Causal models provide a framework for precisely representing complex causal structures, where specific models can be used to efficiently predict, infer, and explain the world. At the same time, we often do not know the full causal structure a priori and so must learn it from data using a causal model search algorithm. This chapter provides a general overview of causal models and their uses, with a particular focus on causal graphical models (the (...) most commonly used causal modeling framework) and methods for learning such models from observational and experimental data. The chapter concludes with two examples of productive causal search and modeling in experimental philosophy. (shrink)

Part of Allen et al.’s criticism of Hamilton’s rule makes sense only if we are interested in social adaptation rather than merely social selection. Under the assumption that we are interested in casually modeling social adaptation, I illustrate how graphical causal models of social adaptation can be useful for predicting evolution by adaptation. I then argue for two consequences of this approach given some of the recent philosophical literature. I argue Birch’s claim that the proper way to (...) understand Hamilton’s rule is as providing an organizational framework for causal models is incorrect. I provide an account of a causally adequate decomposition of evolutionary change due to social adaptation and show that my account is superior to Okasha’s. (shrink)

There are simple mechanical systems that elude causal representation. We describe one that cannot be represented in a single directed acyclic graph. Our case suggests limitations on the use of causal graphs for causal inference and makes salient the point that causal relations among variables depend upon details of causal setups, including values of variables.

Mechanist philosophers have examined several strategies scientists use for discovering causal mechanisms in neuroscience. Findings about the anatomical organization of the brain play a central role in several such strategies. Little attention has been paid, however, to the use of network analysis and causal modeling techniques for mechanism discovery. In particular, mechanist philosophers have not explored whether and how these strategies incorporate information about the anatomical organization of the brain. This paper clarifies these issues in the light (...) of the distinction between structural, functional and effective connectivity. Specifically, we examine two quantitative strategies currently used for causal discovery from functional neuroimaging data: dynamic causal modeling and probabilistic graphical modeling. We show that dynamic causal modeling uses findings about the brain’s anatomical organization to improve the statistical estimation of parameters in an already specified causal model of the target brain mechanism. Probabilistic graphical modeling, in contrast, makes no appeal to the brain’s anatomical organization, but lays bare the conditions under which correlational data suffice to license reliable inferences about the causal organization of a target brain mechanism. The question of whether findings about the anatomical organization of the brain can and should constrain the inference of causal networks remains open, but we show how the tools supplied by graphical modeling methods help to address it. (shrink)

Humans often attribute the things that happen to one or another actual cause. In this chapter, we survey some recent philosophical and psychological research on causal attribution. We pay special attention to the relation between graphical causal modeling and theories of causal attribution. We think that the study of causal attribution is one place where formal and experimental techniques nicely complement one another.

Within the causal modeling literature, debates about the Causal Faithfulness Condition have concerned whether it is probable that the parameters in causal models will have values such that distinct causal paths will cancel. As the parameters in a model are fixed by the probability distribution over its variables, it is initially puzzling what it means to assign probabilities to these parameters. I propose that to assign a probability to a parameter in a model is to (...) treat that parameter as a function of a variable in an augmented model. By combining this proposal with widely adopted principles regarding which variables must be included in a model, I argue that the various proposed counterexamples to CFC involving coordinated parameters are not genuine counterexamples. I then consider the cases in which CFC fails due not to coordination, but by coincidence, and propose explanatory and predictive bases for ruling out such coincidences without presuming that they are improbable. The aim of the proposed defenses is not to show that CFC never fails, but rather to argue that its use in a particular context may be defended using general modeling assumptions rather than by relying on claims about how often it fails. (shrink)

Social scientists report difficulties in drawing out testable predictions from the literature on intersectionality theory. We alleviate that difficulty by showing that some characteristic claims of the intersectionality literature can be interpreted causally. The formalism of graphical causal modeling allows claims about the causal effects of occupying intersecting identity categories to be clearly represented and submitted to empirical testing. After outlining this causal interpretation of intersectional theory, we address some concerns that have been expressed in (...) the literature claiming that membership in demographic categories can have causal effects. (shrink)

Curie’s Principle says that any symmetry property of a cause must be found in its effect. In this article, I consider Curie’s Principle from the point of view of graphical causal models, and demonstrate that, under one definition of a symmetry transformation, the causal modeling framework does not require anything like Curie’s Principle to be true. On another definition of a symmetry transformation, the graphical causal modeling formalism does imply a version of Curie’s (...) Principle. These results yield a better understanding of the logical landscape with respect to the relationship between Curie’s Principle and graphical causal modeling. (shrink)

This article assesses how people reason with categories whose features are related in causal cycles. Whereas models based on causal graphical models have enjoyed success modeling category-based judgments as well as a number of other cognitive phenomena, CGMs are only able to represent causal structures that are acyclic. A number of new formalisms that allow cycles are introduced and evaluated. Dynamic Bayesian networks represent cycles by unfolding them over time. Chain graphs augment CGMs by allowing (...) the presence of undirected links that model feedback relations between variables. Unfolded chain graphs are chain graphs that unfold over time. An existing model of causal cycles is also evaluated. Four experiments in which subjects reason about categories with cyclically related features provided evidence against DBNs and alpha centrality and for the two types of chain graphs. Chain graphs—a mechanism for representing the equilibrium distribution of a dynamic system—may thus be good candidates for modeling how people reason causally with complex systems. Applications of chain graphs to areas of cognition other than category-based judgments are discussed. (shrink)

We describe a unification of old and recent ideas for formulating graphical models to explain time series data, including Granger causality, semi-automated search procedures for graphical causal models, modeling of contemporaneous influences in times series, and heuristic generalized additive model corrections to linear models. We illustrate the procedures by finding a structure of exogenous variables and mediating variables among time series of remote geospatial indices of ocean surface temperatures and pressures. The analysis agrees with known exogenous (...) drivers of the indices, not assumed in the analysis. Automated search applied to the residuals after regressing each series on its lags and the lags of its Granger causes yields a graphical model of “comtemporaneous” causal relations identical with the qualitative graphical relations from the time series. A similar analysis produces reasonable results when applied to candidate climate indices obtained by a clustering method from sea surface temperature and sea level pressure data. (shrink)

We describe a unification of old and recent ideas for formulating graphical models to explain time series data, including Granger causality, semi-automated search procedures for graphical causal models, modeling of contemporaneous influences in times series, and heuristic generalized additive model corrections to linear models. We illustrate the procedures by finding a structure of exogenous variables and mediating variables among time series of remote geospatial indices of ocean surface temperatures and pressures. The analysis agrees with known exogenous (...) drivers of the indices, not assumed in the analysis. Automated search applied to the residuals after regressing each series on its lags and the lags of its Granger causes yields a graphical model of “comtemporaneous” causal relations identical with the qualitative graphical relations from the time series. A similar analysis produces reasonable results when applied to candidate climate indices obtained by a clustering method from sea surface temperature and sea level pressure data. (shrink)

Causal Modeling Semantics (CMS, e.g., Galles and Pearl 1998; Pearl 2000; Halpern 2000) is a powerful framework for evaluating counterfactuals whose antecedent is a conjunction of atomic formulas. We extend CMS to an evaluation of the probability of counterfactuals with disjunctive antecedents, and more generally, to counterfactuals whose antecedent is an arbitrary Boolean combination of atomic formulas. Our main idea is to assign a probability to a counterfactual (A ∨ B) > C at a causal model M (...) as a weighted average of the probability of C in those submodels that truthmake A∨ B (Briggs 2012; Fine 2016, 2017). The weights of the submodels are given by the inverse distance to the original model M, based on a distance metric proposed by Eva, Stern, and Hartmann (2019). Apart from solving a major problem in the epistemology of counterfactuals, our paper shows how work in semantics, causal inference and formal epistemology can be fruitfully combined. (shrink)

I highlight a metaphysical concern that stands in the way of more widespread adoption of causal modeling techniques such as causal Bayes nets. Researchers in some fields may resist adoption due to concerns that they don't 'really' understand what they are saying about a system when they apply such techniques. Students in these fields are repeated exhorted to be cautious about application of statistical techniques to their data without a clear understanding of the conditions required for those (...) techniques to yield genuine insight into the data. They are acutely aware that anyone can chuck some data into a software package and get what looks like an answer, even though these tests may not be well-defined for the data on which they can apparently be run. This is thus a healthy skepticism for uptake of causal modeling methods, which points directly to the need for a metaphysical understanding of causation in order to successfully use the modeling methods. Without a clear understanding of what the methods are committing to, including what it means to say that there exists a causal relationship, researchers have limited ability to identify potentially bad output, or to independently verify results. (shrink)

This paper brings together Thompson's naive action explanation with interventionist modeling of causal structure to show how they work together to produce causal models that go beyond current modeling capabilities, when applied to specifically selected systems. By deploying well-justified assumptions about rationalization, we can strengthen existing causal modeling techniques' inferential power in cases where we take ourselves to be modeling causal systems that also involve actions. The internal connection between means and end (...) exhibited in naive action explanation has a modal strength like that of distinctively mathematical explanation, rather than that of causal explanation. Because it is stronger than causation, it can be treated as if it were merely causal in a causal model without thereby overextending the justification it can provide for inferences. This chapter introduces and demonstrate the usage of the Rationalization condition in causal modeling, where it is apt for the system(s) being modeled, and to provide the basics for incorporating R variables into systems of variables and R arrows into DAGs. Use of the Rationalization condition supplements causal analysis with action analysis where it is apt. (shrink)

Causal modeling methods such as path analysis, used in the social and natural sciences, are also highly relevant to philosophical problems of probabilistic causation and statistical explanation. We show how these methods can be effectively used (1) to improve and extend Salmon's S-R basis for statistical explanation, and (2) to repair Cartwright's resolution of Simpson's paradox, clarifying the relationship between statistical and causal claims.

An important question for the causal modeling approach is how to integrate non‐causal dependence relations such as asymmetric supervenience into the approach. The most prominent proposal to that effect (due to Gebharter) is to treat those dependence relationships as formally analogous to causal relationships. We argue that this proposal neglects some crucial differences between causal and non‐causal dependencies, and that in the context of causal modeling non‐causal dependence relationships should be represented (...) as mutual dependence relationships. We develop a new kind of model – “hybrid models” ‐ based on this suggestion, and formulate a set of axioms for those models. Our formalism has important implications for Kim's exclusion problem: whereas Gebharter's framework vindicates Kim's causal exclusion objection against nonreductive physicalism, our framework has no such implication, and can help non‐reductive physicalists vindicate the efficacy of high‐level properties. A further benefit of our formalism is that it yields a natural and plausible way of thinking about interventions in multi‐level contexts. (shrink)

Recent philosophical studies of probabilistic causation and statistical explanation have opened up the possibility of unifying philosophical approaches with causal modeling as practiced in the social and biological sciences. This unification rests upon the statistical tools employed, the principle of common cause, the irreducibility of causation to statistics, and the idea of causal process as a suitable framework for understanding causal relationships. These four areas of contact are discussed with emphasis on the relevant aspects of (...) class='Hi'>causal modeling. (shrink)

Graphical models are a powerful tool for causal model specification. Besides allowing for a hierarchical representation of variable interactions, they do not require any a priori specification of the functional dependence between variables. The construction of such graphs hence often relies on the mere testing of whether or not model variables are marginally or conditionally independent. The identification of causal relationships then solely requires some general assumptions on the relation between stochastic and causal independence, such as (...) the Causal Markov Condition and the Faithfulness Condition (Spirtes et al. 2000; Pearl 2000). However, a procedure would require further assumptions to hold. Namely those the independence tests themselves are based on. In continuous settings, Spirtes et al. (2000) suggest causal inference based on a very restrictive formulation of independence, that is, vanishing partial correlations. Such a measure does, however, limit the applicability of causal inference to linear systems. This constitutes a serious drawback especially for the social sciences where an a priori specification of the functional form proves difficult or at odds with linearity. In short: graphical models theoretically reduce specification uncertainty regarding functional dependence, but their implementation in practice deprives them of this virtue. In this paper we investigate how causal structures in continuous settings can be identified when both functional forms and probability distributions of the variables remain unspecified. We focus on tests exploiting the fact that if X and Y are conditionally independent given a set of variables Z, the two conditional densities f (X|Y, Z) and f (X|Z) must coincide. We start by estimating the conditional densities f(X|Y, Z) and f(X|Z) via nonparametric techniques (kernel methods). We proceed by testing if some metric expressing the distance between these very conditional densities is sufficiently close to zero. Out of several metrics available in the literature to express such distance we choose two, the Euclidean, and the Hellinger distance. We investigate in a Monte Carlo study how different tests involving either measure are able to detect statistical independence, conditioned on a small set of variables. One limitation may result from nonparametric density estimation being subject to the curse of dimensionality. As the number of variables increases, the estimated empirical density converges at a slower rate to its population value. To compensate this drawback we use a local bootstrap procedure which consists of resampling the data for each test. While local bootstrap strongly increases the computational time of the test, it succeeds in counterbalancing the curse of dimensionality. (shrink)

In everyday life, as well as in science, we have to deal with and act on the basis of partial (i.e. incomplete, uncertain, or even inconsistent) information. This observation is the source of a broad research activity from which a number of competing approaches have arisen. There is some disagreement concerning the way in which partial or full ignorance is and should be handled. The most successful approaches include both quantitative aspects (by means of probability theory) and qualitative aspect (by (...) means of graphical or causal models or logic). Some of these approaches have important impacts on various disciplines including philosophy, computer science, statistics, mathematics, physics, and social science. Most notably, the relation between causal and probabilistic information is a topic of interest in all of these fields. The general question of how uncertainty is related to ignorance, and the connection thereof to causality, have been the key topics of the international summer school at the University of Konstanz, Germany, in August 2004. This was the third event in a series of summer schools organized by the interdisciplinary research group “Philosophy, Probability, and Modeling”. The group was in operation from September 1st, 2001, until August 31, 2005. The first summer school, held in September 2002, focused on the application of probability theory to topics of philosophical interest. Problems and questions that arise when probabilistic models and techniques are being applied in the special sciences were then discussed during the second summer school, held in July 2003. The fourth and final event in the series, in August 2005, was devoted to philosophical questions related to the application and interpretation of probabilities in physics. Each of the four summer schools attracted 40–50 people from many different countries. It was an inspiring forum for an interdisciplinary discussion among researchers and students from many different areas. This special issue collects a selection of the invited and contributed papers presented at the summer school in 2004. We acknowledge the generous support of the Center for Junior Research Fellows at the University of Konstanz, the Gesellschaft für analytische Philosophie e.V., the Centre for Philosophy of Natural and Social Science at the London School of Economics, the Alexander von Humboldt Foundation, the Federal Ministry of Education and Research and the Program for the Investment in the Future (ZIP) of the German Government through a Sofja Kovalevskaja Award. We thank the referees of the papers for their work, and James Moor for his interest in dedicating a special issue of this journal to Causality, Uncertainty and Ignorance. (shrink)

Recent studies on probabilistic causation and statistical explanation (Cartwright 1979; Salmon 1984), I believe, have opened up the possibility of a genuine unification between philosophical approaches and causal modeling (CM) in the social, behavioral and biological sciences (Wright 1934; Blalock 1964; Asher 1976). This unification rests on the statistical tools employed, the principle of common cause, the irreducibility of causation to probability or statistics, and the idea of causal process as a suitable framework for understanding causal (...) relationships. The aim of this paper is to draw attention to these four areas of contact by focusing on the relevant aspects of CM.Causal analysis in the social sciences is based on two fundamental notions: model and method. A causal model is an idealized picture of the causal relationships in the world. Method, on the other hand, refers to certain statistical techniques that are used to evaluate and test a causal model using data which consist of joint observations on the model variables. (shrink)

In (Gebharter 2014) I suggested a framework for modeling the hierarchical organization of mechanisms. In this short addendum I want to highlight some connections of my approach to the statistics and machine learning literature and some of its limitations not mentioned in the paper.

Drawing substantive conclusions from linear causal models that perform acceptably on statistical tests is unreasonable if it is not known how alternatives fare on these same tests. We describe a computer program, TETRAD, that helps to search rapidly for plausible alternatives to a given causal structure. The program is based on principles from statistics, graph theory, philosophy of science, and artificial intelligence. We describe these principles, discuss how TETRAD employs them, and argue that these principles make TETRAD an (...) effective tool. Finally, we illustrate TETRAD's effectiveness by applying it to a multiple indicator model of Political and Industrial development. A pilot version of the TETRAD program is described in this paper. The current version is described in our forthcoming Discovering Causal Structure: Artificial Intelligence for Statistical Modeling. (shrink)

Brandon claims that to explain adaptation one must specify fitnesses in each selective environment and specify the distribution of individuals across selective environments. Glymour claims, using an example of the adaptive evolution of costly plasticity in a symmetric environment, that there are some predictive or explanatory tasks for which Brandon’s claim is limited. In this paper, I provide necessary conditions for carrying out Brandon’s task, produce a new version of the argument for his claim, and show that Glymour’s reasons for (...) making his claim are problematic. I provide a few interpretations of Glymour’s argument but ultimately raise worries for what I take to be the key premises. (shrink)

This paper examines the adequacy of causal graph theory as a tool for modeling biological phenomena and formalizing biological explanations. I point out that the causal graph approach reaches it limits when it comes to modeling biological phenomena that involve complex spatial and structural relations. Using a case study from molecular biology, DNA-binding and -recognition of proteins, I argue that causal graph models fail to adequately represent and explain causal phenomena in this field. The (...) inadequacy of these models is due to their failure to include relevant spatial and structural information in a way that does not render the model non-explanatory, unmanageable, or inconsistent with basic assumptions of causal graph theory. (shrink)

Some cases show that counterfactual conditionals (‘counterfactuals’ for short) are inherently ambiguous, equivocating between forward-tracking and backtracking counterfactu- als. Elsewhere, I have proposed a causal modeling semantics, which takes this phenomenon to be generated by two kinds of causal manipulations. (Lee 2015; Lee 2016) In an important paper (Hiddleston 2005), Eric Hiddleston offers a different causal modeling semantics, which he claims to be able to explain away the inherent ambiguity of counterfactuals. In this paper, I (...) discuss these two semantic treatments and argue that my (bifurcated) semantics is theoretically more promising than Hiddleston’s (unified) semantics. (shrink)

Philosophers have long analyzed the truth-condition of counterfactual conditionals in terms of the possible-worlds semantics advanced by Lewis [13] and Stalnaker [23]. In this paper, I argue that, from the perspective of philosophical semantics, the causal modeling semantics proposed by Pearl [17] and others (e.g., Briggs [3]) is more plausible than the Lewis-Stalnaker possible-worlds semantics. I offer two reasons. First, the possible-worlds semantics has suffered from a specific type of counterexamples. While the causal modeling semantics can (...) handle such examples with ease, the only way for the possible-worlds semantics to do so seems to cost it its distinctive status as a philosophical semantics. Second, the causal modeling semantics, but not the possible-worlds semantics, has the resources enough for accounting for both forward-tracking and backtracking counterfactual conditionals. (shrink)

These are chapters from a book forthcoming from MIT Press. Comments to the author at [email protected] would be most welcome. Still time for changes.

We construct a causal-modeling semantics for both indicative and counterfactual conditionals. As regards counterfactuals, we adopt the orthodox view that a counterfactual conditional is true in a causal model M just in case its consequent is true in the submodel M∗, generated by intervening in M, in which its antecedent is true. We supplement the orthodox semantics by introducing a new manipulation called extrapolation. We argue that an indicative conditional is true in a causal model M (...) just in case its con- sequent is true in certain submodels M∗, generated by extrapolating M, in which its antecedent is true. We show that the proposed semantics can account for some important minimal pairs nicely and naturally. We also prove a theorem showing under what conditions intervention and extrapolation will yield the same result, and thus explain how counterfactual and indicative conditionals would behave in a causal-modeling semantics. (shrink)

Effective recommendations on healthy food choice need to be personalized and sent out on a large scale. In this paper, we present a model of automatic message selection tailored on the characteristics of the recipient and focused on the reduction of red meat consumption. This model is obtained through the collaboration between social psychologists and artificial intelligence experts. Starting from selected psychosocial models on food choices and the framing effects of recommendation messages, we involved a sample of Italian participants in (...) an experiment in which they: filled out a first questionnaire, which was aimed at detecting the psychosocial antecedents of the intention to eat red/processed meat; read messages differing as to the framing of the hypothetical consequences of reducing versus not reducing red/processed meat consumption; filled out a second questionnaire, which was aimed at detecting participants’ reaction to the messages, as well as any changes in their intention to consume red/processed meat. Data collected were then employed to learn both the structure and the parameters of a Graphical Causal Model based on a Dynamic Bayesian Network, aimed to predicting the potential effects of message delivery from the observation of the psychosocial antecedents. Such probabilistic predictor is intended as the basis for developing automated interactions strategies using Deep Reinforcement Learning techniques. Discussion focuses on how to develop automatic interaction strategies able to foster mindful eating, thanks to considering the psychosocial characteristics of the people involved; sending messages tailored on these characteristics; adapting interaction strategies according to people’s reactions. (shrink)

Understanding the neural basis of schizophrenia (SZ) is important for shedding light on the neurobiological mechanisms underlying this mental disorder. Structural and functional alterations in the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), hippocampus, and medial prefrontal cortex (MPFC) have been implicated in the neurobiology of SZ. However, the effective connectivity among them in SZ remains unclear. The current study investigated how neuronal pathways involving these regions were affected in first-episode SZ using functional magnetic resonance imaging (fMRI). Forty-nine patients (...) with a first-episode of psychosis and diagnosis of SZ—according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision—were studied. Fifty healthy controls (HCs) were included for comparison. All subjects underwent resting state fMRI. We used spectral dynamic causal modeling (DCM) to estimate directed connections among the bilateral ACC, DLPFC, hippocampus, and MPFC. We characterized the differences using Bayesian parameter averaging (BPA) in addition to classical inference (t-test). In addition to common effective connectivity in these two groups, HCs displayed widespread significant connections predominantly involved in ACC not detected in SZ patients, but SZ showed few connections. Based on BPA results, SZ patients exhibited anterior cingulate cortico-prefrontal-hippocampal hyperconnectivity, as well as ACC-related and hippocampal-dorsolateral prefrontal-medial prefrontal hypoconnectivity. In summary, spectral DCM revealed the pattern of effective connectivity involving ACC in patients with first-episode SZ. This study provides a potential link between SZ and dysfunction of ACC, creating an ideal situation to associate mechanisms behind SZ with aberrant connectivity among these cognition and emotion-related regions. (shrink)

Peter Spirtes, Clark Glymour, Richard Scheines, Christopher Meek, S. Fineberg, E. Slate. Prediction and Experimental Design with Graphical Causal Models.

This paper presents a formalism that combines useful properties of both logic and probabilities. Like logic, the formalism admits qualitative sentences and provides symbolic machinery for deriving deductively closed beliefs and, like probability, it permits us to express if-then rules with different levels of firmness and to retract beliefs in response to changing observations. Rules are interpreted as order-of-magnitude approximations of conditional probabilities which impose constraints over the rankings of worlds. Inferences are supported by a unique priority ordering on rules (...) which is syntactically derived from the knowledge base. This ordering accounts for rule interactions, respects specificity considerations and facilitates the construction of coherent states of beliefs. Practical algorithms are developed and analyzed for testing consistency, computing rule ordering, and answering queries. Imprecise observations are incorporated using qualitative versions of Jeffrey's rule and Bayesian updating, with the result that coherent belief revision is embodied naturally and tractably. Finally, causal rules are interpreted as imposing Markovian conditions that further constrain world rankings to reflect the modularity of causal organizations. These constraints are shown to facilitate reasoning about causal projections, explanations, actions and change. (shrink)

Recording of neural activity during grasping actions in macaques showed that grasp-related sensorimotor transformations are accomplished in a circuit constituted by the anterior part of the intraparietal sulcus (AIP), the ventral (F5) and the dorsal (F2) region of the premotor area. In humans, neuroimaging studies have revealed the existence of a similar circuit, involving the putative homolog of macaque areas AIP, F5, and F2. These studies have mainly considered grasping movements performed with the right dominant hand and only a few (...) studies have measured brain activity associated with a movement performed with the left non-dominant hand. As a consequence of this gap, how the brain controls for grasping movement performed with the dominant and the non-dominant hand still represents an open question. A functional magnetic resonance imaging (fMRI) experiment has been conducted, and effective connectivity (dynamic causal modeling, DCM) was used to assess how connectivity among grasping-related areas is modulated by hand (i.e., left and right) during the execution of grasping movements toward a small object requiring precision grasping. Results underlined boosted inter-hemispheric couplings between dorsal premotor cortices during the execution of movements performed with the left rather than the right dominant hand. More specifically, they suggest that the dorsal premotor cortices may play a fundamental role in monitoring the configuration of fingers when grasping movements are performed by either the right and the left hand. This role becomes particularly evident when the hand less-skilled (i.e., the left hand) to perform such action is utilized. The results are discussed in light of recent theories put forward to explain how parieto-frontal connectivity is modulated by the execution of prehensile movements. (shrink)

Erratum to: Synthese 191:1925–1930 DOI:10.1007/s11229-013-0380-3 The authors were unaware that points in their article appeared in “Caveats for Causal Reasoning with Equilibrium Models,” by Denver Dash and Marek Druzdzel, published in S. Benferhat and P. Besnard : European Conferences on Symbolic and Quantitative Approaches to Reasoning with Uncertainty 2001, Lecture Notes in Artificial Intelligence 2143, pp. 192–203. The authors were unaware of this essay and would like to apologize to the authors for failing to cite their excellent work.

Contemporary action theory is generally concerned with giving theories of action ontology. In this paper, we make the novel proposal that the standard view in action theory—the Causal Theory of Action—should be recast as a “model”, akin to the models constructed and investigated by scientists. Such models often consist in fictional, hypothetical, or idealized structures, which are used to represent a target system indirectly via some resemblance relation. We argue that recasting the Causal Theory as a model can (...) not only accomplish the goals of causal theorists, but also give the theory greater flexibility in responding to common objections. (shrink)

Aging is accompanied by stereotyped changes in functional brain activations, for example a cortical shift in activity patterns from posterior to anterior regions is one hallmark revealed by functional magnetic resonance imaging (fMRI) of aging cognition. Whether these neuronal effects of aging could potentially contribute to an amelioration of or resistance to the cognitive symptoms associated with psychopathology remains to be explored. We used a visual illusion paradigm to address whether aging affects the cortical control of perceptual beliefs and biases. (...) Our aim was to understand the effective connectivity associated with volitional control of ambiguous visual stimuli and to test whether greater top-down control of early visual networks emerged with advancing age. Using a bias training paradigm for ambiguous images we found that older participants (n = 16) resisted experimenter-induced visual bias compared to a younger cohort (n = 14) and that this resistance was associated with greater activity in prefrontal and temporal cortices. By applying Dynamic Causal Models for fMRI we uncovered a selective recruitment of top-down connections from the middle temporal to Lingual gyrus (LIN) by the older cohort during the perceptual switch decision following bias training. In contrast, our younger cohort did not exhibit any consistent connectivity effects but instead showed a loss of driving inputs to orbitofrontal sources following training. These findings suggest that perceptual beliefs are more readily controlled by top-down strategies in older adults and introduce age-dependent neural mechanisms that may be important for understanding aberrant belief states associated with psychopathology. (shrink)

The Lotka–Volterra predator-prey-model is a widely known example of model-based science. Here we reexamine Vito Volterra’s and Umberto D’Ancona’s original publications on the model, and in particular their methodological reflections. On this basis we develop several ideas pertaining to the philosophical debate on the scientific practice of modeling. First, we show that Volterra and D’Ancona chose modeling because the problem in hand could not be approached by more direct methods such as causal inference. This suggests a philosophically (...) insightful motivation for choosing the strategy of modeling. Second, we show that the development of the model follows a trajectory from a “how possibly” to a “how actually” model. We discuss how and to what extent Volterra and D’Ancona were able to advance their model along that trajectory. It turns out they were unable to establish that their model was fully applicable to any system. Third, we consider another instance of model-based science: Darwin’s model of the origin and distribution of coral atolls in the Pacific Ocean. Darwin argued more successfully that his model faithfully represents the causal structure of the target system, and hence that it is a “how actually” model. (shrink)