Shared brain regions have been found for processing action and language, including the left inferior frontal gyrus, the premotor cortex, and the inferior parietal lobule. However, in the context of action and language generation that shares the same action semantics, it is unclear whether the activity patterns within the overlapping brain regions would be the same. The changes in effective connectivity affected by these activity patterns are also unclear. In this fMRI study, participants were asked to perform hand action and (...) verb generation tasks toward object pictures. We identified shared and specific brain regions for the two tasks in the left PMC, IFG, and IPL. The mean activation level and multi-voxel pattern analysis revealed that the activity patterns in the shared sub-regions were distinct for the two tasks. The dynamic causal modeling results demonstrated that the information flows for the two tasks were different across the shared sub-regions. These results provided the first neuroimaging evidence that the action and verb generation were task context driven in the shared regions, and the distinct patterns of neural information flow across the PMC-IFG-IPL neural network were affected by the polymodal processing in the shared regions. (shrink)

With their focus on human production and consumption activities, cities incur massive energy consumption and CO2 emissions. An intercity connection is a typical complex system in which the interaction between cities is crucial for developing low-carbon outputs within the urban agglomeration. This paper presents the construction of the CO2 emission network of an urban agglomeration in the Yangtze River middle reaches megalopolis, based on the gravity model. Combined with social network analysis, a multilevel analysis framework is proposed to deal with (...) the complexity, spatiality, and visualization of the CO2 emission network with reference to the network features, structural equivalence, and the rich-club phenomenon. The following results emerged: firstly, the spatial structure of the CO2 emissions was characterized by low robustness and compactness, indicating disunity among the studied cities. Secondly, there was found to be a strong correlation between regionalism and intercity connections, with geographically close cities playing a similar role in the network. Thirdly, the “rich-club” cities, including Wuhan, Changsha, Xiaogan, and Zhuzhou, dominated the connections, covering more than 87.1% of the network in the Yangtze River Middle Reaches Megalopolis. (shrink)

Today, cities account for the majority of global energy consumption and CO2 emissions. The interaction between cities is critical for regional low-carbon development. At this time, China has turned to the full opening of the carbon trading market as an important policy tool for achieving its ambitious emission reduction goals. This paper attempts to explore the spatial relationships among cities from the perspective of carbon trading. A “multiscenarios across different spatial scales” analysis framework applied to the allocation and trading of (...) CO2 emission quotas among cities in China is proposed. Based on this framework, the carbon trading networks of 182 cities in China are specifically simulated under four different scenarios, with a comparative analysis of the networks’ complexity made from different perspectives. The results of the study are as follows: firstly, significant spatial network correlations exist between the cities’ carbon trading under each scenario. Secondly, on a national scale, there are more inner connections in carbon trading networks, with stronger correlations and robustness, while the degree of connection of intercity carbon trading is higher overall on a regional scale. Thirdly, on a national scale, no obvious core nodes exist in the network, while core nodes do exist in the overall network and in each region under the regional scale. Fourthly, cities in the central region have the highest core position overall. Finally, based on the research results, practical guidance in using the framework for achieving carbon reduction, promoting economic growth, and balancing regional development, as well as the important inspiration for policy formulation, is further discussed. (shrink)

International education is impacted by multiple discourses, in particular the discourse of university as an educational institution responsible for producing and curating knowledge for the public good, pursuing truth and transforming student life, and the neoliberal marketing discourse which portrays the university as a business organization providing a service for international students as customers/consumers. Following a multimodal discourse analytic perspective, this study examines ‘Why Choose’ webpages of one British and two Australian universities to identify how the apparently conflicting higher education (...) and neoliberal marketing discourses are managed in the interdiscursive space using language, images and videos. The results reveal that ‘Why Choose’ webpages are hybrid texts where the discourse of higher education is upheld in relation to the neoliberal marketing discourse through multimodal strategies of accentuation, infusion and progression. The study argues for the necessity of undertaking a multimodal discourse approach to understand how various positions are negotiated interdiscursively in online media. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)