The ArgumentIn the first part of this paper, issues concerning an “epistemology of time” are raised. The Derridean theme of the historial movement of a trace is connected to Prigogine's notion of an operator-time. It is suggested that both conceptions can be used to characterize the dynamics of experimental systems in contemporary science. It is argued that such systems have, to speak with Hacking, “a life of their own” and that this is precisely the reason for their inherent unpredictability.In (...) the second part, a case from the history of virology and cytomorphology is presented. The movement of a particular experimental system is followed in its peculiar tension between deferring and becoming different—i.e., between the persistence of a problem and the vagaries of its successive transformations. They are rendered possible by novel technical implementations, but they are not determined in any meaningful sense on a mere technological level.In conclusion, a point is made for a deconstructive approach to the history of science. (shrink)

Berichte zur Wissenschaftsgeschichte, Volume 45, Issue 3, Page 301-305, September 2022.

Berichte zur Wissenschaftsgeschichte, Volume 45, Issue 3, Page 301-305, September 2022.

Attention to scientific practice offers a novel response to philosophical queries about how conceptual understanding is empirically accountable. The locus of the issue is thereby shifted, from perceptual experience to experimental and fieldwork interactions. More important, conceptual articulation is shown to be not merely ?spontaneous? and intralinguistic, but instead involves a establishing a systematic domain of experimental operations. The importance of experimental practice for conceptual understanding is especially clearly illustrated by cases in which entire domains of scientific (...) investigation were first made accessible to articulated conceptual understanding. We thereby see more clearly how experimental systems themselves, and not merely the theories and models they make possible, have an intentional directedness and ?representational? import. (shrink)

: The main contribution of this paper for social studies of scientific practice is to use and further elaborate the concept of experimental system. It is expanded from mere epistemic concerns to also incorporate the built-in practicality and societal relevance of scientific research. For this, an analysis of object construction by a potato-biotechnology research group is presented. The group's object of activity is conceptualized as a dual one comprising both the epistemic and applied objectives. The application object points (...) to the virus-resistant cultivated potato under construction, the epistemic object to the knowledge on the virus-resistance mechanism. Two major phases of the group's work are perceived as distinct experimental systems. The transition between them is analysed in terms of a gradual evolution characterised by network collaboration, ad hoc improvization, resistance, opportunism and informal interaction. (shrink)

Data production in experimental sciences depends on localised experimental systems, but the epistemic properties of data transcend the contingencies of the processes that produce them. Philosophers often believe that experimental systems instantiate but do not produce the epistemic properties of data. In this paper, we argue that experimental systems' local functioning entails intrinsic capacities to produce the epistemic properties of data. We develop this idea by applying Derrida's model of arche-writing to study a case of theory-oriented (...) experimental practice. Derrida's model relativises or dissolves the conceptual distinction between the moment of data production and a subsequent moment of data dissemination. It thus has consequences for understanding both data production (despite being intrinsically local, data production a priori generates transferrable and modellable information) and data dissemination (when modelling information, researchers needs to refer this information to the context of its production). We study a case of data production in a non-exploratory experimental system designed to test a pre-existing hypothesis in visual neuroscience. A case of theory-oriented experimental practice should allow us to identify the autonomous functioning of experimental systems in data production more clearly, insofar as it allows us to study the limits of pre-existing theory in the activities of these systems. We suggest that pre-existing concepts, hypotheses and theories condition the relevance but not the production of experimental data. (shrink)

This article explores the development of a rat model of mother-infant relationships from its origins in the psychosomatic investigations of the mid-1960s to its elaboration into a theoretical system in neurobiology. I reconstruct the research trajectory of a group of neurobiologists in the United States, with a focus on the experimental practices they adopted while building this animal model. Providing a microhistory of this decade-long undertaking, I show that what drove the development of the model in practice was (...) a serendipitous finding about infants’ response to maternal separation. Detected inadvertently, the pup’s separation response acquired an epistemic significance of its own and reoriented the experimental system towards unanticipated paths. To explain this intriguing phenomenon, the neurobiologists kept on refining their material manipulations and stabilizing their experimental outcomes. They thus established a series of causal relationships that connected dysregulations of the infant’s physiological systems to disruptions in maternal care. As important as this interactive stabilization of technique and objects in the laboratory was how the researchers theorized the network of relationships derived from this technically constituted objectivity. Highlighting the practice-driven aspects of model-building, I demonstrate that what facilitated this theoretical process was an integrated design of complementary experiments. The outcome of each separate experiment of the research program came to bear upon the outcomes of other experiments, informing the development of future manipulations. It was this strategically driven integration process that allowed the experimenters to build expanding networks of causal relationships and consolidate them into a neurobiological theory. (shrink)

It is generally accepted that the development of the modern sciences is rooted in experiment. Yet for a long time, experimentation did not occupy a prominent role, neither in philosophy nor in history of science. With the ‘practical turn’ in studying the sciences and their history, this has begun to change. This paper is concerned with systems and cultures of experimentation and the consistencies that are generated within such systems and cultures. The first part of the paper exposes the forms (...) of historical and structural coherence that characterize the experimental exploration of epistemic objects. In the second part, a particular experimental culture in the life sciences is briefly described as an example. A survey will be given of what it means and what it takes to analyze biological functions in the test tube. (shrink)

Masui Kiyoshi (1887–1981), a prominent Japanese geneticist, is best known for inventing the sex-sorting method of chicks and his contributions to experimental genetics in Japan. Masui drew inspiration from Goldschmidt’s sex determination theory and used chickens, transplantation techniques, and his own “chick sexing” methods in his scientific work. This paper examines the intersection of genetics and industrial breeding by tracing the evolution of Masui’s experimental systems. During the early 20th century, poultry farming emerged as a significant industry in (...) Japan, resulting in the development of standardized organisms and techniques for chicken farming. Masui, a professor at Tokyo Imperial University, collaborated with the Imperial Zootechnical Experimental Station to use these organisms as models for sex determination theory while exploring their further industrial possibilities. First, the paper show how Masui viewed chickens as epistemological objects and transformed his anatomical discoveries into standardized industrial practices. Next, it describes how Masui’s collaboration with German geneticist Richard Goldschmidt led to new academic questions about sex determination mechanisms and how he integrated his knowledge of chicken physiology into his research on “experimental gynandromorphs” to elaborate the theories. Lastly, the paper discusses the biotechnological ideals that Masui aimed to achieve and how they were co-constructed with his mass-production method of intersex chickens from the early 1930s. The trajectory of Masui’s experimental systems highlights the dynamic relationship between agroindustry and genetics in the early twentieth century and demonstrates the ‘biology of history’ in which the biological processes of organisms intertwine with their epistemological history. (shrink)

This paper presents a narrative history of technologies in cancer research circa 1920-1978 and a theoretical perspective on the complex, intertwined relationships between scientific problems, material practices and technologies, concepts and theories, and other historical circumstances. The history presents several active lines of research and technology development in the genetics of cancer in the United States which were constitutive of protooncogene work in its current form. I write this history from the perspective of technology development. Scientists participating in cancer research (...) created tools with which to study their problems of interest, but the development of the tools also influenced the questions asked and answered in the form of concepts and theories developed. These tools included genetic ideas of the 1920s, inbred mouse colonies, chemicals and antibiotics developed during World War Two, tissue cultures and their technical procedures, and viruses. I examine these tools as standardized experimental systems that standardized materials as well as practices in laboratories. Inbred animals, tissue culture materials and methods, and tumor viruses as experimental systems gave materiality to 'genes' and 'cancer'. They are technical-natural objects that stand-in for nature in the laboratory. (shrink)

This study explores the history of nanotechnology from the perspective of protein engineering, which differs from the history of nanotechnology that has arisen from mechanical and materials engineering; it also demonstrates points of convergence between the two. Focusing on directed evolution—an experimental system of molecular biomimetics that mimics nature as an inspiration for material design—this study follows the emergence of an evolutionary experimental system from the 1960s to the present, by detailing the material culture, practices, and (...) techniques involved. Directed evolution, as an aspect of nanobiotechnology, is also distinct from the dominant biotechnologies of the 20th century. The experimental systems of directed evolution produce new ways of thinking about molecular diversity that could affect concepts concerning both biology and life. (shrink)

The emergence of human communication systems is typically investigated via 2 approaches with complementary strengths and weaknesses: naturalistic studies and computer simulations. This study was conducted with a method that combines these approaches. Pairs of participants played video games requiring communication. Members of a pair were physically separated but exchanged graphic signals through a medium that prevented the use of standard symbols (e.g., letters). Communication systems emerged and developed rapidly during the games, integrating the use of explicit signs with information (...) implicitly available to players and silent behavior-coordinating procedures. The systems that emerged suggest 3 conclusions: (a) signs originate from different mappings; (b) sign systems develop parsimoniously; (c) sign forms are perceptually distinct, easy to produce, and tolerant to variations. (shrink)

Experimental Semiotics (ES) is the study of novel forms of communication that communicators develop in laboratory tasks whose designs prevent them from using language. Thus, ES relates to pragmatics in a “pure,” radical sense, capturing the process of creating the relation between signs and their interpreters as biological, psychological, and social agents. Since such a creation of meaning-making from scratch is of central importance to language evolution research, ES has become the most prolific experimental approach in this field (...) of research. In our paper, we report the results of a study on the scope of recent ES and evaluate the ways in which it is relevant to the study of language origins. We coded for multiple levels across 13 dimensions related to the properties of the emergent communication systems or properties of the study designs, such as type of goal (coordination versus referential), modality of communication, absence or presence of turn-taking, or the presence of vertical vs. horizontal transmission. We discuss our findings and our classification, focusing on the advantages and limitations of those trends in ES, and in particular their ecological validity in the context of bootstrapping communication and the evolution of language. (shrink)

According to the so-called Quantum Darwinist approach, the emergence of "classical islands" from a quantum background is assumed to obey a (selection) principle of maximal information. We illustrate this idea by considering the coupling of two oscillators (modes). As our approach suggests that the classical limit could have emerged throughout a long and progressive Evolution mechanism, it is likely that primitive living organisms behave in a "more quantum", "less classical" way than more evolved ones. This brings us to seriously consider (...) the possibility to measure departures from classicality exhibited by biological systems. We describe an experimental proposal the aimed at revealing the presence of entanglement in the biophotonic radiation emitted by biological sources. (shrink)

According to the so-called Quantum Darwinist approach, the emergence of “classical islands” from a quantum background is assumed to obey a principle of maximal information. We illustrate this idea by considering the coupling of two oscillators. As our approach suggests that the classical limit could have emerged throughout a long and progressive Evolution mechanism, it is likely that primitive living organisms behave in a “more quantum”, “less classical” way than more evolved ones. This brings us to seriously consider the possibility (...) to measure departures from classicality exhibited by biological systems. We describe an experimental proposal the aimed at revealing the presence of entanglement in the biophotonic radiation emitted by biological sources. (shrink)

Johann Gottlob Krüger’s Experimental psychology is commonly considered as one of the first empirical anthropologies in the German-speaking space. On closer examination, however, the foundations of his psychology appear to be both Wolffian rationalism and an epistemological empiricism of Lockean origins. His methodical conception of experimentalism, thus, expands Wolffian empirical psychology. On this basis, Krüger also supplies a quite precarious defence of materialism, and a view of experiments on humans that conflicts radically with present standards.

This chapter contains section titled: The Diversity of Experimental Practices in Biology Model Organisms Experimental Systems and the “New Experimentalism” in Biology The Nature of Evidence Objectivity and Realism Acknowledgment References Further Reading.

The Hooks et al. review of microbiota-gut-brain literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: highlighting capabilities of advanced systems-biology “-omics” techniques for microbiome research and recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

Computational modeling plays an important role in prediction and optimization of real systems and processes. Models usually have some parameters which should be set up to the proper value. Therefore, parameter estimation is known as an important part of the modeling and system identification. It usually refers to the process of using sampled data to estimate the optimum values of parameters. The accuracy of model can be increased by adjusting its parameters to the optimum value which need a richer (...) dataset. One simple solution for having a richer dataset is increasing the amount of data, but that can be costly and time consuming. When using data from animals or people, it is especially important to have a proper plan. There are several available methods for parameter estimation in dynamical systems; however there are some basic differences in chaotic systems due to their sensitivity to initial condition. Accordingly, in this paper, a new cost function which is proper for chaotic systems is applied to the chaotic one-dimensional map. Then the efficiency of a newly introduced intelligent method experimental design in extracting proper data is investigated. The results show the success of the proposed method. (shrink)

THE MORAL SYSTEM OF SHAKESPEARE INTRODUCTION WHAT IS IMPLIED IN "THE MORAL SYSTEM OF SHAKESPEARE " The title of this work, The Moral System of Shakespeare,..

This paper is expected to introduce a novel memductor-based chaotic system. The local dynamical entities, such as the basic dynamical behavior, the divergence, the stability of equilibrium set, and the Lyapunov exponent, are all investigated analytically and numerically to reveal the dynamic characteristics of the new memductor-based chaotic system as the system parameters and the initial state of memristor change. Subsequently, an active control method is derived to study the synchronous stability of the novel memductor-based chaotic (...) class='Hi'>system through making the synchronization error system asymptotically stable at the origin. Further to these, a memductor-based chaotic circuit is designed, realized, and applied to construct a new memductor-based secure communication circuit by employing the basic electronic components and memristor. Furthermore, the design principle of the memductor-based chaotic circuit is thoroughly analyzed and the concept of “the memductor-based chaotic circuit defect quantification index” is proposed for the first time to verify whether the chaotic output is consistent with the mathematical model. A good qualitative agreement is shown between the simulations and the experimental validation results. (shrink)

Philosophy of Experimental Biology explores some central philosophical issues concerning scientific research in experimental biology, including genetics, biochemistry, molecular biology, developmental biology, neurobiology, and microbiology. It seeks to make sense of the explanatory strategies, concepts, ways of reasoning, approaches to discovery and problem solving, tools, models and experimental systems deployed by scientific life science researchers and also integrates developments in historical scholarship, in particular the New Experimentalism. It concludes that historical explanations of scientific change that are based (...) on local laboratory practice need to be supplemented with an account of the epistemic norms and standards that are operative in science. This book should be of interest to philosophers and historians of science as well as to scientists. (shrink)

The controversy of neuroanatomy on the principal structure of the nervous systems, which took place at the end of the nineteenth century, is described. Two groups of scientists are identified: one that favoured the idea of a discrete cellular organization of the nervous tissue, and one that favoured a syncytial organization. These two interpretations arose from different histological techniques that produced conflicting pictures of the organization of the nervous tissue. In an experimental reexamination of the techniques used at the (...) end of the nineteenth century, the present study concerns the impact of these different histological procedures on the controversy about the principle nature of the nervous tissue. This controversy could not be resolved by neuroanatomy itself until the 1950s when electron microscopy was introduced into neurobiology. Thus, in a critical period of the conceptual development of neurosciences, neuroanatomy failed to establish a proper base for an interpretation of the functional morphology of nervous tissues. (shrink)

Experimental design is one aspect of a scientific method. A well-designed, properly conducted experiment aims to control variables in order to isolate and manipulate causal effects and thereby maximize internal validity, support causal inferences, and guarantee reliable results. Traditionally employed in the natural sciences, experimental design has become an important part of research in the social and behavioral sciences. Experimental methods are also endorsed as the most reliable guides to policy effectiveness. Through a discussion of some of (...) the central concepts associated with experimental design, including controlled variation and randomization, this chapter will provide a summary of key ethical issues that tend to arise in experimental contexts. In addition, by exploring assumptions about the nature of causation and by analyzing features of causal relationships, systems, and inferences in social contexts, this chapter will summarize the ways in which experimental design can undermine the integrity of not only social and behavioral research but policies implemented on the basis of such research. (shrink)

The experimental philosophy of law is a recent movement that aims to inform traditional debates in jurisprudence by conducting empirical research. This paper introduces and provides a systematic overview of the main lines of research in this field. It also covers the most important debates in the literature regarding the implications of these findings for the philosophy and theory of law. It argues that three challenges arise when addressing (old) legal-philosophical questions in (new) experimental ways by drawing normative (...) implications from empirical data: such implications are value-driven, depend on explanations of empirical findings and vary across legal systems. (shrink)

My paper draws on examples from molecular biology, the details of which I have developed elsewhere (Rheinberger 1992, 1993, 1995, 1997). Here, I can give only a brief outline of my argument. Reduction of complexity is a prerequisite for experimental research. To make sense of the universe of living beings, the modern biologist is bound to divide his world into fragments in which parameters can be defined, quantities measured, qualities identified. Such is the nature of any "experimental (...) class='Hi'>system." Ontic complexity has to be reduced in order to make experimental research possible. The complexity of the research object, however, is epistemically retained in the rich context of an experimental landscape, where the eruption of "volcanic systems" can change the scenery dramatically as the result of particular, unprecedented findings. (shrink)