Once regarded as cellular ‘debris’ extracellular vesicles (EVs) emerge as one of the most intriguing entities in cancer pathogenesis. Intercellular trafficking of EVs challenges the notion of cancer cell autonomy, and highlights the multicellular nature of such fundamental processes as stem cell niche formation, tumour stroma generation, angiogenesis, inflammation or immunity. Recent studies reveal that intercellular exchange mediated by EVs runs deeper than expected, and includes molecules causative for cancer progression, such as oncogenes (epidermal growth factor receptor, Ras), and tumour (...) suppressors (PTEN). The uptake of oncogenic EVs (oncosomes) by various cells may profoundly change their biology, signalling patterns and gene expression, and in some cases cause their overt tumorigenic conversion. Moreover, EVs circulating in blood and present in body fluids provide an unprecedented access to the molecular circuitry driving cancer cells, and new technologies are being developed to exploit this property as a source of unique cancer biomarkers. (shrink)

Aurel Kolnai was born in Budapest, in 1900 and died in London, in 1973. He was, according to Karl Popper and the late Bernard Williams, one of the most original, provocative, and sensitive philosophers of the twentieth century. Kolnai's moral philosophy is best described in his own words as intrinsicalist, non-naturalist, non-reductionist", which took its original impetus from Scheler's value ethics, and was developed by using a natural phenomenologist method. The unique combination of linguistic analysis and phenomenology yields highly original (...) ideas on classical fields of moral theory, such as responsibility and free will, the meaning of right and wrong, the universalisability of ethical norms, the role of moral emotions, internalism vs externalism, to mention a few. The volume presents a selection of essays by Kolnai, including his main political theoretical work, "What is Politics About", available in English here for the first time. The second half of the book Kolnai's work is analyzed in a series of essays by eminent scholars. (shrink)

This interesting book is a compilation of the lectures and discussions held during a four-day event "Grand Challenges for Science in the 21st Century" organized by Para Limes at the Nanyang Technological University in Singapore. The elite group of speakers included Nobel laureate Sydney Brenner who called on all scientists to adopt a truth-seeking approach and not be afraid of challenging assumptions. The other panellists were Martin Rees, Astronomer Royal and past President of the Royal Society, the much-cited Terrence Sejnowski (...) from the renowned Salk Institute for Biological Studies, the well-known keynote speaker in economics and complexity sciences Brian Arthur, the former President of the European Research Council Helga Nowotny and the Director of the Parmenides Center for the Conceptual Foundations of Science Eors Szathmary. The lively sessions were moderated by the Danish writer Tor Norretranders. The panel tackled topics from evolution and the origin of the universe to modern technologies and artificial intelligence. The challenges presented during the event are bound to get the reader thinking about what may lie ahead in our future. (shrink)

Teacher morality is a comprehensive term that includes cognitive (e.g., moral cognitions), emotional (e.g., moral emotions), behavioral (e.g., moral behaviors), and causal (e.g., moral reasons) asp...