Griffin's panexperientialism as perennial philosophy -- Stengers on Whitehead on God -- Rawlsian political liberalism and process thought -- Hartshorne, the process concept of God, and pacifism -- Butler and grievable lives -- Wordsworth, Whitehead, and the romantic reaction.

"The time-honored dualism of the mutually exclusive systems of thought, mechanistic biology on the one hand and vitalism on the other, expresses a pair of theoretical approaches which are both inadequate. We shall show how they can be replaced by an abstractly descriptive system of a different type that is far better adapted to the nature of biology"--Preface.

Although the basis of modern biology is Cartesian, Descartes’s theories of biology have been more often ridiculed than studied. Yet, Dennis Des Chene demonstrates, the themes, arguments, and vocabulary of his mechanistic biology pervade the writings of many seventeenth-century authors. In his illuminating account of Cartesian physiology in its historical context, Des Chene focuses on the philosopher’s innovative reworking of that field, including the nature of life, the problem of generation, and the concepts of health and illness. Des Chene begins (...) by surveying works that Descartes would likely have encountered, from late Aristotelian theories of the soul to medical literature and treatises on machines. The Cartesian theory of vital operations is examined, with particular attention to the generation of animals. Des Chene also considers the role of the machine-model in furnishing a method in physiology, the ambiguities of the notion of machine, and of Descartes’s problem of simulation. Finally, he looks at,the various kinds of unity of the body, both in itself and in its union with the soul. Spirits and Clocks continues Des Chene’s highly regarded exploration -- begun in his previous book, Life’s Form -- of the scholastic and Cartesian sciences as well as the dialogue between these two worldviews. Introduction 1 Part One - Tales of the Bête-Machine [ 1 ] - Self-Movers 13 [ 2 ] - Where Do Machines Come From? 32 [ 3 ] - The Uses of Usus 53 Part Two - Machines, Mechanisms, Bodies, Organs [ 4 ] - Tools of Knowledge 71 [ 5 ] - Jeux D’Artifice 103 [ 6 ] - Unity of the Body 116 Conclusion 153 Bibliography 159 Index 177. (shrink)

Most theisms and atheisms share an assumption about what divine action would look like; if God is real and acts in the world, then God acts through intervention, invading the mechanistic world as an alien agent. Whitehead's Religious Thought takes dead aim at this contention, arguing that such conceptions of divine intervention emerge from and reinforce a problematic dualism that permeates western theological discourse. Throughout his text Daniel A. Dombrowski links dualistic conceptions of human experience with metaphysical dualism, but also (...) argues that materialistic or mechanistic conceptions of the universe all presume the same basic constituents: machines and ghosts. Materialism rids the world of ghosts and... (shrink)

Men think in terms of models. Their sense organs abstract the events which touch them; their memories store traces of these events as coded symbols; and they may recall them according to patterns which they learned earlier, or recombine them in patterns that are new. In all this, we may think of our thought as consisting of symbols which are put in relations or sequences according to operating rules. Both symbols and operating rules are acquired, in part directly from interaction (...) with the outside world, and in part from elaboration of this material through internal recombination. Together, a set of symbols and a set of rules may constitute what we may call a calculus, a logic, a game or a model. Whatever we call it, it will have some structure, i.e., some pattern of distribution of relative discontinuities, and some “laws” of operation. (shrink)

Elsasser outlines in an informal but meticulous fashion an organismic biology which promises, in his opinion, to combine the best features of epigenetic vitalism and preformationist mechanism. Mechanistic reductionism is for Elsasser an unverifiable metaphysical hypothesis; i.e., if the postulate of infinite homogenous classes is dropped from the axiomatics of Van Neumann's proof that the state of any system is, in principle, Quantum Mechanically determinable, it becomes combinatorically obvious that biological systems and classes are radically inhomogenous [[sic]], a fact (...) which operationally bars the way to any complete reductionism. The door is thus opened to an open-ended theoretical biology in which all questions do not have a truth-functional equivalent answer according to the axioms and laws of the science, and prediction in the science becomes statistical in a nonabsolute way. Elsasser is a physicist with more than a casual acquaintance with biology and his argument benefits by his obvious expertise in both of these areas. Philosophically, however, he is a lightweight and relies, in particular, too much on the ontological ice that might be cut by operationalism. Theories are not verified in the stringent operational sense; they are confirmed in a way which is not logically tied to the requirement that all laws be inductively established. Elsasser, however, has so much to say on the problem of reductionism in biology that is of obvious value that the book is easily recommended over these caveats.—E. A. R. (shrink)

According to vitalism, living organisms differ from machines and all other inanimate objects by being endowed with an indwelling immaterial directive agency, ‘vital force,’ or entelechy . While support for vitalism fell away in the late nineteenth century many biologists in the early twentieth century embraced a non vitalist philosophy variously termed organicism/holism/emergentism which aimed at replacing the actions of an immaterial spirit with what was seen as an equivalent but perfectly natural agency—the emergent autonomous activity of the whole (...) class='Hi'>organism. Organicists hold that organisms unlike machines are ‘more than the sum of their parts’ and predict that the vital properties of living things can never be explained in terms of mechanical analogies and that the reductionist agenda is doomed to failure. Here we review the current status of the mechanist and organicist conceptions of life particularly as they apply to the cell. We argue that despite the advances in biological knowledge over the past six decades since the molecular biological revolution, especially in the fields of genetics and cell biology the unique properties of living cells have still not been simulated in mechanical systems nor yielded to reductionist—analytical explanations. And we conclude that despite the dominance of the mechanistic–reductionist paradigm through most of the past century the possibility of a twentyfirst century organicist revival cannot be easily discounted. (shrink)

The relation between organisms and machines is very old. Over a century ago, the French historian and philosopher Alfred Victor Espinas observed that from the Greeks onwards the intelligibility of the organic world presupposed a comparison with technical objects. Aristotle, for instance, associated living organs with mechanical artefacts in order to understand animals ‘movements. In the modern period, Descartes, Borelli and other mechanists defended the idea that organisms are, in reality, machines. Today, philosophers and scientists still argue that the genome (...) is like a software and the brain is like a computer. In this article I reconsider the relation between organisms and machines from the perspective of the German geographer and philosopher Ernst Kapp, one of the founding fathers of the Philosophy of Technology. Breaking with a long and venerable philosophical tradition, Kapp argued that machines are, in reality, “organic projections”. Organisms are not machines; they are an imitation or reflection of the organic world. First of all, I clarify the hypothesis of “organic projection”. Secondly, I consider some of the philosophical consequences that such a hypothesis entails over the debate between machinists and anti-mechanists. Finally, and following the previous considerations, I defend the importance of reconnecting the philosophy of technology with philosophy of biology in order to better understand the development of contemporary biology. (shrink)

The relation between organisms and machines is very old. Over a century ago, the French historian and philosopher Alfred Victor Espinas observed that from the Greeks onwards the intelligibility of the organic world presupposed a comparison with technical objects. Aristotle, for instance, associated living organs with mechanical artefacts in order to understand animals ‘movements. In the modern period, Descartes, Borelli and other mechanists defended the idea that organisms are, in reality, machines. Today, philosophers and scientists still argue that the genome (...) is like a software and the brain is like a computer. In this article I reconsider the relation between organisms and machines from the perspective of the German geographer and philosopher Ernst Kapp, one of the founding fathers of the Philosophy of Technology. Breaking with a long and venerable philosophical tradition, Kapp argued that machines are, in reality, “organic projections”. Organisms are not machines; they are an imitation or reflection of the organic world. First of all, I clarify the hypothesis of “organic projection”. Secondly, I consider some of the philosophical consequences that such a hypothesis entails over the debate between machinists and anti-mechanists. Finally, and following the previous considerations, I defend the importance of reconnecting the philosophy of technology with philosophy of biology in order to better understand the development of contemporary biology. (shrink)

The organism is neither a discovery like the circulation of the blood or the glycogenic function of the liver, nor a particular biological theory like epigenesis or preformationism. It is rather a concept which plays a series of roles – sometimes overt, sometimes masked – throughout the history of biology, and frequently in very normative ways, also shifting between the biological and the social. Indeed, it has often been presented as a key-concept in life science and the ‘theorization’ of (...) Life, but conversely has also been the target of influential rejections: as just an instrument of transmission for the selfish gene, but also, historiographically, as part of an outdated ‘vitalism’. Indeed, the organism, perhaps because it is experientially closer to the ‘body’ than to the ‘molecule’, is often the object of quasi-affective theoretical investments presenting it as essential, sometimes even as the pivot of a science or a particular approach to nature, while other approaches reject or attack it with equal force, assimilating it to a mysterious ‘vitalist’ ontology of extra-causal forces, or other pseudo-scientific doctrines. This paper does not seek to adjudicate between these debates, either in terms of scientific validity or historical coherence; nor does it return to the well-studied issue of the organism-mechanism tension in biology. Recent scholarship has begun to focus on the emergence and transformation of the concept of organism, but has not emphasized so much the way in which organism is a shifting, ‘go-between’ concept – invoked as ‘natural’ by some thinkers to justify their metaphysics, but then presented as value-laden by others, over and against the natural world. The organism as go-between concept is also a hybrid, a boundary concept or an epistemic limit case, all of which partly overlap with the idea of ‘nomadic concepts’. Thereby the concept of organism continues to function in different contexts – as a heuristic, an explanatory challenge, a model of order, of regulation, etc. – despite having frequently been pronounced irrelevant and reduced to molecules or genes. Yet this perpetuation is far removed from any ‘metaphysics of organism’, or organismic biology. (shrink)

The new mechanists and the autonomy approach both aim to account for how biological phenomena are explained. One identifies appeals to how components of a mechanism are organized so that their activities produce a phenomenon. The other directs attention towards the whole organism and focuses on how it achieves self-maintenance. This paper discusses challenges each confronts and how each could benefit from collaboration with the other: the new mechanistic framework can gain by taking into account what happens outside (...) individual mechanisms, while the autonomy approach can ground itself in biological research into how the actual components constituting an autonomous system interact and contribute in different ways to realize and maintain the system. To press the case that these two traditions should be constructively integrated we describe how three recent developments in the autonomy tradition together provide a bridge between the two traditions: (1) a framework of work and constraints, (2) a conception of function grounded in the organization of an autonomous system, and (3) a focus on control. (shrink)

The organism is neither a discovery like the circulation of the blood or the glycogenic function of the liver, nor a particular biological theory like epigenesis or preformationism. It is rather a concept which plays a series of roles, sometimes masked, often normative, throughout the history of biology. Indeed, it has often been presented as a key-concept in life science and its ‘theorization’, but conversely has also been the target of influential rejections: as just an instrument of transmission for (...) the selfish gene, but also, historiographically, as part of an outdated ‘vitalism’. Indeed, the organism, perhaps because it is experientially closer to the ‘body’ than to the ‘molecule’, is often the object of quasi-affective theoretical investments presenting it as essential, as the pivot of a science or a particular approach to nature, while other approaches reject or attack it with equal force, assimilating it to a mysterious ‘vitalist’ ontology of extra-causal forces, or other pseudo-scientific doctrines. I do not seek to adjudicate between these debates, either regarding scientific validity or historical coherence; nor do I return to the well-studied issue of the organism-mechanism tension in biology. Recent scholarship has begun to discuss the emergence and transformation of the organism concept, but has not emphasized the way the latter is a shifting, ‘go-between’ concept – invoked as ‘natural’ by some thinkers to justify their metaphysics, but then presented as value-laden by others, over and against the natural world. The organism as go-between concept is also a hybrid, a boundary concept or a limit case, which continues to function in different contexts – as a heuristic, an explanatory challenge, a model of order, of regulation, etc. – despite having frequently been pronounced irrelevant and reduced to molecules or genes. Yet this perpetuation is far removed from any ‘metaphysics of organism’, or organismic biology. (shrink)

This rangy and precise book deserves to be read even by those historians who think they are bored with Descartes. While offering surprising and detailed readings of bewildering texts like theDescription of the Human Body, Des Chene constructs a powerful, sad narrative of the Cartesian disenchantment of the body. Along the way he also delivers provocative views on topics as various as teleology, the role of illustrations in the history of mechanism, theories of the sexual differentiation of the foetus, (...) and problems of simulation in scientific method. (shrink)

Model organisms became an indispensable part of experimental systems in molecular developmental and cell biology, constructed to investigate physiological and pathological processes. They are thought to play a crucial role for the elucidation of gene function, complementing the sequencing of the genomes of humans and other organisms. Accordingly, historians and philosophers paid considerable attention to various issues concerning this aspect of experimental biology. With respect to the representational features of model organisms, that is, their status as models, the main focus (...) was on generalization of phenomena investigated in such experimental systems. Model organisms have been said to be models for other organisms or a higher taxon. This, however, presupposes a representation of the phenomenon in question. I will argue that prior to generalization, model organisms allow researchers to built generative material models of phenomena – structures, processes or the mechanisms that explain them – through their integration in experimental set-ups that carve out the phenomena from the whole organism and thus represent them. I will use the history of zebrafish biology to show how model organism systems, from around 1970 on, were developed to construct material models of molecular mechanisms explaining developmental or physiological processes. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 40.1 (2002) 122-123 [Access article in PDF] Book Review Spirits and Clocks: Machine & Organism in Descartes Dennis Des Chene. Spirits and Clocks: Machine & Organism in Descartes. Ithaca, NY and London: Cornell University Press, 2001. Pp. xiii + 181. Cloth, $39.95. Confronted with the thousandth "entirely new" interpretation of the Cartesian mind-body union, one sometimes wonders whether anything new can (...) in fact be said about the great Descartes. Once again, after his invaluable and prize-winning Physiologia (Cornell University Press, 1996), Des Chene proves that a serious historian, with a keen awareness of historical context, actually can. Unlike the usual accounts of Descartes's animal-machine, Des Chene does not concentrate on the all too familiar set of questions whether or not machines can think, sense, etc. Instead, Des Chene interprets the machine-metaphor the way Descartes meant it to be, viz. as a model for explaining animal and human physiology instead of (cognitive) psychology. Des Chene's central claim is that the Traité de l'Homme and Descartes's later (unpublished) physiological tracts are an attempt to replace scholastic commentaries on Aristotle's De Anima, itself discussed in this book's companion volume Life's Forms (Cornell University Press, 2000). Spirits and Clocks investigates how Descartes's general mechanistic program (outlined in Physiologia) is applied to the field of animal and human life. This project in itself had a far more lasting influence than Descartes's specific and often bizarre physiological explanations. Therefore, Des Chene rightly concentrates on the philosophical aspects of Descartes's general project of "mechanizing" physiology. His short but illuminating book studies a wide range of ontological, epistemological, and even aesthetic aspects of the machine metaphor and, although this is not the express goal [End Page 122] of the book, it also sheds new light on the epistemology and metaphysics of the Meditations. In this sense Spirits and Clocks is not only a significant contribution to the history of biology but first and foremost a must for historians of philosophy.Des Chene explains that the use of a machine model in physiology was neither new nor entirely unacceptable to the Aristotelians. What is new is Descartes's use of it. His mechanistic understanding of the body as a machine is incompatible with accepting the soul as the source of life and the principle of all our physiological and psychological capacities, while Aristotelians had no problem in accepting both the soul and certain machine models of the body. (Aristotle himself uses the lever to explain animal motion.) Des Chene sketches Descartes's attempt to explain all physiological processes by means of the physical properties of material parts that obey the general laws of motion, excluding all talk of ends. In this context, the use of illustrations is of considerable importance: though they cannot per se convey a denial of a "soul-model" of physiology, they strongly suggest that the (mechanistically understood) machine is all there is to say about the functions of human and animal bodies. Des Chene offers an interesting, albeit sometimes somewhat speculative and ahistoric, discussion of the aesthetic aspects of the machine model.As Des Chene showed in his Physiologia, the rejection of teleology is one of the main goals of Descartes's physics. However, although Descartes may be successful in rejecting the view that stones fall down from some kind of desire to reach their final destiny, he is less successful in denying that the eye is meant for seeing (and hence for our self-preservation). Des Chene gives a truly fascinating account of the limits of Descartes's denial of teleology in physiology. This includes questions about the physical unity of the human body: how can I explain why I have this body and how can I even identify this body as a unit without invoking ends? Similarly, Descartes takes the healthy, "normally" functioning body as the norm of his investigations. But, again, can he do so without acknowledging some form of teleology? Descartes's answer in most of these cases is that the final goals... (shrink)

Both in biology and psychology there has been a tendency on the part of many investigators to focus solely on the mature organism and ignore development. There are many reasons for this, but an important one is that the explanatory framework often invoked in the life sciences for understanding a given phenomenon, according to which explanation consists in identifying the mechanism that produces that phenomenon, both makes it possible to side-step the development issue and to provide inadequate resources (...) for actually explaining development. When biologists and psychologists do take up the question of development, they find themselves confronted with two polarizing positions of nativism and empiricism. However, the mechanistic framework, insofar as it emphasizes organization and recognizes the potential for self-organization, does in fact provide the resources for an account of development which avoids the nativism-empiricism dichotomy. (shrink)

This article deals with the concept of “mechanism” from a historical point of view, focusing on its relationship with the evolution of hylomorphism in the 17th century. I try to address the following questions: is mechanism structurally bound to materialism or does it rather represent a form of complete determinism, reconcilable with an “updated” version of hylomorphism? In the first part of the essay, I make the point that the very notion of “mechanism” must be clarified by (...) means of a distinction between Boylean experimental mechanism and what Daniel Garber has called the “pre-history of the Mechanical Philosophy”. My aim is to highlight how the deterministic (and nominalistic) hylomorphism developed in the 17th Century came quite close to mechanism. In this framework, I present the ‘strange case’ of Marin Cureau de La Chambre (1594-1669), which represents a characteristic compromise – based on the possibility of a not bodily extension – between a deterministic mechanization of the lower functions of the vegetative and sensitive soul and Campanella’s panpsychism. (shrink)

Pathological gaming among adolescents has been reported to hamper the achievement of a balanced life and to threaten the development of social competencies. Despite the increasing social concerns on the adolescent users, however, the mechanism of gaming behavior of adolescents has not been sufficiently examined. This study explored the mechanism of pathological gaming among adolescents from 3-year longitudinal data of 778 Korean adolescent gamers, by analyzing the effects of negative affects on the degree of pathological gaming through the (...) mediation variables based on the stimulus-organism-response framework. Latent class analysis was used to uncover potential risk groups, and through partial least squares-structural equation modeling analysis, the mediation pathways to pathological gaming were compared between the risk group and the non-risk group. The results highlighted the key role of academic stress on the degree of pathological gaming. In the entire group, academic stress primarily increased pathological gaming through self-control. The mediation path of self-control was the most influential result in the risk group. Aggression was the key mediator between loneliness and pathological gaming in the non-risk group. The theoretical and practical implications of the results were discussed. (shrink)

Double 11 shopping carnival, celebrated by the most successful electronic-commerce Chinese company, Alibaba, has always been the online shopping festival with the highest turnover and involves the largest number of consumers and enterprises in China. This study integrates the elaboration likelihood model and stimulus-organism-response theory to study the dual-processing path of information, which drives customers’ behavioral intention on Double 11. There are 454 valid samples of data are collected, and the research model is tested using the partial least squares (...) method. Results show that in the Double 11 context, two different processing mechanisms affect consumers’ behavioral intention. Thereinto, consumers’ behavioral intention is more affected by the peripheral path than the central path. The affective experience affected by the information stimulus has a greater impact on the behavioral intention than cognitive experience. Furthermore, we find situational involvement have different moderating effects on the relationship between two experiences and behavioral intention. (shrink)

Kant was well versed in many of the debates taking place in the life sciences during his day. One of the more central areas of contention concerned the proper means for discriminating between material bodies composed of organised parts (like clocks or automatons) and living material bodies composed of organised parts (like plants and animals). For many theorists, it seemed clear that the physically organised structure of a body was distinct from any vital forces responsible for the life processes or (...) metabolism at work within it. This was the approach taken by the chemist Georg Stahl (1659-1734), for example, who resisted attempts to provide a mechanical account of metabolism, arguing instead that only something like a physis or anima could explain a living body’s capacity for the movement of otherwise inert material parts. This was a position which Kant appears to have appreciated when, in discussing the issue in 1766, he exclaimed “I am convinced that Stahl, who is disposed to explain animal processes in organic terms, was frequently closer to the truth than [the mechanists] Hofmann or Boerhaave, to name but a few” (2:331). And indeed, by 1790 Kant would reach conclusions similar to Stahl’s regarding the manner by which we must reflectively judge animal processes to be operating, given that for Stahl the biological body was best taken to be a complex, self-organising system of material parts and a purposive force or physis responsible for their ongoing interrelation. (shrink)

Causation is important when considering how an organism maintains health, why disease arises in a healthy person, and how one may intervene to change the course of a disease. This paper explores the form of causative relationships in health, disease and intervention, with particular regard to the pathological and biopsychosocial models. Consistent with the philosophical view of dispositionalism, we believe that objects are the fundamental relata of causation. By accepting the broad scope of the biopsychosocial model, we argue that (...) psychological and social constructs be considered objects. We think that this 'biopsychosocial dispositionalism' offers the flexibility required to describe causation throughout health, disease and intervention pathways. When constructing mechanistic chains to describe causative pathways, we argue that an object will causally connect with others through actions; transfers of energy from one object to another, initiated by the manifestation of one or more dispositional property. Finally, our analysis of causative interactions utilises the concept that a common form of interaction exists between disease and intervention pathways. This common form will always be an object, but the mode of interaction will vary with each disease. We describe how intervention may act through objects being shared between converging mechanistic chains, or through the removal and/or insertion of objects in such chains. We believe that this analysis provides novel insight to the forms of causative transactions that can occur. In addition, we hope that the findings of this analysis represent the first step towards developing a framework for appraising the composition of mechanistic theories. (shrink)

In recent years, there has been an escalation in cases of cyber violence, which has had a chilling effect on users' behavior toward social media sites. This article explores the causes behind cyber violence and provides empirical data for developing means for effective prevention. Using elements of the stimulus–organism–response theory, we constructed a model of cyber-violence behavior. A closed-ended questionnaire was administered to collect data through an online survey, which results in 531 valid responses. A proposed model was tested (...) using partial least squares structural equation modeling using SmartPLS 3.0, v. Research findings show that information inequality is a strong external stimulus with a significant positive impact on digital distrust and negative emotion. However, the effects of information overload on digital distrust and the adverse effects of communication overload on negative emotions should not be ignored. Both digital distrust and negative emotions have significant positive impacts on cyber violence and cumulatively represent 11.5% changes in cyber violence. Furthermore, information overload, communication overload, information inequality, and digital distrust show a 27.1% change in negative emotions. This study also presents evidence for competitive mediation of digital distrust by information overload, information inequality, and cyber violence. The results of this study have implications for individual practitioners and scholars, for organizations, and at the governmental level regarding cyber-violence behavior. To test our hypotheses, we have constructed an empirical, multidimensional model, including the role of specific mediators in creating relationships. (shrink)

The mechanistic model depicts scientific explanations as involving the discovery of multi-level, organized components that constitute a target phenomenon. Meanwhile, sensorimotor enactivism purports to offer a scientifically informed account of perceptual experience as a skill-laden interactive relationship, constitutively involving both perceiver and world, rather than as an agent-bound representation of the world. Insofar as sensorimotor enactivism identifies an empirically tractable phenomenon – skillful agent-world interaction – and mechanistic explanation establishes the subpersonal components of this phenomenon, the two approaches allow for (...) a fruitful division of labor in investigating perceptual experience. On closer inspection, however, two challenges arise. First, the “representation challenge” arises because promising attempts to set out implementational details of our sensorimotor interaction with the world implicate cognitive representations, creating tension with sensorimotor enactivism’s nonrepresentational commitments. Second, the “reconstitution challenge” arises when mechanistic explanation not only uncovers the components of some established phenomenon but plays a role in “reconstituting” this phenomenon. This means that, through investigating mechanisms, perceptual experience may be reconceived such that its constituents are wholly organism-bound. We explore both challenges to the compatibility of mechanism and sensorimotor enactivism and examine possible solutions. The result is a clearer understanding of the tensions and opportunities for learning between the frameworks. (shrink)

My understanding is that proximate explanations concern adaptive mechanism and that ultimate explanations concern adaptive rationale. Viewed in this light, the two kinds of explanation are quite distinct, but they interact in a complementary way to give a full understanding of biological adaptations. In contrast, Laland et al. (2013)—following a literal reading of Mayr (Science 134:1501–1506, 1961)—have characterized ultimate explanations as concerning any and all mechanisms that have operated over the course of an organism’s evolutionary history. This has (...) unfortunate consequences, such as allowing random drift to form the basis for ultimate explanations, and allowing proximate and ultimate explanations to bleed into each other until their distinction is meaningless. Here, I suggest Laland et al’s explanatory framework of “reciprocal causation” is not conducive to successful biological science, and that they have misunderstood key elements of the theory of Darwinian adaptation. (shrink)

Causation is important when considering: how an organism maintains health; why disease arises in a healthy person; and, how one may intervene to change the course of a disease. This paper explores the form of causative relationships in health, disease and intervention, with particular regard to the pathological and biopsychosocial models. Consistent with the philosophical view of dispositionalism, we believe that objects are the fundamental relata of causation. By accepting the broad scope of the biopsychosocial model, we argue that (...) psychological and social constructs be considered objects. We think that this ‘biopsychosocial dispositionalism’ offers the flexibility required to describe causation throughout health, disease and intervention pathways. When constructing mechanistic chains to describe causative pathways, we argue that an object will causally connect with others through actions; transfers of energy from one object to another, initiated by the manifestation of one or more dispositional property. Finally, our analysis of causative interactions utilises the concept that a common form of interaction exists between disease and intervention pathways. This common form will always be an object, but the mode of interaction will vary with each disease. We describe how intervention may act through objects being shared between converging mechanistic chains, or through the removal and/or insertion of objects in such chains. We believe that this analysis provides novel insight to the forms of causative transactions that can occur. In addition, we hope that the findings of this analysis represent the first step towards developing a framework for appraising the composition of mechanistic theories. (shrink)

A new evolutionary concept is presented, based on the principle of biological diversity by organismal adaptation, more specifically the origin of the first variations and the process leading to speciation. The article suggests the mechanism of stimulation as the major promoter of genetic variation, making an overall assessment and accurate to the natural phenomenon responsible for this evolutionary step. Constantly, environmental forces interact with the organism, favoring changes to the organs toward adaptation. Stimulation focuses on this action?reaction between (...) organism and environment, trying to decipher the causes/consequences resulting. The article also addresses possible relationships and constraints with neo-Darwinism. (shrink)

Thanks to genetic and biochemical advances on the molecular mechanism of circadian rhythms in Drosophila, theoretical models closely related to experimental observations can be considered for the regulatory mechanism of the circadian clock in this organism. Modeling is based on the autoregulatory negative feedback exerted by a complex between PER and TIM proteins on the expression of per and tim genes. The model predicts the occurrence of sustained circadian oscillations in continuous darkness. When incorporating light‐induced TIM degradation, (...) the model accounts for damping of oscillations in constant light, entrainment of the rhythm by light‐dark cycles of varying period or photoperiod, and phase shifting by light pulses. The model further provides a molecular dynamical explanation for the permanent or transient suppression of circadian rhythmicity triggered in a variety of organisms by a critical pulse of light. Finally, the model shows that to produce a robust rhythm the various clock genes must be expressed at the appropriate levels since sustained oscillations only occur in a precise range of parameter values. BioEssays 22:84–93, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

This article examines the comparison between a reductionist mechanistic paradigm and the Goethean paradigm, that provides a vision of an informed universe.

We are at the crux of a return of animals to the battlefield. Framed as an improvement over current limitations of biomimetic devices, couplings of microelectrical mechanical systems with insect bodies are currently being designed and created in laboratories, with funding from military agencies. Moving beyond the external attachment of computerized ‘backpacks’, MEMS are being implanted into larval stages to allow for living tissue to envelop otherwise fragile circuitry and electronics: the creation of bioelectronic interfaces. The weaponization of animals, with (...) insect cyborgs as a first step—a foundation for the remaking of more complex species—is an anthropocentric solution to an anthropocentric problem. Speciesism is the normative context in which technoscientific discourse and such approaches to nanoscience and nanotechnology are situated. This is a network of actors and relationships within and across science and society. Animals are framed as mechanical devices that can be dis/enhanced for human ends. This paper engages with the remaking of species, the blurring of boundaries between mechanism and organism, and the implications of the effective disappearance of the animal as key sociotechnological challenges. (shrink)

In China, online sales continue to grow against the generally adverse effects of the COVID-19 pandemic on economic development. Although advertisers favor online targeted advertising for its precision, consumers may find it intrusive and avoid it. This study constructed a conceptual model based on Stimulus-Organism-Response theory, Approach-Avoidance Theory, and Brand Avoidance Theory to investigate the influence mechanism of consumers’ perceived risk on the avoidance behavior of online targeted advertising via an online survey. Collected 436 validated data was analyzed (...) through structural equation method in AMOS statistical software. Results showed that the positively influenced advertising avoidance, and negative emotions mediated the relationship between perceived performance risk, time-loss risk, freedom risk, and advertising avoidance, but perceived privacy risk did not influence advertising avoidance through negative emotions. Perceived COVID-19 risk moderates the effect of negative emotions on advertising avoidance. The findings provide important insights for helping governments, advertisers and online platforms into which risk perceptions influence advertising avoidance, and suggests ways to mitigate consumers risk perceptions for the mutual benefit of brands and users. (shrink)

The emergence of new biological traits is landmarks of evolutionary progress. However, when, how, and why do they appear? We propose a universal mechanism, a Buffering Mechanism of Evolution to understand these questions. We speculate that all organisms possess this potential buffer capacity. This capacity would be triggered by the pressures, natural or artificial, to express the intrinsic potential variants. The potential buffer capacity of the organism increases for further selections as evolutionary progress occurs. The higher the (...) evolutionary level of the organism, the greater the potential buffer capacity, and importantly, the buffer capacity versus the pressures of selections will result. However, when the pressures are far more than the potential capacity of the targets, the natural or artificial pressures then compromise the genetic buffering system resulting in possible species extinction if the emergence of new traits fails. (shrink)

The machine-organism analogy has played a pivotal role in the history of Western philosophy and science. Notwithstanding its apparent simplicity, it hides complex epistemological issues about the status of both organism and machine and the nature of their interaction. What is the real object of this analogy: organisms as a whole, their parts or, rather, bodily functions? How can the machine serve as a model for interpreting biological phenomena, cognitive processes, or more broadly the social and cultural transformations (...) of the relations between individuals, and between individuals and the environments in which they live? Wired Bodies. New Perspectives on the Machine-Organism Analogy provides the reader with some of the latest perspectives on this vast debate, addressing three major topics:1) the development of a ‘mechanistic’ framework in medicine and biology; 2) the methodological issues underlying the use of ‘simulation’ in cognitive science; 3) the interaction between humans and machines according to 20th-century epistemology. (shrink)

In the Critique of the Power of Judgment, Kant calls purposiveness the “lawfulness of the contingent”. I argue that this should be interpreted not as lawfulness assumed in order to remove unacceptable mechanical indeterminacy, but rather as an additional kind of lawfulness which, in the case of organisms, inexplicably coincides with mechanical determination. Schelling adapts Kant’s notion of natural purposiveness in his own conception of the relation between mechanism and organism. He states in his 1798 work, On the (...) World Soul, that nature is “lawless in its lawfulness, and lawful in its lawlessness”. This should be interpreted similarly: there is a coincidence of two orders of lawfulness in nature. However, while Kant maintains that the coincidence or unity of these two orders is inexplicable for beings like us, Schelling explains the unity by assigning these laws to distinct levels of operation in nature. Organic organization is generated by a second-order operation of an organic principle on the first-order mechanical forces that are characteristic of matter. Schelling thereby builds on Kant’s third Critique framework in a creative way in order to offer a more fully unified account of nature. In this account, mechanism and organism maintain distinct roles but are both grounded in a further, higher principle. (shrink)

Is organicism inherently Christian-friendly, and for that matter, is mechanism inherently religion nonfriendly? They have tended to be, but the story is much more complicated. The long history of the intertwined metaphors of nature taken as an organism, versus that of nature as a machine, reveals that both metaphors have flourished in the endeavors of philosophers, scientists, and persons of faith alike. Different kinds of Christians have been receptive to both organicist and mechanistic models, just as various kinds (...) of nonreligious scientists have been receptive to both holistic and machine metaphors. Although, it is true, organicism has been generally more attractive to persons of faith than mechanism, an overview of the rich and varied history of allegiances to these metaphors—religious and nonreligious alike—shows that debate is much more interesting and complex. A brief inspection of conversation surrounding recent scientific discoveries shows that this debate between metaphors is still very much alive today. (shrink)

The field of machine perception is based on standard informational and computational approaches to perception. But naturalistic informational theories are widely regarded as being inadequate, while purely syntactic computational approaches give no account of perceptual content. Thus there is a significant need for a novel, purely naturalistic perceptual theory not based on informational or computational concepts, which could provide a new paradigm for mechanistic perception. Now specifically evolutionary naturalistic approaches to perception have been—perhaps surprisingly—almost completely neglected for this purpose. Arguably (...) perceptual mechanisms enhance evolutionary fitness by facilitating sensorily mediated causal interactions between an organism Z and items X in its environment. A ‘reflexive’ theory of perception of this kind is outlined, according to which an organism Z perceives an item X just in case X causes a sensory organ zi of Z to cause Z to acquire a disposition toward the very same item X that caused the perception. The rest of the paper shows how an intuitively plausible account of mechanistic perception can be developed and defended in terms of the reflexive theory. Also, a compatibilist option is provided for those who wish to preserve a distinct informational concept of perception. (shrink)

There are several conceptions of man in the history of philosophy. However, two considerable tendencies are recurring throughout modern history. A human being can be perceived as a complex mechanism or as a living organism. The response to the query has essential consequences in different areas. The article aims to provide a view of humankind that builds upon an organic conception of life, nature, and human beings, especially as elaborated by A. N. Whitehead and some of his followers. (...) The article also briefly examines the emergence and development of a mechanistic view. The historical overview exposes the close relationship between the worldview of a given era and the understanding of man. Finally, the article argues that the organic conceptions of life developed in the first half of the 20th century provide an essential alternative to mechanistic views and could help us to deal with several problems we are currently encountering. (shrink)

This article sets in with the question whether current or foreseeable transformer-based large language models (LLMs), such as the ones powering OpenAI’s ChatGPT, could be language users in a way comparable to humans. It answers the question negatively, presenting the following argument. Apart from niche uses, to use language means to act. But LLMs are unable to act because they lack intentions. This, in turn, is because they are the wrong kind of being: agents with intentions need to be autonomous (...) organisms while LLMs are heteronomous mechanisms. To conclude, the article argues, based on structural aspects of transformer-based LLMs, that these LLMs have taken a first step away from mechanistic artificiality to autonomous self-constitution, which means that these models are (slowly) moving into a direction that someday might result in non-human, but equally non-artificial agents, thus subverting the time-honored Kantian distinction between organism and mechanism. (shrink)

The universe, in Chinese eyes, is a harmonious organism; its pattern of movement is inherent and not imposed from without; and the world of man, being a part of the universe, follows a similar pattern. (Derk Bodde, Harmony and Conflict in ...

This essay examines A. N. Whitehead’s philosophy of organism as a basis for an ecological ethics. His views are compared with those of deep ecologists and several problems with his panpsychism are considered in connection with the notion of intrinsic value in nature. In spite of problems raised by critics, this essay concludes that Whitehead’s philosophy provides a world view that offers a corrective to the disastrous course set by views that regard nature as an inert mechanism.

The question of specific properties of life compared to nonliving things accompanied biology throughout its history. At times this question generated major controversies with largely diverging opinions. Basically, mechanistic thinkers, who tried to understand organismic functions in terms of nonliving machines, were opposed by those who tried to describe specific properties or even special forces being active within living entities. As this question included the human body, these controversies always have been of special relevance to our self-image and also touched (...) practical issues of medicine. During the second half of the twentieth century, it seemed to be resolved that organisms are explainable basically as physicochemical machines. Especially from the perspective of molecular biology, it seemed to be clear that organisms need to be explained solely by the chemical functions of their component parts, although some resistance to this view never ceased. This research program has been working quite successfully, so that science today knows a lot about the physiological and chemical processes within organisms. However, again new doubts arise questioning whether the mere continuation of this analytical approach will finally generate a fundamental understanding of living entities. At the beginning of the twenty-first century the quest for a new synthesis actually comes from analytical empiricists themselves. The hypothesis of the present paper is that empirical research has been developed far enough today, that it reveals by itself the materials and the prerequisites to understand more of the specific properties of life. Without recourse to mysterious forces, it is possible to generate answers to this age-old question, just using recent, empirically generated knowledge. This view does not contradict the results of reductionistic research, but rather grants them meaning within the context of organismic systems and also may increase their practical usefulness. Although several of these properties have been discussed before, different authors usually concentrated on a single one or some of them. The paper describes ten specific properties of living entities as they can be deduced from contemporary science. The aim is to demonstrate that the results of empirical research show both the necessity as well as the possibility of the development of a new conception of life to build a coherent understanding of organismic functions. (shrink)

ArgumentThis article addresses the doctrinal controversy over the various characterizations of irritability and sensibility. In the middle of the eighteenth century, this scientific debate involved some encyclopaedist physicians, Albrecht von Haller (1709–1777), Jean-Jacques Ménuret de Chambaud (1733–1815), and Théophile de Bordeu (1722–1776). The doctor from Bern described irritability as an experimental property of the muscle fibers and made it the basis of a neo-mechanism in which organic reactions are related to the degree of irritation of the fibers. The practitioners (...) from Montpellier considered sensibility, a property of living matter, to be a spontaneous activity of the organ and developed around this notion an original conception of the organism as the sum of the specific lives of each part. Beyond conceptual divergences, two ways of thinking whose philosophical presuppositions (conception of living matter, mechanism, and organicism), were in opposition, while their epistemological principles (experience versus observation) and their medical practices (active medicine and expectant medicine) went on to evolve in different directions. The privileged place granted to experimentation and assessment enabled physiology to be articulated as an autonomous scientific discipline; the pre-eminence of observation and attention to the radical specificity of the living being constituted the bases of clinical medicine. (shrink)

ABSTRACTTo assess the strength of Lloyd's conception of analogy, in particular, his innovative conceptual apparatus ‘the multidimensionality of reality’ and ‘the semantic stretch’, I propose the notion of hermeneutic mechanism as a rival tool of investigation. Hermeneutic mechanism manifests in the interaction of negative and positive hermeneutic forces, the dynamic interdependence between ideal universality and contextualized individuality, and the organism-like ‘hermeneutic circle’. I argue that hermeneutic mechanism not only offers a meta-methodological perspective for appreciating Lloyd's methodological (...) development of analogy for cross-cultural studies, but also incorporates both Lloyd's quest for diversity and his critique of logical dichotomy, and moreover overcomes the explicatory flaw in his ‘multidimensionality of reality’ and colour metaphor. (shrink)

Several protective cellular mechanisms protect against the accumulation of reactive oxygen species (ROS) and the concomitant oxidative stress. Therefore, any reduction in glucose or fatty acid flux into cells leading to a decrease in the production of reducing equivalents would also lead to a decreased ROS production and protect cells against oxidative stress. In the presence of insulin, FOXO proteins are localized from the nucleus to the cytoplasm and degraded. An increase in cellular glucose uptake will lead to increased production (...) of ROS. This in turn activates the stress‐responsive Jun‐N‐terminal kinase (JNK), which promotes nuclear translocation of FOXO proteins, upregulating some important target genes including stress resistance. Consequently, insulin resistance should result in decreased cellular ROS production. For this reason, insulin resistance could be a physiological mechanism activated at the cellular level in response to conditions stimulating ROS production and leading to the prevention of oxidative stress, and extension of life. Concerning the whole organism, however, IR is a maladaptive process in the long term causing a diabetic state. BioEssays 29:811–818, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Early modern automata, understood as efforts to ‘model’ life, to grasp its singular properties and/or to unveil and demystify its seeming inaccessibility and mystery, are not just fascinating liminal, boundary, hybrid, crossover or go-between objects, while they are all of those of course. They also pose a direct challenge to some of our common conceptions about mechanism and embodiment. They challenge the simplicity of the distinction between a purported ‘mechanistic’ worldpicture, its ontology and its goals, and on the other (...) hand an attempt to understand ourselves and animals more broadly as flesh-and-blood, affective entities (that is, not just breathing and perspiring, but also desiring and ‘sanguine’ machines, as La Mettrie might have put it). In what follows I reflect on the complexity of early modern mechanism faced with the (living) body, and its mirror image, contemporary theories of embodiment. At times, embodiment theory seems to be governed by a fascination with what the Artificial Life researcher Ezequiel Di Paolo has called ‘biochauvinism’ (Di Paolo, “Extended Life”): an unquestioned belief that ‘living bodies are special’. Yet how does the theorist define this special status? The question is apparently a simple one, or at least promptly yields an aporia which appears simple: to borrow a provocative phrase from Terry Eagleton, embodiment theory is obsessed by the body but terrified of biology. Yet at the same time, at least since Hubert Dreyfus and Andy Clark’s groundbreaking works, embodiment has been a legit part of cognitive science, yielding the even more recently emerged field of ‘embodied cognition’ (see the work of Larry Shapiro), which seeks to depart from traditional cognitive science, especially the latter’s understanding of cognition as computational, in order to instead underscore “the significance of an organism’s body in how and what the organism thinks,” in Shapiro’s words. (shrink)

A common and enduring early modern intuition is that materialists reduce organisms in general and human beings in particular to automata. Wasn’t a famous book of the time entitled L’Homme-Machine? In fact, the machine is employed as an analogy, and there was a specifically materialist form of embodiment, in which the body is not reduced to an inanimate machine, but is conceived as an affective, flesh-and-blood entity. We discuss how mechanist and vitalist models of organism exist in a more (...) complementary relation than hitherto imagined, with conceptions of embodiment resulting from experimental physiology. From La Mettrie to Bernard, mechanism, body and embodiment are constantly overlapping, modifying and overdetermining one another; embodiment came to be scientifically addressed under the successive figures of vie organique and then milieu intérieur, thereby overcoming the often lamented divide between scientific image and living experience. (shrink)