One notable area in analytic metaphysics that has seen a revival of Aristotelian and scho- lastic inspired metaphysics is the return to a more robust construal of the notion of essence, what some have labelled “real” or “serious” essentialism. However, it is only recently that this more robust notion of essence has been implemented into the debate on truthmaking, mainly by the work of E. J. Lowe. The first part of the paper sets out to explore the scholastic roots of (...) essential dependence as well as an account of truthmaking for accidental predications in terms of accidents. Along the way, the author examines the dialectical role the possibility of separated accidents in the Eucharist play with respect to developing a scholastic account of truthmaking as essential dependence. In conclusion the author utilises Aquinas’s hylomorphic ontology to suggest a new way forward for an essentialist account of truthmaking. (shrink)

It has recently been suggested that realism about some subject matter is best construed as the claim that the facts pertaining to this subject matter are essentially independent from the mind, in a sense to be explained, and not as the admittedly weaker claim that they are modally independent from the mind. In this paper, I argue that this proposal is liable to trivialize the realist's position and is biased against his irrealist opponent.

The author expounds critically Roderick Chisholm's theory of modal mereology and undertakes to redeploy and reconcile this with the Lesniewski-Tarski theory of part-whole, modally augmented. An argument is presented for the principle that what belongs to an aggregate as a part belongs essentially to it. This principle is argued not to imply that every part of an ordinary substance is essentially part of it (such substances not being aggregates), and to give no particular support to Roderick Chisholm's postulation of entia (...) successiva in substitution for ships, trees, and houses as ordinary conceived. Entia successiva are not good candidates for identification with these. (shrink)

I defend a novel view of how social kinds (e.g., money, women, permanent residents) depend on our mental states. In particular, I argue that social kinds depend on our mental states in the following sense: it is essential to them that they exist (partially) because certain mental states exist. This analysis is meant to capture the very general way in which all social kinds depend on our mental states. However, my view is that particular social kinds also depend on (...) our mental states in more specific ways—some of them causal, others metaphysical. I defend a minimal but metaphysically important notion of essence—one that takes as primary that the essential properties of a kind constitute its identity—and argue that this minimal notion of essence is all that is needed to vindicate my claim that social kinds are essentially mind-dependent. (shrink)

Ontological dependence is a relation—or, more accurately, a family of relations—between entities or beings. For there are various ways in which one being may be said to depend upon one or more other beings, in a sense of “depend” that is distinctly metaphysical in character and that may be contrasted, thus, with various causal senses of this word. More specifically, a being may be said to depend, in such a sense, upon one or more other beings for its existence (...) or for its identity. Some varieties of ontological dependence may be analyzed in modal terms—that is, in terms of distinctly metaphysical notions of possibility and necessity—while others seem to demand an analysis in terms of the notion of essence. The latter varieties of ontological dependence may accordingly be called species of essential dependence. Notions of ontological dependence are frequently called upon by metaphysicians in their proposed analyses of other metaphysically important notions, such as the notion of substance. (shrink)

_"The Essential Plotinus_ is a lifesaver. For many years my students in Greek and Roman Religion have depended on it to understand the transition from antiquity to the Middle Ages. The translation is crisp and clear, and the excerpts are just right for an introduction to Plotionus's many-layered view of the world and humankind’s place in it." --F. E. Romer, University of Arizona.

ABSTRACT A Third-Person-Based or Third-Personal Judgment-Dependent account of mental content implies that, as an a priori matter, facts about a subject’s mental content are precisely captured by the judgments of a second-person or an interpreter. Alex Byrne, Bill Child, and others have discussed attributing such a view to Donald Davidson. This account significantly departs from a First-Person-Based or First-Personal Judgment-Dependent account, such as Crispin Wright’s, according to which, as an a priori matter, facts about intentional content are constituted by the (...) judgments of the subject herself, formed under certain optimal or cognitively ideal conditions. I will argue for two claims: (1) Attributing a Third-Personal Judgment-Dependent account to Davidson is unjustified; Davidson’s view is much closer to a non-reductionist First-Personal Judgment-Dependent account. (2) Third-Personal accounts rest on a misconstrual of the role of an interpreter in the First-Personal accounts; the notion of an interpreter still plays an essential role in the latter ones. (shrink)

The essentially comparative conception of value entails that the value of a state of affairs does not depend solely upon features intrinsic to the state of affairs, but also upon extrinsic features, such as the set of feasible alternatives. It has been argued that this conception of value gives us reason to abandon the transitivity of the better than relation. This paper shows that the support for intransitivity derived from this conception of value is very limited. On its most plausible (...) interpretations, it merely provides a necessary, but not sufficient, condition for intransitivity. It is further argued that the essentially comparative conception of value appears to support a disjunctive conclusion: there is incommensurability of value or betterness is not transitive. Of these two alternatives, incommensurability is preferable, because it is far less threatening to our other axiological commitments. (shrink)

Linguistic expressions frequently make reference to the situation in which they are uttered. In fact, there are expressions whose whole point of use is to relate to their context of utterance. It is such expressions that this article is primarily about. However, rather than presenting the richness of pertinent phenomena (cf. Anderson & Keenan 1985), it concentrates on the theoretical tools provided by the (standard) two-dimensional analysis of context dependence, essentially originating with Kaplan (1989)--with a little help from Stalnaker (...) (1978) and Lewis (1979a, 1980), and various predecessors including Kamp (1971) and Vlach (1973). The current article overlaps in content with the account in Zimmermann (1991), which is however much broader (and at times deeper).. (shrink)

The relation of ontological dependence or grounding, expressed by the terminology of separation and priority in substance, plays a central role in Aristotle’s Categories, Metaphysics, De Anima and elsewhere. The article discusses three current interpretations of this terminology. These are drawn along the lines of, respectively, modal-existential ontological dependence, essential ontological dependence, and grounding or metaphysical explanation. I provide an opinionated introduction to the topic, raising the main interpretative questions, laying out a few of the exegetical (...) and philosophical options that influence one’s reading, and locating questions of Aristotle scholarship within the discussion of ontological dependence and grounding in contemporary metaphysics. (shrink)

Is economics always self-corrective? Do erroneous theorems permanently disappear from the market of economic ideas? _Intellectual Path Dependence in Economics _argues that errors in economics are not always corrected. Although economists are often critical and open-minded, unfit explanations are nonetheless able to reproduce themselves. The problem is that theorems sometimes survive the intellectual challenges in the market of economic ideas even when they are falsified or invalidated by criticism and an abundance of counter-evidence. A key question which often gets (...) little or no attention is: why do economists not reject theories when they have been refuted by evidence and falsified by philosophical reasoning? This book explores the answer to this question by examining the phenomenon of intellectual path dependence in the history of economic thought. It argues that the key reason why economists do not reject refuted theories is the epistemic costs of starting to use new theories. Epistemic costs are primarily the costs of scarcity of the most valued element in academic production: time. Epistemic scarcity overwhelmingly dominates the evolution of scientific research in such a way that when researchers start off a new research project, they allocate time between replicable and un-replicable research. This book is essential reading for anyone interested in the methodology, philosophy and history of economics. (shrink)

A significant reorientation is currently under way in analytic metaphysics, away from an almost exclusive focus on questions of existence and towards a greater concentration on questions concerning the dependence of one type of phenomenon on another. Surprisingly, despite the central role dependence has played in philosophy since its inception, interest in a systematic study of this concept has only recently surged among contemporary metaphysicians. In this paper, I focus on a promising account of ontological dependence in (...) terms of a non-modal and sufficiently constrained conception of essence developed by Kit Fine. I argue that even this essentialist account is, as it stands, not fine-grained enough to recognize different varieties of dependence which ought to be distinguished even within the realm of ontology. In some cases, an entity may be ontologically dependent on its essential constituents out of which it is constructed; but in other cases, an entity may be ontologically dependent on another for a different reason. A framework which glosses over these differences does not offer a proper diagnosis of why one entity ontologically depends on another. (shrink)

Prenatal screening can lead to the detection and diagnosis of significantly life-limiting conditions affecting the unborn child. Recognizing the difficulties facing parents who decide to continue the pregnancy, some have proposed perinatal hospice as a new modality of care. Although the medical literature has begun to devote significant attention to these practices, systematic philosophical reflection on perinatal hospice has been relatively limited. Drawing on Alasdair MacIntyre’s account of the virtues of acknowledged dependence, I contend that perinatal hospice manifests and (...) facilitates virtues essential to living well with human dependency and vulnerability. For this reason, perinatal hospice deserves broad support within society. (shrink)

In this paper I offer a defence of a Russellian analysis of the referential uses of incomplete (mis)descriptions, in a contextual setting. With regard to the debate between a unificationist and an ambiguity approach to the formal treatment of definite descriptions (introduction), I will support the former against the latter. In 1. I explain what I mean by "essentially" incomplete descriptions: incomplete descriptions are context dependent descriptions. In 2. I examine one of the best versions of the unificationist “explicit” approach (...) given by Buchanan and Ostertag. I then show that this proposal seems unable to treat the normal uses of misdescriptions. I then accept the challenge of treating misdescriptions as a key to solving the problem of context dependent descriptions. In 3. I briefly discuss Michael Devitt’s and Joseph Almog’s treatments of referential descriptions, showing that they find it difficult to explain misdescriptions. In 4. I suggest an alternative approach to DD as contextuals, under a normative epistemic stance. Definite descriptions express (i) what a speaker should have in mind in using certain words in a certain context and (ii) what a normal speaker is justified in saying in a context, given a common basic knowledge of the lexicon. In 5. I define a procedure running on contextual parameters (partiality, perspective and approximation) as a means of representing the role of pragmatics as a filter for semantic interpretation. In 6. I defend my procedural approach against possible objections concerning the problem of the boundaries between semantics and pragmatics, relying on the distinction between semantics and theory of meaning. (shrink)

The notion of fundamentality is supposed to play an important role in philosophical inquiry and scientific theorising. Yet there is no consensus on how to formulate it in precise terms. According to a promising view, fundamentality is a form of ontological independence. This view has the merit of capturing a natural connection between fundamentality and ontological dependence. However, it has been recently argued that it is possible that there are fundamental and yet ontologically dependent entities; therefore, we should not (...) characterise the fundamental in terms of ontological independence. My aim is to show that such a possibility does not threaten a conception of fundamentality as a form of ontological independence. I illustrate this claim by providing a definition of equifundamentality and showing that fundamental and yet ontologically dependent entities can be treated as equifundamental. (shrink)

In this paper, I first of all define various kinds of ontological dependence, motivating these definitions by appeal to examples. My contention is that whenever we need, in metaphysics, to appeal to some notion of existential or identity-dependence, one or other of these definitions will serve our needs adequately, which one depending on the case in hand. Then I respond to some objections to one of these proposed definitions in particular, namely, my definition of (what I call) (...) class='Hi'>essential identity-dependence. Finally, I show how a similar approach can be applied in the theory of truthmaking, by offering an account of the truthmaking relation which defines it in terms of a type of essential dependence. I also say why I think that this approach is preferable to one which treats the truthmaking relation as primitive. More generally, my view is that accounts of dependence or ‘grounding’ which treat these notions as primitive are less satisfactory than my own position, which is that in all cases a suitable definition is forthcoming if we look hard enough. (shrink)

Temkin's Essentially Comparative View of moral ideals says that goodness is comparison set dependent: the goodness of an outcome is relativized to a set of outcomes. This view does not entail that betterness is intransitive; indeed, it provides the resources for maintaining transitivity. However, it does entail that the structure of goodness is more complex than is standardly supposed. It thereby demands a modification of the standard connection between goodness and decision. I set out this challenge, canvas some options, and (...) show that Temkin vacillates between two of them. (shrink)

The present paper discusses two interesting phenomena concerning phi-features on plural pronouns: plural pronouns that denote atomic individuals, and plural pronouns with more than one binder. A novel account of these two phenomena is proposed, according to which all occurrences of phi-features are both semantically and morphologically relevant. For such a ‘uniformly semantic account’ of phi-features, dependent plural pronouns constitute a theoretical challenge, while partial binding is more or less straightforwardly accounted for. In order to make sense of the semantic (...) effects of the phi-features on dependent plural pronouns, the following idea is pursued: the phi-features on a dependent plural pronoun reflect the range of values that the pronoun takes, rather than the particular value it denotes at a time. This idea is implemented in a compositional semantics by making use of choice functions. An appealing feature of the present account is that, unlike its predecessors, it accounts for dependent plural pronouns without c-commanding antecedents in essentially the same way as for those with c-commanding antecedents. It is also shown how this account of dependent plural pronouns can straightforwardly be augmented with set indices to account for partial binding. (shrink)

In his analysis of “the essential tension between tradition and innovation” Thomas S. Kuhn focused on the apparent paradox that, on the one hand, normal research is a highly convergent activity based upon a settled consensus, but, on the other hand, the ultimate effect of this tradition-bound work has invariably been to change the tradition. Kuhn argued that, on the one hand, without the possibility of divergent thought, fundamental innovation would be precluded. On the other hand, without a strong (...) emphasis on convergent thought, science would become a mess created by continuous theory changes and scientific progress would again be precluded. On Kuhn’s view, both convergent and divergent thought are therefore equally necessary for the progress of science. In this paper, I shall argue that a similar fundamental tension exists between the demands we see for novel insights of an interdisciplinary nature and the need for established intellectual doctrines founded in the classical disciplines. First, I shall revisit Kuhn’s analysis of the essential tension between tradition and innovation. Next, I shall argue that the tension inherent in interdisciplinary research between, on the one hand, intellectual independence and critical scrutiny and, on the other hand, epistemic dependence and trust is a complement to Kuhn’s essential tension within mono-disciplinary science between convergent and divergent thought. (shrink)

Arising and emptiness are the two essential Buddhist concepts, which when understood, lead to the highest school of Buddhist philosophy.

The spirited part, thumos, plays a complex and often disputed role in Plato's account of the soul. The doctrine of the soul as specifically tri‐partitioned seems to depend on a substantial conception of thumos as fundamental and non‐reducible. Building on John Cooper's contribution in the discussion of the topic, this article aims to show that the role of thumos is characterised by an indispensable, deep‐rooted urge for dignified self‐preservation. The view is supported by Plato's own examples, and discussed with regards (...) to Myles Burnyeat's account of thumos as an essentially social phenomenon. The main claim is that in order to preserve the Platonist idea of thumos as fundamental one should discard Burnyeat's characterisation of thumos as unequivocally social, and instead advocate a view of thumos as concerned with a particular form of self‐preservation, which Cooper's account suggests, but does not fully elaborate. (shrink)

Rawls famously argued against meritocratic conceptions of distributive justice on the grounds that the accumulation of merit is an unavoidably lucky process, both because of differences in early environment, and innate talents. Thomas Mulligan (2018a) has recently provided a novel defense of meritocracy against the “luck objection”, arguing that both sources of luck would be mostly eliminated in a meritocracy. While a system of fair equality of opportunity ensures that differences in social class or early environment do not lead to (...) differences in the accumulation of merit, Kripke’s essentiality of origin thesis means that our genetic endowments, and thus our innate talents, could not have been any other way. But if we could not fail to have our innate talents, Mulligan argues, then it is not a matter of luck that we have them, and so the merits we accumulate on their basis are not so luck-dependent. This paper argues that Mulligan’s appeal to the essentiality of origin thesis fails to rescue meritocratic conceptions of distributive justice from the luck objection for two reasons. First, even granting essentiality of origin and fair equality of opportunity, the contingencies of the market and the social environment mean that having some innate talents is far luckier than having others. And second, the appeal to essentiality of origin misses the underlying motivation for the luck objection, and ignores the intimate connection between desert and responsibility. (shrink)

COVID-19 knows no boundaries, but political responses to it certainly do. Much has been made about how the pandemic has revealed the Hobbesian nature of political power, but this picture of politics occludes from vision the interdependent nature of our current international order. In particular, it overlooks the fact that much of the goods, services, capital, and people that societies rely on in order to function are sourced from outside the domestic state. And, conversely, it overlooks the extent to which (...) the policy responses taken in one state have considerable effects on the options available, and the outcomes suffered, in other jurisdictions. This paper seeks to correct this oversight, by highlighting two duties that states bear towards one another in the context of this crisis, by virtue of their participation in international trade relationships. Trade grounds duties of justice between trade partners by making them dependent upon one another in order to realize their respective duties of domestic justice. This dependence, in turn, grounds a duty of stability, and a duty of accountability. Having explained and argued for these two duties, the paper discusses the implications of taking these two duties seriously in the context of states’ policy responses to the COVID-19 crisis. (shrink)

The usefulness of contextually guided processors is investigated a little further. A more general use for binding V1 cell responses than the one in Phillips & Singer's target article is proposed, which takes into account that strong responses of these cells can mean more than the presence of lines and edges. The possibility of different grouping depending on the activities of neighboring cells is essential to the approach.

Recent theories of critical thinking have stressed the importance of taking into consideration in critical enquiry the perspectives, or presuppositions, of both the speaker whose statements are under scrutiny and the critic himself. The purpose of the paper is to explore this idea from an epistemological (rather than a pedagogical or psychological) point of view. The problem is first placed within the general context of critical thinking theory. Three types of perspective-dependence are then described, and the consequences of each (...) for the possibility of critical discussion discussed. It is concluded that although it is essential in critical discussion to take the other’s perspective into consideration, perspective-dependence does not exclude the possibility of criticism. (shrink)

A member of Jehovah’s Witnesses agreed to receive blood when alone, but rejected it once the elders were present. She insisted that the elders should stay, they were allowed to do so, and she bled to death. Was it all right to allow her to have the elders present when she made her final decision? Was it all right to allow her to bleed to death? It was, according to an anti-paternalist principle, which I have earlier defended on purely utilitarian (...) grounds. The thrust of the present argument is that the principle stands even in cases with context-sensitive preferences. However, my utilitarian argument to this effect must now rely on something other than J.S. Mill’s standard presumption that in most cases the individual makes the right choices for herself. A reference to the general trust in the system of healthcare is essential to the utilitarian defense of the anti-paternalistic principle. (shrink)

The aim of this study is to look at the the syntactic calculus of Bar-Hillel and Lambek, including semantic interpretation, from the point of view of constructive type theory. The syntactic calculus is given a formalization that makes it possible to implement it in a type-theoretical proof editor. Such an implementation combines formal syntax and formal semantics, and makes the type-theoretical tools of automatic and interactive reasoning available in grammar.In the formalization, the use of the dependent types of constructive type (...) theory is essential. Dependent types are already needed in the semantics of ordinary Lambek calculus. But they also suggest some natural extensions of the calculus, which are applied to the treatment of morphosyntactic dependencies and to an analysis of selectional restrictions. Finally, directed dependent function types are introduced, corresponding to the types of constructive type theory. (shrink)

The present argument assumes that teaching through modeling attempts to teach the intellectual virtues not primarily as an independent goal of education as, for example, a way to build good character, but for its value to inquiry. I argue that intellectual vices (such as being gullible, dogmatic, pigheaded, or prejudiced)—while harmful to inquiry in certain ways—are essential to its well functioning. Furthermore, to the extent that teaching models critical inquiry, there are educational lessons for which some students ought to (...) take a dogmatic or narrow minded commitment to certain hypotheses or positions; and then, insofar as this modeling works, it will promote these intellectual vices. In Part I of what follows, I develop my argument; in Part II, I respond to the objection that diversity of ideas and attitudes need not—and ought not—call upon the promotion of intellectual vices. (shrink)

There are two ways of interpreting the argument for the existence of essential indexicals; one of them is too strong, the other one is compatible with reductionist positions.

Reductive physicalism is a minority view in contemporary philosophy as well as in science, and therefore arguments for endorsing it often amount to arguments against the alternative views, in particular so-called non-reductive physicalism. In this paper we put forward a new argument for reductive physicalism, according to which it is the best account of the empirical data that we have. In particular, we show that: (a) a reductive physicalist theory of the mind forms an essential part of the very (...) argument for the existence of an external world: if one rejects psychophysical identity physicalism, one’s case for believing in the existence of an external world is substantially weakened; and (b) the success of a physical account of the mind is the most important criterion for the success of (future) physics; and (c) reductive physicalism is the only approach in which relying on science in order to account for the external world makes sense; and finally, (d) within reductive physicalism, one can provide a new criterion for theory preference in science, and a new argument for scientific realism. In our physicalist view the experience forms the initial data, which is then reduced to fundamental physics. (shrink)

This book provides a detailed yet accessible guide to basic terminology and concepts of Indian Buddhism in all its forms. The eight chapters elucidate the principle branches of Buddhism, the Three Treasures, the elements of existence, the Seals of the Law, dependent origination, the Four Noble Truths, religious practice, and the defilements.

Jeffrey King argues that nothing has truth conditions except by being taken to be true or false by rational agents. But – for good reason – King claims that propositions possess truth conditions essentially and intrinsically. I will argue that King cannot have both: if the truth conditions of a proposition depend on the reactions of rational agents, then the possession of truth conditions can't follow from the intrinsic nature or existence of the proposition. This leaves two options. Either, nothing (...) can do the job that motivates positing propositions. Or, there is no need to explain what bestows a truth condition on a proposition. (shrink)

According to Armstrong (amongst others) ‘any truth, should depend for its truth for something “outside” it’ where this one-way dependency is explained in terms of the asymmetric relationship that obtains between a truth and its truth-maker. But there’s no need to appeal to truth-makers to make sense of this dependency. The truth of a proposition is essentially determined by the interlocking semantic mechanism of reference and satisfaction which already ensures that the truth-value of a proposition depends on how things stand (...) outside it. By contrast, how things stand outside of a proposition is determined by other worldly mechanisms that have nothing to do with truth. (shrink)

Proponents of enactivism should be interested in exploring what notion of action best captures the type of action-perception link that the view proposes, such that it covers all the aspects in which our doings constitute and are constituted by our perceiving. This article proposes and defends the thesis that the notion of sensorimotor dependencies is insufficient to account for the reality of human perception, and that the central enactive notion should be that of perceptual practices. Sensorimotor enactivism is insufficient because (...) it has no traction on socially dependent perceptions, which are essential to the role and significance of perception in our lives. Since the social dimension is a central desideratum in a theory of human perception, enactivism needs a notion that accounts for such an aspect. This article sketches the main features of the Wittgenstein-inspired notion of perceptual practices as the central notion to understand perception. Perception, I claim, is properly understood as woven into a type of social practices that includes food, dance, dress, music, etc. More specifically, perceptual practices are the enactment of culturally structured, normatively rich techniques of commerce of meaningful multi- and inter-modal perceptible material. I argue that perceptual practices explain three central features of socially dependent perception: attentional focus, aspects’ saliency, and modal-specific harmony-like relations. (shrink)

The article explores the idea that according to Spinoza finite thought and substantial thought represent reality in different ways. It challenges “acosmic” readings of Spinoza's metaphysics, put forth by readers like Hegel, according to which only an infinite, undifferentiated substance genuinely exists, and all representations of finite things are illusory. Such representations essentially involve negation with respect to a more general kind. The article shows that several common responses to the charge of acosmism fail. It then argues that we must (...) distinguish the well-founded ideality of representations of finite things from mere illusoriness, insofar as for Spinoza we can have true knowledge of what is known only abstractly. Finite things can be seen as well-founded beings of reason. The article also proposes that within Spinoza's framework it is possible to represent a finite thing without drawing on representations of mind-dependent entities. (shrink)

The paper proposes and defends the following characterization of response dependent property: a property is response-dependent iff there is a response-dependence biconditional for a concept signifying it which holds in virtue of the nature of the property. Finding out whether a property is such is to a large extent a posteriori matter. Finally, colors are response dependent: they are essentially tied to issuing the relevant experiences, so that having those experiences does give access to their, dispositional, nature. Finally, some (...) important contrary views are critically discussed in the paper. (shrink)

My dissertation explores the nature of artifacts – things like chairs, tables, and pinball machines – and addresses the question of whether there is anything essential to being an artifact and a member of a particular artifact kind. My dissertation offers new arguments against both the anti-essentialist and current essentialist proposals. Roughly put, the view is that artifacts are successful products of an intention to make something with certain features constitutive of an artifact kind. The constitutive features are often (...) functional features, but may include structural, material, aesthetic, and other features. I further explore the ways in which artifacts are mind-dependent and I argue that this dependence is disjunctive. Not only do they depend on the intentions of their makers, but they also can depend on social groups or public norms and thus artifacts have an importantly social dimension and I argue that this disjunctive account applies not to artifact kinds but to individual artifacts depending on their context of creation. (shrink)

This paper asks when a natural disease kind is truly 'reactive' and when it is merely associated with a corresponding social kind. I begin with a permissive account of real kinds and their structure, distinguishing natural kinds, indifferent kinds and reactive kinds as varieties of real kind characterised by super-explanatory properties. I then situate disease kinds within this framework, arguing that many disease kinds prima facie are both natural and reactive. I proceed to distinguish ‘simple dependence’, ‘secondary dependence’ (...) and ‘essential dependence’ between a natural kind and its classification, and argue that a natural kind is only really reactive, in an important sense, under conditions of essential dependence. On this basis, I offer a principled hypothesis for why psychiatric kinds tend to be more metaphysically unstable than paradigm somatic disease kinds. (shrink)

This article aims to test the hypothesis that metaphysical grounding is an instance of essentially ordered (or per se ) causation, a species of causation identified by medieval philosophers and theologians like Aquinas and Scotus, but largely forgotten from then on. The article reviews some of the consensus of grounding theorists on the nature of metaphysical grounding (or ontological dependence) compared to some of the crucial characteristics of essentially ordered causal series as articulated by scholastic and neo-Aristotelian philosophers then (...) and now. The authors emphasize their similarities, which they hold is enough to render strongly plausible the thesis that grounding is essentially ordered causation (G = EOC). Moreover, they highlight the potential benefits of this identification both for theories of grounding and EOC, especially as it concerns matters of fundamentality. Finally, they consider the limits of their hypothesis. (shrink)

Cyclin‐dependent kinase 5 (Cdk5) is recognized as an essential molecule in the brain, where it regulates several neuronal activities, including cytoskeletal remodeling and synaptic transmission. While activity of Cdk5 has primarily been associated with neurons, there are now substantial data indicating that the kinase's activity and function are more general. An increasing body of evidence has established Cdk5 kinase activity, the presence of the Cdk5 activators, p35 and p39, and Cdk5 functions in non‐neuronal cells, including myocytes, pancreatic β‐cells, monocytic (...) and neutrophilic leucocytes, glial cells and germ cells. In this review, we present the diverse roles of Cdk5 in several extraneuronal paradigms. The unique properties of each of the different cell types appear to involve distinct means of Cdk5 regulation and function. The potential mechanisms through which Cdk5 regulates extraneuronal cell activities such as exocytosis, gene transcription, wound healing and senescence are discussed. BioEssays 28: 1023–1034, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

The earliest recorded philosophical use of the term "phusis" occurs in the fragments of Heraclitus (most notably at B1 and B123). Phusis, in the non-philosophical writings relevant to Heraclitus’s time (e.g. from Homer to Aeschylus and Pindar), was generally used to characterize the external physical appearance of something. Heraclitus, on the other hand, seems to have used the term in the completely opposite manner: an object’s phusis is hidden (kruptesthai) and greater (kreissōn) than the external appearance (B123 and B54). Despite (...) this difference, Heraclitus’s use has an affinity with the common use in his time: phusis is used to characterize things. In B1, for example, Heraclitus makes it clear that he is interested in explaining the nature of each thing as opposed to some cosmic principle of Nature. By examining various fragments, I make the case that the phusis of a thing, for Heraclitus, can be defined as the set of opposites necessarily inherent in an object upon which all objects of that kind depend for their existence. The interesting result is that Heraclitus’s novel use of phusis happens to be the foundation for one of the ways in which opposites form a unity. This particular thesis states that there are essential properties inherent in objects which are pairs of opposites sufficient to determine the unity of the object in question. If this is right, then we can read some fragments which contain descriptions of worldly objects (e.g. bows, lyres, rivers, barley drinks etc.) in a new light. These descriptions of worldly objects might not be meant to stand as metaphoric symbols for cosmic principles, as is often thought; rather, they can be read as instances of Heraclitus attempting to do a metaphysics of objects. (shrink)

All professional ethics are dependent on the epistemology of the profession. The possibility of following a code of ethics, whether the official one or an alternative code, is dependent on being able to obtain knowledge and understand the world. Professional knowledge has to be based on inferences from limited information. Statistics provides the optimal methods for making such inferences, and thus ethical professional conduct requires individual or collective understanding of some statistical thcory and practice. This is demonstrated using the medical (...) profession as an example. Statistical methods are essential in all areas of medicine, in routine medical practice, in screening for disease and in research. Evidence from medical journals, textbooks and research bodies shows that the statistical basis for ethical conduct is lacking. However, there are attempts to improve the situation. (shrink)

This paper has two goals. The first goal is to show that the structuralists’ claims about dependence are more significant to their view than is generally recognized. I argue that these dependence claims play an essential role in the most interesting and plausible characterization of this brand of structuralism. The second goal is to defend a compromise view concerning the dependence relations that obtain between mathematical objects. Two extreme views have tended to dominate the debate, namely (...) the view that all mathematical objects depend on the structures to which they belong and the view that none do. I present counterexamples to each of these extreme views. I defend instead a compromise view according to which the structuralists are right about many kinds of mathematical objects (roughly, the algebraic ones), whereas the anti-structuralists are right about others (in particular, the sets). I end with some remarks about how to understand the crucial notion of dependence, which despite being at the heart of the debate is rarely examined in any detail. (shrink)

This paper presents a new take on how argument dependencies in natural language are established and constrained. The paper starts with a rather standard view that (quantificational) argument dependencies are operator-variable dependencies. The interesting twist the paper offers is to eliminate the need for syntax that serves to enforce what the operator-variable dependencies are. Instead the role of ensuring grammatical and generally unambiguous forms is taken up by semantics imposing what are dependency requirements for any interpretation to go through at (...) evaluation time. With this viewpoint there emerges an essential need for localities as the hiding of (embedded) expression material, together with a (limited) form of garbage collection to release grammatical resources used in the current locality for reuse in subsequent localities. (shrink)

By reviewing most of the neurobiology of consciousness, this article highlights some major reasons why a successful emulation of the dynamics of human consciousness by artificial intelligence is unlikely. The analysis provided leads to conclude that human consciousness is epigenetically determined and experience and context-dependent at the individual level. It is subject to changes in time that are essentially unpredictable. If cracking the code to human consciousness were possible, the result would most likely have to consist of a temporal pattern (...) code simulating long-distance signal reverberation and de-correlation of all spatial signal contents from temporal signals. In the light of the massive evidence for complex interactions between implicit (non-conscious) and explicit (conscious) contents of representation, the code would have to be capable of making implicit (non-conscious) processes explicit. It would have to be capable of a progressively less and less arbitrary selection of temporal activity patterns in a continuously developing neural network structure identical to that of the human brain, from the synaptic level to that of higher cognitive functions. The code’s activation thresholds would depend on specific temporal signal coincidence probabilities, vary considerably with time and across individual experience data, and would therefore require dynamically adaptive computations capable of emulating the properties of individual human experience. No known machine or neural network learning approach has such potential. (shrink)

Sanchez and Sanchez have selected, edited, translated, and introduced some of the most influential texts in Mexican philosophy, which constitute a unique and robust tradition that will challenge and complicate traditional conceptions of philosophy. The texts collected here are organized chronologically and represent a period of Mexican thought and culture that emerged from the Mexican Revolution of 1910 and which culminated in la filosofia de lo mexicano (the philosophy of Mexicanness). Though the selections reflect on a variety of philosophical questions, (...) collectively they represent a growing tendency to take seriously the question of Mexican national identity as a philosophical question--especially given the complexities of Mexico's indigenous and European ancestries, a history of colonialism, and a growing dependency on foreign money and culture. More than an attempt to describe the national character, however, the texts gathered here represent an optimistic period in Mexican philosophy that aimed to affirm Mexican culture and philosophy as a valuable, if not urgent, contribution to universal culture. (shrink)

SR proteins are essential for the splicing of messenger RNA precursors in vitro, where they also alter splice site selection in a concentration‐dependent manner. Although experiments involving overexpression or dominant mutations have confirmed that these proteins can influence RNA processing decisions in vivo, similar results with loss‐of‐function mutations have been lacking. Now, a system for genetic depletion of the chicken B cell line DT40 has revealed that the SR protein ASF/SF2 (alternative splicing factor/splicing factor 2) is essential for (...) viability in these cells(1). This study opens the way for a complete functional dissection of this protein, and other SR proteins, in vivo. (shrink)

No word in English is shorter than the word I.' And yet no word is more important in philosophy. When Descartes said I think therefore I am' he produced something that was both about himself and a universal formula. The word I' is called an indexical' because its meaning always depends on who says it. Other examples of indexicals are you,' here,' this' and now.' John Perry discusses how these kinds of words work, and why they express important philosophical thoughts. (...) He shows that indexicals pose a challenge to traditional assumptions about language and thought. Over the years a number of these papers, now included in this book, have sparked lively debates and have been influential in philosophy, linguistics and other areas of cognitive science. With seven new papers, including the previously unpublished What Are Indexicals?,' the present volume expands on an earlier version of this book published in the early nineties. Also included are the well-known papers Frege on Demonstratives,' Cognitive Significance and New Theories of Reference,' Evading the Slingshot,' The Prince and the Phone booth', Fodor on Psychological Explanations', and related papers on situation semantics, direct reference, and the structure of belief. This book also includes afterwords written by the author that discuss responses to his work by Gareth Evans, Robert Stalnaker, Barbara Partee, Howard Wettstein and others. (shrink)

Furthermore, moral facts do seem to bear an intimate relationship to our moral attitudes and capacities. It is perhaps inconceivable that, at the end of moral deliberation and inquiry, fully rational human beings invested with our moral concepts could be radically incorrect in their moral beliefs. Moral properties seem to be essentially knowable. We hope that the fundamental truths of physics are epistemically available to us, but our conception of the physical world certainly does not guarantee it. However implausible, it (...) is certainly conceivable that the cognitive capacities that are our evolutionary inheritance, adapted for survival in the terrestrial niche in which our ancestors found themselves, are not well suited for doing cosmology. Is a similar pessimism about our ability to know the moral facts even coherent? I don’t think so. No matter how difficult it is to arrive at correct moral judgments, barring ignorance of any relevant non-moral empirical facts, the moral facts are by their very nature within our reach. And it is difficult to see how this could be so unless moral properties are in some way dependent on us. (shrink)