Since, it has become clear that individuality is not to be considered as a given, but rather as something which needs to be explained. How has individuality emerged through evolution, and how has it subsequently been maintained? In particular, why is it that multicellular organisms appeared and persisted, despite the obvious interest of each cell of favoring its own replication? Several biologists see the immune system as one of the key components for explaining the maintenance of multicellular organisms’ individuality. Indeed, (...) the immune system exerts a constant surveillance on all the constituents of the organism, including “cheaters” like tumor cells, which favor their own replication at the expense of the whole organism. In most cases, the immune system eliminates those cheaters. This is the “immune surveillance” hypothesis, first suggested by Burnet and Thomas. In this paper, I account for recent findings on immune surveillance in order to determine the precise role of the immune system in the emergence and maintenance of individuality. This investigation gives rise to a critical question for the domain of biological individuality: should immunity be considered as something unique to multicellular organisms? If it is indeed unique, should the multicellular organism be considered as an individual to a higher degree than any other living entity? If it is not unique, what precisely are the equivalents of the immune system in other living individuals? (shrink)

After two years of global pandemic, it is no surprise that immunization is now at the center of our experience. From the medicalization of politics to the disciplining of individuals, from lockdowns to mass vaccination programs, contemporary societies seem to be firmly embedded in a syndrome of immunity. To understand the ambivalent effects of this development, it is necessary to go back to its modern genesis, when the languages of law, politics, and medicine began to merge into the biopolitical (...) regime we have been living under for some time. This regime places a high priority on immunization and security: no security is more important than health security. The Covid-19 pandemic has taken the dynamic of immunization to a new level: for the first time in history, we see societies seeking to achieve generalized immunity in their entire populations through vaccination. This allows us to glimpse the possibility of a “common immunity” that strengthens the relation between community and immunity. The dramatic tensions we have experienced in recent years between security and freedom, norm and exception, power and existence, all refer to the complex relationship between community and immunity, the decisive features of which are reconstructed in this book. Building on the prescient argument originally developed two decades ago in Immunitas, Roberto Esposito demonstrates in this new book how the pandemic and our responses to it have brought into sharp relief the fundamental biopolitical conditions of our contemporary societies. (shrink)

© 2015 Elsevier Inc.Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland is the only organ developing predominantly after birth, we utilized it as a powerful system to study (...) adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ -producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation. Plaks et al. (shrink)

An immunizing strategy is an argument brought forward in support of a belief system, though independent from that belief system, which makes it more or less invulnerable to rational argumentation and/or empirical evidence. By contrast, an epistemic defense mechanism is defined as a structural feature of a belief system which has the same effect of deflecting arguments and evidence. We discuss the remarkable recurrence of certain patterns of immunizing strategies and defense mechanisms in pseudoscience and other belief systems. Five different (...) types will be distinguished and analyzed, with examples drawn from widely different domains. The difference between immunizing strategies and defense mechanisms is analyzed, and their epistemological status is discussed. Our classification sheds new light on the various ways in which belief systems may achieve invulnerability against empirical evidence and rational criticism, and we propose our analysis as part of an explanation of these belief systems’ enduring appeal and tenacity. (shrink)

In this paper I aim to illuminate the significance of thought insertion for debates about the first-person concept. My starting point is the often-voiced contention that thought insertion might challenge the thesis that introspection-based self-ascriptions of psychological properties are immune to error through misidentification relative to the first-person concept. In the first part of the paper I explain what a thought insertion-based counterexample to this immunity thesis should be like. I then argue that various thought insertion-involving scenarios do not give (...) rise to successful counterexamples to the immunity of the target class of self-ascriptions. In the second part of the paper I turn to defend a Metasemantic Explanation of why the immunity thesis holds. The Metasemantic Explanation rests on a reference-fixing story about the mental ‘I’ whose key contention is that introspective impressions play an essential role in fixing its reference. It is part of my argument in favour of the proposed reference-fixing story, as well as of the Metasemantic Explanation, that they respect the paradigmatic features of self-ascriptions of inserted thoughts. (shrink)

In Immunity, Alfred Tauber sets forth a new theory of immunology that rejects the common principle of self and non-self, and the immune system's role as a protector of the self from external threats. Rather than serving to defend an independent entity, he argues, immunity participates in a large, complex eco-system of porous and flexible boundaries. Tauber's new approach to immunology necessitates a new biology in which symbiosis is the rule, not the exception.

In this collection of newly commissioned essays, the contributors present a variety of approaches to it, engaging with historical and empirical aspects of the subject as well as contemporary philosophical work.

I argue that immunity to error through misidentification primarily characterizes thoughts that are 'implicitly' de se, as opposed to thoughts that involve an explicit self-identification. Thoughts that are implicitly de se involve no reference to the self at the level of content: what makes them de se is simply the fact that the content of the thought is evaluated with respect to the thinking subject. Or, to put it in familiar terms : the content of the thought is a property (...) which the thinking subject self-ascribes (as in the Loar/Lewis/Chisholm analysis). After answering an objection (to the effect that immunity can affect explicit de se thoughts), I extend the analysis to demonstrative thoughts, which also exhibit the property of immunity to error through misidentification. (shrink)

Any plausible position in the ethics of war and political violence in general will include the requirement of protection of civilians (non-combatants, common citizens) against lethal violence. This requirement is particularly prominent, and particularly strong, in just war theory. Some adherents of the theory see civilian immunity as absolute, not to be overridden in any circumstances whatsoever. Others allow that it may be overridden, but only in extremis. The latter position has been advanced by Michael Walzer under the heading of (...) “supreme emergency.” In this paper, I look into some of the issues of interpretation and application of Walzer’s “supreme emergency” view and some of the criticisms that have been levelled against it. I argue that Walzer’s view is vague and unacceptable as it stands, but that the alternatives proposed by critics such as Brian Orend, C.A.J. Coady, and Stephen Nathanson are also unattractive. I go on to construct a position that is structurally similar to Walzer’s, but more specific and much less permissive, which I term the “moral disaster” view. According to this view, deliberate killing of civilians is almost absolutely wrong. (shrink)

Imagine a future in which a country’s government is thinking about whether to pursue human enhancement. There are several ways that humans might be enhanced, among them physical aids, pharmaceutical interventions, and genetic modification. In this imagined scenario...

Adaptive immunity provides the unique ability to respond to a nearly infinite range of antigenic determinants. Given the inherent plasticity of the adaptive immune system, a series of tolerance mechanisms exist to reduce reactivity toward self. While this reduces the probability of autoimmunity, it also creates an important gap in adaptive immunity: the ability to recognize microbes that look like self. As a variety of microbes decorate themselves in self‐like carbohydrate antigens and tolerance reduces the ability of adaptive immunity to (...) react with self‐like structures, protection against molecular mimicry likely resides within the innate arm of immunity. In this review, we will explore the potential consequences of microbial molecular mimicry, including factors within innate immunity that appear to specifically target microbes expressing self‐like antigens, and therefore provide protection against molecular mimicry. (shrink)

This article is concerned with an exploration of a family of systems—called immune logics—that arise from certain dualizations of the well-known family of infectious logics. The distinctive feature of the semantic of infectious logics is the presence of a certain “infectious” semantic value, by which two different though equivalent things are meant. On the one hand, it is meant that these values are zero elements for all the operations in the underlying algebraic structure. On the other hand, it is meant (...) that these values behave in a value-in-value-out fashion for all the operations in the underlying algebraic structure. Thus, in a rather informal manner, we will refer to immune logics as those systems whose underlying semantics count with a certain “immune” semantic value behaving in a way that is somewhat dual to that of the infectious values. In a more formal manner, carrying out this dualization will prove to be not as straightforward as one could imagine, since the two characterizations of infectiousness discussed above lead to two different outcomes when one tries to conduct them. We explore these alternatives and provide technical results regarding them, and the various logical systems defined using such semantics. (shrink)

Intended both as an introduction to the thought of the Italian philosopher Roberto Esposito and as a mapping of current biopolitical practice, this essay traces the contributions and the limits of recent Italian contributions to the discussion of biopolitics. The essay offers a summary of Esposito's insight into the relation of community and immunity and compares his thinking to other philosophers who take immunity as their object of study . Campbell goes on to read Esposito's privileging of bios in the (...) light of Giorgio Agamben's emphasis on zōē, while making reference as well to Antonio Negri and Michael Hardt's understanding of biopower. He concludes by arguing that the stakes of Esposito's analysis for an affirmative biopolitics concern fundamentally the nature of community and its opening to all life forms as bios. (shrink)

Artificial Immune Systems (AIS) are intelligent algorithms derived on the principles inspired by human immune system. In this research work, electroencephalography (EEG) signals for four distinct motor movement of human limbs are detected and classified using Negative Selection Classification Algorithm (NSCA). For this study, a widely studied open source EEG signal database (BCI IV - Graz dataset 2a, comprising 9 subjects) has been used. Mel Frequency Cepstral Coefficients (MFCCs) are extracted as selected feature from recorded EEG signals. Dimensionality reduction of (...) data is carried out by applying two hidden layered stacked auto-encoder. Genetic Algorithm (GA) optimized detectors (Artificial Lymphocytes) are trained using Negative Selection Algorithm (NSA) for detection and classification of four motor movements. The trained detectors consist of four sets of detectors, each set is trained for detection and classification of one of the four movements from the other three movements. The optimized radius of detector is small enough not to mis-detect the sample. Euclidean distance of each detector with every training dataset sample is taken and compared with optimized radius of detector as a non-self detector. Our proposed approach achieved a mean classification accuracy of 86.39% for limb movements over 9 subjects with a maximum individual subject classification accuracy of 97.5 % for subject number eight. (shrink)

This is one of the first books in a new series that will publish the very best work in the philosophy of biology. The series will be non-sectarian in character, will extend across the broadest range of topics, and will be genuinely interdisciplinary. The Immune Self is a critical study of immunology from its origins at the end of the nineteenth century to its contemporary formulation. The book offers the first extended philosophical critique of immunology, in which the function of (...) the term 'self' that underlies the structure of current immune theory is analysed. However, this analysis is carefully integrated into a broad survey of the major scientific developments in immunology, a discussion of their historical context, and a review of the conceptual arguments that have moulded this sophisticated modern science. (shrink)

This paper responds to arguments due to Joel Smith and Annalisa Coliva that try to show that James Pryor’s notion of wh-misidentification is philosophically uninteresting, and perhaps even spurious. It also proposes definitions of wh-misidentification and immunity to wh-misidentification which try to improve in various ways on the characterisations that standardly figure in the literature, and explores the relationship between misidentification and the epistemic structures characteristic of some kinds of Gettier cases.

Da Ré and Szmuc argue that while there is a symmetry between ‘infectious’ and ‘immune’ logics, this symmetry fails w.r.t. extending an algebra with an immune or an infectious element. In this paper, I show that the symmetry also fails w.r.t. defining a new logical operation from a given set of primitive (Boolean) operations. I use the case of the material conditional to illustrate this point.

This is one of the first books in a new series that will publish the very best work in the philosophy of biology. The series will be non-sectarian in character, will extend across the broadest range of topics, and will be genuinely interdisciplinary. The Immune Self is a critical study of immunology from its origins at the end of the nineteenth century to its contemporary formulation. The book offers the first extended philosophical critique of immunology, in which the function of (...) the term 'self' that underlies the structure of current immune theory is analysed. However, this analysis is carefully integrated into a broad survey of the major scientific developments in immunology, a discussion of their historical context, and a review of the conceptual arguments that have moulded this sophisticated modern science. (shrink)

Are bodily self-ascriptions immune to error through misidentification? According to the Inside mode view, one cannot be mistaken about whose body part it is when experiencing them from the inside. Here I shall consider two possible objections to bodily immunity. On the one hand, I shall briefly envisage two cases of misidentification: somatoparaphrenia and the Rubber Hand illusion. I shall show that none of them challenges the immunity principle. On the other hand, I shall highlight a more serious issue for (...) bodily immunity, namely, the multimodal nature of bodily self-knowledge. Very few bodily self-ascriptions are based on grounds that are purely or exclusively from the inside. I shall evaluate the consequences of multimodality for bodily immunity. (shrink)

Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient energy to engage in defensive or homeostatic processes. Such “immunometabolism” is governed through intermediate metabolites, and has a vital role in regulating immune‐cell function. The underlying metabolic reactions are shaped by the abundance and accessibility of specific nutrients, as well as the overall metabolic status of the host. Here, we discuss how different immune‐cell types gain a sufficient (...) energy supply. We then explain how immune cells perform various functions under challenged conditions and expend energy to sustain homeostasis. Finally, we speculate on how the immune‐cell metabolic profile might be modulated in health and disease, by manipulating nutrient availability. By such intervention, the recovery of patient with dysregulated immune system responses might be sped up and the fitness of an individual efficiently restored. (shrink)

A self-ascription is a thought or sentence in which a predicate is self-consciously ascribed to oneself. Self-ascriptions are best expressed using the first-person pronoun. Mental self-ascriptions are ascriptions to oneself of mental predicates (predicates that designate mental properties), non-mental self-ascriptions are ascriptions to oneself of non-mental predicates (predicates that designate non-mental properties). It is often claimed that there is a range of self-ascriptions that are immune to error through misidentification relative to the first-person pronoun (IEM for short). What this means, (...) and exactly which self-ascriptions are properly classed as IEM, is a topic hotly disputed. Some claim that only mental self-ascriptions are IEM, others claim that some non-mental self-ascriptions are IEM. Before this question can be decided, it needs to be judged exactly what it means to say that a self-ascription is IEM. And here we stumble across the fact that there are, at least, two non-equivalent ways of defining the phenomenon1. I will be claiming that one of these definitions should be rejected. (shrink)

Behavioral immune system describes psychological mechanisms that detect cues to infectious pathogens in the immediate environment, trigger disease-relevant responses and facilitate behavioral avoidance/escape. BIS activation elicits a perceived vulnerability to disease which can result in conformity with social norms. However, a response to superficial cues can result in aversive responses to people that pose no actual threat, leading to an aversion to unfamiliar others, and likelihood of prejudice. Pathogen-neutralizing behaviors, therefore, have implications for social interaction as well as illness behaviors (...) and responses to health communications. In this study, we investigate how PVD influences conformity, attitudes to other people and to lockdown regulations through the lens of the Reinforcement Sensitivity Theory. RST describes personality in terms of biologically-driven approach and avoidance motivations which support personal goals. Participants from the United Kingdom public completed an RST personality questionnaire and then read either coronavirus morbidity-mortality statistics and current United Kingdom government lifestyle regulations, just the regulations, or no information at all. They all completed the Perceived Vulnerability to Disease scale to assess BIS-relevant Germ Aversion and Perceived Infectability, followed by questions measuring social conformity, warmth toward others and attitudes toward lockdown measures. Significantly lower PVD scores were observed in the no-information condition, with the other conditions showing no difference. In terms of RST, approach behaviors related to goal-drive persistence work alongside fear in explaining conformity to social norms. Reward related approach behaviors partially explained warmth toward others, indicating that social rewards gained through interaction continue to be strong drivers of behavior. We found no role for RST traits in attitudes toward lockdown. Overall, coronavirus-related behavior is not driven purely by fear, but also by social and/or protection goals regulated by approach motivation. This study presents new insights into public perceptions of coronavirus and government regulated lifestyle restrictions, helping to explain social behaviors in terms of biologically driven mechanisms. Such understanding is vital if we are to successfully motivate public behavior to constrain spread of the virus. (shrink)

In this article, Roberto Esposito lays out the genealogical pathways linking the three major concepts around which his most recent work has wound its way: community, immunity, and biopolitics. Although immunity is necessary to the preservation of our life, when driven beyond a certain threshold it forces life into a sort of cage where not only our freedom gets lost but also the very meaning of our existence – that opening of existence outside itself that takes the name of communitas. (...) A hermeneutics informed by immunity can allow the category of community to regain a new political significance, without ending up in a substantialist metaphysics. This task is dictated by the urgent need for an affirmative biopolitics – a horizon of meaning – in which life would no longer be the object but somehow the subject of politics. But what sort of shape would this take? Where would we trace its symptoms? And with what objectives? A preliminary answer focuses on breaking the vise grip between public and private that threatens to crush the common, by seeking instead to expand the space of the common, in the fight, for example, against the planned privatization of water and the battle over energy sources. (shrink)

Host‐pathogen arms race is a universal, central aspect of the evolution of life. Most organisms evolved several distinct yet interacting strategies of anti‐pathogen defense including resistance to parasite invasion, innate and adaptive immunity, and programmed cell death (PCD). The PCD is the means of last resort, a suicidal response to infection that is activated when resistance and immunity fail. An infected cell faces a decision between active defense and altruistic suicide or dormancy induction, depending on whether immunity is “deemed” capable (...) of preventing parasite reproduction and consequent infection of other cells. In bacteria and archaea, immunity genes typically colocalize with PCD modules, such as toxins‐antitoxins, suggestive of immunity‐PCD coupling, likely mediated by shared proteins that sense damage and “predict” the outcome of infections. In type VI CRISPR‐Cas systems, the same enzyme that inactivates the target RNA might execute cell suicide, in a case of ultimate integration of immunity and PCD. (shrink)

In recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive immune systems. One question that has not been addressed yet is the transgenerational aspect of the CRISPR-Cas9-based response. If immunity is acquired and inherited, how to distinguish evolutionary from immunological adaptation? To shed light (...) on this issue and obtain conceptual clarity, I will investigate the inheritance of small RNA responses to pathogens in the nematode C. elegans as a further potential instantiation of a transgenerational adaptive immune system. I will explore how to make sense of systems that lie at the crossroads between genetic, immunological, and evolutionary spheres and explore the consequences of a transgenerational perspective on immune systems for immunology and its philosophy. (shrink)

In their recent article, Brown et al analyse several ethical aspects around immunity passports and put forward some recommendations for implementing them. Although they offer a comprehensive perspective, they overlook two essential aspects. First, while the authors consider the possibility that immunological passports may appear to discriminate against those who do not possess them, the opposite viewpoint of immune people is underdeveloped. We argue that if a person has been tested positive for and recovered from COVID-19, becoming immune to it, (...) she cannot be considered a hazard to public health and, therefore, the curtailment of her fundamental rights is not legitimate. Second, they omit that vaccine distribution will create similar problems related to immunity-based licenses. Vaccine certificates will de facto generate a sort of immunity passport. In the next phases of the pandemic, different immunity statuses will be at stake, because the need to identify who can spread COVID-19 is unavoidable. If a person does not pose a threat to public health because she cannot spread the infection, then her right to freedom of movement should be respected, regardless of how she acquired that immunity. (shrink)

We define and study a new notion called k-immunity that lies between immunity and hyperimmunity in strength. Our interest in k-immunity is justified by the result that θ does not k-tt reduce to a k-immune set, which improves a previous result by Kobzev [7]. We apply the result to show that Φ′ does not btt-reduce to MIN, the set of minimal programs. Other applications include the set of Kolmogorov random strings, and retraceable and regressive sets. We also give a new (...) characterization of effectively simple sets and show that simple sets are not btt-cuppable. (shrink)

Although inadequate immunization is a significant public health problem, as covid-19 is an urgent reminder, it has been largely ignored in amateur youth sports. By comparison, safety issues such as...

It has long been taken for granted that the immune system’s capacity to protect an individual from infection and disease depends on the power of the system to distinguish between self and nonself. However, accumulating data have undermined this fundamental concept. Evidence against the self/nonself discrimination model left researchers in need of a new overarching framework able to capture the immune system’s reactivity. Here, I highlight that along with the self/nonself model, another powerful representation of the immune system’s reactivity has (...) been developed in the twentieth century immunology. According to this alternative view, the immune system is not a killer of nonself strangers but a peace-maker helping to establish harmony with the environment. The balance view of the system has never become part of the dominant paradigm. However, it is gaining more and more currency as new research develops. Advances in mucosal immunology confirm that instead of distinguishing between self and foreign the immune system reacts to microbial, chemical and self-induced alterations to produce responses that counterbalance effects of these changes. (shrink)

Since Sydney Shoemaker published his seminal article ‘Self-Reference and Self-Awareness’ in 1968, the notion of ‘Immunity to Error through Misidentification’ has received much attention. It crops up in discussions of personal identity, indexical thought and introspection, and has been used to interpret remarks made by philosophers from Wittgenstein to William James. The precise significance of IEM is often unspecified in these discussions, however. It is unclear, for example, whether it constitutes an important status of judgments, whether it explains an important (...) characteristic of judgments, or whether it merely marks an important characteristic of judgments. Nevertheless, reference to IEM abounds, making this obscure notion seem all the more significant. (shrink)

Since Sydney Shoemaker published his seminal article ‘Self-Reference and Self-Awareness’ in 1968, the notion of ‘Immunity to Error through Misidentification’ has received much attention. It crops up in discussions of personal identity, indexical thought and introspection, and has been used to interpret remarks made by philosophers from Wittgenstein to William James. The precise significance of IEM is often unspecified in these discussions, however. It is unclear, for example, whether itconstitutesan important status of judgments, whether itexplainsan important characteristic of judgments, or (...) whether it merelymarksan important characteristic of judgments. Nevertheless, reference to IEM abounds, making this obscure notion seem all the more significant. (shrink)

In this paper we introduce a paradigm of experiment which, we believe, is of interest both in psychology and philosophy. There the subject wears an HMD (head-mount display), and a camera is set up at the upper corner of the room, in which the subject is. As a result, the subject observes his own body through the HMD. We will mainly focus on the philosophical relevance of this experiment, especially to the thesis of so-called 'immunity to error through misidentification relative (...) to the first-person pronoun'. We will argue that one experiment conducted in this setting, which we call the bodily illusion experiment, provides a counterexample to that thesis. (shrink)

The protection of noncombatants from deadly violence is the centrepiece of any account of ethical and legal constraints on war. It was a major achievement of moral progress from early modern times to World War I. Yet it has been under constant attrition since - perhaps never more so than in our time, with its 'new wars', the spectre of weapons of mass destruction, and the global terrorism alert. -/- Civilian Immunity in War, written in collaboration by eleven authors, provides (...) the first comprehensive analysis of all main aspects of this highly topical subject. It considers the arguments for rejection of civilian immunity and the main theories of the grounds and proper scope of this immunity, both deontological (just war theory) and consequentialist. Separate chapters examine the historical development of the idea of civilian immunity, its standing in current international law, and the problem of "collateral damage": of harming civilians without intent, as a side-effect of attacks on military targets. The volume also addresses a string of specific issues. Civilian immunity has undergone much attrition with the development of air warfare and the tendency of military conflict to degenerate into "total" war. On the other hand, modern military technology with its precision guidance missiles and "smart" bombs opens up the possibility of restricting deadly violence to its proper targets and staying clear of civilian life, limb, and property. Another pressing issue is the fate of women in war in light of mass rapes characteristic of some 'new wars'. (shrink)

Saying ┌ that ψ is F ┐ when one should have said ┌ that φ is F ┐ involves making one of two different kinds of error. Either the wrong nominal term (┌ ψ ┐ instead of ┌ φ ┐) is ascribed to the right object or the right nominal term is ascribed to the wrong object. Judgments susceptible to one kind of error are immune to the other. Indexical terms such as ‘here’ and ‘now’ exhibit a corresponding pattern of (...) immunity and susceptibility to error, which suggests that they are complex demonstratives. This should also apply to ‘I’. (shrink)

In this paper we address the issue of how to think about immunity. Many immunological writings suggest a straightforward option: the view that the immune system is primarily a system of defense, which naturally invites the talk of strong immunity and strong immune response. Despite their undisputable positive role in immunology, such metaphors can also pose a risk of establishing a narrow perspective, omitting from consideration phenomena that do not neatly fit those powerful metaphors. Building on this analysis, we argue (...) two things. First, we argue that the immune system is involved not only in defense. Second, by disentangling various possible meanings of ‘strength’ and ‘weakness’ in immunology, we also argue that such a construal of immunity generally contributes to the distortion of the overall picture of what the immune system is, what it does, and why it sometimes fails. Instead, we propose to understand the nature of the immune system in terms of contextuality, regulation, and trade-offs. We suggest that our approach provides lessons for a general understanding of the organizing principles of the immune system in health and disease. For all this to work, we discuss a wide range of immunological phenomena. (shrink)

Autobiographical memories typically give rise either to memory reports (“I remember going swimming”) or to first person past-tense judgements (“I went swimming”). This article focuses on first person past-tense judgements that are (epistemically) based on autobiographical memories. Some of these judgements have the IEM property of being immune to error through misidentification. This article offers an account of when and why first person past-tense judgements have the IEM property.

In the following pages we propose a theory on cognitive systems and the common strategies of perception, which are at the basis of their function. We demonstrate that these strategies are easily seen to be in place in known cognitive systems such as vision and language. Furthermore we show that taking these strategies into consideration implies a new outlook on immune function calling for a new appraisal of the immune system as a cognitive system.

Roberto Esposito (1998; 2002; 2008) examines how immunological apparatuses originally designed to protect communities end up undermining communities. This paper explores comparatively his view on the interplay between community and immunity with Giorgio Agamben’s and Jacques Derrida’s, although in their works these notions appear under other labels. Beyond pointing out their similarities, the paper concludes by analyzing what, in our view, constitute the raison d’être of their ultimate and irreconcilable differences: Agamben’s approach is _antinomic_, while Derrida’s is _aporetic_ and Esposito’s (...) is rather _dialectical_. (shrink)

Novel regulatory elements that enabled expression of pre‐existing immune genes in reproductive tissues and novel immune genes with pregnancy‐specific roles in eutherians have shaped the evolution of mammalian pregnancy by facilitating the emergence of novel mechanisms for immune regulation over its course. Trade‐offs arising from conflicting fitness effects on reproduction and host defenses have further influenced the patterns of genetic variation of these genes. These three mechanisms (novel regulatory elements, novel immune genes, and trade‐offs) played a pivotal role in refining (...) the regulation of maternal immune systems during pregnancy in eutherians, likely facilitating the establishment of prolonged direct maternal–fetal contact in eutherians without causing immunological rejection of the genetically distinct fetus. (shrink)

Judgments based on episodic memory are often thought to be immune to errors of misidentification (IEM). Yet there is a certain category of episodic memories, viz. observer memories, that seems to threaten IEM. In the resulting debate, some say that observer memories are a threat to the IEM enjoyed by episodic memory (Michaelian, 2021); others say that they pose no such threat (Fernández, 2021; Lin, 2020). In this paper, we argue for a middle way. First, we frame the debate, claiming (...) that the existing literature lacks a satisfying definition both of observer memories and of the precise issue of errors of identification in such memories. Then, we contribute to the debate by challenging an anti-separatist view about the relation between phenomenal and intentional features of observer memories that looms behind this debate. On this view, if the rememberer's self is a phenomenal feature of the memory, by implication it is also built into the intentional content. We reject this view and offer a moderate separatist account. Distinguishing between empirically-grounded species of observer memories, we say that the phenomenal self sometimes is, and sometimes is not built into the intentional content of the memory, and this results in different implications for IEM. (shrink)

We examine the multiplicity of complementation amongst subspaces of V ∞ . A subspace V is a complement of a subspace W if V ∩ W = {0} and (V ∪ W) * = V ∞ . A subspace is called fully co-r.e. if it is generated by a co-r.e. subset of a recursive basis of V ∞ . We observe that every r.e. subspace has a fully co-r.e. complement. Theorem. If S is any fully co-r.e. subspace then S has (...) a decidable complement. We give an analysis of other types of complements S may have. For example, if S is fully co-r.e. and nonrecursive, then S has a (nonrecursive) r.e. nowhere simple complement. We impose the condition of immunity upon our subspaces. Theorem. Suppose V is fully co-r.e. Then V is immune iff there exist M 1 , M 2 ∈ L(V ∞ ), with M 1 supermaximal and M 2 k-thin, such that $M_1 \oplus V = M_2 \oplus V = V_\infty$ . Corollary. Suppose V is any r.e. subspace with a fully co-r.e. immune complement W (e.g., V is maximal or V is h-immune). Then there exist an r.e. supermaximal subspace M and a decidable subspace D such that $V \oplus W = M \oplus W = D \oplus W = V_\infty$ . We indicate how one may obtain many further results of this type. Finally we examine a generalization of the concepts of immunity and soundness. A subspace V of V ∞ is nowhere sound if (i) for all Q ∈ L(V ∞ ) if $Q \supset V$ then Q = V ∞ , (ii) V is immune and (iii) every complement of V is immune. We analyse the existence (and ramifications of the existence) of nowhere sound spaces. (shrink)

In the following excerpt from Bios, Esposito sketches the template of immunity as a response to what he calls a "hermeneutic block" in Foucault's notion of biopolitics. After singling out those moments of greatest tension in Foucault's reading of biopolitics especially as it relates to Nazi thanatopolitics, Esposito sets out in detail the most important features of what he calls the immunization paradigm. Consisting of three dispositifs, namely sovereignty, property, and liberty, the immunitary paradigm has for Esposito a decisively (...) modern inflection. Indeed modern biopolitics cannot be thought apart from the mode by which communities immunize or protect themselves. (shrink)

We extend Meyer's 1972 investigation of sets of minimal indices. Blum showed that minimal index sets are immune, and we show that they are also immune against high levels of the arithmetic hierarchy. We give optimal immunity results for sets of minimal indices with respect to the arithmetic hierarchy, and we illustrate with an intuitive example that immunity is not simply a refinement of arithmetic complexity. Of particular note here are the fact that there are three minimal index sets located (...) in Π3 − Σ3 with distinct levels of immunity and that certain immunity properties depend on the choice of underlying acceptable numbering. We show that minimal index sets are never hyperimmune; however, they can be immune against the arithmetic sets. Lastly, we investigate Turing degrees for sets of random strings defined with respect to Bagchi's size-function s. (shrink)

Are those judgments that we make on the basis of our memories immune to error through misidentification? In this paper, I discuss a phenomenon which seems to suggest that they are not; the phenomenon of observer memory. I argue that observer memories fail to show that memory judgments are not IEM. However, the discussion of observer memories will reveal an interesting fact about the perspectivity of memory; a fact that puts us on the right path towards explaining why memory judgments (...) are indeed IEM. The main tenet in the account of IEM to be proposed is that this aspect of memory is grounded, on the one hand, on the intentionality of perception and, on the other hand, on the relation between the intentionality of perception and that of memory. (shrink)