Kant maintains that his Critique of Pure Reason follows a “synthetic method” which he distinguishes from the analytic method of the Prolegomena by saying that the Critique “rests on no other science” and “takes nothing as given except reason itself”. The paper presents an account of the synthetic method of the Critique, showing how it is related to Kant’s conception of the Critique as the “science of an a priori judging reason”. Moreover, the author suggests, (...) understanding its synthetic method sheds light on the structure of the Transcendental Deduction, and its function in the work as a whole. (shrink)

In the present paper I shall deal with Adam Smith's application of the analytic-synthetic method, which he considered to be the scientific method par excellence. I shall concentrate on some shortcomings in Smith's arguments and endeavour to explain them as resulting from a particular interpretation of the aforesaid method. The peculiarity of Smith's interpretation was that he omitted the analysis and that he thought the synthesis reflects the composition of an object out of pre-existing elements which (...) are endowed with ‘essential qualities’. I shall then try to show that this methodological concept presupposed the view that society is a compound of independent individuals, i.e. an aggregate of Robinson Crusoes. Finally I shall discuss possible political reasons for this view. On the systematic level, I shall argue that political and scientific partisanship do not necessarily stand in contradiction to objective knowledge, and on the historical level, I shall plead for a ‘Social History of Ideas’.1. (shrink)

In so-called ethorobotics and robot-supported social cognitive neurosciences, robots are used as scientific tools to study animal behavior and cognition. Building on previous epistemological analyses of biorobotics, in this article it is argued that these two research fields, widely differing from one another in the kinds of robots involved and in the research questions addressed, share a common methodology, which significantly differs from the “synthetic method” that, until recently, dominated biorobotics. The methodological novelty of this strategy, the research (...) opportunities that it opens, and the theoretical and technological challenges that it gives rise to, will be discussed with reference to the peculiarities of the two research fields. Some broad methodological issues related to the generalization of results concerning robot-animal interaction to theoretical conclusions on animal-animal interaction will be identified and discussed. (shrink)

Sympathetic commentators on Kant’s account of physical knowledge agree that while philosophy of science has much to gain from Kant’s notion of constitutive a priori principles, Kant’s conceptual and methodological resources are inconsistent with the possibility of scientific change. In this article, I argue that this received view is lacking since Kant’s claim that a unique set of a priori principles structures our knowledge for all time is not central to his account of the constitutive a priori. Two underemphasized points (...) of Kant’s theory bear this out. First, Kant applies ‘a priori’ widely to include non-truth-evaluable elements of knowledge. As such, Kant primarily understands the necessity that attaches to these elements in light of the constitutive role they play in knowledge rather than in terms of truth for all time. Second, Kant uses two methods to establish the existence of constitutive a priori principles: the analytic and the synthetic. On my interpretation, while scientific change has discredited the analytic method, the synthetic method remains viable. In this way, I offer a new perspective on the ways in which Kant’s theory of the constitutive a priori can ground Neo-Kantian philosophies of science like those of Hans Reichenbach and Michael Friedman. (shrink)

In recent years, a number of research projects have been proposed whose goal is to build large-scale simulations of brain mechanisms at unprecedented levels of biological accuracy. Here it is argued that the roles these simulations are expected to play in neuroscientific research go beyond the “synthetic method” extensively adopted in Artificial Intelligence and biorobotics. In addition we show that, over and above the common goal of simulating brain mechanisms, these projects pursue various modelling ambitions that can be (...) sharply distinguished from one another, and that correspond to conceptually different interpretations of the notion of “biological accuracy”. They include the ambition to reach extremely deep levels in the mechanistic decomposition hierarchy, to simulate networks composed of extremely large numbers of neural units, to build systems able to generate rich behavioural repertoires, to simulate “complex” neuron models, to implement the “best” theories available on brain structure and function. Some questions will be raised concerning the significance of each of these modelling ambitions with respect to the various roles played by simulations in the study of the brain. (shrink)

In England, higher education institutions, together with the schools whose staff they train, are being required to incorporate synthetic phonics as one of the key approaches to the teaching of reading. Yet even if synthetic phonics can be identified as one of the component ‘skills’ of reading, an assumption vigorously contested in this paper, it does not follow that it can or should be taught explicitly and independently of reading for meaning. Imposing such a ‘method’ is, at (...) a deep level, incompatible with teachers acting as teachers and potentially constitutes a kind of abuse of early readers. Moreover, because of the conceptual difficulties confronting any attempt to specify synthetic phonics as an approach, there cannot exist, in principle, empirical research that actually supports its value. Current policy in England since the Rose Report, at least, assumes the opposite. All this cannot be dismissed as a little local difficulty for England concerning the teaching of reading English with all its spelling irregularities: there are broader implications for the relationship between research and teaching, together with continuing tendencies to impose ‘teacher proof’ approaches on schools and their staff in many countries. (shrink)

This article addresses Kant's distinction between a synthetic and an analytic method in philosophy. I will first consider how some commentators have accounted for Kant's distinction and analyze some passages in which Kant defined the analytic and the synthetic method. I will suggest that confusion about Kant's distinction arises because he uses it in at least two different senses. I will then identify a specific way in which Kant accounts for this distinction when he is differentiating (...) between mathematical and philosophical syntheses. I will examine Kant's arguments in the Critique of Pure Reason with the latter sense of the distinction in mind. I will evaluate if he uses the analytic or the synthetic method and if the synthetic method is able to identify, without a previous consideration of some sort of given knowledge, sufficient conditions for deriving some aspects of our knowledge. (shrink)

In England, Higher Education institutions, together with the schools whose staff they train, are being required to incorporate synthetic phonics as one of the key approaches to the teaching of reading. Yet even if synthetic phonics can be identified as one of the component ‘skills’ of reading, an assumption vigorously contested in this paper, it does not follow that it can or should be taught explicitly and independently of reading for meaning. Imposing such a ‘method’ is, at (...) a deep level, incompatible with teachers acting as teachers and potentially constitutes a kind of abuse of early readers. Moreover, because of the conceptual difficulties confronting any attempt to specify synthetic phonics as an approach, there cannot exist, in principle, empirical research that actually supports its value. Current policy in England since the Rose Report, at least, assumes the opposite. All this cannot be dismissed as a little local difficulty for England concerning the teaching of reading English with all its spelling irregularities: there are broader implications for the relationship between research and teaching, together with continuing tendencies to impose ‘teacher proof’ approaches on schools and their staff in many countries. (shrink)

Synthetic biology is an emerging technology that asks for inclusive reflection on how people frame the field. To unravel how we can facilitate such reflection, this study evaluates the Frame Reflection Lab. Building upon playfulness design principles, the FRL comprises a workshop with video-narratives and co-creative group exercises. We studied how the FRL facilitated frame reflection by organizing workshops with various student groups. Analysis of 12 group conversations and 158 mini-exit surveys yielded patterns in first-order reflection as well as (...) patterns in second-order reflection. Also patterns in participants’ framing of synthetic biology could be induced; participants’ viewpoints converged to some extent, yet with openness to individual viewpoint differences. Although the FRL method fortified the reflection processes of participants, the narratives and the workshop’s flexible format could inhibit the reflection too. Therefore, we advise designers of future frame reflection methods to apply stronger conversational facilitation and narratives of slightly mysterious yet identifiable narrators, in case e.g. video-narratives are created and used to scaffold the reflection process. Nevertheless, we argue that the use of a playful frame reflection method like the FRL could function well as a step to precede more application-specific deliberation or decision-making on synthetic biology and as a method for the collection of contemporary citizen viewpoints plus rationales underlying these, for the further responsible development of the emerging field. (shrink)

Synthetic biology is an emerging technology that asks for inclusive reflection on how people frame the field. To unravel how we can facilitate such reflection, this study evaluates the Frame Reflection Lab. Building upon playfulness design principles, the FRL comprises a workshop with video-narratives and co-creative group exercises. We studied how the FRL facilitated frame reflection by organizing workshops with various student groups. Analysis of 12 group conversations and 158 mini-exit surveys yielded patterns in first-order reflection as well as (...) patterns in second-order reflection. Also patterns in participants’ framing of synthetic biology could be induced; participants’ viewpoints converged to some extent, yet with openness to individual viewpoint differences. Although the FRL method fortified the reflection processes of participants, the narratives and the workshop’s flexible format could inhibit the reflection too. Therefore, we advise designers of future frame reflection methods to apply stronger conversational facilitation and narratives of slightly mysterious yet identifiable narrators, in case e.g. video-narratives are created and used to scaffold the reflection process. Nevertheless, we argue that the use of a playful frame reflection method like the FRL could function well as a step to precede more application-specific deliberation or decision-making on synthetic biology and as a method for the collection of contemporary citizen viewpoints plus rationales underlying these, for the further responsible development of the emerging field. (shrink)

Many scientific models in biology are how-possibly models. These models depict things as they could be, but do not necessarily capture actual states of affairs in the biological world. In contemporary philosophy of science, it is customary to treat how-possibly models as second-rate theoretical tools. Although possibly important in the early stages of theorizing, they do not constitute the main aim of modelling, namely, to discover the actual mechanism responsible for the phenomenon under study. In the paper it is argued (...) that this prevailing picture does not do justice to the synthetic strategy that is commonly used in biological engineering. In synthetic biology, how-possibly models are not simply speculations or eliminable scaffolds towards a single how-actually model, but indispensable design hypotheses for a field whose ultimate goal is to build novel biological systems. The paper explicates this by providing an example from the study of alternative genetic systems by synthetic biologist Steven Benner and his group. The case will also highlight how the method of synthesis, even when it fails, provides an effective way to limit the space of possible models for biological systems. (shrink)

In some applications, researchers using the synthetic control method (SCM) to evaluate the effect of a policy may struggle to determine whether they have identified a “good match” between the control group and treated group. In this paper, we demonstrate the utility of the mean and maximum Absolute Standardized Mean Difference (ASMD) as a test of balance between a synthetic control unit and treated unit, and provide guidance on what constitutes a poor fit when using a (...) class='Hi'>synthetic control. We explore and compare other potential metrics using a simulation study. We provide an application of our proposed balance metric to the 2013 Los Angeles (LA) Firearm Study [9]. Using Uniform Crime Report data, we apply the SCM to obtain a counterfactual for the LA firearm-related crime rate based on a weighted combination of control units in a donor pool of cities. We use this counterfactual to estimate the effect of the LA Firearm Study intervention and explore the impact of changing the donor pool and pre-intervention duration period on resulting matches and estimated effects. We demonstrate how decision-making about the quality of a synthetic control can be improved by using ASMD. The mean and max ASMD clearly differentiate between poor matches and good matches. Researchers need better guidance on what is a meaningful imbalance between synthetic control and treated groups. In addition to the use of gap plots, the proposed balance metric can provide an objective way of determining fit. (shrink)

Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie (...) into two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge-making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems. (shrink)

Synthetic biology is often described as a project that applies rational design methods to the organic world. Although humans have influenced organic lineages in many ways, it is nonetheless reasonable to place synthetic biology towards one end of a continuum between purely ‘blind’ processes of organic modification at one extreme, and wholly rational, design-led processes at the other. An example from evolutionary electronics illustrates some of the constraints imposed by the rational design methodology itself. These constraints reinforce the (...) limitations of the synthetic biology ideal, limitations that are often freely acknowledged by synthetic biology’s own practitioners. The synthetic biology methodology reflects a series of constraints imposed on finite human designers who wish, as far as is practicable, to communicate with each other and to intervene in nature in reasonably targeted and well-understood ways. This is better understood as indicative of an underlying awareness of human limitations, rather than as expressive of an objectionable impulse to mastery over nature. (shrink)

In this article I offer an opinionated overview of the central elements of Kant’s philosophical methodology during the critical period. I begin with a brief characterization of how Kant conceives of the aims of human inquiry – focusing on the idea that inquiry ideally aims at not just cognition (Erkenntnis), but also the more demanding cognitive achievements that Kant labels insight (Einsehen) and comprehension (Begreifen). Then I explore the implications of this picture for philosophy — emphasizing Kant’s distinction between critical (...) and doctrinal phases of philosophical inquiry, with the first of these playing both a negative and a positive role with respect to the second. Then, I will argue that this positive role is possible, according to Kant, only insofar as philosophy follows what I call a “capacities-first” methodology – that is, one that treats basic cognitive capacities (such as reason) and their self-conscious activities as fundamental (in both a cognitive sense and in an explanatory sense) for the sort of philosophy human beings are capable of. It is this methodology, I will argue, that allows Kant to introduce the first principles that philosophy in its doctrinal phase requires in a manner that is neither arbitrary nor (at least obviously) incompatible with Kant’s own critical restrictions on cognition. I conclude by discussing some of the implications of this methodological picture – including the methodological significance of self-consciousness and regressive or “transcendental” arguments, Kant’s distinction between analytic and synthetic methods in philosophy, and Kant’s conception of reason as autonomous. (shrink)

In their publications during the 1820s, Jakob Steiner and Julius Plücker frequently derived the same results while claiming different methods. This paper focuses on two such results in order to compare their approaches to constructing figures, calculating with symbols, and representing geometric magnitudes. Underlying the repetitive display of similar problems and theorems, Steiner and Plücker redefined synthetic and analytic methods in distinctly personal practices.

Scientists are developing a technique called in vitro gametogenesis or IVG to generate synthetic gametes for research and, potentially, for treating infertility. What would it mean for feminist concerns over the future of reproductive practice and biotechnological development if egg and sperm cells could be produced in laboratory conditions? In this article, I take on the question by discussing the emerging technique of IVG through the speculative feminist analysis of ambiguous reproductive futures. Feminist cultural and science studies scholars have (...) explored the transformative effects of biomedicine on reproduction through science fiction novels and other cultural products. I theorise the speculative and visionary in biomedicine in the context of ethnographic methodology by drawing on ‘thought experiments’ conducted with stem cell scientists as shared acts of future-oriented contemplation. I develop the figure of SF proposed by Donna Haraway to investigate how science facts and speculative fabulation together shape futurities of reproduction. I propose including shifting frontiers in feminist thinking of the SFs in bioscience. Biomedical research aims to shift the borders between what is known and not known in reproductive biology, subsequently raising new technical, ethical and political issues in terms of stratified reproduction. The article shows that synthetic gametes are anticipated to intensify selective procreation. Simultaneously, IVG is seen to forge new biogenetic relationships and possibilities for non-normative reproduction and kin-making. Following Haraway, I argue that by ‘staying with the trouble’ of these biotechnological visions, feminist speculative analytics on technoscience offers a valuable tool to envision more hopeful and equal futures together with scientists. (shrink)

Computation and philosophy intersect three times in this essay. Computation is considered as an object, as a method, and as a model used in a certain line of philosophical inquiry concerning the relation of mind to matter. As object, the question considered is whether computation and related notions of mental representation constitute the best ways to conceive of how physical systems give rise to mental properties. As method and model, the computational techniques of artificial life and embodied evolutionary (...) connectionism are used to conduct prosthetically enhanced thought experiments concerning the evolvability of mental representations. Central to this essay is a discussion of the computer simulation and evolution of three‐dimensional synthetic animals with neural network controllers. The minimally cognitive behavior of finding food by exhibiting positive chemotaxis is simulated with swimming and walking creatures. These simulations form the basis of a discussion of the evolutionary and neurocomputational bases of the incremental emergence of more complex forms of cognition. Other related work has been used to attack computational and representational theories of cognition. In contrast, I argue that the proper understanding of the evolutionary emergence of minimally cognitive behaviors is computational and representational through and through. (shrink)

This is a contribution to the idea that some proofs in first-order logic are synthetic. Syntheticity is understood here in its classical geometrical sense. Starting from Jaakko Hintikka’s original idea and Allen Hazen’s insights, this paper develops a method to define the ‘graphical form’ of formulae in monadic and dyadic fraction of first-order logic. Then a synthetic inferential step in Natural Deduction is defined. A proof is defined as synthetic if it includes at least one (...) class='Hi'>synthetic inferential step. Finally, it will be shown that the proposed definition is not sensitive to different ways of driving the same conclusion from the same assumptions. (shrink)

The engineering-based approach of synthetic biology is characterized by an assumption that ‘engineering by design’ enables the construction of ‘living machines’. These ‘machines’, as biological machines, are expected to display certain properties of life, such as adapting to changing environments and acting in a situated way. This paper proposes that a tension exists between the expectations placed on biological artefacts and the notion of producing such systems by means of engineering; this tension makes it seem implausible that biological systems, (...) especially those with properties characteristic of living beings, can in fact be produced using the specific methods of engineering. We do not claim that engineering techniques have nothing to contribute to the biotechnological construction of biological artefacts. However, drawing on Descartes’s and Kant’s thinking on the relationship between the organism and the machine, we show that it is considerably more plausible to assume that distinctively biological artefacts emerge within a paradigm different from the paradigm of the Cartesian machine that underlies the engineering approach. We close by calling for increased attention to be paid to approaches within molecular biology and chemistry that rest on conceptions different from those of synthetic biology’s engineering paradigm. (shrink)

Computation and philosophy intersect three times in this essay. Computation is considered as an object, as a method, and as a model used in a certain line of philosophical inquiry concerning the relation of mind to matter. As object, the question considered is whether computation and related notions of mental representation constitute the best ways to conceive of how physical systems give rise to mental properties. As method and model, the computational techniques of artificial life and embodied evolutionary (...) connectionism are used to conduct prosthetically enhanced thought experiments concerning the evolvability of mental representations. Central to this essay is a discussion of the computer simulation and evolution of three-dimensional synthetic animals with neural network controllers. The minimally cognitive behavior of finding food by exhibit- ing positive chemotaxis is simulated with swimming and walking creatures. These simulations form the basis of a discussion of the evolutionary and neurocomputa- tional bases of the incremental emergence of more complex forms of cognition. Other related work has been used to attack computational and representational theories of cognition. In contrast, I argue that the proper understanding of the evolutionary emergence of minimally cognitive behaviors is computational and representational through and through. (shrink)

This paper uses the theory of technoscience to shed light on the current criticisms against the emerging science of Artificial Life. We see that the science of Artificial Life is criticized for the synthetic nature of its research and its over reliance on computer simulations which is seen to be contrary to the traditional goals and methods of science. However, if we break down the traditional distinctions between science and technology using the theory of technoscience, then we can begin (...) to see that all science has a synthetic nature and reliance on technology. Artificial Life researchers are not heretical practitioners of some pseudoscience; they are just more open about their reliance on technology to help realize their theories and modeling. Understanding that science and technology are not as disparate as was once thought is an essential step in helping us create a more humane technoscience in the future. (shrink)

Synthetic biology is an increasingly high‐profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA‐based device construction, genome‐driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie (...) into two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge‐making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems. BioEssays 30:57–65, 2008. © 2007 Wiley Periodicals, Inc. (shrink)

The term “synthetic biology” is a popular label of an emerging biotechnological field with strong claims to robustness, modularity, and controlled construction, finally enabling the creation of new organisms. Although the research community is heterogeneous, it advocates a common denominator that seems to define this field: the principles of rational engineering. However, it still remains unclear to what extent rational engineering—rather than “tinkering” or the usage of random based or non-rational processes—actually constitutes the basis for the techniques of (...) class='Hi'>synthetic biology. In this article, we present the results of a quantitative bibliometric analysis of the realized extent of rational engineering in synthetic biology. In our analysis, we examine three issues: (1) We evaluate whether work at three levels of synthetic biology (parts, devices, and systems) is consistent with the principles of rational engineering. (2) We estimate the extent of rational engineering in synthetic biology laboratory practice by an evaluation of publications in synthetic biology. (3) We examine the methodological specialization in rational engineering of authors in synthetic biology. Our analysis demonstrates that rational engineering is prevalent in about half of the articles related to synthetic biology. Interestingly, in recent years the relative number of respective publications has decreased. Despite its prominent role among the claims of synthetic biology, rational engineering has not yet entirely replaced biotechnological methods based on “tinkering” and non-rational principles. (shrink)

Distance Interpreting (DI) is a form of technology-mediated interpreting which has gained traction due to the high demand for multilingual conferences, live-streaming programs, and public service sectors. The current study synthesized the DI literature to build a framework that represents the construct and measurement of cognitive load in DI. Two major areas of research were identified, i.e., causal factors and methods of measuring cognitive load. A number of causal factors that can induce change in cognitive load in DI were identified (...) and reviewed. These included factors derived from tasks (e.g., mode of presentation), environment (e.g., booth type), and interpreters (e.g., technology awareness). In addition, four methods for measuring cognitive load in DI were identified and surveyed: subjective methods, performance methods, analytical methods, and psycho-physiological methods. Together, the causal factors and measurement methods provide a multifarious approach to delineating and quantifying cognitive load in DI. This multidimensional framework can be applied as a tool for pedagogical design in interpreting programs at both the undergraduate and graduate levels. It can also provide implications for other fields of educational psychology and language learning and assessment. (shrink)

Deep learning algorithms are rapidly changing the way in which audiovisual media can be produced. Synthetic audiovisual media generated with deep learning—often subsumed colloquially under the label “deepfakes”—have a number of impressive characteristics; they are increasingly trivial to produce, and can be indistinguishable from real sounds and images recorded with a sensor. Much attention has been dedicated to ethical concerns raised by this technological development. Here, I focus instead on a set of issues related to the notion of (...) class='Hi'>synthetic audiovisual media, its place within a broader taxonomy of audiovisual media, and how deep learning techniques differ from more traditional approaches to media synthesis. After reviewing important etiological features of deep learning pipelines for media manipulation and generation, I argue that “deepfakes” and related synthetic media produced with such pipelines do not merely offer incremental improvements over previous methods, but challenge traditional taxonomical distinctions, and pave the way for genuinely novel kinds of audiovisual media. (shrink)

This paper analyzes the notion of possibility in biology and demonstrates how synthetic biology can provide understanding on the modal dimension of biological systems. Among modal concepts, biological possibility has received surprisingly little explicit treatment in the philosophy of science. The aim of this paper is to argue for the importance of the notion of biological possibility by showing how it provides both a philosophically and biologically fruitful category as well as introducing a new practically grounded way for its (...) assessment. More precisely, we argue that synthetic biology can provide tools to scientifically anchor reasoning about biological possibilities. Two prominent strategies for this are identified and analyzed: the design of functionally new-to-nature systems and the redesign of naturally occurring systems and their parts. These approaches allow synthetic biologists to explore systems that are not normally evolutionarily accessible and draw modal inferences that extend in scope beyond their token realizations. Subsequently, these results in synthetic biology can also be relevant for discussions on evolutionary contingency, providing new methods and insight to the study of various sources of unactualized possibilities in biology. (shrink)

In the Critique of Teleological Judgment, Kant endorses a distinct model of causal explanation. He claims that we explain natural wholes as the causal effect of their parts and the forces governing them, i. e., we explain mechanistically or following the analytic-synthetic method of modern science. According to McLaughlin’s influential interpretation, Kant endorses in this, without argument, the predominant scientific method of his time. The text suggests, however, that we explain mechanistically according to the constitution of our (...) discursive understanding. The paper attempts to reconstruct the argument establishing this claim. (shrink)

Educational literature has tended to focus, explicitly and implicitly, on two kinds of task orientation: the ability either to focus on a single task, or to multi-task. A third form of orientation characterises many highly successful people. This is the ability to combine several tasks into one: to ‘kill two birds with one stone’. This skill characterises people with initiative, who exercise judgment, deliberation and creative imagination in their personal organisation. The motivation to work in this way indicates personal commitment (...) rather than mere compliance. Focusing on its development educationally implies a shift from either/or, linear, methodical, mechanical and technicist thinking to encouraging individual and collective responsibility, initiative and risk-taking, resulting in unpredictable outcomes. The emphasis on judgment renders the issues as ethical rather than narrowly instrumental. Dominant ethical approaches are, therefore, considered in relation to this in terms of its application for teaching. (shrink)

A majority opinion seems to have emerged in scholarly analysis of the assortment of technologies that have been given the label “synthetic biology.” According to this view, society should allow the technology to proceed and even provide it some financial support, while monitor­ing its progress and attempting to ensure that the development leads to good outcomes. The near‐consensus is captured by the U.S. Presidential Commission for the Study of Bioethical Issues in its report New Directions: The Ethics of (...) class='Hi'>Synthetic Biology and Emerging Technologies, which arguably marked the end of a preliminary round of analysis about the ethical and policy questions raised by synthetic bi­ology. Like a number of other, earlier documents issued by various groups around the world, the re­port called attention to questions about how the technology will be used; whether it might be mis­used; what sorts of accidents might happen along the way; the economic, environmental, and social impacts of the eventual applications; whether the very idea of “synthetic biology” should be trou­bling; and how the debate over all of these ques­tions will be conducted. Also like most similar documents, however, while it called for careful monitoring and oversight of technology, it did not recommend any significant new constraints on its development and use. The commission's stance was that it would be “imprudent either to declare a moratorium on synthetic biology until all risks can be determined and mitigated, or to simply ‘let science rip,’ regardless of the likely risks.”In this report, we will take stock of the current consensus, comment on some of the major points of disagreement, and identify the next steps for the debate. In part I, we offer a brief overview of the research and applications commonly grouped together under the heading of synthetic biology, partly in order to set the stage for the rest of the discussion and partly because we want to highlight some conceptual problems that attend the very la­bel given this field. In parts II, III, and IV, we take up, respectively, three broad classes of concerns that arise in the context of synthetic biology: con­cerns about the intrinsic or inherent value of do­ing synthetic biology, concerns about the concrete harms and benefits of doing synthetic biology, and concerns about justice. Addressing these concerns requires a method for bringing the public's values to bear on policy‐making concerning emerging biotechnologies; in part V, we discuss the chal­lenges in developing such a method. (shrink)

Combining the communicative language competence model and the perspective of multimodal research, this research proposes a research framework for oral communicative competence under the multimodal perspective. This not only truly reflects the language communicative competence but also fully embodies the various contents required for assessment in the basic attributes of spoken language. Aiming at the feature sparseness of the user evaluation matrix, this paper proposes a feature weight assignment algorithm based on the English spoken category keyword dictionary and user search (...) records. The algorithm is mainly based on the self-built English oral category classification dictionary and converts the user’s query vector into a user-English-speaking type vector. Through the calculation rules proposed in this paper, the target user’s preference score for a specific type of spoken English is obtained, and this score is assigned to the unrated item of the original user’s feature matrix as the initial starting score. At the same time, in order to solve the problem of insufficient user similarity calculation accuracy, a user similarity calculation algorithm based on “Synonyms Cilin Extended Edition” and search records is proposed. The algorithm introduces “Synonyms Cilin” to calculate the correlation between the semantic items, vocabulary, and query vector in the user query record to obtain the similarity between users and finally gives a user similarity calculation that integrates user ratings and query vectors method. For the task of Chinese grammar error correction, this article uses two methods of predicting the relationship between words in the corpus, Word2Vec and GloVe, to train the word vectors of different dimensions and use the word vectors to represent the text features of the experimental samples, avoiding sentences brought by word segmentation. On the basis of word vectors, the advantages and disadvantages of CNN, LSTM, and SVM models in this shared task are analyzed through experimental data. The comparative experiment shows that the method in this paper has achieved relatively good results. (shrink)

The Presidential Commission for the Study of Bioethical Issues released its first report, New Directions: The Ethics of Synthetic Biology and Emerging Technologies, on December 16, 2010.1 President Barack Obama had requested this report following the announcement last year that the J. Craig Venter Institute had created the world’s first self-replicating bacterial cell with a completely synthetic genome. The Venter group’s announcement marked a significant scientific milestone in synthetic biology, an emerging field of research that aims to (...) combine the knowledge and methods of biology, engineering, and related disciplines in the design of chemically synthesized DNA to create organisms with novel or enhanced .. (shrink)

Although the emerging field of synthetic biology looks back on barely a decade of development, the stakes are high. It is a multidisciplinary research field that aims at integrating the life sciences with engineering and the physical/chemical sciences. The common goal is to design and construct novel biological components, functions and systems in order to implement, in a controlled way, biological devices and production systems not necessarily found in nature. Among the many potential applications are novel drugs and pesticides, (...) cancer treatments, biofuels, and new materials. According to the most optimistic visions, synthetic biology may thus lead to a biotechnological revolution by transforming microorganisms into ‘factories’ of sorts, which could eventually displace conventional industrial methods. (shrink)

Kant's philosophy promises to explain various synthetic a priori claims. Yet, as several of his commentators have noted, it is hard to see how these explanations could work unless they themselves rested on unexplained synthetic a priori claims. Since Kant appears to demand explanations for all synthetic a priori claims, it would seem that his project fails on its own terms. I argue, however, that Kant holds that explanations are required only for synthetic a priori claims (...) about (purportedly) experience-independent entities, and that his project rests on a rationalist method of reflection that justifies certain basic synthetic a priori claims. (shrink)

This paper addresses the issue of stipulation in three cases of implicit definitions. It argues that the alleged implicit definitions do not have a purely stipulative status. Stipulation of the vehicles of the implicit definitions in question should end up with true postulates. However, those postulates should not be taken to be true only in virtue of stipulation since they have extra commitments. Horwich’s worry emerges in all three kinds of implicit definitions under consideration, since the existence of meanings so (...) that the alleged postulates are true depends on extra requirements that should be fulfilled. Moreover, if Ramseyfication method is applied to the three kinds of implicit definition, they are split up into two components from which the first one is broadly factual while the second one is purely stipulative. The paper argues that their definitional task in each case should be assigned to their second component i.e. their Carnap-conditional. (shrink)

In his famous article “The Unreasonable Effectiveness of Mathematics in the Natural Sciences” Eugen Wigner argues for a unique tie between mathematics and physics, invoking even religious language: “The miracle of the appropriateness of the language of mathematics for the formulation of the laws of physics is a wonderful gift which we neither understand nor deserve”. The possible existence of such a unique match between mathematics and physics has been extensively discussed by philosophers and historians of mathematics. Whatever the merits (...) of this claim are, a further question can be posed with regard to mathematization in science more generally: What happens when we leave the area of theories and laws of physics and move over to the realm of mathematical modeling in interdisciplinary contexts? Namely, in modeling the phenomena specific to biology or economics, for instance, scientists often use methods that have their origin in physics. How is this kind of mathematical modeling justified? (shrink)

One of the most active areas of research in semi-supervised learning has been to study methods for constructing good ensembles of classifiers. Ensemble systems are techniques that create multiple models and then combine them to produce improved results. These systems usually produce more accurate solutions than a single model would. Specially, multi-view ensemble systems improve the accuracy of text classification because they optimize the functions to exploit different views of the same input data. However, despite being more promising than the (...) single-view approaches, document datasets often have no natural multiple views available. This study proposes an algorithm to generate a synthetic view from a standard text dataset. The model generates a new view from the standard bag-of-words approach using an algorithm based on hidden Markov models. To show the effectiveness of the proposed HMM-based synthetic view generation method, it has been integrated in a co-training ensemble system and tested with four text corpora: Reuters, 20 Newsgroup, TREC Genomics and OHSUMED. The results obtained are promising, showing a significant increase in the efficiency of the ensemble system compared to a single-view approach. (shrink)

The rapidity with which new sciences are being formed and the older ones are becoming further specialized calls for a complementary effort to interrelate the sciences. A genuine synthetization must be completely open to all future discoveries and developments within science. Such an openness would be possible only if scientific understanding possesses certain invariable patterns according to which the synthetization could be constructed. Lonergan's Insight (New York, 1958) seems to have uncovered these basic and irrevisable patterns. Not only do they (...) demonstrate the complementarity of classical and statistical methods but the isomorphic Emergent Probability operative in world-process may well provide the framework for an open synthetization. In the present essay this possibility is demonstrated by interrelating, according to it, certain generic fields of the scientific endeavor, from physics to cultural anthropology. (shrink)

« La méthode synthétique de Hamelin »: cet article pourrait être assez bien résumé par les raisons qui l'ont fait écrire. La méthode synthétique de Hamelin a paru mériter une considération particulière, parce que la synthèse semble trop souvent négligée par la philosophie contemporaine, alors qu'elle a toujours été et sans doute demeure une tâche essentielle de la philosophie. En second lieu, le rationalisme et l'idéalisme de Hamelin ne sont pas, comme tant d'autres, un programme toujours à remplir et jamais (...) rempli: ils osent affronter de façon méthodique et claire l'explication du réel par la pensée. On a essayé de faire ressortir comment cette entreprise pouvait permettre d'avancer dans l'intelligence de l'être. On a tenté de montrer ensuite pourquoi la dialectique hamelinienne s'arrêtait en fait à l'être fini et comment, pour construire synthétiquement ce dernier, elle était contrainte de se le donner au départ. « Hamelin's Synthetic Method »: In order to summarize this article, we need only to recall the reasons for which it was written. First of all we thought that Hamelin's synthetic method deserved a special consideration, because the synthetic prospect was too often neglected in contemporary philosophy, while this prospect has ever been and remains an essential task of philosophy. Secondly, Hamelin's rationalism and idealism are not, as many others, mere programs never fulfilled and always in project: Hamelin did not fear to face the real world and explain it by reason. We tried to indicate how this attempt could improve the rational understanding of being. Finally we wanted to show that in fact Hamelin's dialectic did not go any further than finite being and was compelled, in order to build up this latter through a synthetical process, to take it as given. (shrink)

Kant's distinction between analytic and synthetic method is connected to the so-called Aristotelian model of science and has to be interpreted in a (broad) directional sense. With the distinction between analytic and synthetic judgments the critical Kant did introduced a new way of using the terms 'analytic'-'synthetic', but one that still lies in line with their directional sense. A careful comparison of the conceptions of the critical Kant with ideas of the precritical Kant as expressed in (...) _Ãœber die Deutlichkeit, leads to the interpretation defended here of Kant's distinction between analytic and synthetic judgments within his philosophy of mathematics. (shrink)

Stephen Finlay’s proposed methodology for defending the central theses of his impressive Confusion of Tongues is an underexplored aspect of this work.1 1 His official methodology is analytic : A reduction of normative to non-normative vocabulary. Here, I argue that taking this official line at face-value forces the reader to conclude that the reductions at the heart of that book cannot be correct. In contrast, a philosophical methodology that does not proceed via analyses would better support those reductions, then understood (...) as non-analytic. As we’ll see below, there are independent, empirical reasons to reject a philosophical methodology that proceeds via analyses. I conclude that there is a method for the study of ethical language that better serves Finlay’s primary philosophical aims. The lesson, though, is generalizable: Given the array of normative and meta-normative theories, we want a semantics for normative discourse to be capable of expressing, we should expect that the more plausible such views will not be defended via analyses. (shrink)

Synthetic genomics is a new field of research in which small DNA pieces are assembled in a series of steps into whole genomes. The highly reduced genomes of host‐associated bacteria are now being used as models for de novo synthesis of small genomes in the laboratory. Bacteria with the smallest genomes identified in nature provide nutrients to their hosts, such as amino acids, co‐factors and vitamins. Comparative genomics of these bacteria enables predictions to be made about the gene sets (...) required for core cellular functions and the associated metabolic network for the biosynthesis of host‐selected compounds. Synthetic biology may ultimately enable researchers to make customized cell‐specific organelles for the production and delivery of drugs to humans and domestic animals. Synthetic genomics may also become the method of choice for functional analyses of genes and genomes from bacteria that cannot be cultivated in the laboratory. (shrink)

In this paper, I argue, first, that Hegel defended a version of the analytic/synthetic distinction—that, indeed, his version of the distinction deserves to be called Kantian. For both Kant and Hegel, the analytic/synthetic distinction can be explained in terms of the discursive character of cognition: insofar as our cognition is discursive, its most basic form can be articulated in terms of a genus/species tree. The structure of that tree elucidates the distinction between analytic and synthetic judgments. Second, (...) I argue that Hegel has an interesting and so far unexplored argument for the analytic/synthetic distinction: Hegel argues that the systematic relationship between concepts expressed in a genus/species tree can only be expressed through synthetic judgments. Third and finally, I explore some of the implications that the arguments in the first two parts of the essay have for understanding the way in which Hegel differs from Kant. I argue that Hegel accepts Kant's point that discursive cognition cannot be used to cognize the absolute. However, Hegel thinks that we can, nevertheless, cognize the absolute. I explore the character of this non-discursive cognition and argue that we can understand Hegel's glosses on this form of cognition—as simultaneously analytic and synthetic and as having a circular structure—through contrasting it with his account of discursive cognition. As a consequence, I argue that we must give up on attempts to understand ‘the dialectical method’ and ‘speculative cognition’ on the model of discursive cognition. (shrink)