

La selección natural ayuda a resolver el misterio de la vida pero no es aplicable para explicar la diversidad cultural. La selección natural es vista, por una parte, como un componente de la imaginación de un mundo industrial cambiante, y, por la otra, como un medio de producir diferencias en el seno de procesos sociales que son claves en la distribución de los genes humanos. La genética es intencionalmente traducida en el mundo social: se subvierte la biología y se la (...) somete a la agencia humana. Tal es una ruptura esencial que enmarca el reservorio genético en el novedoso mundo humano. Los seres humanos deliberan acerca de su condición y, al hacerlo, cooptan la naturaleza. No obstante, esto no es un proceso evidente sino que en sí mismo está infiltrado por los procesos neurológicos, una poderosa razón para mantener una visión dialéctica de la relación entre los genes y los humanos. (shrink)

The Lasallian District of Medellin, Colombia requested Corporación Universitaria Lasallista to analyze the formation process received by postulants to De La Salle Brothers in Istmina, Colombia, from 2002 to 2010. Academic, religious, pedagogical, apostolic and personal formation experiences received there were analyzed in this case study –from a qualitative approach– by means of semi-structured interviews and focus groups. Personal and apostolic formations stand out among the results due to the characteristics of Istmina as a proper place for sensibilization and subjugation (...) in proof of vocation. However, the reach of integral formation is questioned because academic formation presented meaningful deficiencies. In conclusion, even though formation experiences in vulnerable contexts are appreciated –and contextualization of learning is deemed meaningful–, participants agree in the necessity of developing strong competences to face educational and apostolic practices. (shrink)

Though laughter and smiles are a part of our everyday lives, they are not always used appropriately. We need to learn how to laugh, to educate our sense of humor. This book is a meditation on humor in general, the humor we deploy and perceive on a day-to-day basis, and on the ethical dimensions that underpin it. It puts forward a new ethical theory, placing humor at the Archimedean point from which to further our understanding as moral subjects, offering explanations (...) as to our moral conduct and pointing the way towards ethical improvement as both individuals and as a group. After defining what humor is and portraying the current state of play among experts on the subject, the author sets out based on the major contributions made by the great philosophers. Then, taking in such fundamental ethical categories as moral sentiment, virtue, duty, capacity and responsibility, he puts forward his own ethical theory (what he refers to as the ethics of humor), based on both linguistic and biological rational. He unveils a new medical/philosophical method: clinical ethics, capable of interpreting humor as a point where ethics and health intersect. This volume also points out various means by which this ethical theory might be brought to bear on fields such as healthcare, business, education, politics, the mass media and everyday life. Above all, it discovers the role that good humor has to play in health and the instruments used to measure it. Juan Carlos Siurana argues that good humor gives expression to freedom, is universal, and contains within itself the basis of a cross-cultural ethical approach, one that is well worth understanding and teaching. Given that humor crosses over into every dimension of our personal and professional lives, the book is aimed at a broad, multidisciplinary public (philosophers, medical practitioners, nurses, company executives, teachers, politicians, psychologists, journalists, etc.), as well as anyone with an interest in the various registers of humor. He offers both theoretical and practical tools for the ethical improvement of professions, organizations and the public at large. (shrink)