The interactions between genetic and environmental risk factors contribute to the aetiology of complex human diseases. Genome‐wide association studies (GWAS) have revealed that most of the genetic variants associated with complex diseases are located in the non‐coding part of the genome, preferentially within enhancers. Enhancers are distal cis‐regulatory elements composed of clusters of transcription factors binding sites that positively regulate the expression of their target genes. The generation of genome‐wide maps for histone marks (e.g., H3K27ac), chromatin accessibility and transcription factor (...) and coactivator (e.g., p300) binding profiles have enabled the identification of enhancers across many human cell types and tissues. Nonetheless, the functional and pathological consequences of the majority of disease‐associated genetic variants located within enhancers seem to be rather minor under normal conditions, thus questioning their medical relevance. Here we propose that, due to the prevalence of enhancer redundancy, the pathological effects of many disease‐associated non‐coding genetic variants might be preferentially (or even only) manifested under environmental stress. (shrink)

Interactomics aims to characterize all interactions formed between molecules that comprise our body. Although it emerged from quantitative biophysics, it has devolved into a predominantly qualitative field of science over the past decades. Due to technical limitations at its onset, almost all tools in interactomics are qualitative, which persists in defining the discipline. Here, we argue that interactomics needs to return to a quantitative direction because the technical achievements of the last decade have overcome the original limitations that forced its (...) current path. In contrast to qualitative interactomics which is constrained to charting lists of observed interactions, quantitative interactomics can also uncover answers to key questions such as the strength of interactions or how many of certain complexes can form in cells, thus providing researchers with more immediate proxies for understanding and predicting biological processes. (shrink)

Lysosomal positioning is an important factor in regulating cellular responses, including autophagy. Because proteins encoded by disease‐responsible genes are involved in lysosomal trafficking, proper intracellular lysosomal trafficking is thought to be essential for cellular homeostasis. In the past few years, the mechanisms of lysosomal trafficking have been elucidated with a focus on adapter proteins linking motor proteins to lysosomes. Here, we outline recent findings on the mechanisms of lysosomal trafficking by focusing on adapter protein c‐Jun NH2‐terminal kinase‐interacting protein (JIP) 4, (...) which plays a central role in this process, and other JIP4 functions and JIP family proteins. Additionally, we discuss neuronal diseases associated with aberrance in the JIP family protein. Accumulating evidence suggests that chemical manipulation of lysosomal positioning may be a therapeutic approach for these neuronal diseases. (shrink)

The aim of this article is to argue that what is distinctive about aesthetic experiences has to do with what we do -- not with our perception or evaluation, but with our action and, more precisely, with our interaction with whatever we are aesthetically engaging with. This view goes against the mainstream inasmuch as aesthetic engagement is widely held to be special precisely because it is detached from the sphere of the practical. I argue that taking the interactive nature of (...) aesthetic experiences seriously can help us to understand some of the most important features of aesthetic experiences and the role they play in our life: their normativity, their crucial role in the ways in which the aesthetic domain looms large in our self-image and in the social dimension of aesthetic engagement. (shrink)

Could interacting mindreaders be in a position to know things which they would be unable to know if they were manifestly passive observers? This paper argues that they could. Mindreading is sometimes reciprocal: the mindreader’s target reciprocates by taking the mindreader as a target for mindreading. The paper explains how such reciprocity can significantly narrow the range of possible interpretations of behaviour where mindreaders are, or appear to be, in a position to interact. A consequence is that revisions and extensions (...) are needed to standard theories of the evidential basis of mindreading. The view also has consequences for understanding how abilities to interact combined with comparatively simple forms of mindreading may explain the emergence, in evolution or development, of sophisticated forms of social cognition. (shrink)

Social interaction is both ubiquitous and central to understanding human behavior. Such interactions depend, we argue, on shared intentionality: the parties must form a common understanding of an ambiguous interaction (e.g., one person giving a present to another requires that both parties appreciate that a voluntary transfer of ownership is intended). Yet how can shared intentionality arise? Many well-known accounts of social cognition, including those involving “mind-reading,” typically fall into circularity and/or regress. For example, A’s beliefs and behavior may depend (...) on her prediction of B’s beliefs and behavior, but B’s beliefs and behavior depend in turn on her prediction of A’s beliefs and behavior. One possibility is to embrace circularity and take shared intentionality as imposing consistency conditions on beliefs and behavior, but typically there are many possible solutions and no clear criteria for choosing between them. We argue that addressing these challenges requires some form of we-reasoning, but that this raises the puzzle of how the collective agent (the “we”) arises from the individual agents. This puzzle can be solved by proposing that the will of the collective agent arises from a simulated process of bargaining: agents must infer what they would agree, were they able to communicate. This model explains how, and which, shared intentions are formed. We also propose that such “virtual bargaining” may be fundamental to understanding social interactions. (shrink)

Cognition in work teams has been predominantly understood and explained in terms of shared cognition with a focus on the similarity of static knowledge structures across individual team members. Inspired by the current zeitgeist in cognitive science, as well as by empirical data and pragmatic concerns, we offer an alternative theory of team cognition. Interactive Team Cognition (ITC) theory posits that (1) team cognition is an activity, not a property or a product; (2) team cognition should be measured and studied (...) at the team level; and (3) team cognition is inextricably tied to context. There are implications of ITC for theory building, modeling, measurement, and applications that make teams more effective performers. (shrink)

L(ow) tone in Mandarin Chinese causes both downstep and post-low-bouncing. Downstep refers to the lowering of a H(igh) tone after a L tone, which is usually measured by comparing the H tones in a “H…HLH…H” sentence with a “H…HHH…H” sentence (cross-comparison), investigating whether downstep sets a new pitch register for the scaling of subsequent tones. Post-low-bouncing refers to the raising of a H tone after a focused L tone. The current study investigates how downstep and post-low-bouncing interact with focus and (...) phrasing in Mandarin Chinese. In the experiment, we systematically manipulated (a) the tonal environment by embedding two syllables with either LH or HH tone (syllable X and Y) sentence-medially in the same carrier sentences containing only H tones; (b) boundary strength between X and Y by introducing either a syllable boundary or a phonological phrase boundary; and (c) information structure by either placing a contrastive focus in the HL/HH word (XF), syllable Y (YF), or the sentence-final word (ZF). A wide-focus condition served as the baseline. With systematic control of focus and boundary strength around the L tone, the current study shows that the downstep effect in Mandarin is quite robust, lasting for 3–5 H tones after the L tone, but eventually levelling back again to the register reference line of a H tone. The way how focus and phrasing interact with the downstep effect is unexpected. Firstly, sentence-final focus has no anticipatory effect on shortening the downstep effect; instead, it makes the downstep effect lasts longer as compared to the wide focus condition. Secondly, the downstep effect still shows when the H tone after the L tone is on-focus (YF), in a weaker manner than the wide focus condition, and is overridden by the post-focus-compression. Thirdly, the downstep effect gets greater when the boundary after the L tone is stronger, because the L tone is longer and more likely to be creaky. We further analyzed downstep by measuring the F0 drop between the two H tones surrounding the L tone (sequential-comparison). Comparing it with F0 drop in all-H sentences (i.e., declination), it showed that the downstep effect was much greater and more robust than declination. However, creaky voice in the L tone was not the direct cause of downstep. At last, when the L tone was under focus (XF), it caused a post-low-bouncing effect, which is weakened by a phonological phrase boundary. Altogether, the results showed that although intonation is largely controlled by informative functions, the physical-articulatory controls are relatively persistent, varying within the pitch range of 2.5 semitones. Downstep and post-low-bouncing in Mandarin Chinese thus seem to be mainly due to physical-articulatory movement on varying pitch, with the gradual tonal F0 change meeting the requirement of smooth transition across syllables, and avoiding confusion in informative F0 control. (shrink)

Noting that Benhabib’s ethical theory has seldom been engaged with by sociologists of morality, this paper introduces and interrogates Benhabib’s ethical theory from a sociological perspective. It is argued that Benhabib’s critiques of Enlightenment conceptions of morality complement sociological theories of morality. Her concepts of the ‘concrete’ and ‘generalized’ other and ‘interactive universalism’ can potentially inform recurrent debates in the sociology of morality about the extent to which cultural plurality precludes the possibility of sociologists providing normative judgements, and the extent (...) to which certain features of moral experiences can be taken to be universal. However, Benhabib’s argument that discourse ethics can provide a procedural means to judge between competing moral claims leads her to prioritise the perspective of ‘postconventional’ Western modernism as the means to adjudicate between the moral tolerability of cultural beliefs and practices. This leads her to characterise ‘conventional’ moral systems as subordinate, which succumbs to postcolonial critiques of the role of processes of domination in organising the validity of moral claims. (shrink)

The role of interaction in learning is essential and profound: it must provide the means to solve open problems (those only vaguely specified in advance), but cannot be captured using our familiar formal cognitive tools. This presents an impasse to those confined to present formalisms; but interaction is fundamentally dynamical, not formal, and with its importance thus underlined it invites the development of a distinctively interactivist account of life and mind. This account is provided, from its roots in the interactivist (...) biological constitution of life, through the evolution of the dual internal regulatory capacities expressed as intentionality and intelligence, to its expression in self-directed anticipative learning in persons and in science. (shrink)

Predictive processing models of cognition are promising an elegant way to unite action, perception, and learning. However, in the current formulations, they are species-unspecific and have very little particularly human about them. I propose to examine how, in this framework, humans can be able to massively interact and to build shared worlds that are both material and symbolic.

Everyday joint remembering, from family remembering around the dinner table to team remembering in the operating theatre, relies on the successful interweaving of multiple cognitive, bodily, social and material resources, anchored in specific cultural ecosystems. Such systems for joint remembering in social interactions are composed of processes unfolding over multiple but complementary timescales, which we distinguish for analytic purposes so as better to study their interanimation in practice: (i) faster, lower-level coordination processes of behavioral matching and interactional synchrony occurring at (...) timescale t1; (ii) mid-range collaborative processes which re-evoke past experiences in groups, unfolding at timescale t2; (iii) cooperative processes involved in the transmission of memories over longer periods occurring at timescale t3; and (iv) cultural processes and practices operating within distributed socio-cognitive networks over evolutionary and historical timeframes, unfolding at timescale t4. In this paper we survey studies of how the processes operating across these overlapping and complementary timescales constitute joint remembering in social interactions. We describe coordination, collaboration, cooperation, and culture as complementary aspects of interacting to remember, which we consider as a complex phenomenon unfolding over multiple timescales (t1, t2, t3, t4). (shrink)

Between formal propositional knowledge and embodied skill lies ‘interactional expertise’—the ability to converse expertly about a practical skill or expertise, but without being able to practice it, learned through linguistic socialisation among the practitioners. Interactional expertise is exhibited by sociologists of scientific knowledge, by scientists themselves and by a large range of other actors. Attention is drawn to the distinction between the social and the individual embodiment theses: a language does depend on the form of the bodies of its members (...) but an individual within that community can learn the language without the body. The idea has significance for our understanding of colour-blindness, deafness and other abilities and disabilities. They say that love's a word. (shrink)

In a seminal 1977 article, Rumelhart argued that perception required the simultaneous use of multiple sources of information, allowing perceivers to optimally interpret sensory information at many levels of representation in real time as information arrives. Building on Rumelhart's arguments, we present the Interactive Activation hypothesis—the idea that the mechanism used in perception and comprehension to achieve these feats exploits an interactive activation process implemented through the bidirectional propagation of activation among simple processing units. We then examine the interactive activation (...) model of letter and word perception and the TRACE model of speech perception, as early attempts to explore this hypothesis, and review the experimental evidence relevant to their assumptions and predictions. We consider how well these models address the computational challenge posed by the problem of perception, and we consider how consistent they are with evidence from behavioral experiments. We examine empirical and theoretical controversies surrounding the idea of interactive processing, including a controversy that swirls around the relationship between interactive computation and optimal Bayesian inference. Some of the implementation details of early versions of interactive activation models caused deviation from optimality and from aspects of human performance data. More recent versions of these models, however, overcome these deficiencies. Among these is a model called the multinomial interactive activation model, which explicitly links interactive activation and Bayesian computations. We also review evidence from neurophysiological and neuroimaging studies supporting the view that interactive processing is a characteristic of the perceptual processing machinery in the brain. In sum, we argue that a computational analysis, as well as behavioral and neuroscience evidence, all support the Interactive Activation hypothesis. The evidence suggests that contemporary versions of models based on the idea of interactive activation continue to provide a basis for efforts to achieve a fuller understanding of the process of perception. (shrink)

In The Media and Modernity, Thompson develops an interactional theory of communication media that distinguishes between three basic types of interaction: face-to-face interaction, mediated interaction, and mediated quasi-interaction. In the light of the digital revolution and the growth of the internet, this paper introduces a fourth type: mediated online interaction. Drawing on Goffman’s distinction between front regions and back regions, Thompson shows how mediated quasi-interaction and mediated online interaction create new opportunities for the leakage of information and symbolic content from (...) back regions into front regions, with consequences that can be embarrassing, damaging and, on occasion, hugely disruptive. The growing role of mediated quasi-interaction and mediated online interaction has reconstituted the political field so that political life now unfolds in an information environment that is much more difficult to control, creating a permanently unstable arena in which leaks, revelations and disclosures are always capable of disrupting the most well-laid plans. (shrink)

This paper illustrates cognitive modeling constructs designed to make learning by instruction more robust, including (1) flexible grounding of language to execution, (2) inference of implicit instruction knowledge, and (3) interactive clarification of instructions during both learning and execution.

This book presents one of the first attempts at developing a precise, grammatically rooted, theory of conversation motivated by data from real conversations. The theory has descriptive reach from the micro-conversational - e.g. self-repair at the word level - to macro-level phenomena such as multi-party conversation and the characterization of distinct conversational genres. It draws on extensive corpus studies of the British National Corpus, on evidence from language acquisition, and on computer simulations of language evolution. The theory provides accounts of (...) the opening, middle game, and closing stages of conversation. it also offers a new perspective on traditional semantic concerns such as quanitifcation and anaphora. The Interactive Stance challenges orthodox views of grammar by aruging that, unless we wish to excluse from analysis a large body of frequently occurrring words and constructions, the right way to construe grammar is as a system that characterizes types of talk in interaction. (shrink)

Through theoretical discussion, literature review, and a computational model, this paper poses a challenge to the notion that perspective-taking involves a fixed architecture in which particular processes have priority. For example, considerable work has shown that egocentric perspectives can arise more quickly, with other perspectives (such as of task partners) emerging only secondarily. This theoretical dichotomy is challenged here, and we propose a general view of perspective-taking as an emergent phenomenon governed by the interplay among several cognitive mechanisms. We first (...) describe the pervasive relevance of perspective-taking to cognitive science. A dynamical systems model is then introduced which explicitly formulates the timescale interaction proposed. Implications are discussed, with ideas for future empirical research. (shrink)

Recent years have seen an upsurge of interest in the second-person perspective, not only in philosophy of mind, language, law and ethics, but also in various empirical disciplines such as cognitive neuroscience and developmental psychology. A distinctive and perhaps also slightly puzzling feature of this ongoing discussion is that whereas many contributors insist that a proper consideration of the second-person perspective will have an impact on our understanding of social cognition, joint action, communication, self-consciousness, morality, and so on, there remains (...) considerable disagreement about what exactly a second-person perspective amounts to (see Eilan 2014; Conant and Rödl 2014). What is the difference between adopting a second-person and a third-person perspective on another? How does one relate to another as a you and how does that differ from relating to another as a he, she or they? In the following, I will consider three different proposals and argue that a promising but somewhat overlooked account can be found in the work of Husserl. (shrink)

Leibniz has almost universally been represented as denying that created substances, including human minds and the souls of animals, can causally interact either with one another or with bodies. Yet he frequently claims that such substances are capable of interacting in the special sense of what he calls 'ideal' interaction. In order to reconcile these claims with their favored interpretation, proponents of the traditional reading often suppose that ideal action is not in fact a genuine form of causation but instead (...) a merely apparent influence which serves to 'save the appearances.' I argue that this traditional reading distorts Leibniz's thought and that he actually considers ideal action a genuine (though non-standard) form of causation. (shrink)

Providing an inclusive and quality education for all contributes toward the Sustainable Development Goals of the United Nations. High-quality learning environments based on what works in education benefit all students and can be particularly beneficial for children with disabilities. This article contributes to advance knowledge to enhance the quality of education of students with disabilities that are educated in special schools. This research analyses in which ways, if any, interactive learning environments can be developed in special schools and create better (...) learning opportunities for children with disabilities. A case study was conducted with students with disabilities (N = 36) and teaching staff in a special school, involving interviews and focus groups. We argue that rethinking the learning context by introducing instruction models based on interaction benefit children with disabilities and provide high-quality learning and safe and supportive relationships for these students, thereby promoting their educational and social inclusion. (shrink)

This article explicates the interaction between implicit and explicit processes in skill learning, in contrast to the tendency of researchers to study each type in isolation. It highlights various effects of the interaction on learning (including synergy effects). The authors argue for an integrated model of skill learning that takes into account both implicit and explicit processes. Moreover, they argue for a bottom-up approach (first learning implicit knowledge and then explicit knowledge) in the integrated model. A variety of qualitative data (...) can be accounted for by the approach. A computational model, CLARION, is then used to simulate a range of quantitative data. The results demonstrate the plausibility of the model, which provides a new perspective on skill learning. (PsycINFO Database Record (c) 2012 APA, all rights reserved). (shrink)

Researchers have emphasized the value of authenticity, but not much is known about what makes a person authentic in the eyes of others. Our research takes an interpersonal perspective to examine the determinants of followers’ perceptions of leader authenticity. Building on social identity theory, we propose that two fundamental self-identifications–a leader’s sense of uniqueness and sense of belongingness–interact to influence followers’ perceptions of a leader’s authenticity via perceptions of a leader’s self-concept consistency. In a field study conducted among leader–follower dyads (...) and in a controlled laboratory experiment, we find that when a leader feels a low sense of belongingness, there is a positive relationship between a leader’s sense of uniqueness and perceptions of leader authenticity. When a leader feels a low sense of uniqueness, there is a positive relationship between a leader’s sense of belongingness and perceptions of leader authenticity. This is because followers perceive this leader as having high self-concept consistency. (shrink)

In recent years, a number of philosophers and cognitive scientists have advocated for an ‘interactive turn’ in the methodology of social-cognition research: to become more ecologically valid, we must design experiments that are interactive, rather than merely observational. While the practical aim of improving ecological validity in the study of social cognition is laudable, we think that the notion of ‘interaction’ is not suitable for this task: as it is currently deployed in the social cognition literature, this notion leads to (...) serious conceptual and methodological confusion. In this paper, we tackle this confusion on three fronts: 1) we revise the ‘interactionist’ definition of interaction; 2) we demonstrate a number of potential methodological confounds that arise in interactive experimental designs; and 3) we show that ersatz interactivity works just as well as the real thing. We conclude that the notion of ‘interaction’, as it is currently being deployed in this literature, obscures an accurate understanding of human social cognition. (shrink)

Research on brain or cognitive/affective processes, culture, social interaction, and structural analysis are overlapping but often independent ways humans have attempted to understand the origins of their evolution, historical, and contemporary development. Each level seeks to employ its own theoretical concepts and methods for depicting human nature and categorizing objects and events in the world, and often relies on different sources of evidence to support theoretical claims. Each level makes reference to different temporal bandwidths (milliseconds, seconds, minutes, hours, days, months, (...) years, decades, and centuries) and focuses on different spatio-temporal activities and controlled and non-controlled stimulus conditions. Biological mechanisms and environmental pressures for survival simultaneously created a gradual intersection and enhancement of cognitive/affective skills, cultural practices, and changes in collaborative social interaction and communicative skills. The evolution of a given level of analysis is assumed to have been incremental and overlapping. These innovative and independent ways humans have learned to characterize their brain or cognitive/affective and social/economic/political life often depend on unexamined, representational re-descriptions or cognitive/affective and socio-cultural devices and forms of communication that facilitate the depiction of practices and beliefs we attribute to respondents or subjects and research colleagues. (shrink)

Peer interaction constitutes a focal site for understanding learning orientations and autonomous learning behaviors. Based on 10 h of video-recorded data collected from small-size conversation-for-learning classes, this study, through the lens of Conversation Analysis, analyzes instances in which L2 learners spontaneously exploit learning opportunities from the on-task public talk and make them relevant for private learning in sequential private peer interaction. The analysis of extended negation-for-meaning practices in peer interaction displays how L2 learners orient to public repair for their learning (...) opportunities in an immediate manner and in so doing, how different participation framework is being utilized to maximize their learning outcomes. As these extended repair practices are entirely managed by learners themselves, they yield both efficient and inefficient learning outcomes. Findings reveal that learners frequently resort to their peers to recycle the focal trouble words for learning opportunities, shifting their participating role from the on looking audience to active learners. By reporting the rather under-researched post-repair negotiation-for-meaning sequence in peer interactions, the study highlights the relevance between on-task classroom activities and private learning, contributing to understanding private learning behaviors in the language classroom and learning as a co-constructed activity locally situated in peer interaction. (shrink)

_René Descartes proposed an interactive dualism that posits an interaction between the_ _mind of a human being and some of the matter located in his or her brain. Isaac Newton_ _subsequently formulated a physical theory based exclusively on the material/physical_ _part of Descartes’ ontology. Newton’s theory enforced the principle of the causal closure_ _of the physical, and the classical physics that grew out of it enforces this same principle._ _This classical theory purports to give, in principle, a complete deterministic account (...) of the_ _physically described properties of nature, expressed exclusively in terms of these_ _physically described properties themselves. Orthodox contemporary physical theory_ _violates this principle in two separate ways. First, it injects random elements into the_ _dynamics. Second, it allows, and also requires, abrupt probing actions that disrupt the_ _mechanistically described evolution of the physically described systems. These probing_ _actions are called Process 1 interventions by von Neumann. They are psycho-physical_ _events. Neither the content nor the timing of these events is determined either by any_ _known law, or by the afore-mentioned random elements. Orthodox quantum mechanics_ _considers these events to be instigated by choices made by conscious agents. In von_ _Neumann’s formulation of quantum theory each such intervention acts upon the state of_ _the brain of some conscious agent. Thus orthodox von Neumann contemporary physics_ _posits an interactive dualism similar to that of Descartes. But in this quantum version the_ _effects of the conscious choices upon our brains are controlled, in part, by the known_ _basic rules of quantum physics. This theoretically specified mind-brain connection allows_ _many basic psychological and neuropsychological findings associated with the apparent_ _physical effectiveness of our conscious volitional efforts to be explained in a causal and_ _practically useful way.. (shrink)

Ethical instruction is critical for trainee accountants. Various teaching methods, both active and passive, are normally utilised when teaching accounting ethics. However, students’ learning styles are rarely assessed. This study evaluates the learning styles of accounting students and assesses the interaction of teaching methods and learning styles in an ethics instruction environment. The ethical attitudes and preferred learning styles of a cohort (137) of final year accounting students were evaluated pre-instruction. They were then subject to three different teaching methods while (...) studying ethics during an auditing course. When ethical attitudes and preferred learning styles were re-assessed post-instruction, the teaching methods were found to have influenced active learners more than passive ones. Furthermore, when learning styles matched teaching methods used, usefulness was assessed as high but when learning styles and teaching methods differed, usefulness deteriorated significantly. Students displayed a preference for passive learning styles, despite being so advanced in their education. The implications are that instructors should consider learning styles before deciding on appropriate teaching methods, in accounting ethics environments. (shrink)

Proponents of the so-called “interactive turn in social cognition research” maintain that mainstream research on social cognition has been fundamentally flawed by its neglect of social interaction, and that a new paradigm is needed in order to redress this shortcoming. We argue that proponents of the interactive turn (“interactionists”) have failed to properly substantiate their criticisms of existing research on social cognition. Although it is sometimes unclear precisely what these criticisms of existing theories are supposed to target, we sketch two (...) possibilities: interactionists can either accept the primary explanandum addressed by mainstream social cognition research—namely mindreading—and claim that interactionism contributes some hitherto neglected but necessary component of a successful explanans, or they can argue that mainstream research has focused on a misconceived explanandum. We argue that interactionist claims of both sorts are problematic. (shrink)

The paper presents two empirical cases of expert musicians—a classical string quartet and a solo, free improvisation saxophonist—to analyze the explanatory power and reach of theories in the field of expertise studies and joint action. We argue that neither the positions stressing top-down capacities of prediction, planning or perspective-taking, nor those emphasizing bottom-up embodied processes of entrainment, motor-responses and emotional sharing can do justice to the empirical material. We then turn to hybrid theories in the expertise debate and interactionist accounts (...) of cognition. Attempting to strengthen and extend them, we offer ‘Arch’: an overarching conception of musical interaction as an externalized, cognitive scaffold that encompasses high and low-level cognition, internal and external processes, as well as the shared normative space including the musical materials in which the musicians perform. In other words, ‘Arch’ proposes interaction as a multivariate multimodal overarching scaffold necessary to explain not only cases of joint performance, but equally of solo improvisation. (shrink)

How can we confront the problems of diminished democracy, pervasive economic inequality, and persistent global poverty? Is it possible to fulfill the dual aims of deepening democratic participation and achieving economic justice, not only locally but also globally? Carol C. Gould proposes an integrative and interactive approach to the core values of democracy, justice, and human rights, looking beyond traditional politics to the social conditions that would enable us to realize these aims. Her innovative philosophical framework sheds new light on (...) social movements across borders, the prospects for empathy and solidarity with distant others, and the problem of gender inequalities in diverse cultures, and also considers new ways in which democratic deliberation can be enhanced by online networking and extended to the institutions of global governance. Her book will be of great interest to scholars and upper-level students of political philosophy, global justice, social and political science, and gender studies. (shrink)

DISCOURSE, INTERACTION, AND COMMUNICATION Co-organized by the Department of Logic and Philosophy of Science and the Institute for Logic, Cognition, Language, and Infonnation (ILCLI) both from the University of the Basque Country, tlle Fourth International Colloquium on Cognitive Science (ICCS-95) gathered at Donostia - San Sebastian ti'om May 3 to 6, 1995, with the following as its main topics: 1. Social Action and Cooperation. 2. Cognitive Approaches in Discourse Processing: Grammatical and Semantical Aspects. 3. Models of Infonnation in Communication Systems. (...) 4. Cognitive Simulation: Scope and Limits. More tllan one hundred researchers from all over the world exchanged their most recent contributions to Cognitive Science in an exceptionally fruitful annosphere. In this volume we include a small though representative sample of tlle main papers. They all were invited papers except the one by Peter Juel Henrichsen, a contributed paper tllat merited tlle IBERDROLA - Gipuzkoako Foru Aldundia: Best Paper Award, set up in ICCS-95 for the first time. (shrink)

Numerous eukaryotic DNA processing enzymes, such as DNA polymerases and ligases, bind the processivity factor PCNA, which acts as a platform to recruit and regulate the binding of enzymes to their DNA substrate. Multiple PCNA‐interacting motifs (PIPs) are present in these enzymes, but their individual structural and functional role has been a matter of debate. Recent cryo‐EM reconstructions of high‐fidelity DNA polymerase Pol δ (Pol δ), translesion synthesis DNA polymerase κ (Pol κ) and Ligase 1 (Lig1) bound to a DNA (...) substrate and PCNA demonstrate that the critical interaction with PCNA involves the internal PIP proximal to the catalytic domain. The ancillary PIPs, located in long disordered regions, are instead invisible in the reconstructions, and appear to function as flexible tethers when the enzymes fall off the DNA. In this review, we discuss the recent structural advancements and propose a functional hierarchy for the PIPs in Pol δ, Pol κ, and Lig1. (shrink)

This book makes available five classic studies of the organisation of behaviour in face-to-face interaction. It includes Adam Kendon's well-known study of gaze-direction in interaction, his study of greetings, of the interactional functions of facial expression and of the spatial organisation of naturally occurring interaction, as recorded by means of film or videotape. They represent some of the best work undertaken within the 'natural history' tradition of interaction studies, as originally formulated in the work of Bateson, Birdwhistell and Goffman. Chapter (...) 2, written especially for this new book, provides an historical and theoretical discussion of this tradition, and a new final chapter takes up the theme of the organisation of attention in interaction. The introduction provides details of the circumstances of how each paper came to be written. Each of the papers reprinted is accompanied by a short postscript, placing the work in the context of more recent research. Several of the papers presented in this volume, although widely referred to, have long been difficult to obtain. Their republication will be warmly welcomed by all students and teachers who are concerned with face-to-face interaction. (shrink)

René Descartes proposed an interactive dualism that posits an interaction between the mind of a human being and some of the matter located in his or her brain. Isaac Newton subsequently formulated a physical theory based exclusively on the material/physical part of Descartes’ ontology. Newton’s theory enforced the principle of the causal closure of the physical, and the classical physics that grew out of it enforces this same principle. This classical theory purports to give, in principle, a complete deterministic account (...) of the physically described properties of nature, expressed exclusively in terms of these physically described properties themselves. Orthodox contemporary physical theory violates this principle in two separate ways. First, it injects random elements into the dynamics. Second, it allows, and also requires, abrupt probing actions that disrupt the mechanistically described evolution of the physically described systems. These probing actions are called Process 1 interventions by von Neumann. They are psycho-physical events. Neither the content nor the timing of these events is determined either by any known law, or by the afore-mentioned random elements. Orthodox quantum mechanics considers these events to be instigated by choices made by conscious agents. In von Neumann’s formulation of quantum theory each such intervention acts upon the state of the brain of some conscious agent. Thus orthodox von Neumann contemporary physics posits an interactive dualism similar to that of Descartes. But in this quantum version the effects of the conscious choices upon our brains are controlled, in part, by the known basic rules of quantum physics. This theoretically specified mind-brain connection allows many basic psychological and neuropsychological findings associated with the apparent physical effectiveness of our conscious volitional efforts to be explained in a causal and practically useful way.. (shrink)

Goffman is credited with enriching our understanding of the details of interaction, but not with challenging our theoretical understanding of social organization. While Goffman's position is not consistent, the outlines for a theory of an interaction order sui generis may be found in his work. It is not theoretically adequate to understand Goffman as an interactionist within the dichotomy between agency and social structure. Goffman offers a way of resolving this dichotomy via the idea of an interaction order which is (...) constitutive of self and at the same time places demands on social structure. This has significant implications for our understanding of social organization in general. (shrink)

Starting from Dennett's distinction between personal and sub-personal levels of description, I consider the relationships amongst three levels: the personal level, the level of information-processing mechanisms, and the level of neurobiology. I defend a conception of the relationship between the personal level and the sub-personal level of information-processing mechanisms as interaction without reduction . Even given a nonreductionist conception of persons, philosophical theorizing sometimes supports downward inferences from the personal to the sub-personal level. An example of a downward inference is (...) provided and an objection is considered. (shrink)

This paper examines the ways in which social scientific discourse and classification interact with the objects of social scientific investigation. I examine this interaction in the context of the traditional philosophical project of demarcating the social sciences from the natural sciences. I begin by reviewing Ian Hacking’s work on interactive classification and argue that there are additional forms of interaction that must be treated.

What can interactive robots offer to the study of social behaviour? Philosophical reflections about the use of robotic models in animal research have focused so far on methods involving robots which do not interact with the target system. Yet, leading researchers have claimed that interactive robots may constitute powerful experimental tools to study collective behaviour. Can they live up to these epistemic expectations? This question is addressed here by focusing on a particular experimental methodology involving interactive robots which has been (...) often adopted in animal research. This methodology is shown to differ from other robot-supported methods for the study of animal behaviour analysed in the philosophical literature, chiefly including the synthetic method. It is also discussed whether biomimicry and acceptability are necessary for an interactive robot to be sensibly used in animal research according to this method. (shrink)

This paper examines the phenomenon of ‘interactive kinds’ first identified by Ian Hacking. An interactive kind is one that is created or significantly modified once a concept of it has been formulated and acted upon in certain ways. Interactive kinds may also ‘loop back’ to influence our concepts and classifications. According to Hacking, interactive kinds are found exclusively in the human domain. After providing a general account of interactive kinds and outlining their philosophical significance, I argue that they are not (...) confined to the human realm, but that they can also occur elsewhere. Hence, I conclude by arguing that interactive kinds pose a challenge to scientific realism about kinds by making it difficult to make a distinction between real and non-real kinds. (shrink)

Autistic difficulties with social interaction have primarily been understood as expressions of underlying impairment of the ability to ‘mindread.’ Although this understanding of autism and social interaction has raised controversy in the phenomenological community for decades, the phenomenological criticism remains largely on a philosophical level. This article helps fill this gap by discussing how phenomenology can contribute to empirical methodologies for studying social interaction in autism. By drawing on the phenomenology of Maurice Merleau-Ponty and qualitative data from an ongoing study (...) on social interaction in autism, I discuss how qualitative interviews and participant observation can yield phenomenologically salient data on social interaction. Both, I argue, enjoy their phenomenological promise through facilitating attention to the social-spatial-material fields in and through which social interactions and experiences arise. By developing phenomenologically sound approaches to studying social interaction, this article helps resolve the deficiency of knowledge concerning experiential dimensions of social interaction in autism. (shrink)

Participatory Technology Assessment initiatives have usually been analyzed as if they existed in a social and political vacuum. This article analyzes the linkages that occur, in both directions, between the microcosm set up by a pTA exercise and the real world outside. This dual-dynamics perspective leads to a new way of understanding the function and significance of pTA initiatives. Rather than viewing them as a means to create the ideal conditions for real public debate, they are viewed here as an (...) additional public arena in which sociotechnical controversies are played out. This perspective is developed from the analysis of an interactive technology assessment exercise conducted by the French National Institute for Agricultural Research, on the topic of genetically modified vines. (shrink)

Computational modeling and eye-tracking were used to investigate how phonological and semantic information interact to influence the time course of spoken word recognition. We extended our recent models to account for new evidence that competition among phonological neighbors influences activation of semantically related concepts during spoken word recognition . The model made a novel prediction: Semantic input modulates the effect of phonological neighbors on target word processing, producing an approximately inverted-U-shaped pattern with a high phonological density advantage at an intermediate (...) level of semantic input—in contrast to the typical disadvantage for high phonological density words in spoken word recognition. This prediction was confirmed with a new analysis of the Apfelbaum et al. data and in a visual world paradigm experiment with preview duration serving as a manipulation of strength of semantic input. These results are consistent with our previous claim that strongly active neighbors produce net inhibitory effects and weakly active neighbors produce net facilitative effects. (shrink)

When individuals interact with others, perceived information is transmitted among their brains. The EEG-based hyperscanning technique, which provides an approach to explore dynamic brain activities between two or more interactive individuals and their underlying neural mechanisms, has been applied to study different aspects of social interactions since 2010. Recently there has been an increase in research on EEG-based hyperscanning of social interactions. This paper summarizes the application of EEG-based hyperscanning on the dynamic brain activities during social interactions according to the (...) experimental designs and contents, discusses the possibility of applying inter-brain synchrony to social communication systems and analyzes the contributions and the limitations of these investigations. Furthermore, this paper sheds light on some new challenges to future EEG-based hyperscanning studies and the emerging field of EEG-based hyperscanning for pursuing the broader research field of social interactions. (shrink)

Background:Dignity experience in the daily lives of people living with dementia is influenced by their relational interactions with others. However, literature reviews show that knowledge concerning crucial interactional qualities, preserving their sense of dignity, is limited.Aim:The aim of this study was to explore and describe crucial qualities of relational interactions preserving dignity experience among people with dementia, while interacting with family, social network, and healthcare professionals.Methodology:The study was founded upon Gadamer’s philosophical hermeneutics, and an exploratory design employing qualitative research interviews (...) was conducted.Participants and research context:A total of 11 individuals diagnosed with mild to moderate dementia, living in their own homes, were recruited from two Hospital Memory Clinics in Norway.Ethical considerations:In recruiting persons with dementia as study participants, sensitivity toward their life history, autonomy, integrity, relationships, and dignity is essential. These standards, and the ethical principles of moral sensitivity to their vulnerability, doing no harm, showing justice, and respecting their personal utility, guided our research.Results:Three main interactional qualities preserving the participants’ dignity experience were found: Experiencing love and confirmation; experiencing social inclusion and fellowship; experiencing humane warmth and understanding within a caring culture, while being met as an equal human being. A total of 10 sub-qualities were identified within these 3 main qualities.Discussion and final considerations:Dignity experience among the participants was preserved when certain interactional qualities were present in their interactions with family, social network, and healthcare professionals. While supporting some of the findings of previous studies, this study adds new knowledge on the subject. Knowledge of relational interactions toward preserving dignity experience should be a fundamental part of future dementia care practice. Based on the results of this study, an empirical–theoretical model was developed for this purpose. (shrink)

An important shift is taking place in social cognition research, away from a focus on the individual mind and toward embodied and participatory aspects of social understanding. Empirical results already imply that social cognition is not reducible to the workings of individual cognitive mechanisms. To galvanize this interactive turn, we provide an operational definition of social interaction and distinguish the different explanatory roles – contextual, enabling and constitutive – it can play in social cognition. We show that interactive processes are (...) more than a context for social cognition: they can complement and even replace individual mechanisms. This new explanatory power of social interaction can push the field forward by expanding the possibilities of scientific explanation beyond the individual. (shrink)