Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre‐translational mRNPs are composed of a single transcript, whereas P‐bodies and stress granules are condensates. Both pre‐translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed‐loop configuration. Moreover, assembly of pre‐translational mRNPs in physical RNA regulons is an unlikely event, and co‐regulated translation may occur locally following extracellular cues. We envisage (...) a stochastic mRNP transport mechanism where translational repression of single mRNPs—in combination with microtubule‐mediated cytoplasmic streaming and docking events—are prerequisites for local translation, rather than direct transport. (shrink)

The Hippo pathway, a cascade of protein kinases that inhibits the oncogenic transcriptional coactivators YAP and TAZ, was discovered in Drosophila as a major determinant of organ size in development. Known modes of regulation involve surface proteins that mediate cell‐cell contact or determine epithelial cell polarity which, in a tissue‐specific manner, use intracellular complexes containing FERM domain and actin‐binding proteins to modulate the kinase activities or directly sequester YAP. Unexpectedly, recent work demonstrates that GPCRs, especially those signaling through Galpha12/13 such (...) as the protease activated receptor PAR1, cause potent YAP dephosphorylation and activation. This response requires active RhoA GTPase and increased assembly of filamentous (F‐)actin. Morever, cell architectures that promote F‐actin assembly per se also activate YAP by kinase‐dependent and independent mechanisms. These findings unveil the ability of GPCRs to activate the YAP oncogene through a newly recognized signaling function of the actin cytoskeleton, likely to be especially important for normal and cancerous stem cells. (shrink)

v. 1. A-C -- v. 2. D-F -- v. 3. G-N -- v. 4. O-R -- v. 5. S-Z i apéndix.

En el contexto de la comunicación de masas, el uso rutinario del término “pluralismo” ha generado un desgaste semántico que aconseja una nueva exploración del concepto a la luz de referentes históricos, filosóficos y filológicos adecuados. Este es justamente el objetivo del presente escrito. En efecto, la noción de “pluralismo” asociada a las primitivas formulaciones de la democracia clásica griega tiene muy poco que ver con lo que posteriormente defendió el liberalismo de finales del siglo XVIII y mediados del XIX, (...) un teórico contemporáneo de la democracia como Habermas, o el movimiento posmoderno durante los años ochenta. Si bien es cierto que nadie se opone al pluralismo, también lo es que la adscripción a dicho concepto obedece a parámetros muy diferentes. Habermas y algunos autores posmodernos apuestan por el debate colectivo plural, especialmente el mediático, pero tanto su punto de partida como sus conclusiones resultan divergentes. (shrink)

Leo Strauss's philosophical Bewegung in light of Nietzsche -- The will to power and the philosopher of the future -- Philosophy and the natural right of the eternal return of the same -- The anti-theological religion of the eternal return.

A biography of Pedro Alfonso is proposed from the information today known. There is reproduced our mathematical deduction of the icon Trinitario of a parchment of Chartres of the XIIIth century from a figure precabalística introduced in 1110 by Pedro Alfonso of Huesca and it is presented three other materializations of the «alternated link of three rings any two not linked».

La crítica de arte nació tras la caída de valores absolutos y jueces arbitrarios. Su objetivo era formar a la opinión pública en una sociedad abierta y libre. La crítica de arte de la sociedad postindustrial ha hecho de todo el pasado un valor absoluto. En su formato periodístico que llega más a la mayoría de ciudadanos se ha erigido en juez supremo y arbitrario.

Tras una experiencia de campo, realizando visitas guiadas en un campo de concentración nazi y una intervención en las aulas de cuarto curso de Educación Secundaria, se han detectado unas problemáticas en la enseñanza del Holocausto que se anteponen a los objetivos de la misma: analizar lo que supuso apartar y exterminar a todo aquel que es “diferente”, para reflexionar sobre las exclusiones y discriminaciones actuales. Para resolver dichas problemáticas, en este estudio se propone un enfoque alternativo al tratamiento del (...) Holocausto en las aulas, en primer lugar, atendiendo debidamente a todos los colectivos que fueron víctimas de esta violencia potencial, sin establecer jerarquías en cuanto al grado de sufrimiento, y en segundo lugar, incidiendo en la responsabilidad que tenemos los individuos frente a estos actos de violencia e injusticias sociales, para así contribuir a la formación de una ciudadanía crítica, respetuosa y solidaria. (shrink)

The term theodicy was coined by the philosopher Gottfried Wilhelm Leibniz (1646-1716) and is inherent in the question of how evil can exist if an intrinsically good God guides everything. The publication of this oeuvre initiated intense philosophical and theological discourse in the subsequent centuries, during which many issues that bare upon human well-being were articulated. Also, Leibniz’s rational approach to the relationship between God and evil raised a number of issues related to the topic of belief. This topic has (...) entangled discourses on theodicy with a long-lasting debate on beliefs, which goes back to Antiquity. Recently, a paradigm-shift shed new light on the understanding of belief. Science has begun to address the neurophysiological mechanisms of the processes that underpin belief formation, modulation, and change. The term credition was coined in order to capture and reflect this new and innovative understanding of the fluidity of beliefs and believing. This paper presents various features of a pattern of interrelationships between well-being, theodicy, and credition. (shrink)

The research project of common sense or folk behavior for the specific purposes of advancing epistemology has quickly become one of the largest in experimental philosophy. This chapter explains some of this work as it relates to two positions in epistemology: contextualism and interest relative invariantism (IRI). Naturally, questions arise about the relevance of folk behavior to debates in epistemology. First, there is the dialectical issue concerning the extent to which epistemologists have in fact relied on ordinary behavior in defending (...) their theories. Second, in the cases where epistemologists have made such appeals, people can ask if they have been correct in doing so. And third, assuming correctness in this regard, there is a question about which experimental methods, if any, are pertinent for understanding folk behavior. It is taken takes for granted that epistemologists appeal to ordinary usage and that their doing so in fact informs epistemology. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Parameters have lain at the core of linguistic research in the generative tradition for decades. The theoretical questions they have raised are deep and broad: this reference text investigates how contemporary linguistics has best tried to answer them. This book looks at how parameters might be properly defined and what their locus might be :lexical information, functional heads, the computational system, the phonological branch of the grammar. What kind of data forms trigger acquisition of a parameter? Are parameters necessary or (...) can we study languages without making reference to them? The questions looked at are not just theoretical: how can a theory of parameters be used to help understand second language acquisition, and what contributions can it make to the study of language typology? This is the right time to gather all this information, dispersed in many different kinds of publications by single authors and groups, into one comprehensive volume. (shrink)

Leucipo y los orígenes del atomismo griego.--La ética de Demócrito.--Escepticismo y atomismo en Metrodoro de Quíos.--Anaxarco de Abdera, la búsqueda de la felicidad.--Epicuro y la muerte.

This volume answers the question: Why do we believe what we believe? It examines current research on the concept of beliefs, and the development in our understanding of the process of believing. It takes into account empirical findings in the field of neuroscience regarding the processes that underlie beliefs, and discusses the notion that beyond the interactive exploratory analysis of sensory information from the complex outside world, humans engage in an evaluative analysis by which they attribute personal meaning and relevance (...) to the probabilistic representations of objects and events. Beliefs exert a strong influence on behaviour, decision-making, and identifying and solving problems. Despite their importance, beliefs have until recently not been at the centre of scientific interest. In fact, "belief" is an ill-defined phenomenon. From a transdisciplinary perspective the actual approaches to understanding belief seem incompatible as they attempt to highlight such different topics as "belief - religion", "belief - spirituality", "belief - faith", "belief - knowledge", "belief - attitude", "belief - disbelief", "belief - illusion", and "believing - brain function". This situation contradicts the idea that belief is close to pathological phenomena and that it should be eliminated from scientific discussions. Rather, believing is fundamental for understanding the many problems of every-day life. In fact, the book shows that beliefs are relevant for politics, international affairs, economy, law, or religions also in modern societies. This book presents the increasing scientific interest in beliefs and believing, and reflects the change in focus from the content aspect of belief towards the fluid nature of believing. (shrink)

Because of the COVID-19 pandemic, procrastination has become commonplace due to changes in teaching and learning, which trigger students' academic burnout. As a result, it has increased the intensity of procrastination among students who are enrolled in online learning programs. As a result, students have difficulty as a result of the rapid change from in-person learning to online learning. The study investigates the relationship between academic burnout and procrastination among 150 grade 12 senior high school students. Hence, this study employed (...) a correlational design. Based on the inferential analysis, the r coefficient of 0.71 indicates a high positive correlation between the variables. The p-value of 0.00, which is less than 0.05, leads to the decision to reject the null hypothesis. Hence, a significant relationship exists between academic burnout and academic procrastination among grade 12 senior high school students. (shrink)