How vertebrates evolved different traits for acid excretion to maintain body fluid pH homeostasis is largely unknown. The evolution of Na+/H+ exchanger (NHE)‐mediated NH4+ excretion in fishes is reported, and the coevolution with increased ammoniagenesis and accompanying gluconeogenesis is speculated to benefit vertebrates in terms of both internal homeostasis and energy metabolism response to acidic stress. The findings provide new insights into our understanding of the possible adaptation of fishes to progressing global environmental acidification. In human kidney, titratable H+ and (...) NH4+ comprise the two main components of net acid excretion. V‐type H+‐ATPase‐mediated H+ excretion may have developed in stenohaline lampreys when they initially invaded freshwater from marine habitats, but this trait is lost in most fishes. Instead, increased reliance on NHE‐mediated NH4+ excretion is gradually developed and intensified during fish evolution. Further investigations on more species will be needed to support the hypothesis. Also see the video abstract here https://youtu.be/vZuObtfm-34. (shrink)

The Endosomal Sorting Complexes Required for Transport (ESCRTs) drive membrane remodeling in a variety of cellular processes that include the formation of endosomal intralumenal vesicles (ILVs) during multivesicular body (MVB) biogenesis. During MVB sorting, ESCRTs recognize ubiquitin (Ub) attached to membrane protein cargo and execute ILV formation by controlling the activities of ESCRT‐III polymers regulated by the AAA‐ATPase Vps4. Exactly how these events are coordinated to ensure proper cargo loading into ILVs remains unclear. Here we discuss recent work documenting the (...) ability of Bro1, an ESCRT‐associated Ub‐binding protein, to coordinate ESCRT‐III and Vps4‐dependent ILV biogenesis with upstream events such as cargo recognition. (shrink)

To do theology in the twenty-first century, we must understand Hegel. In this accessible introduction, Tseng examines the philosopher's significant influence on European thought in general and Protestant theology in particular.

Writing firmly in the Reformed tradition, Professor Shao Kai Tseng presents a reinterpretation and critical appreciation of Kant-whose complex philosophy gave rise to the secularization of modern society.

This book responds to the need to help Christians in Asia find a biblical response to pressures in the marketplace. It takes seriously both Scripture and the context Asian Christians function in. It contains a theological framework for grappling with real-time problems, responses from theologians, and actual case studies from the marketplace.

The current study aims to separate conscious and unconscious behaviors by employing both online and offline measures while the participants were consciously performing a task. Using an eye-movement tracking paradigm, we observed participants’ response patterns for distinguishing within-word-boundary and across-word-boundary reverse errors while reading Chinese sentences . The results showed that when the participants consciously detected errors, their gaze time for target words associated with across-word-boundary reverse errors was significantly longer than that for targets words associated with within-word-boundary reverse errors. (...) Surprisingly, the same gaze time pattern was found even when the readers were not consciously aware of the reverse errors. The results were statistically robust, providing converging evidence for the feasibility of our experimental paradigm in decoupling offline behaviors and the online, automatic, and unconscious aspects of cognitive processing in reading. (shrink)

Introduction -- The application of functional linguistics to film -- Cohesion in film -- Analysing action patterns in film -- Conclusion.

Offers a renovated form of Confucian liberalism that forges a reconciliation between the two extremes of anti-Confucian liberalism and anti-liberal Confucianism.

This paper investigates a first-order extension of GL called \. We outline briefly the history that led to \, its key properties and some of its toolbox: the \emph{conservation theorem}, its cut-free Gentzenisation, the ``formulators'' tool. Its semantic completeness is fully stated in the current paper and the proof is retold here. Applying the Solovay technique to those models the present paper establishes its main result, namely, that \ is arithmetically complete. As expanded below, \ is a first-order modal logic (...) that along with its built-in ability to simulate general classical first-order provability―"\" simulating the the informal classical "\"―is also arithmetically complete in the Solovay sense. (shrink)

Conscious visual perception can fail in many circumstances. However, little is known about the causes and processes leading to failures of visual awareness. In this study, we introduce a new signal detection measure termed subjective discriminability of invisibility that allows one to distinguish between subjective blindness due to reduction of sensory signals or to lack of attentional access to sensory signals. The SDI is computed based upon subjective confidence in reporting the absence of a target . Using this new measure, (...) we found that target misses were subjectively indistinguishable from physical absence when contrast reduction, backward masking and flash suppression were used, whereas confidence was appropriately modulated when dual task, attentional blink and spatial uncertainty methods were employed. These results show that failure of visual perception can be identified as either a result of perceptual or attentional blindness depending on the circumstances under which visual awareness was impaired. (shrink)