Rafael Malach is currently a professor in the department of Neurobiology at the Weizmann Institute in Israel. His current research is aimed at understanding how the neuronal circuitry in the human brain translates a stream of sensory stimuli into meaningful perception. Rafael Malach received his PhD in physiological optics from UC Berkeley and did his post-doctorate research at MIT. Originally doing research on the organization of neuronal connections in the primate brain, his focus has recently shifted to the study of (...) the human cerebral cortex using fMRI. Professor Malach has begun this research at Massachusetts General Hospital, exploring a new object-related region called the lateral occipital complex. Since then he expanded this research, studying the human visual cortex using a variety of methods, including adaptation paradigms, backward masking, and more recently naturalistic stimuli--all aimed at deciphering the intriguing link between perceptual experience and brain activity. (shrink)

In this paper we propose substructural propositional logic obtained by da Costa weakening of the intuitionistic negation. We show that the positive fragment of the da Costa system is distributive lattice logic, and we apply a kind of da Costa weakening of negation, by preserving, differently from da Costa, its fundamental properties: antitonicity, inversion, and additivity for distributive lattices. The other stronger paraconsistent logic with constructive negation is obtained by adding an axiom for multiplicative property of weak negation. After that, (...) we define Kripke-style semantics based on possible worlds and derive from it many-valued semantics based on truth-functional valuations for these two paraconsistent logics. Finally, we demonstrate that this model-theoretic inference system is adequate—sound and complete with respect to the axiomatic da Costa-like systems for these two logics. (shrink)

In this paper we consider the class of truth-functional modal many-valued logics with the complete lattice of truth-values. The conjunction and disjunction logic operators correspond to the meet and join operators of the lattices, while the negation is independently introduced as a hierarchy of antitonic operators which invert bottom and top elements. The non-constructive logic implication will be defined for a subclass of modular lattices, while the constructive implication for distributive lattices is based on relative pseudo-complements as in intuitionistic logic. (...) We show that the complete lattices are intrinsically modal, with banal identity modal operator. We define the autoreferential set-based representation for the class of modal algebras, and show that the autoreferential Kripke-style semantics for this class of modal algebras is based on the set of possible worlds equal to the complete lattice of algebraic truth-values. The philosophical assumption is based on the consideration that each possible world represents a level of credibility, so that only propositions with the right logic value can be accepted by this world, then we connect it with paraconsistent properties and LFI logics. The bottom truth value in this complete lattice corresponds to the trivial world in which each formula is satisfied, that is, to the world with explosive inconsistency. The top truth value corresponds to the world with classical logics, while all intermediate possible worlds represent the different levels of paraconsistent logics. (shrink)

The great variety of meditation techniques found in different contemplative traditions presents a challenge when attempting to create taxonomies based on the constructs of contemporary cognitive sciences. In the current issue of Consciousness and Cognition, Travis and Shear add ‘automatic self-transcending’ to the previously proposed categories of ‘focused attention’ and ‘open monitoring’, and suggest characteristic EEG bands as the defining criteria for each of the three categories. Accuracy of current taxonomies and potential limitations of EEG measurements as classifying criteria are (...) discussed. (shrink)

Development of biopharmaceuticals is a challenging issue in bioethics. Unlike conventional, small molecular weight drugs, biopharmaceuticals are proteins derived from DNA technology and hybrid techniques with complex three dimensional structures. Immunogenicity of biopharmaceuticals should always be tested in clinical settings due to low predictive value of preclinical animal models. However, non-human primates and transgenic mice could be used to address certain aspects of immunogenicity. Substantial efforts have been made to reduce NHP use in biopharmaceutical drug development, e.g. study design improvements (...) and changes in regulatory policy. In addition, several expert groups are active in this field. Despite that, there is an increasing trend of use of NHP in preclinical safety testing of biopharmaceuticals, especially regarding monoclonal antibodies. Other potential bioethical issues related biopharmaceutical drug development are their cost/effectiveness ratio, clinical safety assessment, production of biosimilars, and comparison of their efficacy with placebo in countries without intention to market. Identification of the human genome has opened many new bioethical issues. Development of biopharmaceuticals is an important bioethical issue for several reasons. It connects all aspects of contemporary bioethics: bio?medicine, animal welfare and the most recent ad?vances in biotechnology. In particular, biopharmaceutical drug development is a challenging issue regarding treatment of rare diseases. Razvoj biofarmaceutika predstavlja izazov u bioetici. Za razliku od uobicajenih lekova male molekulske mase, biofarmaceutici su proteini kompleksne trodimenzionalne strukture koji se dobijaju tehnologijom rekombinantne DNK i tehnikom hibridoma. Imunogenost biofarmaceutika treba uvek proveriti u klinickim studijama zbog male prediktivne prednosti pretklinickih animalnih modela. Medjutim, primati i transgeni sojevi miseva mogu se upotrebiti da bi se naznacili neki aspekti imunogenosti. Znacajni napori su ucinjeni u cilju smanjenja upotrebe primata u razvoju biofarmaceutika, npr. poboljsanja dizajna istrazivanja i promene u zakonskoj regulativi. Osim toga, u ovoj oblasti su aktivne i pojedine ekspertske grupe. Uprkos tome, postoji rastuci trend upotrebe primata izuzev coveka u pretklinickom ispitivanju bezbednosti biofarmaceutika, posebno kada su u pitanju monoklonska antitela. Druga bioeticka pitanja koja se mogu dovesti u vezu sa razvojem biofarmaceutika su odnos njihove cene i efikasnosti, procena bezbednosti u klinickim uslovima, proizvodnja bioloski slicnih lekova i uporedjivanje njihove efikasnosti sa placebom u zemljama u kojima ne postoji namera o plasmanu. Upoznavanje humanog genoma otvorilo je mnoga bioeticka pitanja. Razvoj biofarmaceutika je vazno bioeticko pitanje iz vise razloga. Ono povezuje sve aspekte savremene bioetike: biomedicinu, dobrobit zivotinja i najnovija dostignuca u biotehnologiji. Posebno, razvoj biofarmaceutika je izazov kada je u pitanju lecenje retkih bolesti. (shrink)

Publication date: 2 May 2019 Source: Author: Zoran Mastilo Aim of this paper is to, by means of comparative analysis, demonstrate that contemporary pension systems are limitation factors of development of the Republic of Srpska, and that they should be reformed and improved. Ultimately, pension systems should be the basis for development of the Republic of Srpska. They should significantly improve strengthening of financial markets, enhancement of capital markets, higher growth rates of the Republic of Srpska, idecrease of unemployment. (...) Private pension funds are to change the habits and ideas of every future insurance holder, aiming to make the pension rights a matter of concern of every individual, instead being the obligation and ballast of the society. Today, stabile financing of pension systems and their funds is becoming increasingly questionable. A gap is emerging between the area of rights gained by law and financial possibilities for their implementation. Pay-as-you-go systems, i.e. systems of inter-generation solidarityare particularly endangered. Adequate systematization of gathered data, i.e. evidence, should provide conclusions that pension systems are a limitation todevelopment of national economy. This claim is present in underdeveloped and developing countries, with developed economies also facing grave problems. (shrink)

Publication date: 28 April 2021 Source: International Letters of Social and Humanistic Sciences Vol. 90 Author: Zoran Mastilo, Nenad Božović, Dejan Mastilo The paper addresses and evaluates the currency board policy and assesses whether the currency board, as a form of monetary policy, is in the function of development of Bosnia and Herzegovina's national economy. In this context, a hypothesis that the currency board provides the foundation for growth and development of a transition economy is being put to the (...) test. To test the hypothesis, the paper compares the movement of economic growth indicators among the countries of South Eastern Europe with the primary focus on Bosnia and Herzegovina. By comparing the obtained results, as well as by applying the correlation and regression analysis, by means of simple linear regression, it is proven that the currency board does not represent an obstacle to economic growth, but is the basis for establishing the stability of the economy and the basis for sustainable growth and development able to adequately respond to shocks. (shrink)

Since in Heyting Arithmetic all atomic formulas are decidable, a Kripke model for HA may be regarded classically as a collection of classical structures for the language of arithmetic, partially ordered by the submodel relation. The obvious question is then: are these classical structures models of Peano Arithmetic ? And dually: if a collection of models of PA, partially ordered by the submodel relation, is regarded as a Kripke model, is it a model of HA? Some partial answers to these (...) questions were obtained in [6], [3], [1] and [2]. Here we present some results in the same direction, announced in [7]. In particular, it is proved that the classical structures at the nodes of a Kripke model of HA must be models of IΔ1 and that the relation between these classical structures must be that of a Δ1-elementary submodel. MSC: 03F30, 03F55. (shrink)

Razvoj biofarmaceutika predstavlja izazov u bioetici. Za razliku od uobicajenih lekova male molekulske mase, biofarmaceutici su proteini kompleksne trodimenzionalne strukture koji se dobijaju tehnologijom rekombinantne DNK i tehnikom hibridoma. Imunogenost biofarmaceutika treba uvek proveriti u klinickim studijama zbog male prediktivne prednosti pretklinickih animalnih modela. Medjutim, primati i transgeni sojevi miseva mogu se upotrebiti da bi se naznacili neki aspekti imunogenosti. Znacajni napori su ucinjeni u cilju smanjenja upotrebe primata u razvoju biofarmaceutika, npr. poboljsanja dizajna istrazivanja i promene u zakonskoj regulativi. (...) Osim toga, u ovoj oblasti su aktivne i pojedine ekspertske grupe. Uprkos tome, postoji rastuci trend upotrebe primata izuzev coveka u pretklinickom ispitivanju bezbednosti biofarmaceutika, posebno kada su u pitanju monoklonska antitela. Druga bioeticka pitanja koja se mogu dovesti u vezu sa razvojem biofarmaceutika su odnos njihove cene i efikasnosti, procena bezbednosti u klinickim uslovima, proizvodnja bioloski slicnih lekova i uporedjivanje njihove efikasnosti sa placebom u zemljama u kojima ne postoji namera o plasmanu. Upoznavanje humanog genoma otvorilo je mnoga bioeticka pitanja. Razvoj biofarmaceutika je vazno bioeticko pitanje iz vise razloga. Ono povezuje sve aspekte savremene bioetike: biomedicinu, dobrobit zivotinja i najnovija dostignuca u biotehnologiji. Posebno, razvoj biofarmaceutika je izazov kada je u pitanju lecenje retkih bolesti. (shrink)

. A paraconsistent logic is a logical system that attempts to deal with contradictions in a discriminating way. In an earlier paper [Notre Dame J. Form. Log. 49, 401–424], we developed the systems of weakening of intuitionistic negation logic, called and, in the spirit of da Costa's approach by preserving, differently from da Costa, the fundamental properties of negation: antitonicity, inversion and additivity for distributive lattices. Taking into account these results, we make some observations on the modified systems of and, (...) and their paraconsistent properties. (shrink)

It is argued that the so-called “absolute space-time theory” is inconsistent, in disagreement with some astronomical observations, and improperly titled.

It is proved that MacLane''s coherence results for monoidal and symmetric monoidal categories can be extended to some other categories with multiplication; namely, to relevant, affine and cartesian categories. All results are formulated in terms of natural transformations equipped with graphs (g-natural transformations) and corresponding morphism theorems are given as consequences. Using these results, some basic relations between the free categories of these classes are obtained.

Let us imagine an actor on stage presenting an impersonation of a certain politician, his manners and his body language. Now, suppose another actor sitting in the audience, impressed by the show and deciding to adopt something of his colleague’s style. He rents another stage and presents an impersonation of the same politician according to what he has learned. What does he actually do? In a certain sense he “imitates” the politician, but in another sense he “imitates” the first actor, (...) whose theatrical style he has adopted.These of course are two entirely different activities, but language marks them both as “imitation.” This lack of differentiation is not a caprice of a particular language; even languages that.. (shrink)

U svetu arhajskog čoveka -- Kožev--"posthumni" mislilac -- Žan Delimo ili apologija pesimizma -- Pitanje tragedije.

The paper offers a formalization of reasoning about distributed multi-agent systems. The presented propositional probabilistic temporal epistemic logic |$\textbf {PTEL}$| is developed in full detail: syntax, semantics, soundness and strong completeness theorems. As an example, we prove consistency of the blockchain protocol with respect to the given set of axioms expressed in the formal language of the logic. We explain how to extend |$\textbf {PTEL}$| to axiomatize the corresponding first-order logic.

This project draft discusses the issues facing a nation state in the dynamic processes of globalization. First, the term globalization is tentatively defined as a decentralized process of condensation and homogenization of space and time. Then, the ambivalent structure of the globalization discourse, i.e. its semantic and pragmatic dimensions, are shown. The neo-liberal viewpoint is explored of the erosion and weakening of the nation state within the global capitalist power, both in terms of its traditional functions, and in terms of (...) its internal and external sovereignty. Against the neo-liberal thesis about the decline of the nation state many empirical arguments have been offered. Some of these are presented in this text. The main point of this argumentation consists in a general view that the decline of the nation state is strongly linked with the process of globalization. In view of the critical argumentation included in the paper, it is argued that in the environment of global processes only the societies which have a strong state behind them have a chance to succeed. Politics, not economy, still dominates international relations. Emphasis on state politics opens a new perspective in discussing the process of globalization. Current globalization processes cannot be judged accurately unless geopolitical interests and the changing balance of world power are understood. Finally, the paper points to the ideological nature of the neo-liberal discourse of globalization, questioning another basic assumption of the latter, namely, the idea that the process of globalization is at the same time a process of emancipation. By challenging the positing of a necessary link between globalization and emancipation we formulate a position that allows for a normative critique of current processes. U nacrtu ovog projekta raspravlja se o izazovima pred kojim se nalazi nacionalna drzava u dinamicnim procesima globalizacije. Prvo se nastoji odrediti pojam globalizacije kao decentralizovani proces kondenzacije i homogenizacije prostora i vremena a zatim se ukazuje na ambivalentnu strukturu diskursa o globalizaciji - njegovu semanticku i pragmaticku dimenziju. Potom se izlaze neoliberalno glediste o eroziji i slabljenju nacionalne drzave usled premoci globalnog kapitalistickog pogona, kako u pogledu njenih tradicionalnih funkcija tako i u pogledu njenog internog i eksternog suvereniteta. Protiv neoliberalne teze o eroziji nacionalne drzave izneseni su mnogi uglavnom empirijski argumenti. Neki od njih su prezentovani u ovom tekstu. Poenta ove argumentacije sastoji se u generalnom stavu da izmedju erozije nacionalne drzave i procesa globalizacije ne postoji jaka veza. U skladu sa prezentovanom kritickom argumentacijom tvrdi se da u uslovima globalizacionih procesa samo ona drustva iza kojih stoji jaka i stabilna drzava imaju izglede na uspeh. Politika a ne ekonomija i dalje dominira medjunarodnim odnosima. Naglasavanje momenta drzavne politike otvara novu perspektivu u razmatranju procesa globalizacije. Tekuci globalizacioni procesi ne mogu se razumeti nezavisno od geopolitickih interesa i promene balansa svetske moci. Tekst se zavrsava ukazivanjem na ideologicnost neoliberalnog diskursa o globalizaciji propitivanjem druge bazicne i nereflektovane pretpostavke ovog diskursa po kojoj su procesi globalizacije u isto vreme i procesi emancipacije. Osporavanjem nuzne veze izmedju globalizacije i emancipacije gradi se pozicija sa koje je moguca normativna kritika tekucih procesa. (shrink)

The author starts from the hypothesis that it is essential for the countries of the region to critically assess the synergy established between systemic, political corruption and a selectively weak,?devious? nature of the state. Moreover, the key dilemma is whether the expanded practice of political rent seeking supports the conclusion that the root of all corruption is in the very existence of the state - particularly in excessive, selective and deforming state interventions and benefits that create a fertile ground for (...) corruption? The author argues that the destructive combination of weak government and rampant political corruption is based on scattered state intervention, while also rule the parties cartel in the executive branch subordinate to parliament, the judiciary and the police. Corrupt exchange takes place with the absence of strong institutional framework and the precise rules of the political and electoral games, control of public finances and effective political and anti-monopoly legislation and practice included. Exit from the current situation can be seen in the realization of effective anti?corruption strategy that integrates preventive and repressive measures and activities and lead to the establishment of principles of good governance. (shrink)

Članak tematizira ulogu kompleksnog mišljenja u razvoju znanstvene spoznaje i mišljenja općenito. Po Vigotskom, kompleksno mišljenje je početna faza u ontogenezi, pa i filogenezi, ljudskog mišljenja i ono je u tom slijedu predpojmovno. Prema istom autoru, ono ima svoju unutarnju genezu koja započinje asocijativnim kompleksima, a završava pseudopojmovima. Kompleksno mišljenje je po svojoj bitifluidno, neograničeno i omogućuje prenošenje značenja. Smatramo da kompleksno mišljenje dolazi do izraza prije svega u uporabi metafora i analogija. Metafore i analogije imaju važnu eksplanatornu i ponekad (...) čak heurističku ulogu u znanstvenom mišljenju. Kompleksno mišljenje dolazi do izražaja na svim razinama i etapama razvoja znanstvenog mišljenja. Metafore mogu biti dijelom kompleksnog mišljenja kao dominantnog načina mišljenja ili u pojmovnoj strukturi kao pomoćni elementi objašnjenja. Analogije predstavljaju izvjesno strukturiranje kompleksnog i pojmovnogmišljenja.Članak tematizira ulogu kompleksnog mišljenja u razvoju znanstvene spoznaje i mišljenja općenito. Po Vigotskom, kompleksno mišljenje je početna faza u ontogenezi, pa i filogenezi, ljudskog mišljenja i ono je u tom slijedu predpojmovno. Prema istom autoru, ono ima svoju unutarnju genezu koja započinje asocijativnim kompleksima, a završava pseudopojmovima. Kompleksno mišljenje je po svojoj bitifluidno, neograničeno i omogućuje prenošenje značenja. Smatramo da kompleksno mišljenje dolazi do izraza prije svega u uporabi metafora i analogija. Metafore i analogije imaju važnu eksplanatornu i ponekad čak heurističku ulogu u znanstvenom mišljenju. Kompleksno mišljenje dolazi do izražaja na svim razinama i etapama razvoja znanstvenog mišljenja. Metafore mogu biti dijelom kompleksnog mišljenja kao dominantnog načina mišljenja ili u pojmovnoj strukturi kao pomoćni elementi objašnjenja. Analogije predstavljaju izvjesno strukturiranje kompleksnog i pojmovnogmišljenja. (shrink)

Raspravljamo o ulozi predpojmovnog kompleksnog mišljenja u znanstvenoj spoznaji i razvoju znanosti. Kompleksno mišljenje sa svom heterogenošću i imaginacijom omogućuje održavanje pojmovne strukture i reorganizaciju cjelokupnih teorijskih mreža, ali to “naplaćuje” latentnim prisustvom protuslovlja i nekonzistentnosti.Članak se nastavlja na našu analizu odnosa između kompleksnog i pojmovnog mišljenja u Aristotelovoj Fizici. Ako je kod Aristotela središnji kompleks pojam “mjesta”, kod Galileija je osnovni kompleks zbirka gibanja-stanja. Galilei još nema izrađenu potpunu pojmovnu strukturu mehanike pa možemo reći da je njegova teorijska osnova (...) uronjena u kompleksnu razinu, ali se oslanja na matematičku strukturu i eksperiment i time uspijeva formirati jednu stabilnu teorijsku organizaciju. Time dobiva osnovu za novu teorijsku sistematizaciju i za formiranje pojmovne strukture kakva je Newtonova. Možemo u izvjesnom smislu reći da je time kompleksno mišljenje u znanosti bilo podignuto na višu razinu i dovedeno u pred-paradigmično razdoblje.We discuss the role of the pre-conceptual complex thought in scientificknowledge and in the development of science. The heterogeneity and imagination of complex thought enables the preservation of the conceptual structure and helps reshape entire theoretical nets, however, its downside is reflected in its latent contradiction and inconsistency. This paper is a continuation of our analysis of the relationship between complex and conceptual thought in Aristotle’s Physics. If Aristotle’s central complex is the notion of “place”, then Galileo’s basic complex is the notion of “ movement”. Since Galileo didn’t have an elaborated conceptual structure of mechanics, we can say that his theoretical basis is “steeped” in the level of complex thought, yet it relies on the mathematical structure and experiment, thereby creating a stable theoretical organization which serves as a basis for the new theoretical systematization and for the shaping of a conceptual structure as Newton’s. Thus, we may claim that, in a certain way, this change raised complex thought in science to a higher level, and brought it to a pre-paradigmatic period. (shrink)

The paper is on the role of complex thought in the development of thought and scientific knowledge. According to Vigotsky, the complex thought is the first phase in the ontogenesis and phylogenesis of human thought. It is in this sense pre-conceptual. Also, according to Vigotsky, the complex thought has its internal genesis which begins with associative complexes and ends in pseudo-concepts. Complex also an explanatory role in scientific thought. Complex thought ppears on all levels and stages of the development of (...) scientific knowledge. Metaphors may appear in the complex thought as a dominant mode of thought or in the conceptual structure as the auxiliary in the explanation. Analogies present a certain structuration of the complex thought, which contributes to the creation of conceptual structure. The place of analogy is thus between a complex thought and conceptual thought. (shrink)

An extension of the notion of dinatural transformation is introduced in order to give a criterion for preservation of dinaturality under composition. An example of an application is given by proving that all bicartesian closed canonical transformations are dinatural. An alternative sequent system for intuitionistic propositional logic is introduced as a device, and a cut-elimination procedure is established for this system.

Raspravljamo o ulozi predpojmovnog kompleksnog mišljenja u znanstvenoj spoznaji i razvoju znanosti. Kompleksno mišljenje sa svom heterogenošću i imaginacijom omogućuje pojmovne strukture i reorganizaciju cjelokupnih teorijskih mreža, ali to 'naplaćuje' latentnim prisustvom protislovja i nekonzistentnosti. Galilei još nema izrađenu potpunu pojmovnu shemu mehanike, pa možemo reći da je njegove teorijska osnova uronjena u kompleksnu razinu, ali se oslanja na matematičku strukturu i eksperiment i time uspjeva formirati jednu stabilnu teorijsku organizaciju. Možemo u izvesnom smislu reći da je time kompleksno mišljenje (...) u znanosti bilo podignuto na višu razinu i dovedeno u pred-paradigmatično razdoblje. (shrink)