The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)
Contributing to the emerging religion and development literature, this study sets out to analyse the role of faith in the context of a particular development approach, 'Use Your Talents' at the Malagasy Lutheran Church in Madagascar. By analysing the views of lay Christian informants with regard to their involvement in the UYT project, the study asked what is the role of faith as an intangible asset in an asset-based community development project? The qualitative data were collected through participant observations and (...) interviews conducted in four congregations across Madagascar in 2018. The results showed that church teachings and biblical stories created a normativity of good and desirable behaviour in the context of the asset-based community development project. Faith may constitute an asset when it promoted the individual's capacity to achieve positive economic and social change.CONTRIBUTION: This research broadened the understanding of religion in the context of asset-based community development projects. The results showed that the participants attributed their engagement in community development to their religious calling. The belief in the existence of a higher power not only seemed to influence individuals to act but also enabled them to feel empowered and have something to contribute. As a contribution to sociology of religion, this study showed that community development can be part of Christians' and congregational holistic activities that depended on local knowledge and resources. Faith not only motivated individuals to engage in community development, but also it seemed to represent the essence of their engagement. (shrink)
This new translation of the first Critique forms part of a fifteen-volume English-language edition of the works of Immanuel Kant under the general editorship of this volume’s editor-translators, Paul Guyer and Allen Wood. The edition, which is almost complete by now, comprises all of Kant’s published works along with extensive selections from his literary remains, his correspondence, and student transcripts of his lecture courses in metaphysics, ethics, logic, and anthropology. The Cambridge edition aims at a consistent English rendition of Kant’s (...) works, both within a given volume and across volumes. In terms of scope and detail, the Cambridge edition is unrivaled in any language, except for the authoritative Academy edition begun under the directorship of Wilhelm Dilthey in 1900, which, however, is still not completed and several volumes of which are in serious need of re-editing. In one case, that of the Opus postumum, the best edition currently available seems to be the one in the Cambridge edition. (shrink)
The topic of this seminar will be the notion of language as it is employed in the philosophy of language. The seminar will be divided into two parts, of somewhat unequal length. The first part will be devoted to the change in the conception of language that marked the transition from structural linguistics to generative linguistics (the so-called "Chomskian revolution"). We will approach this not only as a chapter in the philosophy of language, but also as an important chapter in (...) the philosophy of science, in large part because much of the discussion centers around to what extent, and how, the study of language can be understood as a scientific inquiry, continuous with the other natural sciences. From this discussion, which will be devoted to reading some of the classic literature from the mid-50's to the mid-70's (largely by Chomsky), an articulation of the subject matter of the study of language will emerge, and in particular this will involve an articulation of the relation of syntax, semantics and pragmatics. This will lead us to explore, in the second part of the seminar, the most influential work, that of Grice, especially in "Logic and Conversation" devoted to articulating this distinction. (shrink)
In this critical notice of Gerald Gaus's The Order of Public Reason, I reject two arguments Gaus advances for the claim that social moral rules must be publicly justified.
Descartes's greatest glory was to be the first to articulate, and systematically to defend, the new scientific ideal of explanation in terms of lawfulness. For the realm of matter, lawful connections replaced anthropomorphic volitions as the model of rational explanation. Descartes's use of explanation in terms of lawfulness, inspired by Galileo's beginnings in this enterprise, was vindicated by Newton's subsequent achievement. Replacement of anthropomorphic agency, by causal mechanism, as the explanatory model, was undoubtedly the most profound of the many effects (...) of the new science on our culture. (shrink)
Aristotle and Confucius are pivotal figures in world history; nevertheless, Western and Eastern cultures have in modern times largely abandoned the insights of these masters. Remastering Morals provides a book-length scholarly comparison of the ethics of Aristotle and Confucius. May Sim's comparisons offer fresh interpretations of the central teachings of both men. More than a catalog of similarities and differences, her study brings two great traditions into dialog so that each is able to learn from the other. This is essential (...) reading for anyone interested in virtue-oriented ethics. (shrink)
According to Kant, it is impermissible to treat humanity as a mere means. If we accept Kant's equation of humanity with rational agency, and are literalists about ascriptions of agency to collectives it appears to follow that we may not treat collectives as mere means. On most standard accounts of what it is to treat something as a means this conclusion seems highly implausible. I conclude that we are faced with a range of options. One would be to rethink the (...) equation of humanity with rationality. Another would be to abandon the prohibition on treating as a means. The last would be to abandon literalist construals of attribution of agency to collectives. (shrink)
Are individuals responsible for the consequences of actions taken by their community? What about their community's inaction or its attitudes? In this innovative book, Larry May departs from the traditional Western view that moral responsibility is limited to the consequences of overt individual action. Drawing on the insights of Arendt, Jaspers, and Sartre, he argues that even when individuals are not direct participants, they share responsibility for various harms perpetrated by their communities.
This book offers a readable and compelling introduction to the work of one of the twentieth century's most important and elusive thinkers. Other books have tried to explain Deleuze in general terms. Todd May organizes his book around a central question at the heart of Deleuze's philosophy: how might we live? The author then goes on to explain how Deleuze offers a view of the cosmos as a living thing that provides ways of conducting our lives that we may not (...) have dreamed of. Through this approach the full range of Deleuze's philosophy is covered. Offering a lucid account of a highly technical philosophy, Todd May's introduction will be widely read amongst those in philosophy, political science, cultural studies and French studies. (shrink)
