Cell line immortalisation is a growing component of African genomics research and biobanking. However, little is known about the factors influencing consent to cell line creation and immortalisation in African research settings. We contribute to addressing this gap by exploring three questions in a sample of Xhosa participants recruited for a South African psychiatric genomics study: First, what proportion of participants consented to cell line storage? Second, what were predictors of this consent? Third, what questions were raised by participants during (...) this consent process? 760 Xhose people with schizophrenia and 760 controls were matched to sex, age, level of education and recruitment region. We used descriptive statistics to determine the proportion of participants who consented to cell line creation and immortalization. Logistic regression methods were used to examine the predictors of consent. Reflections from study recruiters were elicited and discussed to identify key questions raised by participants about consent. Approximately 40% of participants consented to cell line storage. The recruiter who sought consent was a strong predictor of participant’s consent. Participants recruited from the South African Eastern Cape, and older participants, were more likely to consent; both these groups were more likely to hold traditional Xhosa values. Neither illness nor education were significant predictors of consent. Key questions raised by participants included two broad themes: clarification of what cell immortalisation means, and issues around individual and community benefit. These findings provide guidance on the proportion of participants likely to consent to cell line immortalisation in genomics research in Africa, and reinforce the important and influential role that study recruiters play during seeking of this consent. Our results reinforce the cultural and contextual factors underpinning consent choices, particularly around sharing and reciprocity. Finally, these results provide support for the growing literature challenging the stigmatizing perception that people with severe mental illness are overly vulnerable as a target group for heath research and specifically genomics studies. (shrink)

Ugandan and South African contemporary women’s narratives reflect on the rapid pace of change in the social lives of women in two countries that are contending with the aftermath of conflict and violence. This article will interrogate how contemporary women writers such as Goretti Kyomuhendo (Whispers from Vera), Zukiswa Wanner (The Madams and Behind Every Successful Man) and Cynthia Jele (Happiness is a Four-Letter Word) are embracing chick-lit as a form of writing, while simultaneously short-circuiting this genre to create (...) an experimental form that allows them to reflect on the realities of women and engage with the contradictions, complexities and ambiguities of contemporary feminine subjectivities. Although chick-lit as a genre has been dismissed as trivial and frivolous, ostensibly because it deals with women’s experiences, this article argues that this particular form of chick-lit is more political and attempts to disrupt the original chick-lit by offering a critique of society. It articulates how women see themselves and their relationships with their parents, spouses and, most importantly, female friends; reflects on the challenges that modern women face in the work environment; interrogates women’s realities concerning love, marriage and motherhood; explores concepts of sexual desire and intimacy; and negotiates the dilemmas of a patriarchal society, while also confronting issues of class and race. These contemporary women writers are adopting this genre because it allows them to reflect on realities that are complex and uncertain, to transform gender relations, to redefine the roles of women and to construct new feminine subjectivities. (shrink)